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Conserved domains on  [gi|2481782589|ref|XP_054912309|]
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toll-like receptor 2 [Poeciliopsis prolifica]

Protein Classification

toll-like receptor( domain architecture ID 11471630)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
655-784 7.68e-30

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 115.11  E-value: 7.68e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  655 FDAFVSYSERDagWVENFLIPELEEpseagssgtsSSGPLSLCLHKRDFLPGQPIMDNIMSAIERSRRTIFVLSENFVQS 734
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLE----------KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAES 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2481782589  735 DWCRYELDFSHFWLFEAGGDAAILILLEPLsKDDVPKRFCKLRKLMSSTT 784
Cdd:smart00255  70 EWCLDELVAALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVFKKNY 118
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
364-568 8.12e-21

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.77  E-value: 8.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 364 LENLQYLDLSDNLLTDLTmaESLchgaPTLKELRVLNISGNPLKSlslISHLVANLLKLTHLDVSRTLYSSMPSACSWPS 443
Cdd:COG4886   135 LTNLKELDLSNNQLTDLP--EPL----GNLTNLKSLDLSNNQLTD---LPEELGNLTNLKELDLSNNQITDLPEPLGNLT 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 444 PLKYLNISRAKLTTTTSCLPR--SLEVLDLSYNDLTGFS--LDLPLLRELYLSGNKFLGLPAGQSFPNLQTLTMQFNTLN 519
Cdd:COG4886   206 NLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2481782589 520 MFGLPELQSFRRLENLQAGYNKFICTCDFVNFLQSQLKQKGNVKLTDRK 568
Cdd:COG4886   286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-246 5.36e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 5.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  61 SLDLSFNNITMVTqTDLTGHSRLRALDLHGNRLAEIhPSAFDSLWSLEELDLSDNQLTFLnPNWLKNVTILERLNLLNNP 140
Cdd:COG4886   163 SLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 141 YSRLGSpsmFFGLVRLRRLKFGGPDLKELrrTDLFGVTELEDLTVHANNLASYDSGTLGDIWPLGRVTLSLHGPFLTNVT 220
Cdd:COG4886   240 LTDLPE---LGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                         170       180
                  ....*....|....*....|....*.
gi 2481782589 221 LAAAVLADVSYPETPIVLQDIDVTGI 246
Cdd:COG4886   315 ILLLLLTTLLLLLLLLKGLLVTLTTL 340
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
655-784 7.68e-30

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 115.11  E-value: 7.68e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  655 FDAFVSYSERDagWVENFLIPELEEpseagssgtsSSGPLSLCLHKRDFLPGQPIMDNIMSAIERSRRTIFVLSENFVQS 734
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLE----------KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAES 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2481782589  735 DWCRYELDFSHFWLFEAGGDAAILILLEPLsKDDVPKRFCKLRKLMSSTT 784
Cdd:smart00255  70 EWCLDELVAALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVFKKNY 118
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
364-568 8.12e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.77  E-value: 8.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 364 LENLQYLDLSDNLLTDLTmaESLchgaPTLKELRVLNISGNPLKSlslISHLVANLLKLTHLDVSRTLYSSMPSACSWPS 443
Cdd:COG4886   135 LTNLKELDLSNNQLTDLP--EPL----GNLTNLKSLDLSNNQLTD---LPEELGNLTNLKELDLSNNQITDLPEPLGNLT 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 444 PLKYLNISRAKLTTTTSCLPR--SLEVLDLSYNDLTGFS--LDLPLLRELYLSGNKFLGLPAGQSFPNLQTLTMQFNTLN 519
Cdd:COG4886   206 NLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2481782589 520 MFGLPELQSFRRLENLQAGYNKFICTCDFVNFLQSQLKQKGNVKLTDRK 568
Cdd:COG4886   286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 655-786 6.67e-19

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 84.72  E-value: 6.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 655 FDAFVSYSERDA-GWVENFLIPELEEPSEAgssgtsssgplsLCLHKRDFLPGQPIMDNIMSAIERSRRTIFVLSENFVQ 733
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIK------------LFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYAS 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2481782589 734 SDWCRYELDFSHFWLFEaGGDAAILILLEPLSKD------DVPKRFCKLRKLMSSTTYL 786
Cdd:pfam01582  69 SGWCLDELVKILECALD-LGQKVIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVL 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-246 5.36e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 5.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  61 SLDLSFNNITMVTqTDLTGHSRLRALDLHGNRLAEIhPSAFDSLWSLEELDLSDNQLTFLnPNWLKNVTILERLNLLNNP 140
Cdd:COG4886   163 SLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 141 YSRLGSpsmFFGLVRLRRLKFGGPDLKELrrTDLFGVTELEDLTVHANNLASYDSGTLGDIWPLGRVTLSLHGPFLTNVT 220
Cdd:COG4886   240 LTDLPE---LGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                         170       180
                  ....*....|....*....|....*.
gi 2481782589 221 LAAAVLADVSYPETPIVLQDIDVTGI 246
Cdd:COG4886   315 ILLLLLTTLLLLLLLLKGLLVTLTTL 340
LRR_8 pfam13855
Leucine rich repeat;
81-140 1.72e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.72e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  81 SRLRALDLHGNRLAEIHPSAFDSLWSLEELDLSDNQLTFLNPNWLKNVTILERLNLLNNP 140
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 364-494 1.52e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 364 LENLQYLDLSDNLLTDLTMAESLCHgaptlkeLRVLNISGNplkSLSLISHLvANLLKLTHLDVS--------------R 429
Cdd:cd21340    45 LTNLTHLYLQNNQIEKIENLENLVN-------LKKLYLGGN---RISVVEGL-ENLTNLEELHIEnqrlppgekltfdpR 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2481782589 430 TLYSSMPSacswpspLKYLNISRAKLTTTTSCLP-RSLEVLDLSYNDLTGFS------LDLPLLRELYLSGN 494
Cdd:cd21340   114 SLAALSNS-------LRVLNISGNNIDSLEPLAPlRNLEQLDASNNQISDLEelldllSSWPSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
356-508 8.02e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.78  E-value: 8.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 356 MPCDTSKLLENLQYLDLSDNLLTDLTMaeslcHGAPTLKELRVLNISgnplkslslISHLVANL-LKLTHLDVSRTLYSS 434
Cdd:PRK15370  274 ISCLPENLPEELRYLSVYDNSIRTLPA-----HLPSGITHLNVQSNS---------LTALPETLpPGLKTLEAGENALTS 339

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2481782589 435 MPSacSWPSPLKYLNISRAKLTTTTSCLPRSLEVLDLSYNDLTGFSLDLP-LLRELYLSGNKFLGLPagQSFPNL 508
Cdd:PRK15370  340 LPA--SLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPaALQIMQASRNNLVRLP--ESLPHF 410
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 83-140 1.11e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 1.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  83 LRALDLHGNRLAEIHPsaFDSLWSLEELDLSDNQLTFLNP--NWLKNVTILERLNLLNNP 140
Cdd:cd21340   122 LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-139 1.33e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  60 LSLDLSFNNITMVTQTDLTGHSRLRALDLHGNRLAEIHPSAFDSLWSLEELDLSDNQLTFLNPNWLKNVTILERLNLLNN 139
Cdd:PLN00113  502 MQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
464-496 2.68e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.68e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2481782589 464 RSLEVLDLSYNDLTGFSL----DLPLLRELYLSGNKF 496
Cdd:pfam13855  25 SNLKVLDLSNNLLTTLSPgafsGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
655-784 7.68e-30

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 115.11  E-value: 7.68e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  655 FDAFVSYSERDagWVENFLIPELEEpseagssgtsSSGPLSLCLHKRDFLPGQPIMDNIMSAIERSRRTIFVLSENFVQS 734
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLE----------KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAES 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2481782589  735 DWCRYELDFSHFWLFEAGGDAAILILLEPLsKDDVPKRFCKLRKLMSSTT 784
Cdd:smart00255  70 EWCLDELVAALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVFKKNY 118
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
364-568 8.12e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.77  E-value: 8.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 364 LENLQYLDLSDNLLTDLTmaESLchgaPTLKELRVLNISGNPLKSlslISHLVANLLKLTHLDVSRTLYSSMPSACSWPS 443
Cdd:COG4886   135 LTNLKELDLSNNQLTDLP--EPL----GNLTNLKSLDLSNNQLTD---LPEELGNLTNLKELDLSNNQITDLPEPLGNLT 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 444 PLKYLNISRAKLTTTTSCLPR--SLEVLDLSYNDLTGFS--LDLPLLRELYLSGNKFLGLPAGQSFPNLQTLTMQFNTLN 519
Cdd:COG4886   206 NLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2481782589 520 MFGLPELQSFRRLENLQAGYNKFICTCDFVNFLQSQLKQKGNVKLTDRK 568
Cdd:COG4886   286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
364-542 8.32e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 8.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 364 LENLQYLDLSDNLLTDLtmAESLCHgaptLKELRVLNISGNPLKSLSLishLVANLLKLTHLDVSRTLYSSMPSACSWPS 443
Cdd:COG4886   112 LTNLESLDLSGNQLTDL--PEELAN----LTNLKELDLSNNQLTDLPE---PLGNLTNLKSLDLSNNQLTDLPEELGNLT 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 444 PLKYLNISRAKLTTTTSCL--PRSLEVLDLSYNDLTGFSLD---LPLLRELYLSGNKFLGLPAGQSFPNLQTLTMQFNTL 518
Cdd:COG4886   183 NLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEPlanLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262

                         170       180
                  ....*....|....*....|....
gi 2481782589 519 NmfGLPELQSFRRLENLQAGYNKF 542
Cdd:COG4886   263 T--DLPPLANLTNLKTLDLSNNQL 284
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 655-786 6.67e-19

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 84.72  E-value: 6.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 655 FDAFVSYSERDA-GWVENFLIPELEEPSEAgssgtsssgplsLCLHKRDFLPGQPIMDNIMSAIERSRRTIFVLSENFVQ 733
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIK------------LFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYAS 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2481782589 734 SDWCRYELDFSHFWLFEaGGDAAILILLEPLSKD------DVPKRFCKLRKLMSSTTYL 786
Cdd:pfam01582  69 SGWCLDELVKILECALD-LGQKVIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVL 126
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 658-742 7.67e-14

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 68.50  E-value: 7.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 658 FVSYSERDAGWVENfLIPELEEpseagssgtsssGPLSLCLHKRDFLPGQPIMDNIMSAIERSRRTIFVLSENFVQSDWC 737
Cdd:pfam13676   2 FISYAGEDRAWAEW-LADALEA------------AGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWC 68


                  ....*
gi 2481782589 738 RYELD 742
Cdd:pfam13676  69 RAEWE 73
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-246 5.36e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 5.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  61 SLDLSFNNITMVTqTDLTGHSRLRALDLHGNRLAEIhPSAFDSLWSLEELDLSDNQLTFLnPNWLKNVTILERLNLLNNP 140
Cdd:COG4886   163 SLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 141 YSRLGSpsmFFGLVRLRRLKFGGPDLKELrrTDLFGVTELEDLTVHANNLASYDSGTLGDIWPLGRVTLSLHGPFLTNVT 220
Cdd:COG4886   240 LTDLPE---LGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                         170       180
                  ....*....|....*....|....*.
gi 2481782589 221 LAAAVLADVSYPETPIVLQDIDVTGI 246
Cdd:COG4886   315 ILLLLLTTLLLLLLLLKGLLVTLTTL 340
LRR_8 pfam13855
Leucine rich repeat;
81-140 1.72e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.72e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  81 SRLRALDLHGNRLAEIHPSAFDSLWSLEELDLSDNQLTFLNPNWLKNVTILERLNLLNNP 140
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-192 4.84e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.64  E-value: 4.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  61 SLDLSFNNitmvtqtDLTGHSRLRALDLHGNRLAEIhPSAFDSLWSLEELDLSDNQLTFLnPNWLKNVTILERLNLLNNP 140
Cdd:COG4886   100 ELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ 170

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2481782589 141 YSRLgsPSMFFGLVRLRRLKFGGPDLKELrRTDLFGVTELEDLTVHANNLAS 192
Cdd:COG4886   171 LTDL--PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTD 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
364-540 2.02e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 2.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 364 LENLQYLDLSDNLLTDLTmaESLchgaPTLKELRVLNISGNPLKSLSLIshlvANLLKLTHLDVSRTLYSSMPSACSWPS 443
Cdd:COG4886   204 LTNLEELDLSGNQLTDLP--EPL----ANLTNLETLDLSNNQLTDLPEL----GNLTNLEELDLSNNQLTDLPPLANLTN 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 444 pLKYLNISRAKLTTTTSCLPRSLEVLDLSYNDLTGFSLDLPLLRELYLSGNKFLGLPAGQSFPNLQTLTMQFNTLNMFGL 523
Cdd:COG4886   274 -LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352

                         170
                  ....*....|....*..
gi 2481782589 524 PELQSFRRLENLQAGYN 540
Cdd:COG4886   353 LLLLNLLSLLLTLLLTL 369
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
360-542 1.17e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 360 TSKLLENLQYLDLSDNLLTDLTMAESLCHGAPTLKELRVLNISGNPLKSLSLISHLVANLLKLTHLDVSRTLYSSMPSAc 439
Cdd:COG4886    36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTN- 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 440 swpspLKYLNISRAKLTTTTSCLPR--SLEVLDLSYNDLTgfSLDLPL-----LRELYLSGNKFLGLPAG-QSFPNLQTL 511
Cdd:COG4886   115 -----LESLDLSGNQLTDLPEELANltNLKELDLSNNQLT--DLPEPLgnltnLKSLDLSNNQLTDLPEElGNLTNLKEL 187

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2481782589 512 TMQFNTLNMFGlPELQSFRRLENLQAGYNKF 542
Cdd:COG4886   188 DLSNNQITDLP-EPLGNLTNLEELDLSGNQL 217
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 364-494 1.52e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 364 LENLQYLDLSDNLLTDLTMAESLCHgaptlkeLRVLNISGNplkSLSLISHLvANLLKLTHLDVS--------------R 429
Cdd:cd21340    45 LTNLTHLYLQNNQIEKIENLENLVN-------LKKLYLGGN---RISVVEGL-ENLTNLEELHIEnqrlppgekltfdpR 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2481782589 430 TLYSSMPSacswpspLKYLNISRAKLTTTTSCLP-RSLEVLDLSYNDLTGFS------LDLPLLRELYLSGN 494
Cdd:cd21340   114 SLAALSNS-------LRVLNISGNNIDSLEPLAPlRNLEQLDASNNQISDLEelldllSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
61-117 2.75e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.75e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2481782589  61 SLDLSFNNITMVTQTDLTGHSRLRALDLHGNRLAEIHPSAFDSLWSLEELDLSDNQL 117
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
356-508 8.02e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.78  E-value: 8.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 356 MPCDTSKLLENLQYLDLSDNLLTDLTMaeslcHGAPTLKELRVLNISgnplkslslISHLVANL-LKLTHLDVSRTLYSS 434
Cdd:PRK15370  274 ISCLPENLPEELRYLSVYDNSIRTLPA-----HLPSGITHLNVQSNS---------LTALPETLpPGLKTLEAGENALTS 339

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2481782589 435 MPSacSWPSPLKYLNISRAKLTTTTSCLPRSLEVLDLSYNDLTGFSLDLP-LLRELYLSGNKFLGLPagQSFPNL 508
Cdd:PRK15370  340 LPA--SLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPaALQIMQASRNNLVRLP--ESLPHF 410
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-248 1.31e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  61 SLDLSFNNITmvTQTDLTGHSRLRALDLHGNRLAEIHPSAfdSLWSLEELDLSDNQLTFLNpnwLKNVTILERLNLLNNP 140
Cdd:COG4886   232 TLDLSNNQLT--DLPELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK---LKELELLLGLNSLLLL 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 141 YSRLGSPSMFFGLVRLRRLKFGGPDLKELRRTDLFGVTELEDLTVHANNLASYDSGTLGDIWPLGRVTLSLHGPFLTNVT 220
Cdd:COG4886   305 LLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384

                         170       180
                  ....*....|....*....|....*...
gi 2481782589 221 LAAAVLADVSYPETPIVLQDIDVTGIQS 248
Cdd:COG4886   385 LLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 366-519 2.48e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 366 NLQYLDLSDNLLTDLTMAeSLCHGAPTLKELRVLNISGNPLKSLSLishlvanllklthldvsRTLYSSMPSacswpspl 445
Cdd:cd00116   194 NLEVLDLNNNGLTDEGAS-ALAETLASLKSLEVLNLGDNNLTDAGA-----------------AALASALLS-------- 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 446 kylnisraklttttscLPRSLEVLDLSYNDLT--------GFSLDLPLLRELYLSGNKFLGLPAGQSFPNLQTLTMQFNT 517
Cdd:cd00116   248 ----------------PNISLLTLSLSCNDITddgakdlaEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELES 311


                  ..
gi 2481782589 518 LN 519
Cdd:cd00116   312 LW 313
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 363-428 2.63e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.63e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2481782589 363 LLENLQYLDLSDNLLTDLtmaESLCHgaptLKELRVLNISGNPLKSLSLISHLVANLLKLTHLDVS 428
Cdd:cd21340   118 LSNSLRVLNISGNNIDSL---EPLAP----LRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLT 176
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
394-525 7.68e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 7.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 394 KELRVLNISGNPLKSL-----SLISHLVANLLKLTHL-----------DVSRTLYSSMPSacSWPSPLKYLNISRAKLTT 457
Cdd:PRK15370  199 EQITTLILDNNELKSLpenlqGNIKTLYANSNQLTSIpatlpdtiqemELSINRITELPE--RLPSALQSLDLFHNKISC 276

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2481782589 458 TTSCLPRSLEVLDLSYNDLTGFSLDLPL-LRELYLSGNKFLGLPAGQSfPNLQTLTMQFNTLNmfGLPE 525
Cdd:PRK15370  277 LPENLPEELRYLSVYDNSIRTLPAHLPSgITHLNVQSNSLTALPETLP-PGLKTLEAGENALT--SLPA 342
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 83-140 1.11e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 1.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  83 LRALDLHGNRLAEIHPsaFDSLWSLEELDLSDNQLTFLNP--NWLKNVTILERLNLLNNP 140
Cdd:cd21340   122 LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
364-536 1.28e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 364 LENLQYLDLSDNLLTDLTMAESLchgaptlKELRVLNISGNPLKSLSLISHLVANLLKLTHLDVSRTLYSSMPSACSWPS 443
Cdd:COG4886   249 LTNLEELDLSNNQLTDLPPLANL-------TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 444 PLKYLNISRAKLTTTTSCLPRSLEVLDLSYNDLTGFSLDLPLLRELYLSGNKFLGLPAGQSFPNLQTLTMQFNTLNMFGL 523
Cdd:COG4886   322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401

                         170
                  ....*....|...
gi 2481782589 524 PELQSFRRLENLQ 536
Cdd:COG4886   402 LLTLALLDAVNTE 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-139 1.33e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  60 LSLDLSFNNITMVTQTDLTGHSRLRALDLHGNRLAEIHPSAFDSLWSLEELDLSDNQLTFLNPNWLKNVTILERLNLLNN 139
Cdd:PLN00113  502 MQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHN 581
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-142 5.70e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 5.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  47 SGFTSVPMIpdqaLSLDLSFNNITMVTQT-----------------------DLTGHSRLRALDLHGNRLAEIHPSAFDS 103
Cdd:PLN00113  422 SEFTKLPLV----YFLDISNNNLQGRINSrkwdmpslqmlslarnkffgglpDSFGSKRLENLDLSRNQFSGAVPRKLGS 497

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2481782589 104 LWSLEELDLSDNQLTFLNPNWLKNVTILERLNLLNNPYS 142
Cdd:PLN00113  498 LSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
448-528 9.26e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.84  E-value: 9.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 448 LNISRAKLTTTTSCLPRSLEVLDLSYNDLTGFSLDLPLLRELYLSGNKFLGLPAGQsfPNLQTLTMQFNTLNMfgLPELQ 527
Cdd:PRK15387  206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLP--PGLLELSIFSNPLTH--LPALP 281


                  .
gi 2481782589 528 S 528
Cdd:PRK15387  282 S 282
PLN03150 PLN03150
hypothetical protein; Provisional
 76-142 9.67e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 9.67e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2481782589  76 DLTGHSRLRALDLHGNRLAEIHPSAFDSLWSLEELDLSDNQLTFLNPNWLKNVTILERLNLLNNPYS 142
Cdd:PLN03150  437 DISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 62-163 1.09e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  62 LDLSFNNITMVTqtDLTGHSRLRALDLHGNRLAEIHPSAFD--SLW----SLEELDLSDNQLTFLNPnwLKNVTILERLN 135
Cdd:cd21340    73 LYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKLTFDprSLAalsnSLRVLNISGNNIDSLEP--LAPLRNLEQLD 148

                          90       100
                  ....*....|....*....|....*....
gi 2481782589 136 LLNNPYSRLGSPS-MFFGLVRLRRLKFGG 163
Cdd:cd21340   149 ASNNQISDLEELLdLLSSWPSLRELDLTG 177
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 57-142 1.58e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  57 DQALSLDLSFNNITMVTQTDLTGHSRLRALDLHGNRLAEIHPSAFDSLWSLEELDLSDNQLTFLNPNWLKNVTILERLNL 136
Cdd:PLN00113  475 KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDL 554


                  ....*.
gi 2481782589 137 LNNPYS 142
Cdd:PLN00113  555 SQNQLS 560
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 364-542 1.71e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 364 LENLQYLDLSDNLLTDLTMAEslchgAPTLKELRVLNISGNplkslSLISHLVANLLKLTHLDV----SRTLYSSMPSAC 439
Cdd:PLN00113  139 IPNLETLDLSNNMLSGEIPND-----IGSFSSLKVLDLGGN-----VLVGKIPNSLTNLTSLEFltlaSNQLVGQIPREL 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589 440 SWPSPLKYLNISRAKLTTTtscLPR------SLEVLDLSYNDLTG---FSL-DLPLLRELYLSGNKFLGlPAGQSFPNLQ 509
Cdd:PLN00113  209 GQMKSLKWIYLGYNNLSGE---IPYeiggltSLNHLDLVYNNLTGpipSSLgNLKNLQYLFLYQNKLSG-PIPPSIFSLQ 284

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2481782589 510 TL-TMQFNTLNMFG-LPEL-QSFRRLENLQAGYNKF 542
Cdd:PLN00113  285 KLiSLDLSDNSLSGeIPELvIQLQNLEILHLFSNNF 320
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 62-188 2.40e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  62 LDLSFNNITmvTQTDLTGHSRLRALDLHGNRLAEIhpSAFDSLWSLEELDLSDNQLT-----FLNPNWLKnvTILERLNL 136
Cdd:cd21340    51 LYLQNNQIE--KIENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLA--ALSNSLRV 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2481782589 137 LNNPYSRLGSPSMFFGLVRLRRLKFGGPDLKELRRT--DLFGVTELEDLTVHAN 188
Cdd:cd21340   125 LNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
464-496 2.68e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.68e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2481782589 464 RSLEVLDLSYNDLTGFSL----DLPLLRELYLSGNKF 496
Cdd:pfam13855  25 SNLKVLDLSNNLLTTLSPgafsGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-142 3.77e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2481782589  62 LDLSFNNITMVTQTDLTGHSRLRALDLHGNRLA-EIHPSAFdSLWSLEELDLSDNQLTFLNPNWLKNVTILERLNLLNNP 140
Cdd:PLN00113  241 LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNN 319


                  ..
gi 2481782589 141 YS 142
Cdd:PLN00113  320 FT 321
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-118 5.25e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 5.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2481782589  61 SLDLSFNNITMVTQTDLTGHSRLRALDLHGNRLAEIHPSAFDSLWSLEELDLSDNQLT 118
Cdd:PLN00113  144 TLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLV 201
LRR_8 pfam13855
Leucine rich repeat;
464-516 5.84e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 5.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2481782589 464 RSLEVLDLSYNDLTGFS----LDLPLLRELYLSGNKFLGLPAG--QSFPNLQTLTMQFN 516
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgafKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
364-406 9.65e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 9.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2481782589 364 LENLQYLDLSDNLLTDLTmAESLCHgaptLKELRVLNISGNPL 406
Cdd:pfam13855  24 LSNLKVLDLSNNLLTTLS-PGAFSG----LPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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