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Conserved domains on  [gi|2472421867|ref|XP_054581600|]
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interferon regulatory factor 7 [Eptesicus fuscus]

Protein Classification

IRF and IRF-3 domain-containing protein( domain architecture ID 10457094)

IRF and IRF-3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IRF-3 super family cl11061
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 291-468 3.39e-46

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


The actual alignment was detected with superfamily member pfam10401:

Pssm-ID: 463076  Cd Length: 180  Bit Score: 159.34  E-value: 3.39e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 291 LHVTIMYKGRTVLQETVGRP-SCVLLYGPPG---FATQAPEPQLVAFPCPAQLPDQKQLHYTEKLLQHVAPGLRLQLRTT 366
Cdd:pfam10401   4 LEITFFYRGRLVLELTVSSPeGCRLSYGPPDpqvALYGPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLLLWVAGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 367 GLWAQRLGKCKVYWEVGGPLGSASPsvpaCLLERNRDTRIFDFGTFFRELVEFQARKRQgSPHCTIYLGFGQDLSAGRPK 446
Cdd:pfam10401  84 GLYAKRLCQSRVFWSGPEAPGGDKP----NKLERDATVKLFDLAKFLRELILFQEGRGR-SPDYTITLCFGEEWPDDKPR 158

                         170       180
                  ....*....|....*....|..
gi 2472421867 447 ERNLVLVKLEPWLCQAYLERVQ 468
Cdd:pfam10401 159 EKKLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 13-121 4.38e-46

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


:

Pssm-ID: 459863  Cd Length: 106  Bit Score: 156.18  E-value: 4.38e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867  13 LFADWLLGEVSSGRYEGLRWLDAARTRFRVPWKHFARKDLG-EADAGIFKAWALARGRWPPSRgagDLPAPegqllAGWK 91
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNqEEDAAIFKAWAVHTGKYREGV---DKPDP-----ATWK 72

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2472421867  92 TNFRCALRSTKRFVMLQDNS-GDPTDPHKVF 121
Cdd:pfam00605  73 TNFRCALNKLPDFEEVKDRSkDDGSDPYKVY 103
PHA03378 super family cl33729
EBNA-3B; Provisional
 132-342 2.13e-05

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.37  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 132 SPGVDQGDHKAPEDAPPTGGAlPGPC---LAGAGESPGPGPARWSPVPVPGAPSPLVSLAAsakdlllealrqscvehll 208
Cdd:PHA03378  690 APGTMQPPPRAPTPMRPPAAP-PGRAqrpAAATGRARPPAAAPGRARPPAAAPGRARPPAA------------------- 749

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 209 eAPAVDPIPPAACGPELPagelelPWAVEGAPSPRSQPQAPMT-----DAGPAPemwQPPPEAEPCTPLVGPlcPQLGLH 283
Cdd:PHA03378  750 -APGRARPPAAAPGRARP------PAAAPGAPTPQPPPQAPPApqqrpRGAPTP---QPPPQAGPTSMQLMP--RAAPGQ 817

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2472421867 284 TEPS---LGPLHVTIMYKGRTVL--QETVGRPSCVLLYGPPGFATQAPEPQLVAFPCPAQLPDQ 342
Cdd:PHA03378  818 QGPTkqiLRQLLTGGVKRGRPSLkkPAALERQAAAGPTPSPGSGTSDKIVQAPVFYPPVLQPIQ 881
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 291-468 3.39e-46

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 159.34  E-value: 3.39e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 291 LHVTIMYKGRTVLQETVGRP-SCVLLYGPPG---FATQAPEPQLVAFPCPAQLPDQKQLHYTEKLLQHVAPGLRLQLRTT 366
Cdd:pfam10401   4 LEITFFYRGRLVLELTVSSPeGCRLSYGPPDpqvALYGPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLLLWVAGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 367 GLWAQRLGKCKVYWEVGGPLGSASPsvpaCLLERNRDTRIFDFGTFFRELVEFQARKRQgSPHCTIYLGFGQDLSAGRPK 446
Cdd:pfam10401  84 GLYAKRLCQSRVFWSGPEAPGGDKP----NKLERDATVKLFDLAKFLRELILFQEGRGR-SPDYTITLCFGEEWPDDKPR 158

                         170       180
                  ....*....|....*....|..
gi 2472421867 447 ERNLVLVKLEPWLCQAYLERVQ 468
Cdd:pfam10401 159 EKKLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 13-121 4.38e-46

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 156.18  E-value: 4.38e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867  13 LFADWLLGEVSSGRYEGLRWLDAARTRFRVPWKHFARKDLG-EADAGIFKAWALARGRWPPSRgagDLPAPegqllAGWK 91
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNqEEDAAIFKAWAVHTGKYREGV---DKPDP-----ATWK 72

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2472421867  92 TNFRCALRSTKRFVMLQDNS-GDPTDPHKVF 121
Cdd:pfam00605  73 TNFRCALNKLPDFEEVKDRSkDDGSDPYKVY 103
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 16-126 1.09e-39

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 139.39  E-value: 1.09e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867   16 DWLLGEVSSGRYEGLRWLDAARTRFRVPWKHFARKDL-GEADAGIFKAWALARGRWPPSrgaGDLPAPegqllAGWKTNF 94
Cdd:smart00348   4 PWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFdEERDAEIFKAYCVARGIYQPG---GRSPDP-----KTWKARL 75

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2472421867   95 RCALRSTKRFVMLQDNSGDPTDPHKVFTLSSE 126
Cdd:smart00348  76 RCALRKSRDFEEIKDASTDPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 11-125 2.62e-36

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 130.10  E-value: 2.62e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867  11 RVLFADWLLGEVSSGRYEGLRWLDAARTRFRVPWKHFARKDLGEADAGIFKAWALARGRWPPSrGAGDlpapegqlLAGW 90
Cdd:cd00103     1 KMRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHDVQEADAKIFKAWAVERGIYQPG-GTPD--------PAEW 71

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2472421867  91 KTNFRCALRSTKRFVMLQDNSGD-PTDPHKVFTLSS 125
Cdd:cd00103    72 KARLLCALRSSRGFEEVKDKSKDtPGDPHRVYRLLP 107
PHA03378 PHA03378
EBNA-3B; Provisional
 132-342 2.13e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.37  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 132 SPGVDQGDHKAPEDAPPTGGAlPGPC---LAGAGESPGPGPARWSPVPVPGAPSPLVSLAAsakdlllealrqscvehll 208
Cdd:PHA03378  690 APGTMQPPPRAPTPMRPPAAP-PGRAqrpAAATGRARPPAAAPGRARPPAAAPGRARPPAA------------------- 749

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 209 eAPAVDPIPPAACGPELPagelelPWAVEGAPSPRSQPQAPMT-----DAGPAPemwQPPPEAEPCTPLVGPlcPQLGLH 283
Cdd:PHA03378  750 -APGRARPPAAAPGRARP------PAAAPGAPTPQPPPQAPPApqqrpRGAPTP---QPPPQAGPTSMQLMP--RAAPGQ 817

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2472421867 284 TEPS---LGPLHVTIMYKGRTVL--QETVGRPSCVLLYGPPGFATQAPEPQLVAFPCPAQLPDQ 342
Cdd:PHA03378  818 QGPTkqiLRQLLTGGVKRGRPSLkkPAALERQAAAGPTPSPGSGTSDKIVQAPVFYPPVLQPIQ 881
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 291-468 3.39e-46

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 159.34  E-value: 3.39e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 291 LHVTIMYKGRTVLQETVGRP-SCVLLYGPPG---FATQAPEPQLVAFPCPAQLPDQKQLHYTEKLLQHVAPGLRLQLRTT 366
Cdd:pfam10401   4 LEITFFYRGRLVLELTVSSPeGCRLSYGPPDpqvALYGPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLLLWVAGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 367 GLWAQRLGKCKVYWEVGGPLGSASPsvpaCLLERNRDTRIFDFGTFFRELVEFQARKRQgSPHCTIYLGFGQDLSAGRPK 446
Cdd:pfam10401  84 GLYAKRLCQSRVFWSGPEAPGGDKP----NKLERDATVKLFDLAKFLRELILFQEGRGR-SPDYTITLCFGEEWPDDKPR 158

                         170       180
                  ....*....|....*....|..
gi 2472421867 447 ERNLVLVKLEPWLCQAYLERVQ 468
Cdd:pfam10401 159 EKKLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 13-121 4.38e-46

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 156.18  E-value: 4.38e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867  13 LFADWLLGEVSSGRYEGLRWLDAARTRFRVPWKHFARKDLG-EADAGIFKAWALARGRWPPSRgagDLPAPegqllAGWK 91
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNqEEDAAIFKAWAVHTGKYREGV---DKPDP-----ATWK 72

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2472421867  92 TNFRCALRSTKRFVMLQDNS-GDPTDPHKVF 121
Cdd:pfam00605  73 TNFRCALNKLPDFEEVKDRSkDDGSDPYKVY 103
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 16-126 1.09e-39

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 139.39  E-value: 1.09e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867   16 DWLLGEVSSGRYEGLRWLDAARTRFRVPWKHFARKDL-GEADAGIFKAWALARGRWPPSrgaGDLPAPegqllAGWKTNF 94
Cdd:smart00348   4 PWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFdEERDAEIFKAYCVARGIYQPG---GRSPDP-----KTWKARL 75

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2472421867   95 RCALRSTKRFVMLQDNSGDPTDPHKVFTLSSE 126
Cdd:smart00348  76 RCALRKSRDFEEIKDASTDPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 11-125 2.62e-36

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 130.10  E-value: 2.62e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867  11 RVLFADWLLGEVSSGRYEGLRWLDAARTRFRVPWKHFARKDLGEADAGIFKAWALARGRWPPSrGAGDlpapegqlLAGW 90
Cdd:cd00103     1 KMRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHDVQEADAKIFKAWAVERGIYQPG-GTPD--------PAEW 71

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2472421867  91 KTNFRCALRSTKRFVMLQDNSGD-PTDPHKVFTLSS 125
Cdd:cd00103    72 KARLLCALRSSRGFEEVKDKSKDtPGDPHRVYRLLP 107
PHA03378 PHA03378
EBNA-3B; Provisional
 132-342 2.13e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.37  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 132 SPGVDQGDHKAPEDAPPTGGAlPGPC---LAGAGESPGPGPARWSPVPVPGAPSPLVSLAAsakdlllealrqscvehll 208
Cdd:PHA03378  690 APGTMQPPPRAPTPMRPPAAP-PGRAqrpAAATGRARPPAAAPGRARPPAAAPGRARPPAA------------------- 749

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 209 eAPAVDPIPPAACGPELPagelelPWAVEGAPSPRSQPQAPMT-----DAGPAPemwQPPPEAEPCTPLVGPlcPQLGLH 283
Cdd:PHA03378  750 -APGRARPPAAAPGRARP------PAAAPGAPTPQPPPQAPPApqqrpRGAPTP---QPPPQAGPTSMQLMP--RAAPGQ 817

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2472421867 284 TEPS---LGPLHVTIMYKGRTVL--QETVGRPSCVLLYGPPGFATQAPEPQLVAFPCPAQLPDQ 342
Cdd:PHA03378  818 QGPTkqiLRQLLTGGVKRGRPSLkkPAALERQAAAGPTPSPGSGTSDKIVQAPVFYPPVLQPIQ 881
PHA03379 PHA03379
EBNA-3A; Provisional
 133-279 1.10e-04

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 45.05  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 133 PGVDQGDHKAPEDAPPTGGALPGPCLAGAGESPGPGPARWSPVPVPGAPSPLVSLAasakdlllealrqscvehlLEAPa 212
Cdd:PHA03379  485 PGVVQDGRPACAPVPAPAGPIVRPWEASLSQVPGVAFAPVMPQPMPVEPVPVPTVA-------------------LERP- 544

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 213 VDPIPPAAC--GPELPAGELEL-------PWavegAPSP-RSQPQAPMTD----------AGPAPEMWQPP--PEAEPCT 270
Cdd:PHA03379  545 VCPAPPLIAmqGPGETSGIVRVrerwrpaPW----TPNPpRSPSQMSVRDrlarlraeaqPYQASVEVQPPqlTQVSPQQ 620


                  ....*....
gi 2472421867 271 PLVGPLCPQ 279
Cdd:PHA03379  621 PMEYPLEPE 629
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 146-316 2.23e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.92  E-value: 2.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867  146 APPTGGALPGPCLAGAGESPGPGPARWSPVPVPGAPSPLVSLAA-SAKDLLLEALRQSCVEHLLEAPAVDPIPPAACGPE 224
Cdd:PRK10263   334 AAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPeGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAE 413

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867  225 LPAGE---LELPWAVEGAPSPRSQPQAPMTD----AGPAPEMWQPPPEAEPCTPLVGPLCPQLGLHTEPSLGPLHVTimy 297
Cdd:PRK10263   414 QPAQQpyyAPAPEQPAQQPYYAPAPEQPVAGnawqAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVV--- 490

                          170
                   ....*....|....*....
gi 2472421867  298 KGRTVLQETvgRPSCVLLY 316
Cdd:PRK10263   491 EPEPVVEET--KPARPPLY 507
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 142-271 2.53e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 142 APEDAPPTGGALPGPCLAGAGESPGPGPARWSPVPVPGAPSPLVSLAASAKDLLLEAlrqscvehllEAPAVDPIPPAAC 221
Cdd:PRK14951  383 RPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPA----------AAPAAVALAPAPP 452

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2472421867 222 GPELPAGElelpwavegAPSPRSQPQAPMTDAGPAPEmwqPPPEAEPCTP 271
Cdd:PRK14951  453 AQAAPETV---------AIPVRVAPEPAVASAAPAPA---AAPAAARLTP 490
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 130-290 5.62e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 5.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 130 GGSPGVDQGDHKAPEDAPPTGGALPGPCLAGAGESPGPGPARWSPVPVPGAPSPLVSLAASAKDLLLEALRQSCVEHLLE 209
Cdd:PRK07764  597 GEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGA 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 210 APAVDPIPPAACGPELPAGelelpwAVEGAPSPRSQPQAPmtdAGPAPEMW-QPPPEAEPCTPLVGPLCPQLGLHTEPSL 288
Cdd:PRK07764  677 APAAPPPAPAPAAPAAPAG------AAPAQPAPAPAATPP---AGQADDPAaQPPQAAQGASAPSPAADDPVPLPPEPDD 747


                  ..
gi 2472421867 289 GP 290
Cdd:PRK07764  748 PP 749
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
142-281 8.07e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 8.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 142 APEDAPPTGGALPGPCLAGAGESPG--PGPARWSPVPVPGAPSPLVSLAASAKDLLLEALRQSCVEHllEAPAVDPIPPA 219
Cdd:PRK12323  422 APARRSPAPEALAAARQASARGPGGapAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAA--PAPADDDPPPW 499

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 220 ACGP-ELPAGELE------LPWAVEGAPSP-RSQPQAPMTDAGPAPEMWQPPPEAEPCTPLVGPLCPQLG 281
Cdd:PRK12323  500 EELPpEFASPAPAqpdaapAGWVAESIPDPaTADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRAS 569
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
133-371 1.00e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 133 PGVDQGDHK-APEDAPPTGGALPGPCL-AGAGESPGPGPARWSPVPVPGAPSPLVSLAASAKDLLLEAL---RQSCVEHL 207
Cdd:PRK12323  365 PGQSGGGAGpATAAAAPVAQPAPAAAApAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALaaaRQASARGP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 208 LEAPAVDPIPPAACGPEL--PAGELELPWAVEGAPSPRSQPQAPmtdagPAPEMWQPPPEAEpctplVGPLCPQLGLHTE 285
Cdd:PRK12323  445 GGAPAPAPAPAAAPAAAArpAAAGPRPVAAAAAAAPARAAPAAA-----PAPADDDPPPWEE-----LPPEFASPAPAQP 514

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 286 PSLGPLHVTIMYKGRTVLQETVGRPSCVllygPPGFATQAPEPQLVAFPCPAQLPDQKQLHYTEKLLQHVAPGLRLQLRT 365
Cdd:PRK12323  515 DAAPAGWVAESIPDPATADPDDAFETLA----PAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLPV 590


                  ....*.
gi 2472421867 366 TGLWAQ 371
Cdd:PRK12323  591 RGLAQQ 596
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 124-268 1.50e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 124 SSEEGCGGSPGVDQGDHKAPEDAPPTGGALPGPCLAGAGESPGPGPARWSPVPVPGAPSPLVSLAASAKDLLLEALRQSC 203
Cdd:PRK07764  640 SAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAA 719

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2472421867 204 VEHLLEAPAVDPIPPAACGPELPAGELELPWAVEGAPSPRSQPQAPMTDAGPAPEMWQPPPEAEP 268
Cdd:PRK07764  720 QPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEE 784
PHA03247 PHA03247
large tegument protein UL36; Provisional
 142-278 1.54e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867  142 APEDAPPTGGALPGPCLAGAGESPGpGPARWSPVPVPGAPSPLVSLAASAKDLLLEALRQSCVEHLL--EAPAVDPIPPA 219
Cdd:PHA03247  2835 QPTAPPPPPGPPPPSLPLGGSVAPG-GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALppDQPERPPQPQA 2913

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867  220 ACGPeLPAGELELPWAVEGAPSPRSQPQAPMT-DAGPAPemwQPPPEAEPCTPLVGPLCP 278
Cdd:PHA03247  2914 PPPP-QPQPQPPPPPQPQPPPPPPPRPQPPLApTTDPAG---AGEPSGAVPQPWLGALVP 2969
PHA03247 PHA03247
large tegument protein UL36; Provisional
 130-278 3.29e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 3.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867  130 GGSPGVDQGDHK---APEDAPPTGGALPGPCLAG---AGESPGPGPARWSPVPVP-GAPSP-LVSLAASAKDLLLEALRQ 201
Cdd:PHA03247  2598 PRAPVDDRGDPRgpaPPSPLPPDTHAPDPPPPSPspaANEPDPHPPPTVPPPERPrDDPAPgRVSRPRRARRLGRAAQAS 2677

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867  202 ScvehlleaPAVDPIPPAACGPELPAGELELPWAVEGAPSPRSQPQAPMTDAGPAPEMWQ---PPPEAEPCTPLV--GPL 276
Cdd:PHA03247  2678 S--------PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARqasPALPAAPAPPAVpaGPA 2749


                   ..
gi 2472421867  277 CP 278
Cdd:PHA03247  2750 TP 2751
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 142-293 3.92e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 3.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 142 APEDAPPTGGALPGPCLAGAGESPGPGPARWSPVPVPGAPSPLVSLAASAKdlllealrqscvehllEAPAVDPIPPAAC 221
Cdd:PRK07764  380 RLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQ----------------PAPAPAPAPAPPS 443

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2472421867 222 GPELPagelelPWAVEGAPSPRSQPQAPMTDAGPAPEMWQPPPEAEPCTPLVGPLCPQLGLHTEPSLGPLHV 293
Cdd:PRK07764  444 PAGNA------PAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDA 509
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 147-290 4.11e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.70  E-value: 4.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 147 PPTGGALPGPCLAGA---GESPGPGPARWSPVPVPGAPSPLVSLAASAKdlllealrqscvehlleAPAVDPIPPAACGP 223
Cdd:PRK14951  366 PAAAAEAAAPAEKKTparPEAAAPAAAPVAQAAAAPAPAAAPAAAASAP-----------------AAPPAAAPPAPVAA 428

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2472421867 224 ELPAgelelPWAVEGAPSPRSQPQAPMTDAGPAPEMWQPPPEAEPCTPLVGPLCPQLGLHTEPSLGP 290
Cdd:PRK14951  429 PAAA-----APAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTP 490
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 169-278 6.89e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 39.45  E-value: 6.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867  169 PARWSPVPVPGAPSPLVSLAAS---AKDLLLEALrQSCVEHLLEAPAVDPIPPAACGPELPAGELELPWAVEGAPSPRSQ 245
Cdd:PHA03309  1597 PSRRMSARPPSRPPAAVILRASwryAEEVAREML-DAAASRFDEADGEDPLPPAACGGKPIAPETLVALCEQRGRGPTSL 1675

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2472421867  246 PQAPMTDAGpapEMWQPPPEAEPCTPLVGPLCP 278
Cdd:PHA03309  1676 PRAPTPRSG---EALAAPRRSGAKDPRQGQYCP 1705
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 210-353 7.64e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 39.30  E-value: 7.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867  210 APAVDPIPPAA--CGPELPAGELELPWavegapSPRSQPQAPMTDAGPAPEMWQPPPE-AEPCTPlvgplcpqlglHTEP 286
Cdd:PRK10263   334 AAPVEPVTQTPpvASVDVPPAQPTVAW------QPVPGPQTGEPVIAPAPEGYPQQSQyAQPAVQ-----------YNEP 396

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2472421867  287 SLGPLHVTIMYKGRTVLQETVGRPSCVLLYGPPGFATQAPEPQLVAFPCPAQLPDQKQLHYTEKLLQ 353
Cdd:PRK10263   397 LQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQ 463
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 146-271 1.00e-02

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 38.51  E-value: 1.00e-02
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472421867 146 APPTGGALPGPCLAGAGESPGPGPAR----------WSPVPVPGAPSPlvsLAASAKDLLLEalrqscvehllEAPavdP 215
Cdd:PRK14959  379 SAPSGSAAEGPASGGAATIPTPGTQGpqgtapaagmTPSSAAPATPAP---SAAPSPRVPWD-----------DAP---P 441

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2472421867 216 IPPAACGPELPAGelelpwAVEGAPSPRSQPQAPMTDAGPAPEMWQP--PPEAEPCTP 271
Cdd:PRK14959  442 APPRSGIPPRPAP------RMPEASPVPGAPDSVASASDAPPTLGDPsdTAEHTPSGP 493
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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