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Conserved domains on  [gi|2462543549|ref|XP_054233650|]
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WD repeat-containing protein 72 isoform X2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-589 1.74e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 87.01  E-value: 1.74e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDS 483
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLRTLKGHTGPVRDVAASA------DGTYLASGSSDK 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  484 CVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVE 563
Cdd:cd00200     74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                          170       180       190
                   ....*....|....*....|....*....|
gi 2462543549  564 NFLIVGCADDSVYIWEIETG----TLERHE 589
Cdd:cd00200    148 TFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-191 3.00e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 3.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   13 QKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLararDFS-KQPYIVSAAENGEMCV 91
Cdd:cd00200     47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKV 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   92 WNVTNGQCVekATLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLIIDAKTLAVVHSFRSSQfpDWINCMCIVHSmri 170
Cdd:cd00200    120 WDVETGKCL--TTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHT--GEVNSVAFSPD--- 188

                          170       180
                   ....*....|....*....|.
gi 2462543549  171 qEDSLLVVSVAGELKVWDLSS 191
Cdd:cd00200    189 -GEKLLSSSSDGTIKLWDLST 208
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-589 1.74e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.01  E-value: 1.74e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDS 483
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLRTLKGHTGPVRDVAASA------DGTYLASGSSDK 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  484 CVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVE 563
Cdd:cd00200     74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                          170       180       190
                   ....*....|....*....|....*....|
gi 2462543549  564 NFLIVGCADDSVYIWEIETG----TLERHE 589
Cdd:cd00200    148 TFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 COG2319
WD40 repeat [General function prediction only];
419-596 1.72e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 1.72e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  419 LICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSLLYphglSSklDQSWMLSGDLDSCVILWDIFTEEILHK 498
Cdd:COG2319    219 LASGSADGTVRL---WDLATGKLL------RTLTGHSGSVRSVAF----SP--DGRLLASGSADGTVRLWDLATGELLRT 283

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  499 FFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIW 578
Cdd:COG2319    284 LTGHSGGVNSVAFSPD-----GKLLASG-SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                          170
                   ....*....|....*...
gi 2462543549  579 EIETGTLERHETGERARI 596
Cdd:COG2319    358 DLATGELLRTLTGHTGAV 375
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-191 3.00e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 3.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   13 QKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLararDFS-KQPYIVSAAENGEMCV 91
Cdd:cd00200     47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKV 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   92 WNVTNGQCVekATLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLIIDAKTLAVVHSFRSSQfpDWINCMCIVHSmri 170
Cdd:cd00200    120 WDVETGKCL--TTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHT--GEVNSVAFSPD--- 188

                          170       180
                   ....*....|....*....|.
gi 2462543549  171 qEDSLLVVSVAGELKVWDLSS 191
Cdd:cd00200    189 -GEKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 5.14e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 5.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549    3 TSLQAVALWGQKAPPHSITaimITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLArardFSkqP-- 78
Cdd:COG2319    109 TGLLLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA----FS--Pdg 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   79 -YIVSAAENGEMCVWNVTNGQCVekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPd 157
Cdd:COG2319    175 kLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGS- 248

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 2462543549  158 wincmciVHSMRIQEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319    249 -------VRSVAFSPDGRLLASGSadGTVRLWDLAT 277
WD40 pfam00400
WD domain, G-beta repeat;
447-489 7.45e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 7.45e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462543549  447 PHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWD 489
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-589 1.74e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.01  E-value: 1.74e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDS 483
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLRTLKGHTGPVRDVAASA------DGTYLASGSSDK 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  484 CVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVE 563
Cdd:cd00200     74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                          170       180       190
                   ....*....|....*....|....*....|
gi 2462543549  564 NFLIVGCADDSVYIWEIETG----TLERHE 589
Cdd:cd00200    148 TFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 COG2319
WD40 repeat [General function prediction only];
419-596 1.72e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 1.72e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  419 LICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSLLYphglSSklDQSWMLSGDLDSCVILWDIFTEEILHK 498
Cdd:COG2319    219 LASGSADGTVRL---WDLATGKLL------RTLTGHSGSVRSVAF----SP--DGRLLASGSADGTVRLWDLATGELLRT 283

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  499 FFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIW 578
Cdd:COG2319    284 LTGHSGGVNSVAFSPD-----GKLLASG-SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                          170
                   ....*....|....*...
gi 2462543549  579 EIETGTLERHETGERARI 596
Cdd:COG2319    358 DLATGELLRTLTGHTGAV 375
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 412-589 1.82e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.06  E-value: 1.82e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  412 YIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWDIF 491
Cdd:cd00200     59 ASADGTYLASGSSDKTIRLWD---------LETGECVRTLTGHTSYVSSVAFSP------DGRILSSSSRDKTIKVWDVE 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  492 TEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCA 571
Cdd:cd00200    124 TGKCLTTLRGHTDWVNSVAFSPDG------TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                          170       180
                   ....*....|....*....|..
gi 2462543549  572 DDSVYIWEIETG----TLERHE 589
Cdd:cd00200    198 DGTIKLWDLSTGkclgTLRGHE 219
WD40 COG2319
WD40 repeat [General function prediction only];
419-596 8.14e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 8.14e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  419 LICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSLLY-PHGlsskldqSWMLSGDLDSCVILWDIFTEEILH 497
Cdd:COG2319    177 LASGSDDGTVRL---WDLATGKLL------RTLTGHTGAVRSVAFsPDG-------KLLASGSADGTVRLWDLATGKLLR 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  498 KFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYI 577
Cdd:COG2319    241 TLTGHSGSVRSVAFSPD-----GRLLASG-SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                          170
                   ....*....|....*....
gi 2462543549  578 WEIETGTLERHETGERARI 596
Cdd:COG2319    315 WDLATGKLLRTLTGHTGAV 333
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-191 3.00e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 3.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   13 QKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLararDFS-KQPYIVSAAENGEMCV 91
Cdd:cd00200     47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKV 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   92 WNVTNGQCVekATLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLIIDAKTLAVVHSFRSSQfpDWINCMCIVHSmri 170
Cdd:cd00200    120 WDVETGKCL--TTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHT--GEVNSVAFSPD--- 188

                          170       180
                   ....*....|....*....|.
gi 2462543549  171 qEDSLLVVSVAGELKVWDLSS 191
Cdd:cd00200    189 -GEKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 5.14e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 5.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549    3 TSLQAVALWGQKAPPHSITaimITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLArardFSkqP-- 78
Cdd:COG2319    109 TGLLLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA----FS--Pdg 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   79 -YIVSAAENGEMCVWNVTNGQCVekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPd 157
Cdd:COG2319    175 kLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGS- 248

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 2462543549  158 wincmciVHSMRIQEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319    249 -------VRSVAFSPDGRLLASGSadGTVRLWDLAT 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 385-591 4.19e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 4.19e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  385 DTMSQSIIDYFSGLKDGagtavVTSSEYIPSlDKLICGC-EDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLY 463
Cdd:cd00200     79 DLETGECVRTLTGHTSY-----VSSVAFSPD-GRILSSSsRDKTIKVWD---------VETGKCLTTLRGHTDWVNSVAF 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  464 PHglssklDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSC 543
Cdd:cd00200    144 SP------DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-----GEKLLSS-SSDGTIKLWDLSTGKC 211

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462543549  544 LLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETG----TLERHETG 591
Cdd:cd00200    212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGecvqTLSGHTNS 263
WD40 COG2319
WD40 repeat [General function prediction only];
403-596 7.75e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 7.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  403 GTAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYphglSSklDQSWMLSGDLD 482
Cdd:COG2319     77 HTAAVLSVAFSPDGRLLASASADGTVRLWD---------LATGLLLRTLTGHTGAVRSVAF----SP--DGKTLASGSAD 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  483 SCVILWDIFTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICcVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPV 562
Cdd:COG2319    142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-----GKLLAS-GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 215

                          170       180       190
                   ....*....|....*....|....*....|....
gi 2462543549  563 ENFLIVGCADDSVYIWEIETGTLERHETGERARI 596
Cdd:COG2319    216 GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249
WD40 COG2319
WD40 repeat [General function prediction only];
419-582 1.12e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 1.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  419 LICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSLLY-PHGlsskldqSWMLSGDLDSCVILWDIFTEEILH 497
Cdd:COG2319    261 LASGSADGTVRL---WDLATGELL------RTLTGHSGGVNSVAFsPDG-------KLLASGSDDGTVRLWDLATGKLLR 324

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  498 KFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYI 577
Cdd:COG2319    325 TLTGHTGAVRSVAFSPD-----GKTLASG-SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398


                   ....*
gi 2462543549  578 WEIET 582
Cdd:COG2319    399 WDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
425-596 1.93e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 1.93e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  425 DGTIIITQALNAAKARLLEDSPPHKVLKGHHQSVTSLLYPhglsskLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAG 504
Cdd:COG2319     48 GARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS------PDGRLLASASADGTVRLWDLATGLLLRTLTGHTG 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  505 PVTSLLMSPEkfklrGEQIICcVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGT 584
Cdd:COG2319    122 AVRSVAFSPD-----GKTLAS-GSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                          170
                   ....*....|..
gi 2462543549  585 LERHETGERARI 596
Cdd:COG2319    196 LLRTLTGHTGAV 207
WD40 COG2319
WD40 repeat [General function prediction only];
14-191 8.59e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 8.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   14 KAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLArardFSKQ-PYIVSAAENGEMC 90
Cdd:COG2319    201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA-----TGKLLrtLTGHSGSVRSVA----FSPDgRLLASGSADGTVR 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   91 VWNVTNGQCVekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPdwincmciVHSMRI 170
Cdd:COG2319    272 LWDLATGELL--RTLTGHSGGV--NSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGA--------VRSVAF 338

                          170       180
                   ....*....|....*....|...
gi 2462543549  171 QEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319    339 SPDGKTLASGSddGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-579 4.11e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 4.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  404 TAVVTSSEYIPSLDKLICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSL-LYPhglssklDQSWMLSGDLD 482
Cdd:cd00200    135 TDWVNSVAFSPDGTFVASSSQDGTIKL---WDLRTGKCV------ATLTGHTGEVNSVaFSP-------DGEKLLSSSSD 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  483 SCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPV 562
Cdd:cd00200    199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPD 272

                          170
                   ....*....|....*..
gi 2462543549  563 ENFLIVGCADDSVYIWE 579
Cdd:cd00200    273 GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
18-191 1.18e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 1.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   18 HSITAIMITDDQRTIVTGSQEGQLCLWNLSHELkisAKELLFGHSASVTCLARARDfskQPYIVSAAENGEMCVWNVTNG 97
Cdd:COG2319     79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFSPD---GKTLASGSADGTVRLWDLATG 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   98 QCVekATLPyRHTAICYyhcSFRMTGEG-WLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPdwincmciVHSMRIQEDSLL 176
Cdd:COG2319    153 KLL--RTLT-GHSGAVT---SVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGA--------VRSVAFSPDGKL 218

                          170
                   ....*....|....*..
gi 2462543549  177 VVSVA--GELKVWDLSS 191
Cdd:COG2319    219 LASGSadGTVRLWDLAT 235
WD40 COG2319
WD40 repeat [General function prediction only];
425-596 2.30e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 2.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  425 DGTIIITQALNAAKARLLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAG 504
Cdd:COG2319      6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASP------DGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  505 PVTSLLMSPekfklrGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGT 584
Cdd:COG2319     80 AVLSVAFSP------DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153

                          170
                   ....*....|..
gi 2462543549  585 LERHETGERARI 596
Cdd:COG2319    154 LLRTLTGHSGAV 165
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-191 2.76e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 2.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   58 LFGHSASVTCLArardFS-KQPYIVSAAENGEMCVWNVTNGQCVEKATLpyrHTaICYYHCSFRMTGEgWLLCCGEYQDV 136
Cdd:cd00200      5 LKGHTGGVTCVA----FSpDGKLLATGSGDGTIKVWDLETGELLRTLKG---HT-GPVRDVAASADGT-YLASGSSDKTI 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462543549  137 LIIDAKTLAVVHSFRssQFPDWINCMCIVHSMRIqedsLLVVSVAGELKVWDLSS 191
Cdd:cd00200     76 RLWDLETGECVRTLT--GHTSYVSSVAFSPDGRI----LSSSSRDKTIKVWDVET 124
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-114 1.14e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 1.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   19 SITAIMITDDQRTIVTGSQEGQLCLWNLShelKISAKELLFGHSASVTCLArardFSKQPYIV-SAAENGEMCVWNVTNG 97
Cdd:cd00200    179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKCLGTLRGHENGVNSVA----FSPDGYLLaSGSEDGTIRVWDLRTG 251

                           90
                   ....*....|....*..
gi 2462543549   98 QCVekATLPyRHTAICY 114
Cdd:cd00200    252 ECV--QTLS-GHTNSVT 265
WD40 COG2319
WD40 repeat [General function prediction only];
14-100 2.71e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 2.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   14 KAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLARARDfskQPYIVSAAENGEMCV 91
Cdd:COG2319    285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLLrtLTGHTGAVRSVAFSPD---GKTLASGSDDGTVRL 356


                   ....*....
gi 2462543549   92 WNVTNGQCV 100
Cdd:COG2319    357 WDLATGELL 365
WD40 COG2319
WD40 repeat [General function prediction only];
10-96 8.16e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 8.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549   10 LWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLARARDfskQPYIVSAAENG 87
Cdd:COG2319    323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA-----TGELLrtLTGHTGAVTSVAFSPD---GRTLASGSADG 394


                   ....*....
gi 2462543549   88 EMCVWNVTN 96
Cdd:COG2319    395 TVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 550-607 1.62e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 1.62e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543549  550 HLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI--ILNCCDDSQLV 607
Cdd:cd00200      8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVrdVAASADGTYLA 67
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-93 3.79e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 3.79e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462543549   19 SITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLArardFSKQ-PYIVSAAENGEMCVWN 93
Cdd:cd00200    221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---LSGHTNSVTSLA----WSPDgKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
447-489 7.45e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 7.45e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462543549  447 PHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWD 489
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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