NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462545550|ref|XP_054234615|]
View 

tetratricopeptide repeat protein 23 isoform X3 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11420945)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
85-268 4.25e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.08  E-value: 4.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550  85 KLAEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAE 164
Cdd:COG0457     6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDA---------------EALYNLGLAYLRLGRYEEALADYEQAL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550 165 RLSKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLH 244
Cdd:COG0457    70 ELDPDD---------------AEALNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126

                         170       180
                  ....*....|....*....|....
gi 2462545550 245 DVSINHFLQAhliiLSRSPSQVEA 268
Cdd:COG0457   127 DEAIEAYERA----LELDPDDADA 146
TPR_12 pfam13424
Tetratricopeptide repeat;
314-386 2.97e-05

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462545550 314 LSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKAITRA 386
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
85-268 4.25e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.08  E-value: 4.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550  85 KLAEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAE 164
Cdd:COG0457     6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDA---------------EALYNLGLAYLRLGRYEEALADYEQAL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550 165 RLSKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLH 244
Cdd:COG0457    70 ELDPDD---------------AEALNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126

                         170       180
                  ....*....|....*....|....
gi 2462545550 245 DVSINHFLQAhliiLSRSPSQVEA 268
Cdd:COG0457   127 DEAIEAYERA----LELDPDDADA 146
TPR_12 pfam13424
Tetratricopeptide repeat;
314-386 2.97e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462545550 314 LSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKAITRA 386
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
TPR_12 pfam13424
Tetratricopeptide repeat;
186-254 3.37e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 3.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462545550 186 ARIRLSFAQVYQGQKKSKEALSHYQAALEYVEISKGETSRECVPILRELAGVEQALGLHDVSINHFLQA 254
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERA 71
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
85-268 4.25e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.08  E-value: 4.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550  85 KLAEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAE 164
Cdd:COG0457     6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDA---------------EALYNLGLAYLRLGRYEEALADYEQAL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550 165 RLSKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLH 244
Cdd:COG0457    70 ELDPDD---------------AEALNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126

                         170       180
                  ....*....|....*....|....
gi 2462545550 245 DVSINHFLQAhliiLSRSPSQVEA 268
Cdd:COG0457   127 DEAIEAYERA----LELDPDDADA 146
TPR_12 pfam13424
Tetratricopeptide repeat;
314-386 2.97e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462545550 314 LSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKAITRA 386
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
TPR_12 pfam13424
Tetratricopeptide repeat;
186-254 3.37e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 3.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462545550 186 ARIRLSFAQVYQGQKKSKEALSHYQAALEYVEISKGETSRECVPILRELAGVEQALGLHDVSINHFLQA 254
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERA 71
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 100-386 4.12e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.49  E-value: 4.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550 100 LKGLSLQAKQHAEKARQILANsIVPPYSENtdvfkfsIELFHTMGRALLSLQKFKEAAENLTKAERLSKELLQcgriike 179
Cdd:COG2956    13 FKGLNYLLNGQPDKAIDLLEE-ALELDPET-------VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE------- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550 180 ewieieARIRLsfAQVYQGQKKSKEALSHYQAALEyveiskgeTSRECVPILRELAGVEQALGLHDVSINHFLQAHLIIL 259
Cdd:COG2956    78 ------ALLEL--AQDYLKAGLLDRAEELLEKLLE--------LDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGP 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550 260 SRSPSQVEAADSAHivahaavasgRHEHHDVAEQYFQESMAHLKDSEgmgRTKFLSIQdefchFLQMTGQKERATSILRE 339
Cdd:COG2956   142 ENAHAYCELAELYL----------EQGDYDEAIEALEKALKLDPDCA---RALLLLAE-----LYLEQGDYEEAIAALER 203

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2462545550 340 SLEAkveafgdfSPEVAETYRLLGGADLAQGNHSGARKKLKKAITRA 386
Cdd:COG2956   204 ALEQ--------DPDYLPALPRLAELYEKLGDPEEALELLRKALELD 242
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 87-214 7.92e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 7.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550  87 AEAHVNLAQGYLQLkGLSLQAKQHAEKARQIlansiVPPYsentdvfkfsIELFHTMGRALLSLQKFKEAAENLTKAERL 166
Cdd:COG3914   112 AEALFNLGNLLLAL-GRLEEALAALRRALAL-----NPDF----------AEAYLNLGEALRRLGRLEEAIAALRRALEL 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462545550 167 SKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQAALE 214
Cdd:COG3914   176 DPDN---------------AEALNNLGNALQDLGRLEEAIAAYRRALE 208
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 31-254 9.33e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 9.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550  31 KLLQTALfQPPREKLHLCEEKAKSYSNSHEYKQAVHELVRCVALTRicygdshwKLAEAHVNLAQGYLQLKGLSlQAKQH 110
Cdd:COG2956    63 RIHQKLL-ERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDP--------DDAEALRLLAEIYEQEGDWE-KAIEV 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550 111 AEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAERLSKEllqcgriikeewieiEARIRL 190
Cdd:COG2956   133 LERLLKLGPENA---------------HAYCELAELYLEQGDYDEAIEALEKALKLDPD---------------CARALL 182

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462545550 191 SFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLHDVSINHFLQA 254
Cdd:COG2956   183 LLAELYLEQGDYEEAIAALERALEQ--------DPDYLPALPRLAELYEKLGDPEEALELLRKA 238
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 97-254 1.29e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.40  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550  97 YLQLKGLSLQAKQHAEKARQILaNSIVPPYSENtdvfkfsIELFHTMGRALLSLQKFKEAAENLTKAERLSKEllqcgri 176
Cdd:COG4783     6 ALYALAQALLLAGDYDEAEALL-EKALELDPDN-------PEAFALLGEILLQLGDLDEAIVLLHEALELDPD------- 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462545550 177 ikeewieiEARIRLSFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLHDVSINHFLQA 254
Cdd:COG4783    71 --------EPEARLNLGLALLKAGDYDEALALLEKALKL--------DPEHPEAYLRLARAYRALGRPDEAIAALEKA 132
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 87-214 2.93e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550  87 AEAHVNLAQGYLQLKGLSlQAKQHAEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAERL 166
Cdd:COG4783    38 PEAFALLGEILLQLGDLD-EAIVLLHEALELDPDEP---------------EARLNLGLALLKAGDYDEALALLEKALKL 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462545550 167 SKEllqcgriikeewieiEARIRLSFAQVYQGQKKSKEALSHYQAALE 214
Cdd:COG4783   102 DPE---------------HPEAYLRLARAYRALGRPDEAIAALEKALE 134
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
52-215 4.01e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.22  E-value: 4.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550  52 AKSYSNSHEYKQAVHELVRCVALTRicygdshwKLAEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANSIvppysentd 131
Cdd:COG0457    49 GLAYLRLGRYEEALADYEQALELDP--------DDAEALNNLGLALQAL-GRYEEALEDYDKALELDPDDA--------- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550 132 vfkfsiELFHTMGRALLSLQKFKEAAENLTKAERLSKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQA 211
Cdd:COG0457   111 ------EALYNLGLALLELGRYDEAIEAYERALELDPDD---------------ADALYNLGIALEKLGRYEEALELLEK 169


                  ....
gi 2462545550 212 ALEY 215
Cdd:COG0457   170 LEAA 173
TPR_12 pfam13424
Tetratricopeptide repeat;
143-214 4.25e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.21  E-value: 4.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462545550 143 MGRALLSLQKFKEAAENLTKAERLSKELLQCGRIIKEEWIEIEARIRLSFAQVYQGQKKSKEALSHYQAALE 214
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 87-214 6.74e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545550  87 AEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANsivppysentdvfkfSIELFHTMGRALLSLQKFKEAAENLTKAERL 166
Cdd:COG4235    17 AEGWLLLGRAYLRL-GRYDEALAAYEKALRLDPD---------------NADALLDLAEALLAAGDTEEAEELLERALAL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462545550 167 SKEllqcgriikeewieiEARIRLSFAQVYQGQKKSKEALSHYQAALE 214
Cdd:COG4235    81 DPD---------------NPEALYLLGLAAFQQGDYAEAIAAWQKLLA 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH