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Conserved domains on  [gi|2516249685|ref|XP_057188201|]
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heparan sulfate glucosamine 3-O-sulfotransferase 6 [Triplophysa rosa]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
116-352 3.08e-42

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 147.87  E-value: 3.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2516249685 116 PQAIIIGVKKGGTRALLEFLRVHPDVRAVGA--EPHFFDRF-YDKGLQWY-RNLMPRTLEGQITMEKTPS-YFITHEAPN 190
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNNHnRSPFLEWYpGDTYFDVAEGPVRLNALPSpRIIKTHLPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2516249685 191 RVFS---MSRATKLIVVVRDPVTRAVSDYTQT----LTKNPGLPTFQnlvfknsstgLIDTSWSAVRIGIYAKHLENWLK 263
Cdd:pfam00685  82 HLLPkslWDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEF----------VEDFLNGKVNCGSYFDHVKGWWK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2516249685 264 YFPLSQFLFVSGEKLVTDPAGEMGRVQDFLGLKR---VVTN--KHFYFNQTKGFPCLKKPE-----GSSRPRCLGKSKgr 333
Cdd:pfam00685 152 LRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeELDKivKHLSFENMKGNPCLNYSKlpkevSPFFRKGLVGDW-- 229

                         250
                  ....*....|....*....
gi 2516249685 334 pHPHMPSEVLHRLREFYRP 352
Cdd:pfam00685 230 -KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
116-352 3.08e-42

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 147.87  E-value: 3.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2516249685 116 PQAIIIGVKKGGTRALLEFLRVHPDVRAVGA--EPHFFDRF-YDKGLQWY-RNLMPRTLEGQITMEKTPS-YFITHEAPN 190
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNNHnRSPFLEWYpGDTYFDVAEGPVRLNALPSpRIIKTHLPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2516249685 191 RVFS---MSRATKLIVVVRDPVTRAVSDYTQT----LTKNPGLPTFQnlvfknsstgLIDTSWSAVRIGIYAKHLENWLK 263
Cdd:pfam00685  82 HLLPkslWDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEF----------VEDFLNGKVNCGSYFDHVKGWWK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2516249685 264 YFPLSQFLFVSGEKLVTDPAGEMGRVQDFLGLKR---VVTN--KHFYFNQTKGFPCLKKPE-----GSSRPRCLGKSKgr 333
Cdd:pfam00685 152 LRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeELDKivKHLSFENMKGNPCLNYSKlpkevSPFFRKGLVGDW-- 229

                         250
                  ....*....|....*....
gi 2516249685 334 pHPHMPSEVLHRLREFYRP 352
Cdd:pfam00685 230 -KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
116-352 3.08e-42

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 147.87  E-value: 3.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2516249685 116 PQAIIIGVKKGGTRALLEFLRVHPDVRAVGA--EPHFFDRF-YDKGLQWY-RNLMPRTLEGQITMEKTPS-YFITHEAPN 190
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNNHnRSPFLEWYpGDTYFDVAEGPVRLNALPSpRIIKTHLPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2516249685 191 RVFS---MSRATKLIVVVRDPVTRAVSDYTQT----LTKNPGLPTFQnlvfknsstgLIDTSWSAVRIGIYAKHLENWLK 263
Cdd:pfam00685  82 HLLPkslWDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEF----------VEDFLNGKVNCGSYFDHVKGWWK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2516249685 264 YFPLSQFLFVSGEKLVTDPAGEMGRVQDFLGLKR---VVTN--KHFYFNQTKGFPCLKKPE-----GSSRPRCLGKSKgr 333
Cdd:pfam00685 152 LRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeELDKivKHLSFENMKGNPCLNYSKlpkevSPFFRKGLVGDW-- 229

                         250
                  ....*....|....*....
gi 2516249685 334 pHPHMPSEVLHRLREFYRP 352
Cdd:pfam00685 230 -KNYFTPEQAEKFDEIYQE 247
Sulfotransfer_3 pfam13469
Sulfotransferase family;
119-295 4.94e-16

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 75.02  E-value: 4.94e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2516249685 119 IIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRFYDKGLQW---YRNLMPRTLEGQITMEKTPSYF-----ITHEAPN 190
Cdd:pfam13469   2 FIVGLPRSGTTLLHRLLAAHPDVRPPEETWFVIPRILALLQAWgksLEALARVPSYARWLCDKSPSHLfhldlLLKAFPD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2516249685 191 rvfsmsraTKLIVVVRDPVTRAVSDYTQTLTKnpGLPTFQNLVFKnsSTGLIDTSWSAVrigiYAKHLENWLKYFPlSQF 270
Cdd:pfam13469  82 --------AKFIHLHRDPVDTVISSYCSLFGF--TLSSYSTAFLR--DIGLALARWSRA----YERLMAARARVPP-GRF 144

                         170       180
                  ....*....|....*....|....*
gi 2516249685 271 LFVSGEKLVTDPAGEMGRVQDFLGL 295
Cdd:pfam13469 145 LDVRYEDLVADPEGTLRRILEFLGL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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