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Conserved domains on  [gi|50303525|ref|XP_451704|]
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uncharacterized protein KLLA0_B03828g [Kluyveromyces lactis]

Protein Classification

HECT-type E3 ubiquitin transferase( domain architecture ID 10561263)

HECT-type E3 ubiquitin transferase such as mammalian E3 ubiquitin-protein ligase E3D that accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 6-348 1.15e-78

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


:

Pssm-ID: 462911  Cd Length: 362  Bit Score: 245.06  E-value: 1.15e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525     6 EYHHWIGAVQLWVENDGQPIATEIPHDRRHINVTIGNKRVITINLPCVVDVNTKGEVQRGKL------FNVRLNEL--KS 77
Cdd:pfam09814   1 ELLPNIRSISVVVSLPSPLKSTRVSLSDDGLLLVRHNGSSETIRLPAEVSVGSSLGRSQLPLpgdelsFRLPLADSssKF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525    78 GKTFDRSSNHIMEKLVAKWMRKDLVKHpFVFYCLDCDTPVISSINCKRIRDMPSEFWADFMDYWHCHKPDMEPHQKGHHV 157
Cdd:pfam09814  81 GSFDLESSLSAQKELEVPWSAKDLSPG-FSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDHDHLATKGY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525   158 AAsetllhryNNPLNPAVGEIMLSDSFIYINKDW-----IPEKFIYDEELVRSRSCNTVIGSFTKEGSVRIGKWNLRAEI 232
Cdd:pfam09814 160 GA--------NSKLVPQEGDGLVGLTFFLLNESDcqglkLSSKPPKDNLSVSCKRCGALLGEVDSLDGLKLYKWALSLQP 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525   233 GGFLDV----FDPSNYVLYQIYNELKAHSIRLFHLKGDD--KRYI-IWVFGIGSCI---QFDKSRMLNNCLKILYRDGKP 302
Cdd:pfam09814 232 SEGSDSiprsFPPESIVAALLLELISRSSTRKFLIQPEDgeTHYLlLWVFNPDLLVsssSSSNSLIAKRAMKVLYKDCID 311

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 50303525   303 AES------EKNQNIAELKVEENsALINFIQHLESVNRQLPEELRLLNEWKV 348
Cdd:pfam09814 312 SEEanslldENDSNVEELELPPE-VFEELLQLLESSNSLLPPSARKFNEWKV 362
 
Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 6-348 1.15e-78

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


Pssm-ID: 462911  Cd Length: 362  Bit Score: 245.06  E-value: 1.15e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525     6 EYHHWIGAVQLWVENDGQPIATEIPHDRRHINVTIGNKRVITINLPCVVDVNTKGEVQRGKL------FNVRLNEL--KS 77
Cdd:pfam09814   1 ELLPNIRSISVVVSLPSPLKSTRVSLSDDGLLLVRHNGSSETIRLPAEVSVGSSLGRSQLPLpgdelsFRLPLADSssKF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525    78 GKTFDRSSNHIMEKLVAKWMRKDLVKHpFVFYCLDCDTPVISSINCKRIRDMPSEFWADFMDYWHCHKPDMEPHQKGHHV 157
Cdd:pfam09814  81 GSFDLESSLSAQKELEVPWSAKDLSPG-FSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDHDHLATKGY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525   158 AAsetllhryNNPLNPAVGEIMLSDSFIYINKDW-----IPEKFIYDEELVRSRSCNTVIGSFTKEGSVRIGKWNLRAEI 232
Cdd:pfam09814 160 GA--------NSKLVPQEGDGLVGLTFFLLNESDcqglkLSSKPPKDNLSVSCKRCGALLGEVDSLDGLKLYKWALSLQP 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525   233 GGFLDV----FDPSNYVLYQIYNELKAHSIRLFHLKGDD--KRYI-IWVFGIGSCI---QFDKSRMLNNCLKILYRDGKP 302
Cdd:pfam09814 232 SEGSDSiprsFPPESIVAALLLELISRSSTRKFLIQPEDgeTHYLlLWVFNPDLLVsssSSSNSLIAKRAMKVLYKDCID 311

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 50303525   303 AES------EKNQNIAELKVEENsALINFIQHLESVNRQLPEELRLLNEWKV 348
Cdd:pfam09814 312 SEEanslldENDSNVEELELPPE-VFEELLQLLESSNSLLPPSARKFNEWKV 362
COG5629 COG5629
Predicted metal-binding protein [Function unknown];
83-352 3.04e-22

Predicted metal-binding protein [Function unknown];


Pssm-ID: 227916  Cd Length: 321  Bit Score: 95.49  E-value: 3.04e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525  83 RSSNHIMEKLVAKWMRKDLVKHPFVFYCLDCDTPVISSINCKRIRDMPSEFWADFMDYWHCHKPDMEphqkghhvaaSET 162
Cdd:COG5629  60 VTVNVYEDKILVPWSDGELARDDTLPDGFRCKQGNEILHSIRSMNDLPSEGWEELIDCWSCHNDYCE----------FKS 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525 163 LLHRYNNPlNPAVGEIMLSDSFIYINKDWIPEKFIYDEEL-VRSRSCNTVIGSFTKEGSVRIGKWNLRAEIGGfLDVFDP 241
Cdd:COG5629 130 MLGGPLTP-RPREGGLLLGDSYLLINDADLEGKVAYGPNFkLHCSFCNARLGLPNDSSIRKLFRYNKEVIPNG-CTKIHP 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525 242 SNYVLYQIYNELKAHSIRLFHLKGDDKRYIIWVFGIGSCIQFDKSRMLNNCLKILYRDGKPAESEK--NQNIAELKVEEN 319
Cdd:COG5629 208 HEDLAYSYLNAYFRDKNVLLLEANQARSYEIWHFYRAILITVEPNRSLSRAEAMKVTIKNTDVPPKitKSTESSEDIPVS 287

                       250       260       270
                ....*....|....*....|....*....|....
gi 50303525 320 SalINFIQH-LESVNRQLPEELRLLNEWKVSYIS 352
Cdd:COG5629 288 S--FNEFYSkLIYDNVMSPTSDIKAGGWKISFVT 319
 
Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 6-348 1.15e-78

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


Pssm-ID: 462911  Cd Length: 362  Bit Score: 245.06  E-value: 1.15e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525     6 EYHHWIGAVQLWVENDGQPIATEIPHDRRHINVTIGNKRVITINLPCVVDVNTKGEVQRGKL------FNVRLNEL--KS 77
Cdd:pfam09814   1 ELLPNIRSISVVVSLPSPLKSTRVSLSDDGLLLVRHNGSSETIRLPAEVSVGSSLGRSQLPLpgdelsFRLPLADSssKF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525    78 GKTFDRSSNHIMEKLVAKWMRKDLVKHpFVFYCLDCDTPVISSINCKRIRDMPSEFWADFMDYWHCHKPDMEPHQKGHHV 157
Cdd:pfam09814  81 GSFDLESSLSAQKELEVPWSAKDLSPG-FSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDHDHLATKGY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525   158 AAsetllhryNNPLNPAVGEIMLSDSFIYINKDW-----IPEKFIYDEELVRSRSCNTVIGSFTKEGSVRIGKWNLRAEI 232
Cdd:pfam09814 160 GA--------NSKLVPQEGDGLVGLTFFLLNESDcqglkLSSKPPKDNLSVSCKRCGALLGEVDSLDGLKLYKWALSLQP 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525   233 GGFLDV----FDPSNYVLYQIYNELKAHSIRLFHLKGDD--KRYI-IWVFGIGSCI---QFDKSRMLNNCLKILYRDGKP 302
Cdd:pfam09814 232 SEGSDSiprsFPPESIVAALLLELISRSSTRKFLIQPEDgeTHYLlLWVFNPDLLVsssSSSNSLIAKRAMKVLYKDCID 311

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 50303525   303 AES------EKNQNIAELKVEENsALINFIQHLESVNRQLPEELRLLNEWKV 348
Cdd:pfam09814 312 SEEanslldENDSNVEELELPPE-VFEELLQLLESSNSLLPPSARKFNEWKV 362
COG5629 COG5629
Predicted metal-binding protein [Function unknown];
83-352 3.04e-22

Predicted metal-binding protein [Function unknown];


Pssm-ID: 227916  Cd Length: 321  Bit Score: 95.49  E-value: 3.04e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525  83 RSSNHIMEKLVAKWMRKDLVKHPFVFYCLDCDTPVISSINCKRIRDMPSEFWADFMDYWHCHKPDMEphqkghhvaaSET 162
Cdd:COG5629  60 VTVNVYEDKILVPWSDGELARDDTLPDGFRCKQGNEILHSIRSMNDLPSEGWEELIDCWSCHNDYCE----------FKS 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525 163 LLHRYNNPlNPAVGEIMLSDSFIYINKDWIPEKFIYDEEL-VRSRSCNTVIGSFTKEGSVRIGKWNLRAEIGGfLDVFDP 241
Cdd:COG5629 130 MLGGPLTP-RPREGGLLLGDSYLLINDADLEGKVAYGPNFkLHCSFCNARLGLPNDSSIRKLFRYNKEVIPNG-CTKIHP 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50303525 242 SNYVLYQIYNELKAHSIRLFHLKGDDKRYIIWVFGIGSCIQFDKSRMLNNCLKILYRDGKPAESEK--NQNIAELKVEEN 319
Cdd:COG5629 208 HEDLAYSYLNAYFRDKNVLLLEANQARSYEIWHFYRAILITVEPNRSLSRAEAMKVTIKNTDVPPKitKSTESSEDIPVS 287

                       250       260       270
                ....*....|....*....|....*....|....
gi 50303525 320 SalINFIQH-LESVNRQLPEELRLLNEWKVSYIS 352
Cdd:COG5629 288 S--FNEFYSkLIYDNVMSPTSDIKAGGWKISFVT 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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