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Conserved domains on  [gi|50304303|ref|XP_452101|]
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uncharacterized protein KLLA0_B12804g [Kluyveromyces lactis]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
126-502 1.81e-19

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 1.81e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 126 GGAVWCIRFSHDGKFMATAGKDEILRIWKViSSPAERLELNQHSISFlksTANAISQlNGQ-LAqyggdtdsaslnSGSS 204
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAV---TSVAFSP-DGKlLA------------SGSD 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 205 NTHVdslgssnanrdgfstkavpqeqqgqtqghrhpyGLGDsycgVFHPNPLVTFHEHTDDILDIDWSKNS-FILTGSMD 283
Cdd:COG2319 183 DGTV---------------------------------RLWD----LATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSAD 225

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 284 KSCKLWHCARPTSLKTFV-HSDFVTAVRFHPeDDRFFLSACLDQKCRLWSILEKQVIFEYD-CGDLITAMDISYDGNYTI 361
Cdd:COG2319 226 GTVRLWDLATGKLLRTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLA 304

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 362 LGTFNGYIHVLITKSLELLFSFNVldkdselkkchrtsrrlkkqssdkakNGPKITGLEFiqkdarnykisSKDvSDWFL 441
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTG--------------------------HTGAVRSVAF-----------SPD-GKTLA 346

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50304303 442 VSSNDSRIRIYTLN-QEFVSVMKGHSNEHSQItahsTVTRSGKaYVVSGSEDHWIYCWKLSD 502
Cdd:COG2319 347 SGSDDGTVRLWDLAtGELLRTLTGHTGAVTSV----AFSPDGR-TLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
126-502 1.81e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 1.81e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 126 GGAVWCIRFSHDGKFMATAGKDEILRIWKViSSPAERLELNQHSISFlksTANAISQlNGQ-LAqyggdtdsaslnSGSS 204
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAV---TSVAFSP-DGKlLA------------SGSD 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 205 NTHVdslgssnanrdgfstkavpqeqqgqtqghrhpyGLGDsycgVFHPNPLVTFHEHTDDILDIDWSKNS-FILTGSMD 283
Cdd:COG2319 183 DGTV---------------------------------RLWD----LATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSAD 225

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 284 KSCKLWHCARPTSLKTFV-HSDFVTAVRFHPeDDRFFLSACLDQKCRLWSILEKQVIFEYD-CGDLITAMDISYDGNYTI 361
Cdd:COG2319 226 GTVRLWDLATGKLLRTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLA 304

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 362 LGTFNGYIHVLITKSLELLFSFNVldkdselkkchrtsrrlkkqssdkakNGPKITGLEFiqkdarnykisSKDvSDWFL 441
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTG--------------------------HTGAVRSVAF-----------SPD-GKTLA 346

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50304303 442 VSSNDSRIRIYTLN-QEFVSVMKGHSNEHSQItahsTVTRSGKaYVVSGSEDHWIYCWKLSD 502
Cdd:COG2319 347 SGSDDGTVRLWDLAtGELLRTLTGHTGAVTSV----AFSPDGR-TLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 127-371 1.15e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.31  E-value: 1.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 127 GAVWCIRFSHDGKFMATAGKDEILRIWKVISSPAER-LELNQHSISFLKSTAN----AISQLNGQL-----------AQY 190
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAASADgtylASGSSDKTIrlwdletgecvRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 191 GGDTD---SASLnsgSSNTHVDSLGSsnanRDGfSTK--AVPQEQQGQT-QGHRHPYglgdsYCGVFHPNPLV------- 257
Cdd:cd00200  90 TGHTSyvsSVAF---SPDGRILSSSS----RDK-TIKvwDVETGKCLTTlRGHTDWV-----NSVAFSPDGTFvasssqd 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 258 ---------------TFHEHTDDILDIDWSKNSF-ILTGSMDKSCKLWHCARPTSLKTFV-HSDFVTAVRFHPeDDRFFL 320
Cdd:cd00200 157 gtiklwdlrtgkcvaTLTGHTGEVNSVAFSPDGEkLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSP-DGYLLA 235

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 50304303 321 SACLDQKCRLWSILEKQVIFEYDCGD-LITAMDISYDGNYTILGTFNGYIHV 371
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSGHTnSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 254-290 2.73e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 2.73e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 50304303    254 NPLVTFHEHTDDILDIDWSKNS-FILTGSMDKSCKLWH 290
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
254-289 4.06e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.06e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 50304303   254 NPLVTFHEHTDDILDIDWSKNS-FILTGSMDKSCKLW 289
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
126-502 1.81e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 1.81e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 126 GGAVWCIRFSHDGKFMATAGKDEILRIWKViSSPAERLELNQHSISFlksTANAISQlNGQ-LAqyggdtdsaslnSGSS 204
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAV---TSVAFSP-DGKlLA------------SGSD 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 205 NTHVdslgssnanrdgfstkavpqeqqgqtqghrhpyGLGDsycgVFHPNPLVTFHEHTDDILDIDWSKNS-FILTGSMD 283
Cdd:COG2319 183 DGTV---------------------------------RLWD----LATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSAD 225

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 284 KSCKLWHCARPTSLKTFV-HSDFVTAVRFHPeDDRFFLSACLDQKCRLWSILEKQVIFEYD-CGDLITAMDISYDGNYTI 361
Cdd:COG2319 226 GTVRLWDLATGKLLRTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLA 304

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 362 LGTFNGYIHVLITKSLELLFSFNVldkdselkkchrtsrrlkkqssdkakNGPKITGLEFiqkdarnykisSKDvSDWFL 441
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTG--------------------------HTGAVRSVAF-----------SPD-GKTLA 346

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50304303 442 VSSNDSRIRIYTLN-QEFVSVMKGHSNEHSQItahsTVTRSGKaYVVSGSEDHWIYCWKLSD 502
Cdd:COG2319 347 SGSDDGTVRLWDLAtGELLRTLTGHTGAVTSV----AFSPDGR-TLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 127-371 1.15e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.31  E-value: 1.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 127 GAVWCIRFSHDGKFMATAGKDEILRIWKVISSPAER-LELNQHSISFLKSTAN----AISQLNGQL-----------AQY 190
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAASADgtylASGSSDKTIrlwdletgecvRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 191 GGDTD---SASLnsgSSNTHVDSLGSsnanRDGfSTK--AVPQEQQGQT-QGHRHPYglgdsYCGVFHPNPLV------- 257
Cdd:cd00200  90 TGHTSyvsSVAF---SPDGRILSSSS----RDK-TIKvwDVETGKCLTTlRGHTDWV-----NSVAFSPDGTFvasssqd 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 258 ---------------TFHEHTDDILDIDWSKNSF-ILTGSMDKSCKLWHCARPTSLKTFV-HSDFVTAVRFHPeDDRFFL 320
Cdd:cd00200 157 gtiklwdlrtgkcvaTLTGHTGEVNSVAFSPDGEkLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSP-DGYLLA 235

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 50304303 321 SACLDQKCRLWSILEKQVIFEYDCGD-LITAMDISYDGNYTILGTFNGYIHV 371
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSGHTnSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 255-508 6.05e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 6.05e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 255 PLVTFHEHTDDILDIDWSKNS-FILTGSMDKSCKLWHCARPTSLKTFV-HSDFVTAVRFHPeDDRFFLSACLDQKCRLWS 332
Cdd:cd00200  43 LLRTLKGHTGPVRDVAASADGtYLASGSSDKTIRLWDLETGECVRTLTgHTSYVSSVAFSP-DGRILSSSSRDKTIKVWD 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 333 ILEKQVIFEYDC-GDLITAMDISYDGNYTILGTFNGYIHVlitkslellfsFNVldkdselkKCHRTSRRLKKQSSDkak 411
Cdd:cd00200 122 VETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKL-----------WDL--------RTGKCVATLTGHTGE--- 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 412 ngpkITGLEFiqkdarnykisSKDvSDWFLVSSNDSRIRIYTLN-QEFVSVMKGHSNehsqiTAHSTVTRSGKAYVVSGS 490
Cdd:cd00200 180 ----VNSVAF-----------SPD-GEKLLSSSSDGTIKLWDLStGKCLGTLRGHEN-----GVNSVAFSPDGYLLASGS 238

                       250
                ....*....|....*...
gi 50304303 491 EDHWIYCWKLSDEVVKST 508
Cdd:cd00200 239 EDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
255-502 6.97e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 6.97e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 255 PLVTFHEHTDDILDIDWSKN-SFILTGSMDKSCKLWHCARPTSLKTFV-HSDFVTAVRFHPeDDRFFLSACLDQKCRLWS 332
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDgKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSP-DGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 333 ILEKQVIFEYDC-GDLITAMDISYDGNYTILGTFNGYIHVLitkslellfsfnvldkDSELKKCHRTSRRlkkqssdkak 411
Cdd:COG2319 191 LATGKLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLW----------------DLATGKLLRTLTG---------- 244

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 412 NGPKITGLEFiqkdarnykisSKDvSDWFLVSSNDSRIRIYTLN-QEFVSVMKGHSNEHSQItahsTVTRSGKaYVVSGS 490
Cdd:COG2319 245 HSGSVRSVAF-----------SPD-GRLLASGSADGTVRLWDLAtGELLRTLTGHSGGVNSV----AFSPDGK-LLASGS 307

                       250
                ....*....|..
gi 50304303 491 EDHWIYCWKLSD 502
Cdd:COG2319 308 DDGTVRLWDLAT 319
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 127-332 4.59e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 4.59e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 127 GAVWCIRFSHDGKFMATAGKDEILRIWKVISSPAERlELNQHSisflkSTANAISQL-NGQLAQYGGDTDSASLNSGSSN 205
Cdd:cd00200  94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT-TLRGHT-----DWVNSVAFSpDGTFVASSSQDGTIKLWDLRTG 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50304303 206 THVDSLGSSNanRDGFSTKAVPQEQQGQTQGhrhpyglGDSYCGVFHPN---PLVTFHEHTDDILDIDWSKNSFILT-GS 281
Cdd:cd00200 168 KCVATLTGHT--GEVNSVAFSPDGEKLLSSS-------SDGTIKLWDLStgkCLGTLRGHENGVNSVAFSPDGYLLAsGS 238

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 50304303 282 MDKSCKLWHCARPTSLKTFV-HSDFVTAVRFHPeDDRFFLSACLDQKCRLWS 332
Cdd:cd00200 239 EDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 254-290 2.73e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 2.73e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 50304303    254 NPLVTFHEHTDDILDIDWSKNS-FILTGSMDKSCKLWH 290
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
254-289 4.06e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.06e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 50304303   254 NPLVTFHEHTDDILDIDWSKNS-FILTGSMDKSCKLW 289
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 127-154 3.22e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.22e-04
                           10        20
                   ....*....|....*....|....*...
gi 50304303    127 GAVWCIRFSHDGKFMATAGKDEILRIWK 154
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
125-169 5.15e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 5.15e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 50304303 125 NGGAVWCIRFSHDGKFMATAGKDEILRIWKViSSPAERLELNQHS 169
Cdd:COG2319 329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-ATGELLRTLTGHT 372
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 302-332 1.15e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.15e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 50304303    302 HSDFVTAVRFHPeDDRFFLSACLDQKCRLWS 332
Cdd:smart00320  11 HTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
127-153 1.39e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.39e-03
                          10        20
                  ....*....|....*....|....*..
gi 50304303   127 GAVWCIRFSHDGKFMATAGKDEILRIW 153
Cdd:pfam00400  12 GSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
302-332 1.62e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.62e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 50304303   302 HSDFVTAVRFHPeDDRFFLSACLDQKCRLWS 332
Cdd:pfam00400  10 HTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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