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Conserved domains on  [gi|2462548671|ref|XP_054236135|]
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FH1/FH2 domain-containing protein 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
632-1004 2.16e-109

Formin Homology 2 Domain;


:

Pssm-ID: 396655  Cd Length: 372  Bit Score: 347.34  E-value: 2.16e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  632 DSSALPTKRKTVKLFWRELKLAGGHGvsasrfgpcaTLWASLDPVS----VDTARLEHLFESRAKEVLPSK----KAGEG 703
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRG----------TVWDKLDDESfeldGDLSELEELFSAKAKTKKNKKsedkSSSKK 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  704 RRTMTTVLDPKRSNAINIGLTTL-PPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIeeAQLANPDIPLGPAEN 782
Cdd:pfam02181   71 KPKEVSLLDPKRAQNIAILLRKLkLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKL--KEYKGDPSELGRAEQ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  783 FLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGS----QSSGFELS 858
Cdd:pfam02181  149 FLLELSKIPRLEARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGtrrgQAKGFKLS 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  859 YLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLRSLAK-HEL 937
Cdd:pfam02181  229 SLLKLSDTKSTDNKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELSALdEHP 308

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462548671  938 APALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPqaaREVRIMQFCHTLREFALEYR 1004
Cdd:pfam02181  309 DDKFREVLKEFLKSAEEKLDKLESLLREALELFKELVEYFGEDP---KETSPEEFFKILRDFLKEFK 372
Formin_GBD_N super family cl39720
Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of ...
 20-125 3.94e-28

Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of formins also known as formin homology domain-containing proteins (FHOD) pfam02181. This GBD is recruited by Rac and Ras GTPases in cells and plays an essential role for FHOD1-mediated actin remodelling and transcriptional activation, localizes to specific GTPases in cells, and binds to GTPases in vitro. It exhibits structural similarity to the ubiquitin superfold as found, for example, in the Ras-binding domains of c-Raf1 or PI3 kinase, but contains an unusual loop that inserts into the first FH3 repeat.


The actual alignment was detected with superfamily member pfam18382:

Pssm-ID: 465735  Cd Length: 119  Bit Score: 109.75  E-value: 3.94e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671   20 PFPAR----CFRART-----LGGALPPPQAPHQpgrlqcwrrgervgLEDCALQV---SPSGYYLDTELSLEEQREMLEG 87
Cdd:pfam18382   20 PEPTRpptfTFNEDLplseqLAGVHRLLQAPHK--------------LEDCALQVyrdGDYGNYLDLDSSLAEQREELEG 85

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2462548671   88 FYEEiskgRKPTLILRTQLSVRVNAILEKLYSSSGPEL 125
Cdd:pfam18382   86 FQED----RKNSLVLRTQLSVRVHAIIEKLLNSSGREL 119
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 327-543 9.53e-07

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 53.15  E-value: 9.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  327 EDGDIEEAPGAGGRRERRKP-SSEEGKRSRRSlegggCPARAPEPG--------PTGPASPVGPTSSTGPALLTGP--AS 395
Cdd:PTZ00449   530 EEGEHEDSKESDEPKEGGKPgETKEGEVGKKP-----GPAKEHKPSkiptlskkPEFPKDPKHPKDPEEPKKPKRPrsAQ 604

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  396 SPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKlHQTASVWAPESPPVPQSP--PGQAR--LEARFLENVAAAETEKq 471
Cdd:PTZ00449   605 RPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPP-QRPSSPERPEGPKIIKSPkpPKSPKppFDPKFKEKFYDDYLDA- 682

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462548671  472 valAQGRAETLAGAMPNEAGGHPDARQLwdsPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAE 543
Cdd:PTZ00449   683 ---AAKSKETKTTVVLDESFESILKETL---PETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIE 748
 
Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
632-1004 2.16e-109

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 347.34  E-value: 2.16e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  632 DSSALPTKRKTVKLFWRELKLAGGHGvsasrfgpcaTLWASLDPVS----VDTARLEHLFESRAKEVLPSK----KAGEG 703
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRG----------TVWDKLDDESfeldGDLSELEELFSAKAKTKKNKKsedkSSSKK 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  704 RRTMTTVLDPKRSNAINIGLTTL-PPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIeeAQLANPDIPLGPAEN 782
Cdd:pfam02181   71 KPKEVSLLDPKRAQNIAILLRKLkLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKL--KEYKGDPSELGRAEQ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  783 FLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGS----QSSGFELS 858
Cdd:pfam02181  149 FLLELSKIPRLEARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGtrrgQAKGFKLS 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  859 YLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLRSLAK-HEL 937
Cdd:pfam02181  229 SLLKLSDTKSTDNKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELSALdEHP 308

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462548671  938 APALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPqaaREVRIMQFCHTLREFALEYR 1004
Cdd:pfam02181  309 DDKFREVLKEFLKSAEEKLDKLESLLREALELFKELVEYFGEDP---KETSPEEFFKILRDFLKEFK 372
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
 637-1075 1.13e-93

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 305.43  E-value: 1.13e-93
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671   637 PTKRKTVKLFWRELKLAGghgvsasrfgPCATLWASLDPVS-VDTARLEHLFESRAKEVLPSKKAGEGR-------RTMT 708
Cdd:smart00498    5 KPKKKLKPLHWDKLNPSD----------LSGTVWDKIDEESeGDLDELEELFSAKEKTKSASKDVSEKKsilkkkaSQEF 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671   709 TVLDPKRSNAINIGLTTLP-PVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPdIPLGPAENFLMTL 787
Cdd:smart00498   75 KILDPKRSQNLAILLRKLHmSYEEIKEAILEGDEDVLSVDLLEQLLKYAPTKEELKKLREYKEEDP-EELARAEQFLLLI 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671   788 ASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNG----SQSSGFELSYLEKV 863
Cdd:smart00498  154 SNIPYLEERLNALLFKANFEEEVEDLKPQIEKVEAACEELRESKKFRKLLELILAIGNYMNGgsrrGQAYGFKLSSLLKL 233

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671   864 SEVKDTVRRQSLLHHLCSLVLQTRpessdlyseipaltrcakvdfeqltenlgqlerrsraaeesLRSLAKHELAP-ALR 942
Cdd:smart00498  234 SDVKSADNKTTLLHFLVKIIRKKY-----------------------------------------LGGLSDPENLDdKFI 272

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671   943 ARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQaarEVRIMQFCHTLREFALEYRTCRErvlQQQQKQATYRE 1022
Cdd:smart00498  273 EVMKPFLKAAKEKYDKLQKDLSDLKTRFEKLVEYYGEDPK---DTSPEEFFKDFNEFLKEFSKAAE---ENIKKEEEEEE 346

                           410       420       430       440       450
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2462548671  1023 RNKTRGRMITETEKFSGVAGEapSNPSVPVAVSsgpgrgdADSHASMKSLLTS 1075
Cdd:smart00498  347 RRKKLVKETTEYEQSSSRQKE--RNPSMDFEVE-------RDFLGVLDSLLEE 390
Formin_GBD_N pfam18382
Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of ...
 20-125 3.94e-28

Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of formins also known as formin homology domain-containing proteins (FHOD) pfam02181. This GBD is recruited by Rac and Ras GTPases in cells and plays an essential role for FHOD1-mediated actin remodelling and transcriptional activation, localizes to specific GTPases in cells, and binds to GTPases in vitro. It exhibits structural similarity to the ubiquitin superfold as found, for example, in the Ras-binding domains of c-Raf1 or PI3 kinase, but contains an unusual loop that inserts into the first FH3 repeat.


Pssm-ID: 465735  Cd Length: 119  Bit Score: 109.75  E-value: 3.94e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671   20 PFPAR----CFRART-----LGGALPPPQAPHQpgrlqcwrrgervgLEDCALQV---SPSGYYLDTELSLEEQREMLEG 87
Cdd:pfam18382   20 PEPTRpptfTFNEDLplseqLAGVHRLLQAPHK--------------LEDCALQVyrdGDYGNYLDLDSSLAEQREELEG 85

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2462548671   88 FYEEiskgRKPTLILRTQLSVRVNAILEKLYSSSGPEL 125
Cdd:pfam18382   86 FQED----RKNSLVLRTQLSVRVHAIIEKLLNSSGREL 119
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 327-543 9.53e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 53.15  E-value: 9.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  327 EDGDIEEAPGAGGRRERRKP-SSEEGKRSRRSlegggCPARAPEPG--------PTGPASPVGPTSSTGPALLTGP--AS 395
Cdd:PTZ00449   530 EEGEHEDSKESDEPKEGGKPgETKEGEVGKKP-----GPAKEHKPSkiptlskkPEFPKDPKHPKDPEEPKKPKRPrsAQ 604

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  396 SPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKlHQTASVWAPESPPVPQSP--PGQAR--LEARFLENVAAAETEKq 471
Cdd:PTZ00449   605 RPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPP-QRPSSPERPEGPKIIKSPkpPKSPKppFDPKFKEKFYDDYLDA- 682

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462548671  472 valAQGRAETLAGAMPNEAGGHPDARQLwdsPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAE 543
Cdd:PTZ00449   683 ---AAKSKETKTTVVLDESFESILKETL---PETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIE 748
 
Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
632-1004 2.16e-109

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 347.34  E-value: 2.16e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  632 DSSALPTKRKTVKLFWRELKLAGGHGvsasrfgpcaTLWASLDPVS----VDTARLEHLFESRAKEVLPSK----KAGEG 703
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRG----------TVWDKLDDESfeldGDLSELEELFSAKAKTKKNKKsedkSSSKK 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  704 RRTMTTVLDPKRSNAINIGLTTL-PPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIeeAQLANPDIPLGPAEN 782
Cdd:pfam02181   71 KPKEVSLLDPKRAQNIAILLRKLkLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKL--KEYKGDPSELGRAEQ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  783 FLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGS----QSSGFELS 858
Cdd:pfam02181  149 FLLELSKIPRLEARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGtrrgQAKGFKLS 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  859 YLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLRSLAK-HEL 937
Cdd:pfam02181  229 SLLKLSDTKSTDNKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELSALdEHP 308

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462548671  938 APALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPqaaREVRIMQFCHTLREFALEYR 1004
Cdd:pfam02181  309 DDKFREVLKEFLKSAEEKLDKLESLLREALELFKELVEYFGEDP---KETSPEEFFKILRDFLKEFK 372
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
 637-1075 1.13e-93

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 305.43  E-value: 1.13e-93
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671   637 PTKRKTVKLFWRELKLAGghgvsasrfgPCATLWASLDPVS-VDTARLEHLFESRAKEVLPSKKAGEGR-------RTMT 708
Cdd:smart00498    5 KPKKKLKPLHWDKLNPSD----------LSGTVWDKIDEESeGDLDELEELFSAKEKTKSASKDVSEKKsilkkkaSQEF 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671   709 TVLDPKRSNAINIGLTTLP-PVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPdIPLGPAENFLMTL 787
Cdd:smart00498   75 KILDPKRSQNLAILLRKLHmSYEEIKEAILEGDEDVLSVDLLEQLLKYAPTKEELKKLREYKEEDP-EELARAEQFLLLI 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671   788 ASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNG----SQSSGFELSYLEKV 863
Cdd:smart00498  154 SNIPYLEERLNALLFKANFEEEVEDLKPQIEKVEAACEELRESKKFRKLLELILAIGNYMNGgsrrGQAYGFKLSSLLKL 233

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671   864 SEVKDTVRRQSLLHHLCSLVLQTRpessdlyseipaltrcakvdfeqltenlgqlerrsraaeesLRSLAKHELAP-ALR 942
Cdd:smart00498  234 SDVKSADNKTTLLHFLVKIIRKKY-----------------------------------------LGGLSDPENLDdKFI 272

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671   943 ARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQaarEVRIMQFCHTLREFALEYRTCRErvlQQQQKQATYRE 1022
Cdd:smart00498  273 EVMKPFLKAAKEKYDKLQKDLSDLKTRFEKLVEYYGEDPK---DTSPEEFFKDFNEFLKEFSKAAE---ENIKKEEEEEE 346

                           410       420       430       440       450
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2462548671  1023 RNKTRGRMITETEKFSGVAGEapSNPSVPVAVSsgpgrgdADSHASMKSLLTS 1075
Cdd:smart00498  347 RRKKLVKETTEYEQSSSRQKE--RNPSMDFEVE-------RDFLGVLDSLLEE 390
Formin_GBD_N pfam18382
Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of ...
 20-125 3.94e-28

Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of formins also known as formin homology domain-containing proteins (FHOD) pfam02181. This GBD is recruited by Rac and Ras GTPases in cells and plays an essential role for FHOD1-mediated actin remodelling and transcriptional activation, localizes to specific GTPases in cells, and binds to GTPases in vitro. It exhibits structural similarity to the ubiquitin superfold as found, for example, in the Ras-binding domains of c-Raf1 or PI3 kinase, but contains an unusual loop that inserts into the first FH3 repeat.


Pssm-ID: 465735  Cd Length: 119  Bit Score: 109.75  E-value: 3.94e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671   20 PFPAR----CFRART-----LGGALPPPQAPHQpgrlqcwrrgervgLEDCALQV---SPSGYYLDTELSLEEQREMLEG 87
Cdd:pfam18382   20 PEPTRpptfTFNEDLplseqLAGVHRLLQAPHK--------------LEDCALQVyrdGDYGNYLDLDSSLAEQREELEG 85

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2462548671   88 FYEEiskgRKPTLILRTQLSVRVNAILEKLYSSSGPEL 125
Cdd:pfam18382   86 FQED----RKNSLVLRTQLSVRVHAIIEKLLNSSGREL 119
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 327-543 9.53e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 53.15  E-value: 9.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  327 EDGDIEEAPGAGGRRERRKP-SSEEGKRSRRSlegggCPARAPEPG--------PTGPASPVGPTSSTGPALLTGP--AS 395
Cdd:PTZ00449   530 EEGEHEDSKESDEPKEGGKPgETKEGEVGKKP-----GPAKEHKPSkiptlskkPEFPKDPKHPKDPEEPKKPKRPrsAQ 604

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  396 SPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKlHQTASVWAPESPPVPQSP--PGQAR--LEARFLENVAAAETEKq 471
Cdd:PTZ00449   605 RPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPP-QRPSSPERPEGPKIIKSPkpPKSPKppFDPKFKEKFYDDYLDA- 682

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462548671  472 valAQGRAETLAGAMPNEAGGHPDARQLwdsPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAE 543
Cdd:PTZ00449   683 ---AAKSKETKTTVVLDESFESILKETL---PETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIE 748
PHA03247 PHA03247
large tegument protein UL36; Provisional
 337-554 3.76e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 3.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  337 AGGRRERRKPSSEEGKRSRRSLEGGGCPARAPEPGPTGPASPVGPTSSTGPAlltgPASSPVGPPSGLQASVNLFPTISV 416
Cdd:PHA03247  2581 AVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPS----PAANEPDPHPPPTVPPPERPRDDP 2656

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  417 APSADTSSERsiyklhqtasVWAPESPPVPQSPPGQARLEArflenvaaaetekqvalaqgrAETLAGAMPNEAGGHPDA 496
Cdd:PHA03247  2657 APGRVSRPRR----------ARRLGRAAQASSPPQRPRRRA---------------------ARPTVGSLTSLADPPPPP 2705

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462548671  497 RqlwdSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTRAPR 554
Cdd:PHA03247  2706 P----TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR 2759
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
367-544 7.06e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 50.23  E-value: 7.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  367 APEPGPTGPASPVGPTSSTGPALLtgPASSPVGPPSGLQASVNLFPTISVAPSAdTSSERSIYKLHQTASVWAPESPPVP 446
Cdd:PRK07003   357 AFEPAVTGGGAPGGGVPARVAGAV--PAPGARAAAAVGASAVPAVTAVTGAAGA-ALAPKAAAAAAATRAEAPPAAPAPP 433

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  447 QS-----------PPGQARLEARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSP 515
Cdd:PRK07003   434 ATadrgddaadgdAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAP 513

                          170       180
                   ....*....|....*....|....*....
gi 2462548671  516 APcvllrAQRSLAPEPKEPLIPASPKAEP 544
Cdd:PRK07003   514 AA-----ASREDAPAAAAPPAPEARPPTP 537
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
332-516 3.93e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.92  E-value: 3.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  332 EEAPGAGGRRERRKPSSEEGKRSR---RSLEGGGCPARAPEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASV 408
Cdd:PRK07003   359 EPAVTGGGAPGGGVPARVAGAVPApgaRAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADR 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  409 NLFPTISVAPSADTSSERSIYKLHQTASVWAPESPPVPQS-PPGQARLEARFLENVAAAETEKQVALAQGRAETLAGAMP 487
Cdd:PRK07003   439 GDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASaPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASR 518

                          170       180
                   ....*....|....*....|....*....
gi 2462548671  488 NEAGGHPDARQLWDSPEtAPAARTPQSPA 516
Cdd:PRK07003   519 EDAPAAAAPPAPEARPP-TPAAAAPAARA 546
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 360-573 1.21e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.52  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  360 GGGCPARAPEPGPTG-------PASPVGPTSSTGPAllTGPASSPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKLH 432
Cdd:PRK07764   593 GAAGGEGPPAPASSGppeeaarPAAPAAPAAPAAPA--PAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  433 QTASVWAPESPPVPQSPPGQArlearflenvAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTP 512
Cdd:PRK07764   671 AKAGGAAPAAPPPAPAPAAPA----------APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP 740

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462548671  513 QSPAP---CVLLRAQRSLAPE--PKEPLIPASPKAEPIWELPTRAPRLSIGDLDFSDLGEDEDQDM 573
Cdd:PRK07764   741 LPPEPddpPDPAGAPAQPPPPpaPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAM 806
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
388-561 2.11e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.64  E-value: 2.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  388 ALLTGPASSPVGPPSGLQASVNLFPTISVAPSAdtssersiyklhqtasvwAPESPPVPQSPPGQARLEARFLENVAAAE 467
Cdd:PRK12323   362 AFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAA------------------AAPAPAAPPAAPAAAPAAAAAARAVAAAP 423

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  468 TEKQVALaqgraETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAE--PI 545
Cdd:PRK12323   424 ARRSPAP-----EALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDdpPP 498

                          170
                   ....*....|....*..
gi 2462548671  546 WE-LPTRAPRLSIGDLD 561
Cdd:PRK12323   499 WEeLPPEFASPAPAQPD 515
PHA03378 PHA03378
EBNA-3B; Provisional
 334-551 2.75e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.44  E-value: 2.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  334 APGAGGRRE-RRKPSSEEGKRSRRSL-EGGGCPARAPEPGPTGPASPVGPTSST-GPALLTGPASSPVGPPSGLQASVNL 410
Cdd:PHA03378   589 APSYAQTPWpVPHPSQTPEPPTTQSHiPETSAPRQWPMPLRPIPMRPLRMQPITfNVLVFPTPHQPPQVEITPYKPTWTQ 668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  411 FPTISVAPS-ADTSSERSIYKLHQTASVWA--------PESPPVPQSPPGQARLEARflENVAAAETEKQVALAQGRAET 481
Cdd:PHA03378   669 IGHIPYQPSpTGANTMLPIQWAPGTMQPPPraptpmrpPAAPPGRAQRPAAATGRAR--PPAAAPGRARPPAAAPGRARP 746

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462548671  482 LAGAmPNEAGGHPDARQLWDSPETAPAARTPQSP---APCVLLRAQRSLAPEPKEPLIPAS----PKAEPIWELPTR 551
Cdd:PHA03378   747 PAAA-PGRARPPAAAPGRARPPAAAPGAPTPQPPpqaPPAPQQRPRGAPTPQPPPQAGPTSmqlmPRAAPGQQGPTK 822
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 376-553 1.05e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  376 ASPVGPTSSTGPALLTGPASS-PV---GPPSGLQAsvnlfPTISVAPSADTSSERSIYKLHQTASVwAPESPPVPQSPPG 451
Cdd:PRK10263   334 AAPVEPVTQTPPVASVDVPPAqPTvawQPVPGPQT-----GEPVIAPAPEGYPQQSQYAQPAVQYN-EPLQQPVQPQQPY 407

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  452 QARLEARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAPcvllRAQRSLAPEP 531
Cdd:PRK10263   408 YAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAA----QEPLYQQPQP 483

                          170       180
                   ....*....|....*....|....
gi 2462548671  532 KEPliPASPKAEPIWE--LPTRAP 553
Cdd:PRK10263   484 VEQ--QPVVEPEPVVEetKPARPP 505
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 367-517 2.39e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 2.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  367 APEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASVNLFPTISVAPSADtssersiyklhQTASVWAPESPPVP 446
Cdd:PRK14951   363 AFKPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAP-----------PAAAPPAPVAAPAA 431

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462548671  447 QSPPGQArlearflENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAP 517
Cdd:PRK14951   432 AAPAAAP-------AAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGD 495
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
355-553 2.87e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 2.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  355 RRSLEGGGCparAPEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKLHQT 434
Cdd:PRK12323   364 RPGQSGGGA---GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQAS 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  435 ASVWAPESPPVPQSPPgqarlearflenVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSP--ETAPAARTP 512
Cdd:PRK12323   441 ARGPGGAPAPAPAPAA------------APAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPpwEELPPEFAS 508

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 2462548671  513 QSPAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTRAP 553
Cdd:PRK12323   509 PAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAP 549
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 338-544 6.85e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 6.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  338 GGRRERRKPSSEEGKRSRRSLEGGGC--PARAPEPGPTGPASPVGPTSSTGPAlLTGPASSPVGPPSGLQASVNLFPTIS 415
Cdd:PHA03307    81 ANESRSTPTWSLSTLAPASPAREGSPtpPGPSSPDPPPPTPPPASPPPSPAPD-LSEMLRPVGSPGPPPAASPPAAGASP 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  416 VAPSADTSSERSIYKLHQ-----TASVWAPESPPVPQSPPGQARLEARFLENVAAAETEKQVALAQGRAETLAGAMPNEA 490
Cdd:PHA03307   160 AAVASDAASSRQAALPLSspeetARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDS 239

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462548671  491 GGHPDARQLWDSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPliPASPKAEP 544
Cdd:PHA03307   240 SSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPG--PASSSSSP 291
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
336-556 7.84e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 7.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  336 GAGGRRERRKPSSEEGKRSRRSLEGGGCPARAPEPGPTGPAS-PVGPTSSTGPAlltgpASSPvgPPSGLQASVNLFPTI 414
Cdd:PRK12323   371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAaAAARAVAAAPA-----RRSP--APEALAAARQASARG 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  415 SVAPSADTSSersiyklhqTASVWAPESPPVPQSPPGQARLEARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHP 494
Cdd:PRK12323   444 PGGAPAPAPA---------PAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQP 514

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462548671  495 DA--RQLWDSPETAPAARTPQSPAPcvllraqrSLAPEPKEPLIPAsPKAEPIWELPTRAPRLS 556
Cdd:PRK12323   515 DAapAGWVAESIPDPATADPDDAFE--------TLAPAPAAAPAPR-AAAATEPVVAPRPPRAS 569
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 365-575 9.78e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 39.91  E-value: 9.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  365 ARAPEPGPTGPASPVGPTSSTGPALLTGPASSPvGPPSGLQASVNLFPTISVAPSADTSSERSIYKLHQTASVWAPESPP 444
Cdd:PLN03209   336 ADGPKPVPTKPVTPEAPSPPIEEEPPQPKAVVP-RPLSPYTAYEDLKPPTSPIPTPPSSSPASSKSVDAVAKPAEPDVVP 414

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548671  445 VPQSPPGQARLE--------ARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPdarqlwDSPETAP--AARTPQS 514
Cdd:PLN03209   415 SPGSASNVPEVEpaqveakkTRPLSPYARYEDLKPPTSPSPTAPTGVSPSVSSTSSVP------AVPDTAPatAATDAAA 488

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462548671  515 PAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTRAPRLSIGDLDFSDLGEDEDQDMLN 575
Cdd:PLN03209   489 PPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHHAQ 549
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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