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Conserved domains on  [gi|2462547423|ref|XP_054235526|]
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dynein axonemal assembly factor 1 isoform X10 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 25-209 9.31e-43

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 153.79  E-value: 9.31e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  25 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENL 104
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 105 SCLPVLNTLQM------------------------------AHNHLETVEDIQHLQeclRLCVLDLSHNKLSD-PEILSI 153
Cdd:cd21340    87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547423 154 LESMPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 209
Cdd:cd21340   164 LSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
PHA03169 super family cl27451
hypothetical protein; Provisional
 209-421 2.48e-05

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PHA03169:

Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 47.27  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 209 RGGYAAEKEERQQWESRERK-KITDSIEALAMIKQRAEERKRQRESQERGmrsAEDNSPRVPLRLGEMTSSDDGENvpas 287
Cdd:PHA03169   26 HGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTET---AEESRHGEKEERGQGGPSGSGSE---- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 288 aEGKEEPPGDRETRQkmELFVKESFEAKEELCPEKPSGEEPPvEAKREDGGP----EPEGTLPAETLLLSSPVEVKGEDG 363
Cdd:PHA03169   99 -SVGSPTPSPSGSAE--ELASGLSPENTSGSSPESPASHSPP-PSPPSHPGPhepaPPESHNPSPNQQPSSFLQPSHEDS 174

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547423 364 DGEPEGtlPAEAPPPPPPVEVKGEDGDQEPEGTLPAETlllsppvkvKGEDGDREPEG 421
Cdd:PHA03169  175 PEEPEP--PTSEPEPDSPGPPQSETPTSSPPPQSPPDE---------PGEPQSPTPQQ 221
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 25-209 9.31e-43

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 153.79  E-value: 9.31e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  25 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENL 104
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 105 SCLPVLNTLQM------------------------------AHNHLETVEDIQHLQeclRLCVLDLSHNKLSD-PEILSI 153
Cdd:cd21340    87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547423 154 LESMPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 209
Cdd:cd21340   164 LSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-192 4.03e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 4.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  24 TLYLHFKGFDRI-ENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKI-ENLEPLQKLDALNLSNNYIKT 100
Cdd:COG4886   117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 101 I-ENLSCLPVLNTLQMAHNHLETVEDIqhLQECLRLCVLDLSHNKLSDpeiLSILESMPDLRVLNLMGNPvIRQIPNyrr 179
Cdd:COG4886   197 LpEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNNQLTD---LPELGNLTNLEELDLSNNQ-LTDLPP--- 267

                         170
                  ....*....|...
gi 2462547423 180 tvTVRLKHLTYLD 192
Cdd:COG4886   268 --LANLTNLKTLD 278
LRR_9 pfam14580
Leucine-rich repeat;
79-215 4.29e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 62.09  E-value: 4.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  79 IENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNH-LETVEDIQHLQECLRlcVLDLSHNKLSDPEILSILES 156
Cdd:pfam14580  34 IENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRiCRIGEGLGEALPNLT--ELILTNNNLQELGDLDPLAS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462547423 157 MPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAE 215
Cdd:pfam14580 112 LKKLTFLSLLRNPVTNK-PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
PHA03169 PHA03169
hypothetical protein; Provisional
 209-421 2.48e-05

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 47.27  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 209 RGGYAAEKEERQQWESRERK-KITDSIEALAMIKQRAEERKRQRESQERGmrsAEDNSPRVPLRLGEMTSSDDGENvpas 287
Cdd:PHA03169   26 HGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTET---AEESRHGEKEERGQGGPSGSGSE---- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 288 aEGKEEPPGDRETRQkmELFVKESFEAKEELCPEKPSGEEPPvEAKREDGGP----EPEGTLPAETLLLSSPVEVKGEDG 363
Cdd:PHA03169   99 -SVGSPTPSPSGSAE--ELASGLSPENTSGSSPESPASHSPP-PSPPSHPGPhepaPPESHNPSPNQQPSSFLQPSHEDS 174

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547423 364 DGEPEGtlPAEAPPPPPPVEVKGEDGDQEPEGTLPAETlllsppvkvKGEDGDREPEG 421
Cdd:PHA03169  175 PEEPEP--PTSEPEPDSPGPPQSETPTSSPPPQSPPDE---------PGEPQSPTPQQ 221
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-187 1.20e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  86 QKLDALNLSNNYIKTI--ENLSCLPVLNTLQMAHNHLeTVEDIQHLQECLRLCVLDLSHNKLSDpEILSILESMPDLRVL 163
Cdd:PLN00113  475 KRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKL-SGEIPDELSSCKKLVSLDLSHNQLSG-QIPASFSEMPVLSQL 552

                          90       100
                  ....*....|....*....|....*...
gi 2462547423 164 NLMGNPVIRQIP----NYRRTVTVRLKH 187
Cdd:PLN00113  553 DLSQNQLSGEIPknlgNVESLVQVNISH 580
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 25-209 9.31e-43

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 153.79  E-value: 9.31e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  25 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENL 104
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 105 SCLPVLNTLQM------------------------------AHNHLETVEDIQHLQeclRLCVLDLSHNKLSD-PEILSI 153
Cdd:cd21340    87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547423 154 LESMPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 209
Cdd:cd21340   164 LSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-192 4.03e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 4.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  24 TLYLHFKGFDRI-ENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKI-ENLEPLQKLDALNLSNNYIKT 100
Cdd:COG4886   117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 101 I-ENLSCLPVLNTLQMAHNHLETVEDIqhLQECLRLCVLDLSHNKLSDpeiLSILESMPDLRVLNLMGNPvIRQIPNyrr 179
Cdd:COG4886   197 LpEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNNQLTD---LPELGNLTNLEELDLSNNQ-LTDLPP--- 267

                         170
                  ....*....|...
gi 2462547423 180 tvTVRLKHLTYLD 192
Cdd:COG4886   268 --LANLTNLKTLD 278
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-192 2.02e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 2.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423   2 TKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKI- 79
Cdd:COG4886    73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLp 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  80 ENLEPLQKLDALNLSNNYIKTI-ENLSCLPVLNTLQMAHNHLETVEDiqHLQECLRLCVLDLSHNKLSDpeILSILESMP 158
Cdd:COG4886   153 EPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGNQLTD--LPEPLANLT 228

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2462547423 159 DLRVLNLMGNPvIRQIPNYRrtvtvRLKHLTYLD 192
Cdd:COG4886   229 NLETLDLSNNQ-LTDLPELG-----NLTNLEELD 256
LRR_9 pfam14580
Leucine-rich repeat;
79-215 4.29e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 62.09  E-value: 4.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  79 IENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNH-LETVEDIQHLQECLRlcVLDLSHNKLSDPEILSILES 156
Cdd:pfam14580  34 IENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRiCRIGEGLGEALPNLT--ELILTNNNLQELGDLDPLAS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462547423 157 MPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAE 215
Cdd:pfam14580 112 LKKLTFLSLLRNPVTNK-PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-176 3.70e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 3.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  24 TLYLHFKGFDRI-ENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTI 101
Cdd:COG4886   186 ELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL 265

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462547423 102 ENLSCLPVLNTLQMAHNHLETVEdIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPN 176
Cdd:COG4886   266 PPLANLTNLKTLDLSNNQLTDLK-LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-192 1.40e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423   4 SSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLE 83
Cdd:COG4886    14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  84 PLQKLDALNLSNNyiktiENLSCLPVLNTLQMAHNHLETV-EDIQHLQeclRLCVLDLSHNKLSDpeILSILESMPDLRV 162
Cdd:COG4886    94 DLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLT---NLKELDLSNNQLTD--LPEPLGNLTNLKS 163

                         170       180       190
                  ....*....|....*....|....*....|
gi 2462547423 163 LNLMGNPvIRQIPNyrrtVTVRLKHLTYLD 192
Cdd:COG4886   164 LDLSNNQ-LTDLPE----ELGNLTNLKELD 188
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 134-178 1.60e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 45.31  E-value: 1.60e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2462547423 134 RLCVLDLSHNKLSDpeiLSILESMPDLRVLNLMGNPVIRQIPNYR 178
Cdd:pfam12799   2 NLEVLDLSNNQITD---IPPLAKLPNLETLDLSGNNKITDLSDLA 43
LRR_8 pfam13855
Leucine rich repeat;
64-120 1.70e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.70e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462547423  64 TELRCLFLQMNLLRKI--ENLEPLQKLDALNLSNNYIKTIEN--LSCLPVLNTLQMAHNHL 120
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 35-168 8.86e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.63  E-value: 8.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  35 IENLEEYTGLRCLWLQSNGIQK------IENLEAQTELRCLFLQMN------LLRKIENLEPLQKLDALNLSNNYIKT-- 100
Cdd:COG5238   229 AEALKGNKSLTTLDLSNNQIGDegvialAEALKNNTTVETLYLSGNqigaegAIALAKALQGNTTLTSLDLSVNRIGDeg 308

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547423 101 ----IENLSCLPVLNTLQMAHNHLETVEDI---QHLQECLRLCVLDLSHNKLSDP---EILSILESMPDLRVLNLMGN 168
Cdd:COG5238   309 aialAEGLQGNKTLHTLNLAYNGIGAQGAIalaKALQENTTLHSLDLSDNQIGDEgaiALAKYLEGNTTLRELNLGKN 386
PHA03169 PHA03169
hypothetical protein; Provisional
 209-421 2.48e-05

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 47.27  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 209 RGGYAAEKEERQQWESRERK-KITDSIEALAMIKQRAEERKRQRESQERGmrsAEDNSPRVPLRLGEMTSSDDGENvpas 287
Cdd:PHA03169   26 HGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTET---AEESRHGEKEERGQGGPSGSGSE---- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 288 aEGKEEPPGDRETRQkmELFVKESFEAKEELCPEKPSGEEPPvEAKREDGGP----EPEGTLPAETLLLSSPVEVKGEDG 363
Cdd:PHA03169   99 -SVGSPTPSPSGSAE--ELASGLSPENTSGSSPESPASHSPP-PSPPSHPGPhepaPPESHNPSPNQQPSSFLQPSHEDS 174

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547423 364 DGEPEGtlPAEAPPPPPPVEVKGEDGDQEPEGTLPAETlllsppvkvKGEDGDREPEG 421
Cdd:PHA03169  175 PEEPEP--PTSEPEPDSPGPPQSETPTSSPPPQSPPDE---------PGEPQSPTPQQ 221
LRR_8 pfam13855
Leucine rich repeat;
108-170 3.32e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.32e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462547423 108 PVLNTLQMAHNHLETVED--IQHLQeclRLCVLDLSHNKLS--DPEILSileSMPDLRVLNLMGNPV 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLS---NLKVLDLSNNLLTtlSPGAFS---GLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 64-105 5.06e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 5.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2462547423  64 TELRCLFLQMNLLRKIENLEPLQKLDALNLS-NNYIKTIENLS 105
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLA 43
PHA03169 PHA03169
hypothetical protein; Provisional
 215-421 1.24e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 44.96  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 215 EKEERQQWESRERKKITDSIEALAMIKQRAEERKRQ--------RESQERGMRSAEDNSPRVPLRLGEMTSSDDGENVPA 286
Cdd:PHA03169   53 TSGPQVRAVAEQGHRQTESDTETAEESRHGEKEERGqggpsgsgSESVGSPTPSPSGSAEELASGLSPENTSGSSPESPA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 287 SAEGKEEPPGDRETRQKMElfvKESFEAKEELCPE---KPSGEEPPVEAKREDGGPEPEGTLPAET-LLLSSPVEVKGED 362
Cdd:PHA03169  133 SHSPPPSPPSHPGPHEPAP---PESHNPSPNQQPSsflQPSHEDSPEEPEPPTSEPEPDSPGPPQSeTPTSSPPPQSPPD 209

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462547423 363 GDGEPEGTLPAEAPPPPPPVEVKGEDGDQEPEGTLPAETLLLSPPVKVKGEDGDREPEG 421
Cdd:PHA03169  210 EPGEPQSPTPQQAPSPNTQQAVEHEDEPTEPEREGPPFPGHRSHSYTVVGWKPSTRPGG 268
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 86-131 1.52e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 1.52e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462547423  86 QKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLetVEDIQHLQE 131
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 35-170 3.62e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 3.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  35 IENLEEYTGLRCLWLQSNGIQK-----IENLEAQTELRCLFLQMNLLRK------IENLEPLQ-KLDALNLSNNyikTIE 102
Cdd:cd00116    74 LQGLTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLQELKLNNNGLGDrglrllAKGLKDLPpALEKLVLGRN---RLE 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 103 NLSC---------LPVLNTLQMAHNHLeTVEDIQHLQECLR----LCVLDLSHNKLSDPEILSI---LESMPDLRVLNLM 166
Cdd:cd00116   151 GASCealakalraNRDLKELNLANNGI-GDAGIRALAEGLKancnLEVLDLNNNGLTDEGASALaetLASLKSLEVLNLG 229


                  ....
gi 2462547423 167 GNPV 170
Cdd:cd00116   230 DNNL 233
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-192 3.80e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 3.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  15 LYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLS 94
Cdd:COG4886     6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  95 NNYIKTIENLSCLPVLNtlqmahnhLETVEDIQHLQEclrLCVLDLSHNKLSDpeILSILESMPDLRVLNLMGNPvIRQI 174
Cdd:COG4886    86 LLGLTDLGDLTNLTELD--------LSGNEELSNLTN---LESLDLSGNQLTD--LPEELANLTNLKELDLSNNQ-LTDL 151

                         170
                  ....*....|....*...
gi 2462547423 175 PnyrrTVTVRLKHLTYLD 192
Cdd:COG4886   152 P----EPLGNLTNLKSLD 165
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 42-87 5.31e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 5.31e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462547423  42 TGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNllRKIENLEPLQK 87
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN--NKITDLSDLAN 44
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-187 1.20e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  86 QKLDALNLSNNYIKTI--ENLSCLPVLNTLQMAHNHLeTVEDIQHLQECLRLCVLDLSHNKLSDpEILSILESMPDLRVL 163
Cdd:PLN00113  475 KRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKL-SGEIPDELSSCKKLVSLDLSHNQLSG-QIPASFSEMPVLSQL 552

                          90       100
                  ....*....|....*....|....*...
gi 2462547423 164 NLMGNPVIRQIP----NYRRTVTVRLKH 187
Cdd:PLN00113  553 DLSQNQLSGEIPknlgNVESLVQVNISH 580
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 86-192 1.35e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  86 QKLDALNLSNNYIKTI------ENLSCLPVLNTLQMAHNHL---ETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILES 156
Cdd:COG5238   180 NSVETVYLGCNQIGDEgieelaEALTQNTTVTTLWLKRNPIgdeGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462547423 157 MPD---LRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLD 192
Cdd:COG5238   260 LKNnttVETLYLSGNQIGAEGAIALAKALQGNTTLTSLD 298
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 35-188 1.37e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423  35 IENLEEYTGLRCLWLQSNGIQK------IENLEAQTELRCLFLQMNLLRK------IENLEPLQKLDALNLSNNYIKT-- 100
Cdd:COG5238   257 AEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAqg 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547423 101 ----IENLSCLPVLNTLQMAHNHL--ETVEDI-QHLQECLRLCVLDLSHNKLSDPEILSILESM--PDLRVLNLMGNPVI 171
Cdd:COG5238   337 aialAKALQENTTLHSLDLSDNQIgdEGAIALaKYLEGNTTLRELNLGKNNIGKQGAEALIDALqtNRLHTLILDGNLIG 416

                         170
                  ....*....|....*..
gi 2462547423 172 RQIpnyRRTVTVRLKHL 188
Cdd:COG5238   417 AEA---QQRLEQLLERI 430
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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