|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
1182-1794 |
9.19e-164 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 516.70 E-value: 9.19e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1182 DRQGVVELLYHLSIQLESDILPYVVFLIVPLLGRMSDSNEDIRKLATTTFASIIKLVPLEAGIAAPVGLSEELLRGREKE 1261
Cdd:COG0553 134 LLALLLVLLAALLLLLLLLLLLALLLGRLLLLALLLLALEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELEL 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1262 RDFIQQM---MDPSKAKPFKLPVAIKATLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASdqylrsedyk 1338
Cdd:COG0553 214 LAEAAVDafrLRRLREALESLPAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLE---------- 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1339 ktQSEKTRPLPSLIICPPSLTGHWEQEFQQYSPTLNVLVYAGgPSVRYPLQGQVPTADIVVTSYDVARNDVDFLKKYDYN 1418
Cdd:COG0553 284 --LKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDG-TRERAKGANPFEDADLVITSYGLLRRDIELLAAVDWD 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1419 YCVLDEGHIIKNSQSKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIassrnsktss 1498
Cdd:COG0553 361 LVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPI---------- 430
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1499 keQEAGALALEALHKQVLPFMLRRLKEEVLSDLPPKIIQDYYCELSDLQKQLYNDFVKKqknvVEKDIENTAEVENKQHI 1578
Cdd:COG0553 431 --EKGDEEALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYEAVLEY----LRRELEGAEGIRRRGLI 504
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1579 FQALQYMRKLCNHPSLVLNSSHPQfqqvqsylsqtgmdlhdIGHAPKLEALKTLLLECgigiqdvekksnknpsidnVIS 1658
Cdd:COG0553 505 LAALTRLRQICSHPALLLEEGAEL-----------------SGRSAKLEALLELLEEL-------------------LAE 548
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1659 QHRVLIFCQLKDMLDMVENDLLKKHLPSVTfmrLDGSVDSRDRQKVVRKFNEDPSIDCLLLTTKVGGLGLNLTGADTVIF 1738
Cdd:COG0553 549 GEKVLVFSQFTDTLDLLEERLEERGIEYAY---LHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIH 625
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 50310019 1739 VEHDWNPMNDLQAMDRAHRLGQKKVVNVYRIITKGTLEEKIMGLQKFKMNIASTIV 1794
Cdd:COG0553 626 YDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVL 681
|
|
| DUF3535 |
pfam12054 |
Domain of unknown function (DUF3535); This presumed domain is functionally uncharacterized. ... |
636-1073 |
2.33e-153 |
|
Domain of unknown function (DUF3535); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 439 to 459 amino acids in length. This domain is found associated with pfam00271, pfam02985, pfam00176. This domain has two completely conserved residues (P and K) that may be functionally important.
Pssm-ID: 463447 Cd Length: 445 Bit Score: 479.05 E-value: 2.33e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 636 VNSKGQEKSIDFVFSKYLTSILHLLITPIGEqgknyAMDIQHITKPSSSYLINLERKRSNATANSSNVTATY-----SHR 710
Cdd:pfam12054 6 LRSLKPPEALLHAFCPHLSPWLTLLMTPIGV-----PMDASLLLKPSGQPYSPPERRKSKKKEEPPPSDIPSpgrqgSSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 711 VNIDSPMLAGDVTLIGLDIIYNTRVKAAKTLGLTLSFFQESTLRSFFENVLASCLDLPYSTPRMLVAIVLSSFCTNWKEN 790
Cdd:pfam12054 81 HNVDKPMIGGDVTLVGMDVVIRTRIAAAKALGLLLSYWPEESPLDFFTKLLLPYLNSPSALQRLLAAIIIEEWAKNCKKE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 791 QqhNPVPAFMSTLFSSTFLGFLTGATTLPVFRELTPILKALRTQCQSLMTTFVDVGMLPPQRVPAIAIIVKGEPEAGPEA 870
Cdd:pfam12054 161 K--SSSVSTLPETLSEKLLEILENPSRPPYYRELVPYLTRLRTQCQQLLNTFRDVGKVSQSKLPKLAVVVQGEPEAGPGA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 871 FSIQTAEKVQTEFYAKLFSLLPNAQKILAQKPLEDARYRVSLAIESAKESERERQLEVLSSYASAVMLIDGLPNKLNPLI 950
Cdd:pfam12054 239 FSIEQAEKLVGEDYDKLKKSLSPKQKLLALQQLEDRRRRVQAAIEEAKEAKEQRDVRVLAAAAGALVALKGLPKKLNPII 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 951 RSLMDNVKSEKHTILQQTSGDSIVNLISELVSAQKHNVANKIVKNLCGFICVDTSEVPEF--DGTNTTVITTLVKEAASL 1028
Cdd:pfam12054 319 KPLMDSIKKEENEELQQRSADALAHLIDLCVDRGKPGPNDKIVKNLCTFLCVDTSETPEFhpNAKLTDGILTLRKEEDKA 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 50310019 1029 SLQEDSEMKKMTESARIKRKGGMHTLMKLLIKFQEKTLEVVPQLK 1073
Cdd:pfam12054 399 DHADAAKFEEEAKEARIQRRGAKLALEQLAKKFGASLFEKVPKLW 443
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
1287-1522 |
6.34e-139 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 430.62 E-value: 6.34e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASDQYLRSEDYKktqsekTRPLPSLIICPPSLTGHWEQEF 1366
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILASDHHKRANSFN------SENLPSLVVCPPTLVGHWVAEI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPT--LNVLVYAGGPSVRYPLQGQVPTADIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKAVKLINS 1444
Cdd:cd17999 75 KKYFPNafLKPLAYVGPPQERRRLREQGEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKA 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50310019 1445 NHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSRNSKTSSKEQEAGALALEALHKQVLPFMLRR 1522
Cdd:cd17999 155 NHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHKQVLPFLLRR 232
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
1283-1524 |
3.31e-93 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 300.64 E-value: 3.31e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1283 IKATLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASDQylrsedykktqsEKTRPLPSLIICPPSLTGHW 1362
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRK------------EEGRKGPSLVVAPTSLIYNW 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1363 EQEFQQYSPTLNVLVYAGGPSVRyPLQGQVPTADIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKAVKLI 1442
Cdd:cd18012 69 EEEAAKFAPELKVLVIHGTKRKR-EKLRALEDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKAL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1443 NSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSRNSKtsskeqeagalALEALHKQVLPFMLRR 1522
Cdd:cd18012 148 KADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGDEE-----------ALEELKKLISPFILRR 216
|
..
gi 50310019 1523 LK 1524
Cdd:cd18012 217 LK 218
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
1280-1780 |
1.47e-91 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 322.52 E-value: 1.47e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1280 PVAIKATLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdqYLrsEDYKKTQSektrplPSLIICPPSLT 1359
Cdd:PLN03142 163 PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLG---YL--HEYRGITG------PHMVVAPKSTL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1360 GHWEQEFQQYSPTLNVLVYAGGPSVRYPLQGQVPTA---DIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLA 1436
Cdd:PLN03142 232 GNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVAgkfDVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLS 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1437 KAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAkpiASSRNsktssKEQEagalALEALHKQVL 1516
Cdd:PLN03142 312 KTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQ---ISGEN-----DQQE----VVQQLHKVLR 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1517 PFMLRRLKEEVLSDLPPKIIQDYYCELSDLQKQLYndfvkkqKNVVEKDIE--NTAEvENKQHIFQALQyMRKLCNHPSL 1594
Cdd:PLN03142 380 PFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYY-------KALLQKDLDvvNAGG-ERKRLLNIAMQ-LRKCCNHPYL 450
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1595 vlnsshpqFQQVQSYLSQTGMDlHDIGHAPKLEALKTLLLECGigiqdvEKKSnknpsidnvisqhRVLIFCQLKDMLDM 1674
Cdd:PLN03142 451 --------FQGAEPGPPYTTGE-HLVENSGKMVLLDKLLPKLK------ERDS-------------RVLIFSQMTRLLDI 502
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1675 VENDLLKKHLPsvtFMRLDGSVDSRDRQKVVRKFNEDPSID-CLLLTTKVGGLGLNLTGADTVIFVEHDWNPMNDLQAMD 1753
Cdd:PLN03142 503 LEDYLMYRGYQ---YCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQD 579
|
490 500
....*....|....*....|....*..
gi 50310019 1754 RAHRLGQKKVVNVYRIITKGTLEEKIM 1780
Cdd:PLN03142 580 RAHRIGQKKEVQVFRFCTEYTIEEKVI 606
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
1290-1595 |
2.92e-79 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 263.78 E-value: 2.92e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1290 YQQDGVNWLAFL-NKYHLHGILCDDMGLGKTLQTICIIAsdqYLRSEDykktqseKTRPLPSLIICPPSLTGHWEQEFQQ 1368
Cdd:pfam00176 1 YQIEGVNWMLSLeNNLGRGGILADEMGLGKTLQTISLLL---YLKHVD-------KNWGGPTLIVVPLSLLHNWMNEFER 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1369 Y--SPTLNVLVYAGGPSVRYPL---QGQVPTADIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKAVKLIN 1443
Cdd:pfam00176 71 WvsPPALRVVVLHGNKRPQERWkndPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1444 SNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSRNSKTSSKeqeagalaleaLHKQVLPFMLRRL 1523
Cdd:pfam00176 151 TRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGVSR-----------LHKLLKPFLLRRT 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50310019 1524 KEEVLSDLPPKIIQDYYCELSDLQKQLYNDFVKKqknvVEKDIENTAEVENKQH--IFQALQYMRKLCNHPSLV 1595
Cdd:pfam00176 220 KKDVEKSLPPKVEYILFCRLSKLQRKLYQTFLLK----KDLNAIKTGEGGREIKasLLNILMRLRKICNHPGLI 289
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
1287-1474 |
1.33e-70 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 234.38 E-value: 1.33e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdqYLRSEdykktqseKTRPLPSLIICPPSLTGHWEQEF 1366
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLA---YLLKE--------GKERGPVLVVCPLSVLENWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLVYAGGPSVRYPLQGQ--VPTADIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKAVKLINS 1444
Cdd:cd17919 70 EKWTPDLRVVVYHGSQRERAQIRAKekLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRA 149
|
170 180 190
....*....|....*....|....*....|
gi 50310019 1445 NHRLVLTGTPIQNNVVELWSLFDFLMPGFL 1474
Cdd:cd17919 150 KRRLLLTGTPLQNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
1284-1524 |
8.04e-61 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 208.78 E-value: 8.04e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1284 KATLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdqYLRsedykktqsEKTRPLPSLIICPPSLTGHWE 1363
Cdd:cd18009 1 GGVMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLA---HLR---------ERGVWGPFLVIAPLSTLPNWV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1364 QEFQQYSPTLNVLVYAGGPSVR-------YPLQGQVPTADIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLA 1436
Cdd:cd18009 69 NEFARFTPSVPVLLYHGTKEERerlrkkiMKREGTLQDFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1437 KAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAkpiASSRNSKTSSKEQEAGALA---LEALHK 1513
Cdd:cd18009 149 QELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFD---FSSLSDNAADISNLSEEREqniVHMLHA 225
|
250
....*....|.
gi 50310019 1514 QVLPFMLRRLK 1524
Cdd:cd18009 226 ILKPFLLRRLK 236
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
1287-1522 |
4.59e-59 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 203.37 E-value: 4.59e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASdqYLRSEDYKKtqsektrplpSLIICPPSLTGHWEQEF 1366
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSG--MFDSGLIKS----------VLVVMPTSLIPHWVKEF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLVYAGG-PSVRYPLQGQVPTA-DIVVTSYDVARNDVDFLKKYD-----YNYCVLDEGHIIKNSQSKLAKAV 1439
Cdd:cd18001 69 AKWTPGLRVKVFHGTsKKERERNLERIQRGgGVLLTTYGMVLSNTEQLSADDhdefkWDYVILDEGHKIKNSKTKSAKSL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1440 KLINSNHRLVLTGTPIQNNVVELWSLFDFLMPG-FLGTEKMFQERFAKPIASSRNSKTSSKEQEAGALALEALHKQVLPF 1518
Cdd:cd18001 149 REIPAKNRIILTGTPIQNNLKELWALFDFACNGsLLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLRQIIKPY 228
|
....
gi 50310019 1519 MLRR 1522
Cdd:cd18001 229 FLRR 232
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
1286-1524 |
1.44e-56 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 196.44 E-value: 1.44e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1286 TLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdqYLRseDYKKTQSektrplPSLIICPPSLTGHWEQE 1365
Cdd:cd17996 3 TLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLIT---YLM--EKKKNNG------PYLVIVPLSTLSNWVSE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1366 FQQYSPTLNVLVYAGGPSVRYPLQGQVPTA--DIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKAVK-LI 1442
Cdd:cd17996 72 FEKWAPSVSKIVYKGTPDVRKKLQSQIRAGkfNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNtYY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1443 NSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSRNSKTSSKEQEAGALALEALHKQVLPFMLRR 1522
Cdd:cd17996 152 HARYRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTGEQVKIELNEEETLLIIRRLHKVLRPFLLRR 231
|
..
gi 50310019 1523 LK 1524
Cdd:cd17996 232 LK 233
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
1284-1524 |
2.93e-54 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 189.46 E-value: 2.93e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1284 KATLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdqYLRseDYKKTQSektrplPSLIICPPSLTGHWE 1363
Cdd:cd17997 1 GGTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLG---YLK--HYKNING------PHLIIVPKSTLDNWM 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1364 QEFQQYSPTLNVLVYAGGPSVRYP-LQGQVPTA--DIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKAVK 1440
Cdd:cd17997 70 REFKRWCPSLRVVVLIGDKEERADiIRDVLLPGkfDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1441 LINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFakpiassrNSKTSSKEQEAgalALEALHKQVLPFML 1520
Cdd:cd17997 150 LFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWF--------NVNNCDDDNQE---VVQRLHKVLRPFLL 218
|
....
gi 50310019 1521 RRLK 1524
Cdd:cd17997 219 RRIK 222
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
1622-1770 |
6.06e-53 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 181.91 E-value: 6.06e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1622 HAPKLEALKTLLLECgigiqdvekksnknpsidnVISQHRVLIFCQLKDMLDMVENDLLKKHlpsVTFMRLDGSVDSRDR 1701
Cdd:cd18793 9 VSGKLEALLELLEEL-------------------REPGEKVLIFSQFTDTLDILEEALRERG---IKYLRLDGSTSSKER 66
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50310019 1702 QKVVRKFNEDPSIDCLLLTTKVGGLGLNLTGADTVIFVEHDWNPMNDLQAMDRAHRLGQKKVVNVYRII 1770
Cdd:cd18793 67 QKLVDRFNEDPDIRVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
1287-1522 |
2.06e-52 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 183.99 E-value: 2.06e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFlNKYHLHG-ILCDDMGLGKTLQTICIIasdQYLRsedykktQSEKTRPlPSLIICPPSLTGHWEQE 1365
Cdd:cd17995 1 LRDYQLEGVNWLLF-NWYNRRNcILADEMGLGKTIQSIAFL---EHLY-------QVEGIRG-PFLVIAPLSTIPNWQRE 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1366 FQQYSpTLNVLVYAGGPSVR--------YPLQGQVPTA------DIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNS 1431
Cdd:cd17995 69 FETWT-DMNVVVYHGSGESRqiiqqyemYFKDAQGRKKkgvykfDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1432 QSKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFakpiassrnSKTSSKEQeagalaLEAL 1511
Cdd:cd17995 148 NSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF---------GDLKTAEQ------VEKL 212
|
250
....*....|.
gi 50310019 1512 HKQVLPFMLRR 1522
Cdd:cd17995 213 QALLKPYMLRR 223
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
1287-1522 |
2.89e-51 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 180.63 E-value: 2.89e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdqYLrsedykktQSEKTRPLPSLIICPPSLTGHWEQEF 1366
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLA---HL--------ACEKGNWGPHLIVVPTSVMLNWEMEF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLVYAGGPSVRYPL-QG--QVPTADIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKAVKLIN 1443
Cdd:cd18003 70 KRWCPGFKILTYYGSAKERKLKrQGwmKPNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFN 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50310019 1444 SNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIassrnSKTSSKEQEAGALALEALHKQVLPFMLRR 1522
Cdd:cd18003 150 TQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPL-----TAMSEGSQEENEELVRRLHKVLRPFLLRR 223
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
1286-1522 |
2.99e-51 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 180.63 E-value: 2.99e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1286 TLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdqYLRsedykktqseKTRPL--PSLIICPPSLTGHWE 1363
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLS---YLF----------HSQQQygPFLVVVPLSTMPAWQ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1364 QEFQQYSPTLNVLVYAGGPSVR--------YPLQGQVPTADIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKL 1435
Cdd:cd17993 68 REFAKWAPDMNVIVYLGDIKSRdtireyefYFSQTKKLKFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1436 AKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERfakpiassrnsktSSKEQEAGalaLEALHKQV 1515
Cdd:cd17993 148 YEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEE-------------HDEEQEKG---IADLHKEL 211
|
....*..
gi 50310019 1516 LPFMLRR 1522
Cdd:cd17993 212 EPFILRR 218
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
1287-1474 |
3.74e-50 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 176.36 E-value: 3.74e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASDQYlrsedykktqSEKTRPlPSLIICPPSLTGHWEQEF 1366
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHH----------SKLGLG-PSLIVCPATVLKQWVKEF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLV-YAGGPSVRYP------------LQGQVPTADIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQS 1433
Cdd:cd18000 70 HRWWPPFRVVVlHSSGSGTGSEeklgsierksqlIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDA 149
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 50310019 1434 KLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFL 1474
Cdd:cd18000 150 EITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFPPYL 190
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
1287-1522 |
5.65e-50 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 177.86 E-value: 5.65e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLaflnkYHLHGILCDDMGLGKTLQTICIIASDQYLRSEDYKKTQSEKTRPLP------SLIICPPSLTG 1360
Cdd:cd18008 1 LLPYQKQGLAWM-----LPRGGILADEMGLGKTIQALALILATRPQDPKIPEELEENSSDPKKlylsktTLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1361 HWEQEFQQY--SPTLNVLVYAGGPsvRYPLQGQVPTADIVVTSYDVARNDVDFLKKYDYNY----------------CVL 1422
Cdd:cd18008 76 QWKDEIEKHtkPGSLKVYVYHGSK--RIKSIEELSDYDIVITTYGTLASEFPKNKKGGGRDskekeasplhrirwyrVIL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1423 DEGHIIKNSQSKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSRNSktsskeqe 1502
Cdd:cd18008 154 DEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKNDRK-------- 225
|
250 260
....*....|....*....|
gi 50310019 1503 agalALEALHKQVLPFMLRR 1522
Cdd:cd18008 226 ----ALERLQALLKPILLRR 241
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
1287-1522 |
1.35e-49 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 176.80 E-value: 1.35e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAS---------DQYLRSEDYKKTQSEKTRPLPSLIICPPS 1357
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAvlgktgtrrDRENNRPRFKKKPPASSAKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1358 LTGHWEQEFQQYSpTLNVLVYAGG-----PSVRYPlQGQVptaDIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQ 1432
Cdd:cd18005 81 VLYNWKDELDTWG-HFEVGVYHGSrkddeLEGRLK-AGRL---EVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1433 SKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSRNSKTSSKEQEAGALALEALH 1512
Cdd:cd18005 156 SKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELA 235
|
250
....*....|
gi 50310019 1513 KQVLPFMLRR 1522
Cdd:cd18005 236 VKLSKFFLRR 245
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
1287-1471 |
4.75e-48 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 170.26 E-value: 4.75e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdqYLRsedykktqsEKTRPLPSLIICPPSLTGHWEQEF 1366
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLA---YLK---------EIGIPGPHLVVVPSSTLDNWLREF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLVYAGG----PSVRYPLQGQVPTADIVVTSYDVA---RNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKAV 1439
Cdd:cd17998 69 KRWCPSLKVEPYYGSqeerKHLRYDILKGLEDFDVIVTTYNLAtsnPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHL 148
|
170 180 190
....*....|....*....|....*....|..
gi 50310019 1440 KLINSNHRLVLTGTPIQNNVVELWSLFDFLMP 1471
Cdd:cd17998 149 MTINANFRLLLTGTPLQNNLLELMSLLNFIMP 180
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
1287-1522 |
1.65e-46 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 167.30 E-value: 1.65e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdqYLrsedykktQSEKTRPLPSLIICPPSLTGHWEQEF 1366
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLA---HL--------AEEHNIWGPFLVIAPASTLHNWQQEI 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLVYAGGPSVRYPL-----QGQVPTAD----IVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAK 1437
Cdd:cd18002 70 SRFVPQFKVLPYWGNPKDRKVLrkfwdRKNLYTRDapfhVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWK 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1438 AVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSRNSKTSSKEQEagalaLEALHKQVLP 1517
Cdd:cd18002 150 TLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGLNEHQ-----LKRLHMILKP 224
|
....*
gi 50310019 1518 FMLRR 1522
Cdd:cd18002 225 FMLRR 229
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
1287-1522 |
2.01e-45 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 164.77 E-value: 2.01e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWL----AFLNKYHLHG-ILCDDMGLGKTLQTICIIASdqYLRSEDYKKTQSEKtrplpSLIICPPSLTGH 1361
Cdd:cd18004 1 LRPHQREGVQFLydclTGRRGYGGGGaILADEMGLGKTLQAIALVWT--LLKQGPYGKPTAKK-----ALIVCPSSLVGN 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1362 WEQEFQQYSP--TLNVLVYAGGPSVRY---PLQGQVPTADIVVTSYDVARNDVD-FLKKYDYNYCVLDEGHIIKNSQSKL 1435
Cdd:cd18004 74 WKAEFDKWLGlrRIKVVTADGNAKDVKaslDFFSSASTYPVLIISYETLRRHAEkLSKKISIDLLICDEGHRLKNSESKT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1436 AKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSRNSKTSSKEQEAGALALEALHKQV 1515
Cdd:cd18004 154 TKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELT 233
|
....*..
gi 50310019 1516 LPFMLRR 1522
Cdd:cd18004 234 SRFILRR 240
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
1287-1522 |
1.32e-44 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 161.45 E-value: 1.32e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdqYLrsedyKKTQSEktrPLPSLIICPPSLTGHWEQEF 1366
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLW---YL-----AGRLKL---LGPFLVLCPLSVLDNWKEEL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLVYAGGPSVRYPLQGQV---PTADIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKAVKLIN 1443
Cdd:cd18006 70 NRFAPDLSVITYMGDKEKRLDLQQDIkstNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFS 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50310019 1444 SNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMfqERFAKpiassrnsktSSKEQEAGALALEALHKQVLPFMLRR 1522
Cdd:cd18006 150 VDFRLLLTGTPIQNSLQELYALLSFIEPNVFPKDKL--DDFIK----------AYSETDDESETVEELHLLLQPFLLRR 216
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
1287-1534 |
5.16e-42 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 155.21 E-value: 5.16e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASDQYLRSedykktqsektRPLPSLIICPPSLTGHWEQEF 1366
Cdd:cd18064 16 LRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRN-----------IPGPHMVLVPKSTLHNWMAEF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLVYAGGPSVRYPLQGQVPTA---DIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKAVKLIN 1443
Cdd:cd18064 85 KRWVPTLRAVCLIGDKDQRAAFVRDVLLPgewDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1444 SNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFakpiaSSRNSKTSSKeqeagalALEALHKQVLPFMLRRL 1523
Cdd:cd18064 165 TTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWF-----DTNNCLGDQK-------LVERLHMVLRPFLLRRI 232
|
250
....*....|.
gi 50310019 1524 KEEVLSDLPPK 1534
Cdd:cd18064 233 KADVEKSLPPK 243
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
1280-1524 |
6.88e-40 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 148.63 E-value: 6.88e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1280 PVAIKA-TLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASDQYLRSedykktqsektRPLPSLIICPPSL 1358
Cdd:cd18065 8 PSYVKGgTLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRN-----------IPGPHMVLVPKST 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1359 TGHWEQEFQQYSPTLNVLVYAGGPSVRYPLQGQVPTA---DIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKL 1435
Cdd:cd18065 77 LHNWMNEFKRWVPSLRAVCLIGDKDARAAFIRDVMMPgewDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1436 AKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFakpiassrNSKTSSKEQEagalALEALHKQV 1515
Cdd:cd18065 157 SEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWF--------DTKNCLGDQK----LVERLHAVL 224
|
....*....
gi 50310019 1516 LPFMLRRLK 1524
Cdd:cd18065 225 KPFLLRRIK 233
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
1283-1524 |
4.04e-39 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 147.13 E-value: 4.04e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1283 IKATLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdqYLRseDYKKTQSektrplPSLIICPPSLTGHW 1362
Cdd:cd18063 20 INGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALIT---YLM--EHKRLNG------PYLIIVPLSTLSNW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1363 EQEFQQYSPTLNVLVYAGGPSVRYPLQGQVPTA--DIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLakaVK 1440
Cdd:cd18063 89 TYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGkfNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKL---TQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1441 LINSNH----RLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSrNSKTSSKEQEAgALALEALHKQVL 1516
Cdd:cd18063 166 VLNTHYvaprRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT-GERVDLNEEET-ILIIRRLHKVLR 243
|
....*...
gi 50310019 1517 PFMLRRLK 1524
Cdd:cd18063 244 PFLLRRLK 251
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
1283-1524 |
6.10e-38 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 143.65 E-value: 6.10e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1283 IKATLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdqYLRseDYKKTQSektrplPSLIICPPSLTGHW 1362
Cdd:cd18062 20 VNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALIT---YLM--EHKRING------PFLIIVPLSTLSNW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1363 EQEFQQYSPTLNVLVYAGGPSVRYPLQGQVPTA--DIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLakaVK 1440
Cdd:cd18062 89 VYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGkfNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKL---TQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1441 LINSNH----RLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSrNSKTSSKEQEAgALALEALHKQVL 1516
Cdd:cd18062 166 VLNTHYvaprRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT-GEKVDLNEEET-ILIIRRLHKVLR 243
|
....*...
gi 50310019 1517 PFMLRRLK 1524
Cdd:cd18062 244 PFLLRRLK 251
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
1287-1522 |
1.29e-35 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 136.29 E-value: 1.29e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdqYLrsedYKKTQSEKtrplPSLIICPPSLTGHWEQEF 1366
Cdd:cd18054 21 LRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLS---YL----FHQHQLYG----PFLLVVPLSTLTSWQREF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLVYAGGPSVRYPL--------QGQVPTADIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKA 1438
Cdd:cd18054 90 EIWAPEINVVVYIGDLMSRNTIreyewihsQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1439 VKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAkpiassrnsktssKEQEAGalaLEALHKQVLPF 1518
Cdd:cd18054 170 LIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHG-------------KGRENG---YQSLHKVLEPF 233
|
....
gi 50310019 1519 MLRR 1522
Cdd:cd18054 234 LLRR 237
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
1287-1522 |
1.81e-34 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 131.94 E-value: 1.81e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNW-LAFLNKyhlhGILCDDMGLGKTLQTICIIAsdqYLRSEdykktqsektrpLPSLIICPPSLTGHWEQE 1365
Cdd:cd18010 1 LLPFQREGVCFaLRRGGR----VLIADEMGLGKTVQAIAIAA---YYREE------------WPLLIVCPSSLRLTWADE 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1366 FQQYSPTL---NVLVYAGGPSVRYPLQGQvptadIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKAVKLI 1442
Cdd:cd18010 62 IERWLPSLppdDIQVIVKSKDGLRDGDAK-----VVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPL 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1443 --NSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSRNSKTSskeqeaGALALEALHKQVLP-FM 1519
Cdd:cd18010 137 lkRAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRRYCAAKQGGFGWDYS------GSSNLEELHLLLLAtIM 210
|
...
gi 50310019 1520 LRR 1522
Cdd:cd18010 211 IRR 213
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
1308-1522 |
2.60e-34 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 132.59 E-value: 2.60e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1308 GILCDDMGLGKTLQTICIIASDqylrsedykktqsektrplPSLIICPPSLTGHWEQEFQQY--SPTLNVLVYAGGPSVR 1385
Cdd:cd18071 51 GILADDMGLGKTLTTISLILAN-------------------FTLIVCPLSVLSNWETQFEEHvkPGQLKVYTYHGGERNR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1386 YP--LQGQvptaDIVVTSYDVARNDVDF-----LKKYDYNYCVLDEGHIIKNSQSKLAKAVKLINSNHRLVLTGTPIQNN 1458
Cdd:cd18071 112 DPklLSKY----DIVLTTYNTLASDFGAkgdspLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNS 187
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50310019 1459 VVELWSLFDFLMPGFLGTEKMFQERFAKPIasSRNSKTSSKEqeagalaLEALHKQVLpfmLRR 1522
Cdd:cd18071 188 PKDLGSLLSFLHLKPFSNPEYWRRLIQRPL--TMGDPTGLKR-------LQVLMKQIT---LRR 239
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
1287-1522 |
4.22e-34 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 132.21 E-value: 4.22e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWL----AFLNKYHLHG-ILCDDMGLGKTLQTICIIASdqYLRsedykktQSEKTRPL--PSLIICPPSLT 1359
Cdd:cd18067 1 LRPHQREGVKFLyrcvTGRRIRGSHGcIMADEMGLGKTLQCITLMWT--LLR-------QSPQCKPEidKAIVVSPSSLV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1360 GHWEQEFQQY-SPTLNVLVYAGGPS--------VRYPLQGQVPTADIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKN 1430
Cdd:cd18067 72 KNWANELGKWlGGRLQPLAIDGGSKkeidrklvQWASQQGRRVSTPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKN 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1431 SQSKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSRNSKTSSKEQEAGALALEA 1510
Cdd:cd18067 152 SDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQE 231
|
250
....*....|..
gi 50310019 1511 LHKQVLPFMLRR 1522
Cdd:cd18067 232 LISIVNRCIIRR 243
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
1271-1522 |
4.84e-34 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 131.71 E-value: 4.84e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1271 PSKAKPFKLPVAIKATLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIasdQYLRSEDYKKTqsektrplPS 1350
Cdd:cd18053 5 ALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFL---NYLFHEHQLYG--------PF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1351 LIICPPSLTGHWEQEFQQYSPTLNVLVYAGGPSVRYPL--------QGQVPTADIVVTSYDVARNDVDFLKKYDYNYCVL 1422
Cdd:cd18053 74 LLVVPLSTLTSWQREIQTWAPQMNAVVYLGDINSRNMIrthewmhpQTKRLKFNILLTTYEILLKDKSFLGGLNWAFIGV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1423 DEGHIIKNSQSKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKpiasSRNSKTSSkeqe 1502
Cdd:cd18053 154 DEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGK----GREYGYAS---- 225
|
250 260
....*....|....*....|
gi 50310019 1503 agalaleaLHKQVLPFMLRR 1522
Cdd:cd18053 226 --------LHKELEPFLLRR 237
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
1309-1488 |
1.22e-33 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 130.49 E-value: 1.22e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1309 ILCDDMGLGKTLQTICIIASdqYLRsedYKKTQSektRPlpsLIICPPSLTGHWEQEFQQYSP--TLNVLVYAGGPSVRY 1386
Cdd:cd18007 30 ILAHTMGLGKTLQVITFLHT--YLA---AAPRRS---RP---LVLCPASTLYNWEDEFKKWLPpdLRPLLVLVSLSASKR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1387 PLQGQVPTAD------IVVTSYD-----------VARNDVDFLKKYDYNYC---VLDEGHIIKNSQSKLAKAVKLINSNH 1446
Cdd:cd18007 99 ADARLRKINKwhkeggVLLIGYElfrnlasnattDPRLKQEFIAALLDPGPdllVLDEGHRLKNEKSQLSKALSKVKTKR 178
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 50310019 1447 RLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPI 1488
Cdd:cd18007 179 RILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPI 220
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
1287-1522 |
3.12e-33 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 127.94 E-value: 3.12e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASdqyLRSEDYKKTqsektrplPSLIICPPSLTGHWEQEF 1366
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYS---LYKEGHSKG--------PFLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLVYAGGpsvryplqgqvptaDIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKAVKLINSNH 1446
Cdd:cd17994 70 EMWAPDFYVVTYVGD--------------HVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGY 135
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50310019 1447 RLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKpiassrnsktSSKEQEagalaLEALHKQVLPFMLRR 1522
Cdd:cd17994 136 KLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFAD----------ISKEDQ-----IKKLHDLLGPHMLRR 196
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
1287-1522 |
2.49e-32 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 126.88 E-value: 2.49e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWL--AFLNKYHLHG---ILCDDMGLGKTLQTICIIASdqYLRSEDYKktqsekTRPL--PSLIICPPSLT 1359
Cdd:cd18066 1 LRPHQREGIEFLyeCVMGMRVNERfgaILADEMGLGKTLQCISLIWT--LLRQGPYG------GKPVikRALIVTPGSLV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1360 GHWEQEFQQYSPTLNVLVYAGGPSVRYPLQGQVPTADIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQSKLAKAV 1439
Cdd:cd18066 73 KNWKKEFQKWLGSERIKVFTVDQDHKVEEFIASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTAL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1440 KLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSRNSKTSSKEQEAGALALEALHKQVLPFM 1519
Cdd:cd18066 153 TSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARAAELTRLTGLFI 232
|
...
gi 50310019 1520 LRR 1522
Cdd:cd18066 233 LRR 235
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
1287-1522 |
2.40e-31 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 123.61 E-value: 2.40e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFlNKYHLHG-ILCDDMGLGKTLQTICIIaSDQYLRSEDYkktqsektrplPSLIICPPSLTGHWEQE 1365
Cdd:cd18058 1 LREYQLEGMNWLLF-NWYNRKNcILADEMGLGKTIQSITFL-SEIFLMGIRG-----------PFLIIAPLSTITNWERE 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1366 FQQYSpTLNVLVYAGGPSVRY---------------PLQGqVPTADIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKN 1430
Cdd:cd18058 68 FRTWT-EMNAIVYHGSQISRQmiqqyemyyrdeqgnPLSG-IFKFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKN 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1431 SQSKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAkpiassrnsKTSSKEQeagalaLEA 1510
Cdd:cd18058 146 RNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFG---------DLKTEEQ------VKK 210
|
250
....*....|..
gi 50310019 1511 LHKQVLPFMLRR 1522
Cdd:cd18058 211 LQSILKPMMLRR 222
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
1287-1522 |
4.48e-30 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 119.77 E-value: 4.48e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFlNKYHLHG-ILCDDMGLGKTLQTICIIasdqylrSEDYKKTQSEktrplPSLIICPPSLTGHWEQE 1365
Cdd:cd18060 1 LREYQLEGVNWLLF-NWYNRQNcILADEMGLGKTIQSIAFL-------QEVYNVGIHG-----PFLVIAPLSTITNWERE 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1366 FQQYSpTLNVLVYAGGPSVRYPLQGQ-----------VPTA---DIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNS 1431
Cdd:cd18060 68 FNTWT-EMNTIVYHGSLASRQMIQQYemyckdsrgrlIPGAykfDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNR 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1432 QSKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAkpiassrNSKTSSKEQEagalaLEAL 1511
Cdd:cd18060 147 NCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFG-------DLKTEEQVQK-----LQAI 214
|
250
....*....|.
gi 50310019 1512 HKqvlPFMLRR 1522
Cdd:cd18060 215 LK---PMMLRR 222
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
1287-1522 |
1.21e-29 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 118.60 E-value: 1.21e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFlNKYHLHG-ILCDDMGLGKTLQTICIIaSDQYLRSEDYkktqsektrplPSLIICPPSLTGHWEQE 1365
Cdd:cd18059 1 LREYQLEGVNWLLF-NWYNTRNcILADEMGLGKTIQSITFL-YEIYLKGIHG-----------PFLVIAPLSTIPNWERE 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1366 FQQYSpTLNVLVYAGGPSVRYPLQ----------GQVPTADI----VVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNS 1431
Cdd:cd18059 68 FRTWT-ELNVVVYHGSQASRRTIQlyemyfkdpqGRVIKGSYkfhaIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNR 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1432 QSKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAkpiassrNSKTSSKEQEagalaLEAL 1511
Cdd:cd18059 147 NCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFG-------DLKTEEQVQK-----LQAI 214
|
250
....*....|.
gi 50310019 1512 HKqvlPFMLRR 1522
Cdd:cd18059 215 LK---PMMLRR 222
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
1287-1471 |
1.67e-29 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 119.37 E-value: 1.67e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNkyhlhGILCDDMGLGKTLQTICIIAS---------DQYL--RSEDYKKTQSEKTRPL---PSLI 1352
Cdd:cd18070 1 LLPYQRRAVNWMLVPG-----GILADEMGLGKTVEVLALILLhprpdndldAADDdsDEMVCCPDCLVAETPVsskATLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1353 ICPPSLTGHWEQEFQQ-YSPTLNVLVYAGGPSVRYpLQGQVP----TADIVVTSYDVARNDVDF------------LKKY 1415
Cdd:cd18070 76 VCPSAILAQWLDEINRhVPSSLKVLTYQGVKKDGA-LASPAPeilaEYDIVVTTYDVLRTELHYaeanrsnrrrrrQKRY 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50310019 1416 ----------DYNYCVLDEGHIIKNSQSKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMP 1471
Cdd:cd18070 155 eappsplvlvEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGV 220
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
1287-1522 |
1.18e-28 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 116.26 E-value: 1.18e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASdqyLRSEDYKKTqsektrplPSLIICPPSLTGHWEQEF 1366
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYS---LYKEGHTKG--------PFLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLVYAGGPSVR---------------------YPLQGQVPTA-DIVVTSYDVARNDVDFLKKYDYNYCVLDE 1424
Cdd:cd18055 70 QMWAPDFYVVTYTGDKDSRaiirenefsfddnavkggkkaFKMKREAQVKfHVLLTSYELVTIDQAALGSIRWACLVVDE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1425 GHIIKNSQSKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKpiassrnsktSSKEQEag 1504
Cdd:cd18055 150 AHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFAD----------ISKEDQ-- 217
|
250
....*....|....*...
gi 50310019 1505 alaLEALHKQVLPFMLRR 1522
Cdd:cd18055 218 ---IKKLHDLLGPHMLRR 232
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
1287-1522 |
1.56e-27 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 112.41 E-value: 1.56e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIasdqylrsEDYKKTQSEKtrplPSLIICPPSLTGHWEQEF 1366
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFL--------YEILLTGIRG----PFLIIAPLSTIANWEREF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSpTLNVLVYAGGPSVRYPLQ----------GQVPTA----DIVVTSYDVARNDVDFLKKYDYNYCVLDEGHIIKNSQ 1432
Cdd:cd18061 69 RTWT-DLNVVVYHGSLISRQMIQqyemyfrdsqGRIIRGayrfQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKN 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1433 SKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAkpiassrNSKTSSKEQEagalaLEALH 1512
Cdd:cd18061 148 CKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFG-------DLKTEEQVQK-----LQAIL 215
|
250
....*....|
gi 50310019 1513 KqvlPFMLRR 1522
Cdd:cd18061 216 K---PMMLRR 222
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
1287-1469 |
3.65e-27 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 112.19 E-value: 3.65e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFL-NKYHLHGILCDDMGLGKTLQTICIIASDQYLR-----------SEDYKKTQSEKTRPLPSLIIC 1354
Cdd:cd18072 1 LLLHQKQALAWLLWReRQKPRGGILADDMGLGKTLTMIALILAQKNTQnrkeeekekalTEWESKKDSTLVPSAGTLVVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1355 PPSLTGHWEQEFQQY--SPTLNVLVYAGgPSvRYPLQGQVPTADIVVTSYDVARNDVDFLKKYD---------YNYCVLD 1423
Cdd:cd18072 81 PASLVHQWKNEVESRvaSNKLRVCLYHG-PN-RERIGEVLRDYDIVITTYSLVAKEIPTYKEESrssplfriaWARIILD 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 50310019 1424 EGHIIKNSQSKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFL 1469
Cdd:cd18072 159 EAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFL 204
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
1287-1522 |
1.06e-26 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 110.54 E-value: 1.06e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASDqylrsedYKKTQSEKtrplPSLIICPPSLTGHWEQEF 1366
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSL-------YKEGHSKG----PFLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLVYAGGPSVRYPL-QGQVPTAD---------------------IVVTSYDVARNDVDFLKKYDYNYCVLDE 1424
Cdd:cd18056 70 EMWAPDMYVVTYVGDKDSRAIIrENEFSFEDnairggkkasrmkkeasvkfhVLLTSYELITIDMAILGSIDWACLIVDE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1425 GHIIKNSQSKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKpiassrnsktSSKEQEag 1504
Cdd:cd18056 150 AHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFAD----------IAKEDQ-- 217
|
250
....*....|....*...
gi 50310019 1505 alaLEALHKQVLPFMLRR 1522
Cdd:cd18056 218 ---IKKLHDMLGPHMLRR 232
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
1287-1522 |
5.19e-26 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 108.61 E-value: 5.19e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASDqylrsedYKKTQSEKtrplPSLIICPPSLTGHWEQEF 1366
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSL-------YKEGHSKG----PYLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLVYAGGPSVRYPL-QGQVPTAD---------------------IVVTSYDVARNDVDFLKKYDYNYCVLDE 1424
Cdd:cd18057 70 EMWAPDFYVVTYTGDKESRSVIrENEFSFEDnairsgkkvfrmkkeaqikfhVLLTSYELITIDQAILGSIEWACLVVDE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1425 GHIIKNSQSKLAKAVKLINSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKpiassrnsktSSKEQEag 1504
Cdd:cd18057 150 AHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFAD----------ISKEDQ-- 217
|
250
....*....|....*...
gi 50310019 1505 alaLEALHKQVLPFMLRR 1522
Cdd:cd18057 218 ---IKKLHDLLGPHMLRR 232
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
1309-1488 |
2.70e-25 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 106.05 E-value: 2.70e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1309 ILCDDMGLGKTLQTICIIasDQYLRSEDYKKTqsektrplpsLIICPPSLTGHWEQEFQQYSPTlnvlvYAGGPSVR--- 1385
Cdd:cd18069 32 ILAHSMGLGKTLQVISFL--DVLLRHTGAKTV----------LAIVPVNTLQNWLSEFNKWLPP-----PEALPNVRprp 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1386 ---YPLQGQVPTADI---VVTSYDvARNDVdFLKKYDY-------NYCVLDEGHIIKNSQSKLAKAVKLINSNHRLVLTG 1452
Cdd:cd18069 95 fkvFILNDEHKTTAArakVIEDWV-KDGGV-LLMGYEMfrlrpgpDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTG 172
|
170 180 190
....*....|....*....|....*....|....*.
gi 50310019 1453 TPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPI 1488
Cdd:cd18069 173 YPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPI 208
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
1286-1482 |
2.99e-24 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 102.18 E-value: 2.99e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1286 TLRKYQQDGVNWLAFLNKyhlHGILCDDMGLGKTLQTICIIAsdQYLRSEDYKKTqsektrplpsLIICP-PSLTGHWEQ 1364
Cdd:smart00487 8 PLRPYQKEAIEALLSGLR---DVILAAPTGSGKTLAALLPAL--EALKRGKGGRV----------LVLVPtRELAEQWAE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1365 EFQQYSP--TLNVLVYAGGPSVRYPLQGQV-PTADIVVTSYDVARNDV--DFLKKYDYNYCVLDEGHIIKNS--QSKLAK 1437
Cdd:smart00487 73 ELKKLGPslGLKVVGLYGGDSKREQLRKLEsGKTDILVTTPGRLLDLLenDKLSLSNVDLVILDEAHRLLDGgfGDQLEK 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 50310019 1438 AVKLINSN-HRLVLTGTP---IQNNVVELWSLFDFLMPGFLGTEKMFQE 1482
Cdd:smart00487 153 LLKLLPKNvQLLLLSATPpeeIENLLELFLNDPVFIDVGFTPLEPIEQF 201
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
1308-1500 |
4.62e-24 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 103.04 E-value: 4.62e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1308 GILCDDMGLGKTLQTICIIASdqYLRSEDYKKTQSektrplpSLIICPPSLTGHWEQEFQQYSPTLN---------VLVY 1378
Cdd:cd18068 31 CILAHCMGLGKTLQVVTFLHT--VLLCEKLENFSR-------VLVVCPLNTVLNWLNEFEKWQEGLKdeekievneLATY 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1379 AGGPSVRYPLQGQVPTADIVVTSYDVARN-----DVDFLKKY--DYN---------YCVLDEGHIIKNSQSKLAKAVKLI 1442
Cdd:cd18068 102 KRPQERSYKLQRWQEEGGVMIIGYDMYRIlaqerNVKSREKLkeIFNkalvdpgpdFVVCDEGHILKNEASAVSKAMNSI 181
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 50310019 1443 NSNHRLVLTGTPIQNNVVELWSLFDFLMPGFLGTEKMFQERFAKPIASSRNSKTSSKE 1500
Cdd:cd18068 182 RTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNGQCADSTLVD 239
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
1660-1759 |
4.30e-23 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 95.74 E-value: 4.30e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1660 HRVLIFCQLKDMLDMvenDLLKKHLpSVTFMRLDGSVDSRDRQKVVRKFNEDPSIdcLLLTTKVGGLGLNLTGADTVIFV 1739
Cdd:pfam00271 16 GKVLIFSQTKKTLEA---ELLLEKE-GIKVARLHGDLSQEEREEILEDFRKGKID--VLVATDVAERGLDLPDVDLVINY 89
|
90 100
....*....|....*....|
gi 50310019 1740 EHDWNPMNDLQAMDRAHRLG 1759
Cdd:pfam00271 90 DLPWNPASYIQRIGRAGRAG 109
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1678-1759 |
7.93e-19 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 82.64 E-value: 7.93e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1678 DLLKKHLPS--VTFMRLDGSVDSRDRQKVVRKFNEDPSidCLLLTTKVGGLGLNLTGADTVIFVEHDWNPMNDLQAMDRA 1755
Cdd:smart00490 1 EELAELLKElgIKVARLHGGLSQEEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 50310019 1756 HRLG 1759
Cdd:smart00490 79 GRAG 82
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
1287-1473 |
8.97e-18 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 83.88 E-value: 8.97e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVnwLAFLNKYHLHGILCDDMGLGKTLQTICIIAsdQYLRSEDYKKTqsektrplpsLIICPPSLTGHWEQEF 1366
Cdd:cd18011 1 PLPHQIDAV--LRALRKPPVRLLLADEVGLGKTIEAGLIIK--ELLLRGDAKRV----------LILCPASLVEQWQDEL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1367 QQYSPTLNVLVYAGGPSVRYPLQGQVPTA-DIVVTSYDVAR---NDVDFLKKYDYNYCVLDEGHIIKNSQ----SKLAKA 1438
Cdd:cd18011 67 QDKFGLPFLILDRETAAQLRRLIGNPFEEfPIVIVSLDLLKrseERRGLLLSEEWDLVVVDEAHKLRNSGggkeTKRYKL 146
|
170 180 190
....*....|....*....|....*....|....*..
gi 50310019 1439 VKLINSN--HRLVLTGTPIQNNVVELWSLFDFLMPGF 1473
Cdd:cd18011 147 GRLLAKRarHVLLLTATPHNGKEEDFRALLSLLDPGR 183
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
1287-1488 |
6.76e-10 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 61.21 E-value: 6.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1287 LRKYQQDGVNWLaflnKYHLHGILCDDMGLGKTLQTICIIasdQYLRSEDYKKtqsektrplPSLIICPPSLTGH-WEQE 1365
Cdd:cd18013 1 PHPYQKVAINFI----IEHPYCGLFLDMGLGKTVTTLTAL---SDLQLDDFTR---------RVLVIAPLRVARStWPDE 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1366 FQQYS--PTLNVLVYAGGPSVRYP-LQGQvptADIVVTSYDVARNDVD-FLKKYDYNYCVLDEGHIIKNSQSK----LAK 1437
Cdd:cd18013 65 VEKWNhlRNLTVSVAVGTERQRSKaANTP---ADLYVINRENLKWLVNkSGDPWPFDMVVIDELSSFKSPRSKrfkaLRK 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 50310019 1438 AVKLINsnhRLV-LTGTPIQNNVVELWSLFDFLMPG-FLG-TEKMFQERFAKPI 1488
Cdd:cd18013 142 VRPVIK---RLIgLTGTPSPNGLMDLWAQIALLDQGeRLGrSITAYRERWFDPD 192
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
1571-1862 |
5.27e-08 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 58.20 E-value: 5.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1571 EVENKQHIFQALQYMRKLCNHPSLVLNS-------SHPQFQQVQSYLSQTGMDlhdigHaPKLEALKTLllecgigiqdV 1643
Cdd:COG1111 281 ELLETQGVEALLRYLERLEEEARSSGGSkaskrlvSDPRFRKAMRLAEEADIE-----H-PKLSKLREI----------L 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1644 EKKSNKNPSidnvisqHRVLIFCQLKDMLDMVENDLLKKHLPSVTFM------RLDGSVDsRDRQKVVRKF-NEDPSIdc 1716
Cdd:COG1111 345 KEQLGTNPD-------SRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVgqaskeGDKGLTQ-KEQIEILERFrAGEFNV-- 414
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1717 lLLTTKVGGLGLNLTGADTVIFVEHDWNPMNDLQAMDRAHRLGQKKVVnVYriITKGTLEEKIMGLQKFKMNIASTIVNQ 1796
Cdd:COG1111 415 -LVATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKREGRVV-VL--IAKGTRDEAYYWSSRRKEKKMKSILKK 490
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50310019 1797 QNAGLGSMNTHQL-------LDLFDADNIPSQEKVEKKKTVEDVANESGLTgKAKEAVGELKELWDSSQYEEE 1862
Cdd:COG1111 491 LKKLLDKQEKEKLkesaqatLDEFESIKELAEDEINEKDLDEIESSENGAH-VDWREPVLLQVIVSTLAESLE 562
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
1286-1454 |
1.46e-06 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 53.10 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1286 TLRKYQQDGVN-WLAFLNKYHLHGILCDDMGLGKTlqticIIASdqylrsEDYKKTQsektRPLPSLIICP-PSLTGHWE 1363
Cdd:COG1061 80 ELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKT-----VLAL------ALAAELL----RGKRVLVLVPrRELLEQWA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1364 QEFQQYSPtlnvLVYAGGPSVRyplqgqvPTADIVVTSYDVARNDVDFLK-KYDYNYCVLDEGHiikNSQSK-LAKAVKL 1441
Cdd:COG1061 145 EELRRFLG----DPLAGGGKKD-------SDAPITVATYQSLARRAHLDElGDRFGLVIIDEAH---HAGAPsYRRILEA 210
|
170
....*....|...
gi 50310019 1442 INSNHRLVLTGTP 1454
Cdd:COG1061 211 FPAAYRLGLTATP 223
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
1307-1453 |
6.08e-05 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 45.09 E-value: 6.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1307 HGILCDDMGLGKTLQTICIIAsdqylrsedykktQSEKTRPLPSLIICP-PSLTGHWEQEFQQY-SPTLNVLVYAGGPSV 1384
Cdd:cd00046 3 NVLITAPTGSGKTLAALLAAL-------------LLLLKKGKKVLVLVPtKALALQTAERLRELfGPGIRVAVLVGGSSA 69
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50310019 1385 RYPLQGQVPTADIVVTSYDVARNDVDFLKKY---DYNYCVLDEGHII-KNSQSKLAKA---VKLINSNHRLV-LTGT 1453
Cdd:cd00046 70 EEREKNKLGDADIIIATPDMLLNLLLREDRLflkDLKLIIVDEAHALlIDSRGALILDlavRKAGLKNAQVIlLSAT 146
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
1717-1764 |
5.87e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 40.38 E-value: 5.87e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 50310019 1717 LLLTTKVGGLGLNLTGADTVIFVEHDWNPMNDLQAMDRAHRLGQKKVV 1764
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGE 72
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
1644-1737 |
1.16e-03 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 40.95 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310019 1644 EKKSNKNPSIDNVISQHRVLIFCQLKDMLDMVENDLLKKHLPSVTfmrLDGSVDSRDRQKVVRKFNEDPSidCLLLTTKV 1723
Cdd:cd18787 12 EKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAA---LHGDLSQEERERALKKFRSGKV--RVLVATDV 86
|
90
....*....|....
gi 50310019 1724 GGLGLNLTGADTVI 1737
Cdd:cd18787 87 AARGLDIPGVDHVI 100
|
|
| |
