N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the c-Rel family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). c-Rel plays an important role in B cell proliferation and survival.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666   8 PCIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQILNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDG 87
Cdd:cd07933     1 PYVEIFEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSIQILNYTGKGKVRITLVTKNEPYKPHPHDLVGKDCRDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666  88 YYEAEFGQERRPLFFQNLGIRCVKKKEVKEAIISRIRAGINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNLTTAL 167
Cdd:cd07933    81 YYEAEFGPERRVLAFQNLGIQCVRRREVKEAIMLRISRGINPFNVPEEQLLQIEEYDLNVVRLCFQIFLPDEHGNYTTAL 160

                         170
                  ....*....|..
gi 2492366666 168 PPVVSNPIYDNR 179
Cdd:cd07933   161 PPIVSNPIYDNR 172

N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the c-Rel family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). c-Rel plays an important role in B cell proliferation and survival.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666   8 PCIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQILNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDG 87
Cdd:cd07933     1 PYVEIFEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSIQILNYTGKGKVRITLVTKNEPYKPHPHDLVGKDCRDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666  88 YYEAEFGQERRPLFFQNLGIRCVKKKEVKEAIISRIRAGINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNLTTAL 167
Cdd:cd07933    81 YYEAEFGPERRVLAFQNLGIQCVRRREVKEAIMLRISRGINPFNVPEEQLLQIEEYDLNVVRLCFQIFLPDEHGNYTTAL 160

                         170
                  ....*....|..
gi 2492366666 168 PPVVSNPIYDNR 179
Cdd:cd07933   161 PPIVSNPIYDNR 172

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666 186 LRICRVNKNCGSVKGGDEIFLLCDKVQKDDIEVRFVL-----NEWEAKGVFSQADVHRQVAIVFKTPPY-CKAITEPVTV 259
Cdd:cd01177     1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFFEedeeeTVWEAFGDFSQTDVHRQYAIVFRTPPYhDPDITEPVKV 80

                          90       100
                  ....*....|....*....|..
gi 2492366666 260 KMQLRRPSDQEVSESMDFRYLP 281
Cdd:cd01177    81 KIQLKRPSDGERSESVPFTYVP 102

ig-like, plexins, transcription factors;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666  185 ELRICRVNKNCGSVKGGDEIfLLCDKVQKDDIEVRFVLNEWEAKGVFSQAdvhRQVAIVFKTPPY-CKAITEPV-TVKMQ 262
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEI-TLCGKNLKSISVVFVEVGVGEAPCTFSPS---SSTAIVCKTPPYhNIPGSVPVrTVGLR 76

                           90
                   ....*....|....*...
gi 2492366666  263 LRRPSdqevSESMDFRYL 280
Cdd:smart00429  77 NGGVP----SSPQPFTYV 90

N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the c-Rel family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). c-Rel plays an important role in B cell proliferation and survival.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666   8 PCIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQILNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDG 87
Cdd:cd07933     1 PYVEIFEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSIQILNYTGKGKVRITLVTKNEPYKPHPHDLVGKDCRDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666  88 YYEAEFGQERRPLFFQNLGIRCVKKKEVKEAIISRIRAGINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNLTTAL 167
Cdd:cd07933    81 YYEAEFGPERRVLAFQNLGIQCVRRREVKEAIMLRISRGINPFNVPEEQLLQIEEYDLNVVRLCFQIFLPDEHGNYTTAL 160

                         170
                  ....*....|..
gi 2492366666 168 PPVVSNPIYDNR 179
Cdd:cd07933   161 PPIVSNPIYDNR 172

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666   8 PCIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQILNYYGKGKVRITLVTKNDPYKPHPHDLVGK-DCRD 86
Cdd:cd07827     1 PYLEITEQPKQRGHRFRYECEGRSAGSIPGENSTADRKTFPTVKLRNYNGPAKIVVSLVTKDDPPKPHPHQLVGKtDCRD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666  87 GYYEAEFGQERRP-LFFQNLGIRCVKKKEVKEAIISRIRAGINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNLTT 165
Cdd:cd07827    81 GVCEVRLGPKNNMtASFNNLGIQCVRKKDVEEALGQRIQLGIDPFMVHKGPEGNASDIDLNRVRLCFQAFIEDSDGGFTL 160

                         170
                  ....*....|....
gi 2492366666 166 ALPPVVSNPIYDNR 179
Cdd:cd07827   161 PLPPVLSNPIYDKK 174

N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the arthropod Dorsal and Dif (Dorsal-related immunity factor), and similar proteins. Dorsal and Dif are Rel-like transcription factors, which play roles in mediating innate immunity in Drosophila. They are activated via the Toll pathway. Cytoplasmic Dorsal/Dif are inactivated via forming a complex with Cactus, the Drosophila homologue of mammalian I-kappa B proteins. In response to signals, Cactus is degraded and Dorsal/Dif can be transported into the nucleus, where they act as transcription factors. Dorsal is also an essential gene in establishing the proper dorsal/ventral polarity in the developing embryo.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666   8 PCIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQILNYYGKGKVRITLVTKNDPYKPHPHDLVGK-DCRD 86
Cdd:cd07887     1 PYVRIVEQPTSRALRFRYECEGRSAGSIPGANSTSEGKTFPTIQVVNYDGRAVVVVSCVTKDEPFRPHPHNLVGKeGCKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666  87 GYYEAEFGQERRPLFFQNLGIRCVKKKEVKEAIISRIRAGINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNLTTA 166
Cdd:cd07887    81 GVCTKKINPTEMRIVFQKLGIQCVKKKDVEESLKLREEINVDPFRTGFDHKDQINSIDLNVVRLCFQVFLEDENGRFTVP 160

                         170
                  ....*....|...
gi 2492366666 167 LPPVVSNPIYDNR 179
Cdd:cd07887   161 LPPVVSDPIYDKK 173

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666   8 PCIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQILNYYGKGKVRIT--LVTKNDPYKPHPHDLVGKDCR 85
Cdd:cd07886     1 PRLLITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTvcLVWKDPPHRVHPHGLVGKDCP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666  86 DGYYEAEFGQERRPLF-FQNLGIRCVKKKEVKEAIISRIRAGINPFNVPEQQLldIEDCDLNVVRLCFQVFLPDEHGNlT 164
Cdd:cd07886    81 NGICQVTLNPHSSPRHsFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKN--HEEVDMNVVRLCFQASYRDDDGR-K 157

                         170
                  ....*....|....*
gi 2492366666 165 TALPPVVSNPIYDNR 179
Cdd:cd07886   158 DCLSPVLSEPIYDKK 172

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666 187 RICRVNKNCGSVKGGDEIFLLCDKVQKDDIEVRFVLNE-----WEAKGVFSQADVHRQVAIVFKTPPYC-KAITEPVTVK 260
Cdd:pfam16179   1 KICRLSLCSGSVTGGEEIILLCEKVLKDDIKVRFYEEDdgqevWEAEGDFSKTDVHRQVAIVFKTPPYRdPDITEPVTVN 80

                          90       100
                  ....*....|....*....|..
gi 2492366666 261 MQLRRPSDQEVSESMDFRYLPD 282
Cdd:pfam16179  81 IQLRRPSDKATSEPQPFTYLPL 102

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NF-kappa B1 family of transcription factors, a class I member of the NF-kappa B family. In class I NF-kappa Bs, the RHD domain co-occurs with C-terminal ankyrin repeats. NF-kappa B1 is commonly referred to as p105 or p50 (proteolytically processed form). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and REL). NF-kappa B1 is involved in the canonical NF-kappa B signaling pathway which is activated by many agonists and is essential in immune and inflammatory responses, as well as cell survival. p105 is involved in its own specific NF-kappa B signaling pathway which is also implicated in immune and inflammatory responses. p105 may also act as an I-kappa B due to its C-terminal ankyrin repeats. It is also involved in mitogen-activated protein kinase (MAPK) signaling as its degradation leads to the activation of TPL-2, a MAPK kinase kinase which activates ERK pathways.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666   8 PCIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQILNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDG 87
Cdd:cd07935     1 PYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666  88 YYEAEFGQERRPLFFQNLGIRCVKKKEVKEAIISRI----RAGINPFNV--PE-----------QQLLDIE--------- 141
Cdd:cd07935    81 ICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMteacKKGYNPGLLvhPElaylqaegggdRQLTEREkeiirqaav 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2492366666 142 ----DCDLNVVRLCFQVFLPDEHGNLTTALPPVVSNPIYDNR 179
Cdd:cd07935   161 qqtkEMDLSVVRLMFTAFLPDSTGGFTRRLEPVVSDAIYDSK 202

N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Relish; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the arthropod Relish protein, in which the RHD domain co-occurs with C-terminal ankyrin repeats. Family members are sometimes referred to as p110 or p68 (proteolytically processed form). Relish is an NF-kappa B-like transcription factor, which plays a role in mediating innate immunity in Drosophila. It is activated via the Imd (immune deficiency) pathway, which triggers phosphorylation of Relish. IKK-dependent proteolytic cleavage of Relish (which involves Dredd) results in a smaller active form (without the C-terminal ankyrin repeats), which is transported into the nucleus and functions as a transactivator.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666   8 PCIEIIEQPRQRgMRFRYKCEGR-SAGSIPGEHSTDNNRTYPSIQILNYYGKGKVRITLVTKNDPY-KPHPHDLVGKDCR 85
Cdd:cd07884     1 PFLRIVEQPVDK-FRFRYKSEMHgTHGSLLGERSTSSKKTFPTVKLCNYRGQAVIRCSLYQADDNRrKPHVHKLVGKQGD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666  86 DGYYEAEFGQERRP----LFFQNLGIRCVKKKEVKEAIISRiraginpfnvpeqqlldiEDCDLNVVRLCFQVFLPDEHG 161
Cdd:cd07884    80 DDVCDPHDIEVSPEgdyvAMFQNMGIIHTAKKNIPEELYKK------------------KNMNLNQVVLRFQAFAVSANG 141

                         170
                  ....*....|....*.
gi 2492366666 162 NLTTALPPVVSNPIYD 177
Cdd:cd07884   142 HLRPICPPVYSNPINN 157

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2492366666 186 LRICRVNKNCGSVKGGDEIFLLCDKVQKD-DIEVRFvlnewEAKGVFSQADVHrQVAIVFKTPPYckAITEPVTVKMQLR 264
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGsNLRVTF-----GGGVPCSVLSVS-STAIVCTTPPY--ANPGPGPVEVTVD 72

                          90
                  ....*....|....*..
gi 2492366666 265 RPSDQEVSESMDFRYLP 281
Cdd:cd00102    73 RGNGGITSSPLTFTYVP 89

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins and similar proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development. This group also contains the N-terminal RHD sub-domain of the non-calcium regulated tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2492366666   8 PCIEIIEQPRQRgMRFRYKCEGrSAGSIPGehSTDNnrTYPSIQILNYYGKGKVRITLVTKNDPYKPHPHDLVGK 82
Cdd:cd07927     1 YELRIEVQPEPH-HRARYETEG-SRGAVKA--PSTG--GFPTVKLHGYMEPVGLQVFIGTASGRLKPHAFYQVHR 69