|
Name |
Accession |
Description |
Interval |
E-value |
| RRM_ACINU |
cd12432 |
RNA recognition motif (RRM) found in apoptotic chromatin condensation inducer in the nucleus ... |
960-1046 |
4.36e-48 |
|
RNA recognition motif (RRM) found in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins; This subfamily corresponds to the RRM of Acinus, a caspase-3-activated nuclear factor that induces apoptotic chromatin condensation after cleavage by caspase-3 without inducing DNA fragmentation. It is essential for apoptotic chromatin condensation and may also participate in nuclear structural changes occurring in normal cells. Acinus contains a P-loop motif and an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), which indicates Acinus might have ATPase and DNA/RNA-binding activity.
:
Pssm-ID: 409866 [Multi-domain] Cd Length: 90 Bit Score: 165.84 E-value: 4.36e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 960 SNIVHISNLVRPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQD 1039
Cdd:cd12432 1 SRILHIDNLVRPFTLGQLKELLSETGTGVIEGFWMDKIKSHCYVTYSSEEEAVATREALHGVVWPSSNGKRLKVEFVTEE 80
|
....*..
gi 2462539312 1040 ELDYHRG 1046
Cdd:cd12432 81 ELEELIE 87
|
|
| RSB_motif super family |
cl24764 |
RNSP1-SAP18 binding (RSB) motif; The RSB motif on the Acinus protein is the core around which ... |
1155-1185 |
7.81e-12 |
|
RNSP1-SAP18 binding (RSB) motif; The RSB motif on the Acinus protein is the core around which the ASAP complex is built. The apoptosis and splicing-associated protein complex, ASAP, is made up of three proteins, SAP18 (Sin3-associated protein of 18 kDa), RNA-binding protein S1 (RNPS1) and apoptotic chromatin inducer in the nucleus (Acinus). The ASAP complex appears to be an assembly of proteins at the interface between transcription, splicing and NMD, acting as a hub in the network of protein-interactions that regulate gene-expression.
The actual alignment was detected with superfamily member pfam16294:
Pssm-ID: 465085 Cd Length: 91 Bit Score: 62.44 E-value: 7.81e-12
10 20 30
....*....|....*....|....*....|.
gi 2462539312 1155 PPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQ 1185
Cdd:pfam16294 50 PPAKLLDDLFRKTKATPCIYWLPLTPEQIAE 80
|
|
| PTZ00121 super family |
cl31754 |
MAEBL; Provisional |
141-373 |
1.69e-07 |
|
MAEBL; Provisional
The actual alignment was detected with superfamily member PTZ00121:
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 56.30 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 141 LEKQQELLRQRLErEAREAAELEGKSSSI--SEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEE---EEDQETP 215
Cdd:PTZ00121 1488 AKKKAEEAKKKAD-EAKKAAEAKKKADEAkkAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEElkkAEEKKKA 1566
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 216 SRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEMPRVKPEEMMDERPKTRSQEQEVLE 295
Cdd:PTZ00121 1567 EEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEK 1646
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 296 RGGRFTRSQEEA---RKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSppRLTEDRKK-ASLVALPEQTASE 371
Cdd:PTZ00121 1647 KKAEELKKAEEEnkiKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAK--KAEELKKKeAEEKKKAEELKKA 1724
|
..
gi 2462539312 372 EE 373
Cdd:PTZ00121 1725 EE 1726
|
|
| SAP |
smart00513 |
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation; |
72-106 |
1.62e-06 |
|
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
:
Pssm-ID: 128789 [Multi-domain] Cd Length: 35 Bit Score: 45.56 E-value: 1.62e-06
10 20 30
....*....|....*....|....*....|....*
gi 2462539312 72 LQALRVTDLKAALEQRGLAKSGQKSALVKRLKGAL 106
Cdd:smart00513 1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RRM_ACINU |
cd12432 |
RNA recognition motif (RRM) found in apoptotic chromatin condensation inducer in the nucleus ... |
960-1046 |
4.36e-48 |
|
RNA recognition motif (RRM) found in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins; This subfamily corresponds to the RRM of Acinus, a caspase-3-activated nuclear factor that induces apoptotic chromatin condensation after cleavage by caspase-3 without inducing DNA fragmentation. It is essential for apoptotic chromatin condensation and may also participate in nuclear structural changes occurring in normal cells. Acinus contains a P-loop motif and an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), which indicates Acinus might have ATPase and DNA/RNA-binding activity.
Pssm-ID: 409866 [Multi-domain] Cd Length: 90 Bit Score: 165.84 E-value: 4.36e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 960 SNIVHISNLVRPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQD 1039
Cdd:cd12432 1 SRILHIDNLVRPFTLGQLKELLSETGTGVIEGFWMDKIKSHCYVTYSSEEEAVATREALHGVVWPSSNGKRLKVEFVTEE 80
|
....*..
gi 2462539312 1040 ELDYHRG 1046
Cdd:cd12432 81 ELEELIE 87
|
|
| RSB_motif |
pfam16294 |
RNSP1-SAP18 binding (RSB) motif; The RSB motif on the Acinus protein is the core around which ... |
1155-1185 |
7.81e-12 |
|
RNSP1-SAP18 binding (RSB) motif; The RSB motif on the Acinus protein is the core around which the ASAP complex is built. The apoptosis and splicing-associated protein complex, ASAP, is made up of three proteins, SAP18 (Sin3-associated protein of 18 kDa), RNA-binding protein S1 (RNPS1) and apoptotic chromatin inducer in the nucleus (Acinus). The ASAP complex appears to be an assembly of proteins at the interface between transcription, splicing and NMD, acting as a hub in the network of protein-interactions that regulate gene-expression.
Pssm-ID: 465085 Cd Length: 91 Bit Score: 62.44 E-value: 7.81e-12
10 20 30
....*....|....*....|....*....|.
gi 2462539312 1155 PPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQ 1185
Cdd:pfam16294 50 PPAKLLDDLFRKTKATPCIYWLPLTPEQIAE 80
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
141-373 |
1.69e-07 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 56.30 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 141 LEKQQELLRQRLErEAREAAELEGKSSSI--SEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEE---EEDQETP 215
Cdd:PTZ00121 1488 AKKKAEEAKKKAD-EAKKAAEAKKKADEAkkAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEElkkAEEKKKA 1566
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 216 SRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEMPRVKPEEMMDERPKTRSQEQEVLE 295
Cdd:PTZ00121 1567 EEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEK 1646
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 296 RGGRFTRSQEEA---RKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSppRLTEDRKK-ASLVALPEQTASE 371
Cdd:PTZ00121 1647 KKAEELKKAEEEnkiKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAK--KAEELKKKeAEEKKKAEELKKA 1724
|
..
gi 2462539312 372 EE 373
Cdd:PTZ00121 1725 EE 1726
|
|
| SAP |
smart00513 |
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation; |
72-106 |
1.62e-06 |
|
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
Pssm-ID: 128789 [Multi-domain] Cd Length: 35 Bit Score: 45.56 E-value: 1.62e-06
10 20 30
....*....|....*....|....*....|....*
gi 2462539312 72 LQALRVTDLKAALEQRGLAKSGQKSALVKRLKGAL 106
Cdd:smart00513 1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
|
|
| SAP |
pfam02037 |
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ... |
72-106 |
4.46e-06 |
|
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.
Pssm-ID: 460424 [Multi-domain] Cd Length: 35 Bit Score: 44.31 E-value: 4.46e-06
10 20 30
....*....|....*....|....*....|....*
gi 2462539312 72 LQALRVTDLKAALEQRGLAKSGQKSALVKRLKGAL 106
Cdd:pfam02037 1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
129-372 |
8.16e-04 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 43.96 E-value: 8.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 129 EEMSQNSFIKQYLEKQQELLRQRLEREAREAAELE-GKSSSISEEKGDSDDEKPRKGER--------RSSRVRQARAAkl 199
Cdd:pfam17380 294 EKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEmDRQAAIYAEQERMAMERERELERirqeerkrELERIRQEEIA-- 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 200 SEGSQPAEEEEDQ-ETPSRNLRVR----ADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEMPRV 274
Cdd:pfam17380 372 MEISRMRELERLQmERQQKNERVRqeleAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERV 451
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 275 KPEEMMDERPKTRSQEQEVLERGGRFTRSQEEarkshlaRQQQEKEMKTTSPLEEEEREIKSSQgLKEKSKSPSPPRLTE 354
Cdd:pfam17380 452 RLEEQERQQQVERLRQQEEERKRKKLELEKEK-------RDRKRAEEQRRKILEKELEERKQAM-IEEERKRKLLEKEME 523
|
250
....*....|....*...
gi 2462539312 355 DRKKASLVALPEQTASEE 372
Cdd:pfam17380 524 ERQKAIYEEERRREAEEE 541
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RRM_ACINU |
cd12432 |
RNA recognition motif (RRM) found in apoptotic chromatin condensation inducer in the nucleus ... |
960-1046 |
4.36e-48 |
|
RNA recognition motif (RRM) found in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins; This subfamily corresponds to the RRM of Acinus, a caspase-3-activated nuclear factor that induces apoptotic chromatin condensation after cleavage by caspase-3 without inducing DNA fragmentation. It is essential for apoptotic chromatin condensation and may also participate in nuclear structural changes occurring in normal cells. Acinus contains a P-loop motif and an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), which indicates Acinus might have ATPase and DNA/RNA-binding activity.
Pssm-ID: 409866 [Multi-domain] Cd Length: 90 Bit Score: 165.84 E-value: 4.36e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 960 SNIVHISNLVRPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQD 1039
Cdd:cd12432 1 SRILHIDNLVRPFTLGQLKELLSETGTGVIEGFWMDKIKSHCYVTYSSEEEAVATREALHGVVWPSSNGKRLKVEFVTEE 80
|
....*..
gi 2462539312 1040 ELDYHRG 1046
Cdd:cd12432 81 ELEELIE 87
|
|
| RSB_motif |
pfam16294 |
RNSP1-SAP18 binding (RSB) motif; The RSB motif on the Acinus protein is the core around which ... |
1155-1185 |
7.81e-12 |
|
RNSP1-SAP18 binding (RSB) motif; The RSB motif on the Acinus protein is the core around which the ASAP complex is built. The apoptosis and splicing-associated protein complex, ASAP, is made up of three proteins, SAP18 (Sin3-associated protein of 18 kDa), RNA-binding protein S1 (RNPS1) and apoptotic chromatin inducer in the nucleus (Acinus). The ASAP complex appears to be an assembly of proteins at the interface between transcription, splicing and NMD, acting as a hub in the network of protein-interactions that regulate gene-expression.
Pssm-ID: 465085 Cd Length: 91 Bit Score: 62.44 E-value: 7.81e-12
10 20 30
....*....|....*....|....*....|.
gi 2462539312 1155 PPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQ 1185
Cdd:pfam16294 50 PPAKLLDDLFRKTKATPCIYWLPLTPEQIAE 80
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
141-373 |
1.69e-07 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 56.30 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 141 LEKQQELLRQRLErEAREAAELEGKSSSI--SEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEE---EEDQETP 215
Cdd:PTZ00121 1488 AKKKAEEAKKKAD-EAKKAAEAKKKADEAkkAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEElkkAEEKKKA 1566
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 216 SRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEMPRVKPEEMMDERPKTRSQEQEVLE 295
Cdd:PTZ00121 1567 EEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEK 1646
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 296 RGGRFTRSQEEA---RKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSppRLTEDRKK-ASLVALPEQTASE 371
Cdd:PTZ00121 1647 KKAEELKKAEEEnkiKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAK--KAEELKKKeAEEKKKAEELKKA 1724
|
..
gi 2462539312 372 EE 373
Cdd:PTZ00121 1725 EE 1726
|
|
| SAP |
smart00513 |
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation; |
72-106 |
1.62e-06 |
|
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
Pssm-ID: 128789 [Multi-domain] Cd Length: 35 Bit Score: 45.56 E-value: 1.62e-06
10 20 30
....*....|....*....|....*....|....*
gi 2462539312 72 LQALRVTDLKAALEQRGLAKSGQKSALVKRLKGAL 106
Cdd:smart00513 1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
142-372 |
3.95e-06 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 51.68 E-value: 3.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 142 EKQQELLRQRLEREAREAAELEGKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAE----EEEDQETPSR 217
Cdd:PTZ00121 1531 EEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEvmklYEEEKKMKAE 1610
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 218 NLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREapilkEFKEEgEEMPRVKPEEMM----DERPKT---RSQE 290
Cdd:PTZ00121 1611 EAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAE-----ELKKA-EEENKIKAAEEAkkaeEDKKKAeeaKKAE 1684
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 291 QEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPL--EEEEREIKSSQGLK----EKSKSPSPPRLTEDRKKASLVAL 364
Cdd:PTZ00121 1685 EDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELkkAEEENKIKAEEAKKeaeeDKKKAEEAKKDEEEKKKIAHLKK 1764
|
....*...
gi 2462539312 365 PEQTASEE 372
Cdd:PTZ00121 1765 EEEKKAEE 1772
|
|
| SAP |
pfam02037 |
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ... |
72-106 |
4.46e-06 |
|
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.
Pssm-ID: 460424 [Multi-domain] Cd Length: 35 Bit Score: 44.31 E-value: 4.46e-06
10 20 30
....*....|....*....|....*....|....*
gi 2462539312 72 LQALRVTDLKAALEQRGLAKSGQKSALVKRLKGAL 106
Cdd:pfam02037 1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
142-399 |
9.02e-06 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 50.52 E-value: 9.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 142 EKQQELLRQRLEREAREAAELEGKSSSIseEKGDSDDEKPRKGERRSSRVRQARAAK--LSEGSQPAEEE---EDQETPS 216
Cdd:PTZ00121 1363 EEKAEAAEKKKEEAKKKADAAKKKAEEK--KKADEAKKKAEEDKKKADELKKAAAAKkkADEAKKKAEEKkkaDEAKKKA 1440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 217 RNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEMPRVKPEEMMDERPKTRSQEQEVLE- 295
Cdd:PTZ00121 1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEe 1520
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 296 -RGGRFTRSQEEARKSHLARQQQEK----EMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTAS 370
Cdd:PTZ00121 1521 aKKADEAKKAEEAKKADEAKKAEEKkkadELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKL 1600
|
250 260 270
....*....|....*....|....*....|..
gi 2462539312 371 EEETPPP---LLTKEASSPPPHPQLHSEEEIE 399
Cdd:PTZ00121 1601 YEEEKKMkaeEAKKAEEAKIKAEELKKAEEEK 1632
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
142-397 |
5.76e-05 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.83 E-value: 5.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 142 EKQQELLRQRLErEAREAAELEGKSssisEEKGDSDD-----EKPRKGERRSSRVRQARAAKlsEGSQPAEEEEDQEtps 216
Cdd:PTZ00121 1417 KKKADEAKKKAE-EKKKADEAKKKA----EEAKKADEakkkaEEAKKAEEAKKKAEEAKKAD--EAKKKAEEAKKAD--- 1486
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 217 rNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEfKEEGEEMPRVKPEEMMDERPKTRSQEQEVLER 296
Cdd:PTZ00121 1487 -EAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEE-AKKADEAKKAEEKKKADELKKAEELKKAEEKK 1564
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 297 GGRFTRSQEE-----ARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKskspspprltEDRKKASLVALPEQtasE 371
Cdd:PTZ00121 1565 KAEEAKKAEEdknmaLRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAE----------EAKIKAEELKKAEE---E 1631
|
250 260
....*....|....*....|....*.
gi 2462539312 372 EETPPPLLTKEASSPPPHPQLHSEEE 397
Cdd:PTZ00121 1632 KKKVEQLKKKEAEEKKKAEELKKAEE 1657
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
142-381 |
9.56e-05 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.06 E-value: 9.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 142 EKQQELLRQRLErEAREAAELEGKSSSISEEKGDSDDEKPRKGERRSSRVRQA--RAAKLSEGSQPAEE----EEDQETP 215
Cdd:PTZ00121 1328 KKKADAAKKKAE-EAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKadAAKKKAEEKKKADEakkkAEEDKKK 1406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 216 SRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEMPRVKPEEMMDERPKTRSQE----- 290
Cdd:PTZ00121 1407 ADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEakkad 1486
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 291 ------QEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSpSPPRLTEDRKKASLVAL 364
Cdd:PTZ00121 1487 eakkkaEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKA-DELKKAEELKKAEEKKK 1565
|
250
....*....|....*..
gi 2462539312 365 PEQTASEEETPPPLLTK 381
Cdd:PTZ00121 1566 AEEAKKAEEDKNMALRK 1582
|
|
| PLN03124 |
PLN03124 |
poly [ADP-ribose] polymerase; Provisional |
75-210 |
1.27e-04 |
|
poly [ADP-ribose] polymerase; Provisional
Pssm-ID: 215591 [Multi-domain] Cd Length: 643 Bit Score: 46.37 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 75 LRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGE-EMSQNSFIKQYLEKQQELLRQRLE 153
Cdd:PLN03124 5 LKVDELRAALAKRGLDTTGLKAALVRRLDDAIAEDAKTASKSGTKSSAGRKKRRErQDDGDDEPVSPKRIAIDEVKGMTV 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462539312 154 REAREAAELEGKSSSISE----EKGDSDDEKPRKgerRSSRVRQARAAKLSEGSQPAEEEE 210
Cdd:PLN03124 85 RELREAASERGLATTGRKkdllERLCAALESDVK---VGSANGTGEDEKEKGGDEEREKEE 142
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
112-384 |
2.15e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.90 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 112 QKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLErEAREAAEL-EGKSSSISEEKGDSDDEKPRKGERRSSR 190
Cdd:PTZ00121 1084 KEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAE-DARKAEEArKAEDARKAEEARKAEDAKRVEIARKAED 1162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 191 VRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEeEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEE 270
Cdd:PTZ00121 1163 ARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKA-EEERKAEEARKAEDAKKAEAVKKAEEAKKDAEE 1241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 271 MPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSqEEARKSHLARQQQEK----------EMKTTSPLEEEEREIKSSQGL 340
Cdd:PTZ00121 1242 AKKAEEERNNEEIRKFEEARMAHFARRQAAIKA-EEARKADELKKAEEKkkadeakkaeEKKKADEAKKKAEEAKKADEA 1320
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2462539312 341 KEKS-----KSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEAS 384
Cdd:PTZ00121 1321 KKKAeeakkKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAA 1369
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
143-401 |
2.54e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.52 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 143 KQQELLRQRLEREAREAAELEGKSssisEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETpsrnLRVR 222
Cdd:PTZ00121 1315 KKADEAKKKAEEAKKKADAAKKKA----EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADA----AKKK 1386
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 223 ADRNLKTEE-EEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEMPRVKPEEMMDERPKTRSQEQEVLE------ 295
Cdd:PTZ00121 1387 AEEKKKADEaKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEeakkka 1466
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 296 ----RGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLK--EKSKSPSPPRLTEDRKKASLVALPEQTA 369
Cdd:PTZ00121 1467 eeakKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKkaEEAKKADEAKKAEEAKKADEAKKAEEKK 1546
|
250 260 270
....*....|....*....|....*....|..
gi 2462539312 370 SEEETPPPLLTKEASSPPPHPQLHSEEEIEPM 401
Cdd:PTZ00121 1547 KADELKKAEELKKAEEKKKAEEAKKAEEDKNM 1578
|
|
| RRM_SF |
cd00590 |
RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP ... |
963-1022 |
3.77e-04 |
|
RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).
Pssm-ID: 409669 [Multi-domain] Cd Length: 72 Bit Score: 39.96 E-value: 3.77e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462539312 963 VHISNLVRPFTLGQLKELLGRTGTlVEEAFWID----KIKSHCFVTYSTVEEAVATRTALHGVK 1022
Cdd:cd00590 1 LFVGNLPPDTTEEDLRELFSKFGE-VVSVRIVRdrdgKSKGFAFVEFESPEDAEKALEALNGTE 63
|
|
| RRM_ALKBH8 |
cd12431 |
RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and ... |
960-1038 |
8.01e-04 |
|
RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins; This subfamily corresponds to the RRM of ALKBH8, also termed alpha-ketoglutarate-dependent dioxygenase ABH8, or S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8, expressed in various types of human cancers. It is essential in urothelial carcinoma cell survival mediated by NOX-1-dependent ROS signals. ALKBH8 has also been identified as a tRNA methyltransferase that catalyzes methylation of tRNA to yield 5-methylcarboxymethyl uridine (mcm5U) at the wobble position of the anticodon loop. Thus, ALKBH8 plays a crucial role in the DNA damage survival pathway through a distinct mechanism involving the regulation of tRNA modification. ALKBH8 localizes to the cytoplasm. It contains the characteristic AlkB domain that is composed of a tRNA methyltransferase motif, a motif homologous to the bacterial AlkB DNA/RNA repair enzyme, and a dioxygenase catalytic core domain encompassing cofactor-binding sites for iron and 2-oxoglutarate. In addition, unlike other AlkB homologs, ALKBH8 contains an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a C-terminal S-adenosylmethionine (SAM)-dependent methyltransferase (MT) domain.
Pssm-ID: 409865 [Multi-domain] Cd Length: 80 Bit Score: 39.49 E-value: 8.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 960 SNIVHISN--LVRPFTLGQLKELLGRTGTlveeafwIDKI-----KSHCFVTYSTVEEAVATRTALHG--VKWPQSNPKF 1030
Cdd:cd12431 1 TQHLVVANggLGNGVSREQLLEVFEKYGT-------VEDIvmlpgKPYSFVSFKSVEEAAKAYNALNGkeLELPQQNVPL 73
|
....*...
gi 2462539312 1031 LCAdYAEQ 1038
Cdd:cd12431 74 YLS-FVEK 80
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
129-372 |
8.16e-04 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 43.96 E-value: 8.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 129 EEMSQNSFIKQYLEKQQELLRQRLEREAREAAELE-GKSSSISEEKGDSDDEKPRKGER--------RSSRVRQARAAkl 199
Cdd:pfam17380 294 EKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEmDRQAAIYAEQERMAMERERELERirqeerkrELERIRQEEIA-- 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 200 SEGSQPAEEEEDQ-ETPSRNLRVR----ADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEMPRV 274
Cdd:pfam17380 372 MEISRMRELERLQmERQQKNERVRqeleAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERV 451
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 275 KPEEMMDERPKTRSQEQEVLERGGRFTRSQEEarkshlaRQQQEKEMKTTSPLEEEEREIKSSQgLKEKSKSPSPPRLTE 354
Cdd:pfam17380 452 RLEEQERQQQVERLRQQEEERKRKKLELEKEK-------RDRKRAEEQRRKILEKELEERKQAM-IEEERKRKLLEKEME 523
|
250
....*....|....*...
gi 2462539312 355 DRKKASLVALPEQTASEE 372
Cdd:pfam17380 524 ERQKAIYEEERRREAEEE 541
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
56-358 |
1.66e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 42.82 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 56 SRKMAELEEVTLDGKPLQALRVTDLKAALEQRGlAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQ-----PNSQIGEE 130
Cdd:PTZ00121 1169 ARKAEDAKKAEAARKAEEVRKAEELRKAEDARK-AEAARKAEEERKAEEARKAEDAKKAEAVKKAEEakkdaEEAKKAEE 1247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 131 MSQNSFIKQYLEKQQELLRQRLE----REAREAAEL-------EGKSSSISEEKGDSDDEKPRKGERRSSRVRQARA--- 196
Cdd:PTZ00121 1248 ERNNEEIRKFEEARMAHFARRQAaikaEEARKADELkkaeekkKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAeea 1327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 197 -AKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEMPRVK 275
Cdd:PTZ00121 1328 kKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKA 1407
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 276 PEEMMDERPKTRSQE----QEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLK---EKSKSPS 348
Cdd:PTZ00121 1408 DELKKAAAAKKKADEakkkAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKkaeEAKKADE 1487
|
330
....*....|
gi 2462539312 349 PPRLTEDRKK 358
Cdd:PTZ00121 1488 AKKKAEEAKK 1497
|
|
| RRM_TRMT2A |
cd12439 |
RNA recognition motif (RRM) found in tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) and ... |
963-1023 |
3.16e-03 |
|
RNA recognition motif (RRM) found in tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) and similar proteins; This subfamily corresponds to the RRM of TRMT2A, also known as HpaII tiny fragments locus 9c protein (HTF9C), a novel cell cycle regulated protein. It is an independent biologic factor expressed in tumors associated with clinical outcome in HER2 expressing breast cancer. The function of TRMT2A remains unclear although by sequence homology it has a RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), related to RNA methyltransferases.
Pssm-ID: 409873 [Multi-domain] Cd Length: 79 Bit Score: 37.61 E-value: 3.16e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462539312 963 VHISNLVRPFTLGQLKELLGRTGtlveeaFWIDKIK-----SHCFVTYSTVEEAVATRTALHGVKW 1023
Cdd:cd12439 8 IEIKNLPKYIGFGQLKKFLQKLG------LKPHKIKligrqTFAFVTFRNEEDRDKALKVLNGHKW 67
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
129-362 |
8.25e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 40.89 E-value: 8.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 129 EEMSQNSFIKQYLEKQQELLRQ-RLEREAREAAElEGKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAE 207
Cdd:PTZ00121 1590 EEARIEEVMKLYEEEKKMKAEEaKKAEEAKIKAE-ELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK 1668
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539312 208 EEEDQETPSRNLRvRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKefKEEGEEMPRVKPEEMMDERPKTR 287
Cdd:PTZ00121 1669 KAEEDKKKAEEAK-KAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELK--KAEEENKIKAEEAKKEAEEDKKK 1745
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462539312 288 SQEQEVlerggrftrsqEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLV 362
Cdd:PTZ00121 1746 AEEAKK-----------DEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFAN 1809
|
|
| |
