NCBI Conserved Domain Search

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

172-212

2.41e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

Pssm-ID: 459654 Cd Length: 42 Bit Score: 65.64 E-value: 2.41e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462525224  172 GYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTID 212
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

308-345

5.08e-13

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 64.57 E-value: 5.08e-13

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462525224  308 CEEDNGGCSHLCLLSPSepFYTCACPTGVQLQDNGRTC 345
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

417-459

1.70e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 63.00 E-value: 1.70e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224   417 QTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR 459
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

504-546

1.27e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 60.69 E-value: 1.27e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224   504 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKR 546
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1267-1304

1.39e-11

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 60.34 E-value: 1.39e-11

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462525224 1267 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1304
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1345-1379

1.73e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

Pssm-ID: 238060 Cd Length: 35 Bit Score: 59.91 E-value: 1.73e-11

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462525224 1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

460-503

3.96e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.15 E-value: 3.96e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462525224   460 KILVSEDLDEPRAIALHPVMGLMYWTDWGeNPKIECANLDGQER 503
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1307-1341

5.03e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 58.76 E-value: 5.03e-11

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462525224 1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1341
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

719-761

6.78e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.38 E-value: 6.78e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224   719 EHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 761
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

915-950

1.00e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 58.02 E-value: 1.00e-10

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462525224  915 CMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNC 950
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

111-151

2.11e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 57.23 E-value: 2.11e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462525224   111 VVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 151
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

196-238

2.17e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 57.23 E-value: 2.17e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224   196 KIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFR 238
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

614-649

1.16e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 52.24 E-value: 1.16e-08

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462525224  614 CADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC 649
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

762-805

7.13e-08

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 49.91 E-value: 7.13e-08

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462525224   762 QVLVWRDLDNPRSLALDPTKGYIYWTEWgGKPRIVRAFMDGTNC 805
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

34-223

9.49e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 54.70 E-value: 9.49e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224   34 AAQYFPASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGA----VYWTDVSEEAIkqTYLNQTGAAVQ 109
Cdd:COG3391     26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRV--SVIDLATGKVV 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  110 NVVISGlVSPDGLACDWVGKKLYWTDSETNRIEVanLNGTSRKVL-FWQDLDQPRAIALDPAHGYMYWTDWGeTPRIER- 187
Cdd:COG3391    104 ATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVi 179

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2462525224  188 -AGMDGSTRKII--VDSDIYwPNGLTIDLEEQKLYWADA 223
Cdd:COG3391    180 vSVIDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANR 217

NHL super family

cl18310

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

694-887

1.26e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain] Cd Length: 269 Bit Score: 55.02 E-value: 1.26e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  694 SNNHIYWTDVSLKTISR-----AFMNGSSVEHVVEFGLDYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQFRQVLV--- 765
Cdd:cd05819     17 SSGNIYVADTGNNRIQVfdpdgNFITSFGSFGSGDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGgsg 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  766 --WRDLDNPRSLALDPtKGYIYWTEWGGKpRIVRaFMDGTNCMTLVDKVGRAN-------DLTIDyADQRLYWTDLDTNM 836
Cdd:cd05819     96 dgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK-FDPDGEFLTTFGSGGSGPgqfngptGVAVD-SDGNIYVADTGNHR 171

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462525224  837 IE----SSNML---GQERVVIAdDLPHPFGLT-QYSDYIYWTDWNLHSIERADKTSGRN 887
Cdd:cd05819    172 IQvfdpDGNFLttfGSTGTGPG-QFNYPTGIAvDSDGNIYVADSGNNRVQVFDPDGAGF 229

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

375-415

2.11e-07

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 48.75 E-value: 2.11e-07

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462525224   375 VLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSG 415
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1113-1155

1.05e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 46.83 E-value: 1.05e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224  1113 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR 1155
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

1226-1262

1.75e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.08 E-value: 1.75e-06

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462525224 1226 CARDNGGCSHICIAKGDGTpRCSCPVHLVLLQNLLTC 1262
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGY-TCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

547-580

2.53e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.89 E-value: 2.53e-04

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2462525224   547 RTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV 580
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

979-1018

4.94e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.12 E-value: 4.94e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462525224   979 ILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQ 1018
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwGLDVIEVANLDGTN 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1069-1112

1.92e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 37.58 E-value: 1.92e-03

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462525224  1069 VVLRGDRDKPRAIVVNAERGYLYFTNMqdRAAKIERAALDGTER 1112
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

239-273

7.95e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 35.66 E-value: 7.95e-03

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2462525224   239 QKVVEGSLTHP--FALTLSGDTLYWTDWQTRSIHACN 273
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37

Name

Accession

Description

Interval

E-value

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

172-212

2.41e-13

Pssm-ID: 459654 Cd Length: 42 Bit Score: 65.64 E-value: 2.41e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462525224  172 GYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTID 212
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

308-345

5.08e-13

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 64.57 E-value: 5.08e-13

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462525224  308 CEEDNGGCSHLCLLSPSepFYTCACPTGVQLQDNGRTC 345
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

417-459

1.70e-12

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 63.00 E-value: 1.70e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224   417 QTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR 459
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

504-546

1.27e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 60.69 E-value: 1.27e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224   504 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKR 546
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1267-1304

1.39e-11

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 60.34 E-value: 1.39e-11

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462525224 1267 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1304
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1345-1379

1.73e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 59.91 E-value: 1.73e-11

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462525224 1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1268-1304

3.68e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 59.14 E-value: 3.68e-11

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462525224 1268 CSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1304
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

460-503

3.96e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.15 E-value: 3.96e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462525224   460 KILVSEDLDEPRAIALHPVMGLMYWTDWGeNPKIECANLDGQER 503
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1307-1341

5.03e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 58.76 E-value: 5.03e-11

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462525224 1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1341
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

719-761

6.78e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.38 E-value: 6.78e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224   719 EHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 761
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

152-195

9.00e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.38 E-value: 9.00e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462525224   152 KVLFWQDLDQPRAIALDPAHGYMYWTDWGeTPRIERAGMDGSTR 195
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

915-950

1.00e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 58.02 E-value: 1.00e-10

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462525224  915 CMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNC 950
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

480-520

1.11e-10

Pssm-ID: 459654 Cd Length: 42 Bit Score: 57.94 E-value: 1.11e-10

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462525224  480 GLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALD 520
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

111-151

2.11e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 57.23 E-value: 2.11e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462525224   111 VVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 151
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

196-238

2.17e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 57.23 E-value: 2.17e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224   196 KIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFR 238
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1267-1301

3.43e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

Pssm-ID: 197566 Cd Length: 33 Bit Score: 56.49 E-value: 3.43e-10

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2462525224  1267 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDE 1301
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1307-1341

1.37e-09

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 54.56 E-value: 1.37e-09

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462525224 1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1341
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

130-169

1.83e-09

Pssm-ID: 459654 Cd Length: 42 Bit Score: 54.47 E-value: 1.83e-09

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462525224  130 KLYWTDSET-NRIEVANLNGTSRKVLFWQDLDQPRAIALDP 169
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1345-1376

2.01e-09

Pssm-ID: 197566 Cd Length: 33 Bit Score: 54.18 E-value: 2.01e-09

                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462525224  1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1376
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1345-1379

6.49e-09

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 52.64 E-value: 6.49e-09

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462525224 1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

614-649

1.16e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 52.24 E-value: 1.16e-08

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462525224  614 CADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC 649
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

437-477

1.23e-08

Pssm-ID: 459654 Cd Length: 42 Bit Score: 52.16 E-value: 1.23e-08

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462525224  437 RNLYWTDTGTD-RIEVTRLNGTSRKILVSEDLDEPRAIALHP 477
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1307-1338

1.66e-08

Pssm-ID: 197566 Cd Length: 33 Bit Score: 51.48 E-value: 1.66e-08

                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462525224  1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDE 1338
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

762-805

7.13e-08

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 49.91 E-value: 7.13e-08

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462525224   762 QVLVWRDLDNPRSLALDPTKGYIYWTEWgGKPRIVRAFMDGTNC 805
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

358-571

8.03e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 55.09 E-value: 8.03e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  358 RTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVAR 437
Cdd:COG3391      1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  438 NLYWTDTGTDRIEVtrLNGTSRKILVSEDL-DEPRAIALHPVMGLMYWTDWGENpKIecANLDGQERRVLVNASLG-WPN 515
Cdd:COG3391     81 RLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVGaGPH 155

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462525224  516 GLALDLQEGKLYWGDAKTDKI----EVINV-DGTKRRTLLEDKLPHIFGFTLLGDFIYWTD 571
Cdd:COG3391    156 GIAVDPDGKRLYVANSGSNTVsvivSVIDTaTGKVVATIPVGGGPVGVAVSPDGRRLYVAN 216

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

34-223

9.49e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 54.70 E-value: 9.49e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224   34 AAQYFPASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGA----VYWTDVSEEAIkqTYLNQTGAAVQ 109
Cdd:COG3391     26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRV--SVIDLATGKVV 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  110 NVVISGlVSPDGLACDWVGKKLYWTDSETNRIEVanLNGTSRKVL-FWQDLDQPRAIALDPAHGYMYWTDWGeTPRIER- 187
Cdd:COG3391    104 ATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVi 179

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2462525224  188 -AGMDGSTRKII--VDSDIYwPNGLTIDLEEQKLYWADA 223
Cdd:COG3391    180 vSVIDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANR 217

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

694-887

1.26e-07

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 55.02 E-value: 1.26e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  694 SNNHIYWTDVSLKTISR-----AFMNGSSVEHVVEFGLDYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQFRQVLV--- 765
Cdd:cd05819     17 SSGNIYVADTGNNRIQVfdpdgNFITSFGSFGSGDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGgsg 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  766 --WRDLDNPRSLALDPtKGYIYWTEWGGKpRIVRaFMDGTNCMTLVDKVGRAN-------DLTIDyADQRLYWTDLDTNM 836
Cdd:cd05819     96 dgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK-FDPDGEFLTTFGSGGSGPgqfngptGVAVD-SDGNIYVADTGNHR 171

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462525224  837 IE----SSNML---GQERVVIAdDLPHPFGLT-QYSDYIYWTDWNLHSIERADKTSGRN 887
Cdd:cd05819    172 IQvfdpDGNFLttfGSTGTGPG-QFNYPTGIAvDSDGNIYVADSGNNRVQVFDPDGAGF 229

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

657-791

1.29e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 54.31 E-value: 1.29e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  657 VFTSRAAIHRIS-LETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGlDYPEGMAVD 735
Cdd:COG3391     82 LYVANSGSGRVSvIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVD 160

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462525224  736 WMGKNLYWADTGTNRIE--VARLDGQFRQVL-VWRDLDNPRSLALDPTKGYIYWTEWGG 791
Cdd:COG3391    161 PDGKRLYVANSGSNTVSviVSVIDTATGKVVaTIPVGGGPVGVAVSPDGRRLYVANRGS 219

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

383-544

1.34e-07

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 54.63 E-value: 1.34e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  383 HAIAIDYDpleGYVYWTDDEVRAIRR-----AYLDGSGAQTLVNTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 457
Cdd:cd05819     58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  458 SRKIL-----VSEDLDEPRAIALHPVmGLMYWTDWGENpKIECANLDGQERRVL-----VNASLGWPNGLALDlQEGKLY 527
Cdd:cd05819    134 FLTTFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNH-RIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVD-SDGNIY 210

                          170
                   ....*....|....*..
gi 2462525224  528 WGDAKTDKIEVINVDGT 544
Cdd:cd05819    211 VADSGNNRVQVFDPDGA 227

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

375-415

2.11e-07

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 48.75 E-value: 2.11e-07

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462525224   375 VLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSG 415
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

46-178

9.59e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 51.82 E-value: 9.59e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224   46 FANRRDVRLvdAGGVKLESTIVVSGLEDAA--AVDFQfskGAVYWTD-VSEEAIKQtylnQTGAAVQNVV-ISGLVSPDG 121
Cdd:cd14952     70 FGNNRVLKL--AAGSTTQTVLPFTGLNDPTgvAVDAA---GNVYVADtGNNRVLKL----AAGSNTQTVLpFTGLSNPDG 140

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462525224  122 LACDWVGKkLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAhGYMYWTD 178
Cdd:cd14952    141 VAVDGAGN-VYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDTA-GNVYVTD 195

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1113-1155

1.05e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 46.83 E-value: 1.05e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224  1113 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR 1155
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

1226-1262

1.75e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.08 E-value: 1.75e-06

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462525224 1226 CARDNGGCSHICIAKGDGTpRCSCPVHLVLLQNLLTC 1262
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGY-TCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

808-847

2.55e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 45.67 E-value: 2.55e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2462525224   808 LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 847
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

C_rich_MXAN6577

NF041328

MXAN_6577-like cysteine-rich domain;

1262-1357

7.70e-06

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 47.44 E-value: 7.70e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224 1262 CGEppTCSPDQfACATGEIDCIPGAWRCDGfpEC-DDQSDEEGCPVCSAAQFP---CARGQCVDL----RLRCDGEadCQ 1333
Cdd:NF041328    45 CGV--ACGAGQ-TCVAGACGCGPGTVACGG--ACvDTASDPAHCGACGAACAPgqvCEGGACREAcsegLTRCGGA--CV 117

                           90       100
                   ....*....|....*....|....*...
gi 2462525224 1334 D-RSDEAD---CDAICLPNQFrCASGQC 1357
Cdd:NF041328   118 DlATDPLHcgaCGVACDPGES-CRGGAC 144

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

394-434

1.74e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 43.30 E-value: 1.74e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462525224  394 GYVYWTDDEVRA-IRRAYLDGSGAQTLVNTEINDPDGIAVDW 434
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

721-785

2.04e-05

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 47.97 E-value: 2.04e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462525224  721 VVEF-GLDYPEGMAVDWMGkNLYWADTGTNRieVARLD-GQFRQ-VLVWRDLDNPRSLALDPTkGYIY 785
Cdd:cd14952      3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVY 66

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

696-736

2.06e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 42.92 E-value: 2.06e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462525224  696 NHIYWTDVSLK-TISRAFMNGSSVEHVVEFGLDYPEGMAVDW 736
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

740-779

9.53e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 40.99 E-value: 9.53e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462525224  740 NLYWADTGT-NRIEVARLDGQFRQVLVWRDLDNPRSLALDP 779
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

547-580

2.53e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.89 E-value: 2.53e-04

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2462525224   547 RTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV 580
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

727-803

3.90e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 44.20 E-value: 3.90e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  727 DYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQF-RQvlVWR--DLDN----PRSLALDPtKGYIYWTE-WGGkpRIVRA 798
Cdd:cd14956     13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFlRR--FGTtgDGPGqfgrPRGLAVDK-DGWLYVADyWGD--RIQVF 86


                   ....*
gi 2462525224  799 FMDGT 803
Cdd:cd14956     87 TLTGE 91

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

979-1018

4.94e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.12 E-value: 4.94e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462525224   979 ILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQ 1018
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwGLDVIEVANLDGTN 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1069-1112

1.92e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 37.58 E-value: 1.92e-03

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462525224  1069 VVLRGDRDKPRAIVVNAERGYLYFTNMqdRAAKIERAALDGTER 1112
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

782-822

2.73e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 37.14 E-value: 2.73e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462525224  782 GYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDY 822
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

524-562

3.01e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 36.75 E-value: 3.01e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462525224  524 GKLYWGDAKTD-KIEVINVDGTKRRTLLEDKLPHIFGFTL 562
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAV 40

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

216-254

7.38e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 35.98 E-value: 7.38e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462525224  216 QKLYWADAKLSF-IHRANLDGSFRQKVVEGSLTHPFALTL 254
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAV 40

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

239-273

7.95e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 35.66 E-value: 7.95e-03

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2462525224   239 QKVVEGSLTHP--FALTLSGDTLYWTDWQTRSIHACN 273
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37

Name

Accession

Description

Interval

E-value

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

172-212

2.41e-13

Pssm-ID: 459654 Cd Length: 42 Bit Score: 65.64 E-value: 2.41e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462525224  172 GYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTID 212
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

308-345

5.08e-13

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 64.57 E-value: 5.08e-13

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462525224  308 CEEDNGGCSHLCLLSPSepFYTCACPTGVQLQDNGRTC 345
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

417-459

1.70e-12

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 63.00 E-value: 1.70e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224   417 QTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR 459
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

504-546

1.27e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 60.69 E-value: 1.27e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224   504 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKR 546
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1267-1304

1.39e-11

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 60.34 E-value: 1.39e-11

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462525224 1267 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1304
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1345-1379

1.73e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 59.91 E-value: 1.73e-11

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462525224 1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1268-1304

3.68e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 59.14 E-value: 3.68e-11

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462525224 1268 CSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1304
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

460-503

3.96e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.15 E-value: 3.96e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462525224   460 KILVSEDLDEPRAIALHPVMGLMYWTDWGeNPKIECANLDGQER 503
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1307-1341

5.03e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 58.76 E-value: 5.03e-11

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462525224 1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1341
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

719-761

6.78e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.38 E-value: 6.78e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224   719 EHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 761
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

152-195

9.00e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.38 E-value: 9.00e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462525224   152 KVLFWQDLDQPRAIALDPAHGYMYWTDWGeTPRIERAGMDGSTR 195
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

915-950

1.00e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 58.02 E-value: 1.00e-10

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462525224  915 CMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNC 950
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

480-520

1.11e-10

Pssm-ID: 459654 Cd Length: 42 Bit Score: 57.94 E-value: 1.11e-10

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462525224  480 GLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALD 520
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

111-151

2.11e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 57.23 E-value: 2.11e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462525224   111 VVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 151
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

196-238

2.17e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 57.23 E-value: 2.17e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224   196 KIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFR 238
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1267-1301

3.43e-10

Pssm-ID: 197566 Cd Length: 33 Bit Score: 56.49 E-value: 3.43e-10

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2462525224  1267 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDE 1301
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1307-1341

1.37e-09

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 54.56 E-value: 1.37e-09

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462525224 1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1341
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

130-169

1.83e-09

Pssm-ID: 459654 Cd Length: 42 Bit Score: 54.47 E-value: 1.83e-09

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462525224  130 KLYWTDSET-NRIEVANLNGTSRKVLFWQDLDQPRAIALDP 169
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1345-1376

2.01e-09

Pssm-ID: 197566 Cd Length: 33 Bit Score: 54.18 E-value: 2.01e-09

                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462525224  1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1376
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1345-1379

6.49e-09

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 52.64 E-value: 6.49e-09

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462525224 1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

614-649

1.16e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 52.24 E-value: 1.16e-08

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462525224  614 CADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC 649
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

437-477

1.23e-08

Pssm-ID: 459654 Cd Length: 42 Bit Score: 52.16 E-value: 1.23e-08

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462525224  437 RNLYWTDTGTD-RIEVTRLNGTSRKILVSEDLDEPRAIALHP 477
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1307-1338

1.66e-08

Pssm-ID: 197566 Cd Length: 33 Bit Score: 51.48 E-value: 1.66e-08

                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462525224  1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDE 1338
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

762-805

7.13e-08

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 49.91 E-value: 7.13e-08

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462525224   762 QVLVWRDLDNPRSLALDPTKGYIYWTEWgGKPRIVRAFMDGTNC 805
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

358-571

8.03e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 55.09 E-value: 8.03e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  358 RTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVAR 437
Cdd:COG3391      1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  438 NLYWTDTGTDRIEVtrLNGTSRKILVSEDL-DEPRAIALHPVMGLMYWTDWGENpKIecANLDGQERRVLVNASLG-WPN 515
Cdd:COG3391     81 RLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVGaGPH 155

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462525224  516 GLALDLQEGKLYWGDAKTDKI----EVINV-DGTKRRTLLEDKLPHIFGFTLLGDFIYWTD 571
Cdd:COG3391    156 GIAVDPDGKRLYVANSGSNTVsvivSVIDTaTGKVVATIPVGGGPVGVAVSPDGRRLYVAN 216

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

34-223

9.49e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 54.70 E-value: 9.49e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224   34 AAQYFPASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGA----VYWTDVSEEAIkqTYLNQTGAAVQ 109
Cdd:COG3391     26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRV--SVIDLATGKVV 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  110 NVVISGlVSPDGLACDWVGKKLYWTDSETNRIEVanLNGTSRKVL-FWQDLDQPRAIALDPAHGYMYWTDWGeTPRIER- 187
Cdd:COG3391    104 ATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVi 179

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2462525224  188 -AGMDGSTRKII--VDSDIYwPNGLTIDLEEQKLYWADA 223
Cdd:COG3391    180 vSVIDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANR 217

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

694-887

1.26e-07

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 55.02 E-value: 1.26e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  694 SNNHIYWTDVSLKTISR-----AFMNGSSVEHVVEFGLDYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQFRQVLV--- 765
Cdd:cd05819     17 SSGNIYVADTGNNRIQVfdpdgNFITSFGSFGSGDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGgsg 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  766 --WRDLDNPRSLALDPtKGYIYWTEWGGKpRIVRaFMDGTNCMTLVDKVGRAN-------DLTIDyADQRLYWTDLDTNM 836
Cdd:cd05819     96 dgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK-FDPDGEFLTTFGSGGSGPgqfngptGVAVD-SDGNIYVADTGNHR 171

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462525224  837 IE----SSNML---GQERVVIAdDLPHPFGLT-QYSDYIYWTDWNLHSIERADKTSGRN 887
Cdd:cd05819    172 IQvfdpDGNFLttfGSTGTGPG-QFNYPTGIAvDSDGNIYVADSGNNRVQVFDPDGAGF 229

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

657-791

1.29e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 54.31 E-value: 1.29e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  657 VFTSRAAIHRIS-LETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGlDYPEGMAVD 735
Cdd:COG3391     82 LYVANSGSGRVSvIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVD 160

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462525224  736 WMGKNLYWADTGTNRIE--VARLDGQFRQVL-VWRDLDNPRSLALDPTKGYIYWTEWGG 791
Cdd:COG3391    161 PDGKRLYVANSGSNTVSviVSVIDTATGKVVaTIPVGGGPVGVAVSPDGRRLYVANRGS 219

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

383-544

1.34e-07

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 54.63 E-value: 1.34e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  383 HAIAIDYDpleGYVYWTDDEVRAIRR-----AYLDGSGAQTLVNTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 457
Cdd:cd05819     58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  458 SRKIL-----VSEDLDEPRAIALHPVmGLMYWTDWGENpKIECANLDGQERRVL-----VNASLGWPNGLALDlQEGKLY 527
Cdd:cd05819    134 FLTTFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNH-RIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVD-SDGNIY 210

                          170
                   ....*....|....*..
gi 2462525224  528 WGDAKTDKIEVINVDGT 544
Cdd:cd05819    211 VADSGNNRVQVFDPDGA 227

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

375-415

2.11e-07

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 48.75 E-value: 2.11e-07

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462525224   375 VLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSG 415
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

46-178

9.59e-07

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 51.82 E-value: 9.59e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224   46 FANRRDVRLvdAGGVKLESTIVVSGLEDAA--AVDFQfskGAVYWTD-VSEEAIKQtylnQTGAAVQNVV-ISGLVSPDG 121
Cdd:cd14952     70 FGNNRVLKL--AAGSTTQTVLPFTGLNDPTgvAVDAA---GNVYVADtGNNRVLKL----AAGSNTQTVLpFTGLSNPDG 140

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462525224  122 LACDWVGKkLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAhGYMYWTD 178
Cdd:cd14952    141 VAVDGAGN-VYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDTA-GNVYVTD 195

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1113-1155

1.05e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 46.83 E-value: 1.05e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462525224  1113 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR 1155
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

1226-1262

1.75e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.08 E-value: 1.75e-06

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462525224 1226 CARDNGGCSHICIAKGDGTpRCSCPVHLVLLQNLLTC 1262
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGY-TCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

808-847

2.55e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 45.67 E-value: 2.55e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2462525224   808 LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 847
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

346-543

3.66e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 50.08 E-value: 3.66e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  346 KAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTL--VNTE 423
Cdd:COG3391     19 AALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVsvIDLA 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  424 IN----------DPDGIAVDWVARNLYWTDTGTDRieVTRLNGTSRKILVSEDL-DEPRAIALHPVMGLMYWTDWGENpK 492
Cdd:COG3391     99 TGkvvatipvggGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKVVATIPVgAGPHGIAVDPDGKRLYVANSGSN-T 175

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462525224  493 IEC--ANLDGQERRVLVNASLG-WPNGLALDLQEGKLY-------WGDAKTDKIEVINVDG 543
Cdd:COG3391    176 VSVivSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYvanrgsnTSNGGSNTVSVIDLAT 236

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

678-718

5.28e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 44.90 E-value: 5.28e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462525224   678 IPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSV 718
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

NHL_like_6

cd14962

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

385-543

6.56e-06

Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 49.51 E-value: 6.56e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  385 IAIDYDPlEGYVYWTDDEVRAIRRAYLDGSGAQTLVNT-EINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILV 463
Cdd:cd14962     60 IGVAIDA-NGNLYVSDAELGKVFVFDRDGKFLRAIGAGaLFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIG 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  464 S-----EDLDEPRAIALHPvMGLMYWTDWGeNPKIECANLDGQERRV-----LVNASLGWPNGLALDlQEGKLYWGDAKT 533
Cdd:cd14962    139 KrgsgpGEFNLPTDLAVDR-DGNLYVTDTM-NFRVQIFDADGKFLRSfgergDGPGSFARPKGIAVD-SEGNIYVVDAAF 215

                          170
                   ....*....|
gi 2462525224  534 DKIEVINVDG 543
Cdd:cd14962    216 DNVQIFNPEG 225

C_rich_MXAN6577

NF041328

MXAN_6577-like cysteine-rich domain;

1262-1357

7.70e-06

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 47.44 E-value: 7.70e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224 1262 CGEppTCSPDQfACATGEIDCIPGAWRCDGfpEC-DDQSDEEGCPVCSAAQFP---CARGQCVDL----RLRCDGEadCQ 1333
Cdd:NF041328    45 CGV--ACGAGQ-TCVAGACGCGPGTVACGG--ACvDTASDPAHCGACGAACAPgqvCEGGACREAcsegLTRCGGA--CV 117

                           90       100
                   ....*....|....*....|....*...
gi 2462525224 1334 D-RSDEAD---CDAICLPNQFrCASGQC 1357
Cdd:NF041328   118 DlATDPLHcgaCGVACDPGES-CRGGAC 144

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

847-888

9.23e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 44.13 E-value: 9.23e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462525224   847 RVVIADDLPHPFGLT--QYSDYIYWTDWNLHSIERADKTsGRNR 888
Cdd:smart00135    1 RTLLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

394-434

1.74e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 43.30 E-value: 1.74e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462525224  394 GYVYWTDDEVRA-IRRAYLDGSGAQTLVNTEINDPDGIAVDW 434
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL_like_5

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

425-548

1.93e-05

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 48.06 E-value: 1.93e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  425 NDPDGIAVDWvaRNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDE-----PRAIALHPvMGLMYWTDWGeNPKIECANLD 499
Cdd:cd14963     10 NKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGPgefkyPYGIAVDS-DGNIYVADLY-NGRIQVFDPD 85

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462525224  500 GQERRVLVNAS----LGWPNGLALDlqEGKLYWGDAKTDKIEVINVDGTKRRT 548
Cdd:cd14963     86 GKFLKYFPEKKdrvkLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE 136

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

721-785

2.04e-05

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 47.97 E-value: 2.04e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462525224  721 VVEF-GLDYPEGMAVDWMGkNLYWADTGTNRieVARLD-GQFRQ-VLVWRDLDNPRSLALDPTkGYIY 785
Cdd:cd14952      3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVY 66

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

696-736

2.06e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 42.92 E-value: 2.06e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462525224  696 NHIYWTDVSLK-TISRAFMNGSSVEHVVEFGLDYPEGMAVDW 736
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

738-837

2.34e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 47.77 E-value: 2.34e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  738 GKNLYWADTGTNRIEVARLDgQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKpRIVRafMDGTNcMTLVDKV---GR 814
Cdd:COG3391     79 GRRLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RVSV--IDTAT-GKVVATIpvgAG 153

                           90       100
                   ....*....|....*....|...
gi 2462525224  815 ANDLTIDYADQRLYWTDLDTNMI 837
Cdd:COG3391    154 PHGIAVDPDGKRLYVANSGSNTV 176

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

673-797

3.06e-05

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 47.20 E-value: 3.06e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  673 NNDVAIPLTGVKEASALDFDVSNNhIYWTD------VSLKTisrafmnGSSVEHVVEF-GLDYPEGMAVDWMGkNLYWAD 745
Cdd:cd14952     83 TTQTVLPFTGLNDPTGVAVDAAGN-VYVADtgnnrvLKLAA-------GSNTQTVLPFtGLSNPDGVAVDGAG-NVYVTD 153

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462525224  746 TGTNRieVARLD-GQFRQ-VLVWRDLDNPRSLALDpTKGYIYWTEwGGKPRIVR 797
Cdd:cd14952    154 TGNNR--VLKLAaGSTTQtVLPFTGLNSPSGVAVD-TAGNVYVTD-HGNNRVLK 203

NHL_like_5

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

692-837

3.13e-05

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 47.67 E-value: 3.13e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  692 DVSNNHIYWTDVSLKTISRAFMNGssvEHVVEFG--------LDYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQFRQV 763
Cdd:cd14963    108 AIDDGKLYVSDVKKHKVIVFDLEG---KLLLEFGkpgsepgeLSYPNGIAVDEDG-NIYVADSGNGRIQVFDKNGKFIKE 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  764 LVWRDLD-----NPRSLALDPtKGYIY-----------WTEWGGKPRIVRAFMDGTNCMTLvdkvgrANDLTIDyADQRL 827
Cdd:cd14963    184 LNGSPDGksgfvNPRGIAVDP-DGNLYvvdnlshrvyvFDEQGKELFTFGGRGKDDGQFNL------PNGLFID-DDGRL 255

                          170
                   ....*....|
gi 2462525224  828 YWTDLDTNMI 837
Cdd:cd14963    256 YVTDRENNRV 265

Vgb

COG4257

Streptogramin lyase [Defense mechanisms];

663-837

3.88e-05

Streptogramin lyase [Defense mechanisms];

Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 47.32 E-value: 3.88e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  663 AIHRISLETNNND-VAIPlTGVKEASALDFDvSNNHIYWTDVSLKTISR---AfmNGSSVEHVVEFGLDYPEGMAVDWMG 738
Cdd:COG4257     81 RIGRIDPKTGEITtFALP-GGGSNPHGIAFD-PDGNLWFTDQGGNRIGRldpA--TGEVTEFPLPTGGAGPYGIAVDPDG 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  739 kNLYWADTGTNRIevARLD---GQFRQVLVWRDLDNPRSLALDPtKGYIYWTEWGGkpRIVRAFMDGTNCMT---LVDKV 812
Cdd:COG4257    157 -NLWVTDFGANAI--GRIDpdtGTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGS--GRIGRFDPKTGTVTeypLPGGG 230

                          170       180
                   ....*....|....*....|....*
gi 2462525224  813 GRANDLTIDYADqRLYWTDLDTNMI 837
Cdd:COG4257    231 ARPYGVAVDGDG-RVWFAESGANRI 254

NHL_like_5

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

416-577

3.92e-05

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 47.29 E-value: 3.92e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  416 AQTLVNTEINDPDGIAVDwvARNLYWTDTGTDRIEVTRLNGTSRKILVSE-----DLDEPRAIALHPvMGLMYWTDWGeN 490
Cdd:cd14963     93 PEKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPgsepgELSYPNGIAVDE-DGNIYVADSG-N 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  491 PKIECANLDGQERRVLVNASLGW-----PNGLALDlQEGKLYWGDAKTDKIEVINVDGTKRRTL----LED---KLPHif 558
Cdd:cd14963    169 GRIQVFDKNGKFIKELNGSPDGKsgfvnPRGIAVD-PDGNLYVVDNLSHRVYVFDEQGKELFTFggrgKDDgqfNLPN-- 245

                          170       180
                   ....*....|....*....|
gi 2462525224  559 GFTLLGD-FIYWTDWQRRSI 577
Cdd:cd14963    246 GLFIDDDgRLYVTDRENNRV 265

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

385-544

9.19e-05

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 46.12 E-value: 9.19e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  385 IAIDYDpleGYVYWTDDEVRAIRRAYLDGSGAQTL-----VNTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT-- 457
Cdd:cd14956     65 LAVDKD---GWLYVADYWGDRIQVFTLTGELQTIGgssgsGPGQFNAPRGVAVD-ADGNLYVADFGNQRIQKFDPDGSfl 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  458 ----SRKILVSEdLDEPRAIALHPVmGLMYWTDwGENPKIECANLDGQERRVL--VNASLGW---PNGLALDlQEGKLYW 528
Cdd:cd14956    141 rqwgGTGIEPGS-FNYPRGVAVDPD-GTLYVAD-TYNDRIQVFDNDGAFLRKWggRGTGPGQfnyPYGIAID-PDGNVFV 216

                          170
                   ....*....|....*.
gi 2462525224  529 GDAKTDKIEVINVDGT 544
Cdd:cd14956    217 ADFGNNRIQKFTADGT 232

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

740-779

9.53e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 40.99 E-value: 9.53e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462525224  740 NLYWADTGT-NRIEVARLDGQFRQVLVWRDLDNPRSLALDP 779
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

44-180

1.16e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 45.46 E-value: 1.16e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224   44 LLFANRRD--VRLVDAGGVKLESTIVVSGleDAAAVDFQFSKGAVYWTDVSEEAIkQTYLNQTGAAVQnvVISGLVSPDG 121
Cdd:COG3391     82 LYVANSGSgrVSVIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRV-SVIDTATGKVVA--TIPVGAGPHG 156

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462525224  122 LACDWVGKKLYWTDSETNRIE--VANLNGTSRKVL-FWQDLDQPRAIALDPAHGYMYWTDWG 180
Cdd:COG3391    157 IAVDPDGKRLYVANSGSNTVSviVSVIDTATGKVVaTIPVGGGPVGVAVSPDGRRLYVANRG 218

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

727-879

1.59e-04

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 45.35 E-value: 1.59e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  727 DYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQFrqVLVWRD-------LDNPRSLALDPtKGYIYWTEwGGKPRIVRAF 799
Cdd:cd14956    107 NAPRGVAVDADG-NLYVADFGNQRIQKFDPDGSF--LRQWGGtgiepgsFNYPRGVAVDP-DGTLYVAD-TYNDRIQVFD 181

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  800 MDGtncmTLVDKVGR----------ANDLTIDyADQRLYWTDLDTNMIESSNMLGQERVVI--ADDLPHPF----GLTQY 863
Cdd:cd14956    182 NDG----AFLRKWGGrgtgpgqfnyPYGIAID-PDGNVFVADFGNNRIQKFTADGTFLTSWgsPGTGPGQFknpwGVVVD 256

                          170
                   ....*....|....*..
gi 2462525224  864 SD-YIYWTDWNLHSIER 879
Cdd:cd14956    257 ADgTVYVADSNNNRVQR 273

YvrE

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

389-549

2.07e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 44.88 E-value: 2.07e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  389 YDPlEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEiNDPDGIAVD-----WVARN---LYWTDTGTDRIEV--------- 451
Cdd:COG3386     15 WDP-DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADHgrgLVRFDPADGEVTVladeygkpl 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  452 TRLN------------------------------GTSRKILvsEDLDEPRAIALHPVMGLMYWTDWGENpKIECANLDGQ 501
Cdd:COG3386     93 NRPNdgvvdpdgrlyftdmgeylptgalyrvdpdGSLRVLA--DGLTFPNGIAFSPDGRTLYVADTGAG-RIYRFDLDAD 169

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462525224  502 ----ERRVLVNASL--GWPNGLALDlQEGKLYWGDAKTDKIEVINVDGTKRRTL 549
Cdd:COG3386    170 gtlgNRRVFADLPDgpGGPDGLAVD-ADGNLWVALWGGGGVVRFDPDGELLGRI 222

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

421-797

2.48e-04

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 44.62 E-value: 2.48e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  421 NTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTsrkilvsedldepraialhpvmglmYWTDWGENpkiecANLDG 500
Cdd:cd05819      4 PGELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGN-------------------------FITSFGSF-----GSGDG 52

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  501 QerrvlvnasLGWPNGLALDlQEGKLYWGDAKTDKIEVINVDGTKRRTLledklpHIFGFTLLGDF------------IY 568
Cdd:cd05819     53 Q---------FNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASF------GGSGDGDGEFNgprgiavdssgnIY 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  569 WTDWQRRsieRVHKVKASRDVIidqlpdlmglkavnvaKVVGTNpcadrNGGCSHLCFftphatrcgcPIGLellsdmkt 648
Cdd:cd05819    117 VADTGNH---RIQKFDPDGEFL----------------TTFGSG-----GSGPGQFNG----------PTGV-------- 154

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  649 civpeaflvftsraAIHRisletnNNDVAIpltgvkeasaLDFDvsNNHIYWTDVSLKTISRAfmnGSSVEHVVEFglDY 728
Cdd:cd05819    155 --------------AVDS------DGNIYV----------ADTG--NHRIQVFDPDGNFLTTF---GSTGTGPGQF--NY 197

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462525224  729 PEGMAVDWMGkNLYWADTGTNRIEVARLDGQFRQVL-----VWRDLDNPRSLALDPtKGYIYWTEWGGkPRIVR 797
Cdd:cd05819    198 PTGIAVDSDG-NIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAVDS-DGNLYVADTGN-NRIQV 268

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

547-580

2.53e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.89 E-value: 2.53e-04

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2462525224   547 RTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV 580
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36

YvrE

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

84-273

2.79e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 44.50 E-value: 2.79e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224   84 GAVYWTDVSEEAIkQTYLNQTGAAVQNVVISGLVS-----PDG--LACDwVGKKLYWTDSETNRIEV-ANLNGTsrkvlf 155
Cdd:COG3386     19 GRLYWVDIPGGRI-HRYDPDGGAVEVFAEPSGRPNglafdPDGrlLVAD-HGRGLVRFDPADGEVTVlADEYGK------ 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  156 wqDLDQPRAIALDPaHGYMYWTD---WGETPRIERAGMDGSTRkiIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRAN 232
Cdd:COG3386     91 --PLNRPNDGVVDP-DGRLYFTDmgeYLPTGALYRVDPDGSLR--VLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFD 165

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462525224  233 LDGSfrqkvveGSLTHP--FALTLSGD------------TLYWTDWQTRSIHACN 273
Cdd:COG3386    166 LDAD-------GTLGNRrvFADLPDGPggpdglavdadgNLWVALWGGGGVVRFD 213

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

678-779

2.87e-04

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 44.51 E-value: 2.87e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  678 IPLTGVKEASALDFDVSNNhIYWTDVS----LKTISrafmnGSSVEHVVEF-GLDYPEGMAVDWMGkNLYWADTGTNRie 752
Cdd:cd14952     46 LPFTGLYQPQGVAVDAAGT-VYVTDFGnnrvLKLAA-----GSTTQTVLPFtGLNDPTGVAVDAAG-NVYVADTGNNR-- 116

                           90       100
                   ....*....|....*....|....*....
gi 2462525224  753 VARLDGQ--FRQVLVWRDLDNPRSLALDP 779
Cdd:cd14952    117 VLKLAAGsnTQTVLPFTGLSNPDGVAVDG 145

YvrE

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

721-833

3.02e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 44.50 E-value: 3.02e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  721 VVEFGLDYPEGMAVDWMGkNLYWADTGTNRIevARLDGQFRQVLVWRDLDN-PRSLALDPtKGYIYWTEwgGKPRIVRAF 799
Cdd:COG3386      2 LADAGFRLGEGPVWDPDG-RLYWVDIPGGRI--HRYDPDGGAVEVFAEPSGrPNGLAFDP-DGRLLVAD--HGRGLVRFD 75

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2462525224  800 MDGTNCMTLVDKVG----RANDLTIDyADQRLYWTDLD 833
Cdd:COG3386     76 PADGEVTVLADEYGkplnRPNDGVVD-PDGRLYFTDMG 112

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

76-298

3.83e-04

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 44.23 E-value: 3.83e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224   76 AVDfqfSKGAVYWTDVSEEAIKQtyLNQTGAAVQNVVISG-----LVSPDGLACDwVGKKLYWTDSETNRIEVANLNGTS 150
Cdd:cd05819     14 AVD---SSGNIYVADTGNNRIQV--FDPDGNFITSFGSFGsgdgqFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNF 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  151 RKV-----LFWQDLDQPRAIALDPAhGYMYWTDWGETpRIERAGMDGSTRKII-----VDSDIYWPNGLTIDlEEQKLYW 220
Cdd:cd05819     88 LASfggsgDGDGEFNGPRGIAVDSS-GNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVD-SDGNIYV 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  221 ADAKLSFIHRANLDGSF-----RQKVVEGSLTHPFALTLSGD-TLYWTDWQTRSIH-----ACNKRTGGKRKEILSALYS 289
Cdd:cd05819    165 ADTGNHRIQVFDPDGNFlttfgSTGTGPGQFNYPTGIAVDSDgNIYVADSGNNRVQvfdpdGAGFGGNGNFLGSDGQFNR 244


                   ....*....
gi 2462525224  290 PMDIQVLSQ 298
Cdd:cd05819    245 PSGLAVDSD 253

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

727-803

3.90e-04

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 44.20 E-value: 3.90e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  727 DYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQF-RQvlVWR--DLDN----PRSLALDPtKGYIYWTE-WGGkpRIVRA 798
Cdd:cd14956     13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFlRR--FGTtgDGPGqfgrPRGLAVDK-DGWLYVADyWGD--RIQVF 86


                   ....*
gi 2462525224  799 FMDGT 803
Cdd:cd14956     87 TLTGE 91

NHL_like_5

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

423-539

4.25e-04

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 43.82 E-value: 4.25e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  423 EINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDE-----PRAIALHPvMGLMYWTDWGENpKIECAN 497
Cdd:cd14963    146 ELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELNGSPDGKsgfvnPRGIAVDP-DGNLYVVDNLSH-RVYVFD 222

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2462525224  498 LDGQERRVL-----VNASLGWPNGLALDlQEGKLYWGDAKTDKIEVI 539
Cdd:cd14963    223 EQGKELFTFggrgkDDGQFNLPNGLFID-DDGRLYVTDRENNRVAVY 268

NHL_like_6

cd14962

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

112-263

4.36e-04

Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 44.12 E-value: 4.36e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  112 VISGLVSPDGLACDWVGKkLYWTDSETNRIEVANLNgtSRKVLFW-----QDLDQPRAIALDPAhGYMYWTDwGETPRIE 186
Cdd:cd14962      7 PKEALTRPYGVAADGRGR-IYVADTGRGAVFVFDLP--NGKVFVIgnagpNRFVSPIGVAIDAN-GNLYVSD-AELGKVF 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  187 RAGMDGS-TRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSF-----RQKVVEGSLTHPFALTLSGD-TL 259
Cdd:cd14962     82 VFDRDGKfLRAIGAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLlfdigKRGSGPGEFNLPTDLAVDRDgNL 161


                   ....
gi 2462525224  260 YWTD 263
Cdd:cd14962    162 YVTD 165

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

979-1018

4.94e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.12 E-value: 4.94e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462525224   979 ILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQ 1018
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwGLDVIEVANLDGTN 42

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

672-751

7.19e-04

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 42.97 E-value: 7.19e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  672 NNNDVAIPLTGVKEASALDFDVSNNhIYWTDVSLKTISRaFMNGSSVEHVVEF-GLDYPEGMAVDWMGkNLYWADTGTNR 750
Cdd:cd14952    166 STTQTVLPFTGLNSPSGVAVDTAGN-VYVTDHGNNRVLK-LAAGSTTPTVLPFtGLNGPLGVAVDAAG-NVYVADRGNDR 242


                   .
gi 2462525224  751 I 751
Cdd:cd14952    243 V 243

NHL_like_4

cd14955

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...

727-785

8.85e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 42.95 E-value: 8.85e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462525224  727 DYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQFrqVLVW-------RDLDNPRSLALDPTkGYIY 785
Cdd:cd14955     16 NSPSGIAVDSAG-NVYVADTGNNRIQKFDSTGTF--LTKWgssgsgdGQFYSPTGIAVDSD-GNVY 77

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

383-449

1.15e-03

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 42.58 E-value: 1.15e-03

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462525224  383 HAIAIDydpLEGYVYWTDDEVRAIRRayLD-GSGAQT-LVNTEINDPDGIAVDwVARNLYWTDTGTDRI 449
Cdd:cd14952    181 SGVAVD---TAGNVYVTDHGNNRVLK--LAaGSTTPTvLPFTGLNGPLGVAVD-AAGNVYVADRGNDRV 243

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

383-490

1.28e-03

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 42.19 E-value: 1.28e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  383 HAIAIDYDpleGYVYWTD-DEVRAIRRAylDGSGAQT-LVNTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTSRK 460
Cdd:cd14952     97 TGVAVDAA---GNVYVADtGNNRVLKLA--AGSNTQTvLPFTGLSNPDGVAVD-GAGNVYVTDTGNNRVLKLAAGSTTQT 170

                           90       100       110
                   ....*....|....*....|....*....|
gi 2462525224  461 ILVSEDLDEPRAIALHPVmGLMYWTDWGEN 490
Cdd:cd14952    171 VLPFTGLNSPSGVAVDTA-GNVYVTDHGNN 199

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

425-544

1.37e-03

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 42.65 E-value: 1.37e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  425 NDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTSRKILVS-----EDLDEPRAIALHPvMGLMYWTDwGENPKIECANLD 499
Cdd:cd14956     13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFLRRFGTtgdgpGQFGRPRGLAVDK-DGWLYVAD-YWGDRIQVFTLT 89

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462525224  500 GQERRVL-----VNASLGWPNGLALDLQeGKLYWGDAKTDKIEVINVDGT 544
Cdd:cd14956     90 GELQTIGgssgsGPGQFNAPRGVAVDAD-GNLYVADFGNQRIQKFDPDGS 138

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1069-1112

1.92e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 37.58 E-value: 1.92e-03

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462525224  1069 VVLRGDRDKPRAIVVNAERGYLYFTNMqdRAAKIERAALDGTER 1112
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43

YvrE

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

655-797

2.11e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 41.80 E-value: 2.11e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  655 FLVFTSRAAIHRISLETNNNDVAIPLTGVKEASA--LDFDvSNNHIYWTDVSLKTISRAFM----NGSSveHVVEFGLDY 728
Cdd:COG3386     62 LLVADHGRGLVRFDPADGEVTVLADEYGKPLNRPndGVVD-PDGRLYFTDMGEYLPTGALYrvdpDGSL--RVLADGLTF 138

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462525224  729 PEGMAVDWMGKNLYWADTGTNRIEVARL--DGQFRQVLVWRDLD----NPRSLALDpTKGYIYWTEWGGKpRIVR 797
Cdd:COG3386    139 PNGIAFSPDGRTLYVADTGAGRIYRFDLdaDGTLGNRRVFADLPdgpgGPDGLAVD-ADGNLWVALWGGG-GVVR 211

NHL_like_1

cd14953

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...

408-544

2.37e-03

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 42.13 E-value: 2.37e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  408 RAYLDGSGAqtlVNTEINDPDGIAVDwVARNLYWTDTGTDRI-------EVTRLNGTSR------KILVSEDLDEPRAIA 474
Cdd:cd14953    118 AGFSDDGGA---TAAQFNYPTGVAVD-AAGNLYVADTGNHRIrkitpdgVVTTVAGTGGagyagdGPATAAQFNNPTGVA 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  475 LHPvMGLMYWTDWGeNPKIECANLDGQERRVL-------------VNASLGWPNGLALDlQEGKLYWGDAKTDKIEVINV 541
Cdd:cd14953    194 VDA-AGNLYVADRG-NHRIRKITPDGVVTTVAgtgtagfsgdggaTAAQLNNPTGVAVD-AAGNLYVADSGNHRIRKITP 270


                   ...
gi 2462525224  542 DGT 544
Cdd:cd14953    271 AGV 273

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

782-822

2.73e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 37.14 E-value: 2.73e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462525224  782 GYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDY 822
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42

NHL_TRIM71_like

cd14954

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...

726-785

2.93e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 41.38 E-value: 2.93e-03

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462525224  726 LDYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQF-----RQVLVWRDLDNPRSLALDPTkGYIY 785
Cdd:cd14954    117 FNYPWGVAVDSEG-RIYVSDTRNHRVQVFDSDGQFirkfgFEGAGPGQLDSPRGVAVNPD-GNIV 179

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

524-562

3.01e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 36.75 E-value: 3.01e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462525224  524 GKLYWGDAKTD-KIEVINVDGTKRRTLLEDKLPHIFGFTL 562
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAV 40

NHL_like_4

cd14955

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...

726-803

4.25e-03

Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 41.02 E-value: 4.25e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  726 LDYPEGMAVDWMGkNLYWADTGTNRIE--------VARL------DGQFrqvlvwrdlDNPRSLALDPTkGYIYWTEWGG 791
Cdd:cd14955     62 FYSPTGIAVDSDG-NVYVADTGNHRIQkfdstgtfLTKWgssgsgDGQF---------NSPSGIAVDSA-GNVYVTDSGN 130

                           90
                   ....*....|..
gi 2462525224  792 kPRIVRAFMDGT 803
Cdd:cd14955    131 -NRIQKFDSSGT 141

Vgb

COG4257

Streptogramin lyase [Defense mechanisms];

117-277

5.29e-03

Streptogramin lyase [Defense mechanisms];

Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 40.77 E-value: 5.29e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  117 VSPDGlacdwvgkKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAhGYMYWTDWGETpRIERAGM-DGSTR 195
Cdd:COG4257     24 VDPDG--------AVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPD-GNLWFTDNGNN-RIGRIDPkTGEIT 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  196 KIIVDSDIYWPNGLTIDlEEQKLYWADAKLSFIHRANLD-GSFRQKVVEGSLTHPFALTLSGD-TLYWTDWQTRSIHACN 273
Cdd:COG4257     94 TFALPGGGSNPHGIAFD-PDGNLWFTDQGGNRIGRLDPAtGEVTEFPLPTGGAGPYGIAVDPDgNLWVTDFGANAIGRID 172


                   ....
gi 2462525224  274 KRTG 277
Cdd:COG4257    173 PDTG 176

NHL_like_2

cd14957

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...

377-544

5.77e-03

Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 40.71 E-value: 5.77e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  377 QVDDIRHaIAIDYDpleGYVYWTDDEVRAIR-------RAYLDGSGAQTlvNTEINDPDGIAVDwVARNLYWTDTGTDRI 449
Cdd:cd14957     16 QFNTPRG-IAVDSA---GNIYVADTGNNRIQvftssgvYSYSIGSGGTG--SGQFNSPYGIAVD-SNGNIYVADTDNNRI 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525224  450 EV-TRLNGTSRKI----LVSEDLDEPRAIALHPvMGLMYWTDwGENPKIECANLDGQERRVLVNASLGW-----PNGLAL 519
Cdd:cd14957     89 QVfNSSGVYQYSIgtggSGDGQFNGPYGIAVDS-NGNIYVAD-TGNHRIQVFTSSGTFSYSIGSGGTGPgqfngPQGIAV 166

                          170       180
                   ....*....|....*....|....*
gi 2462525224  520 DlQEGKLYWGDAKTDKIEVINVDGT 544
Cdd:cd14957    167 D-SDGNIYVADTGNHRIQVFTSSGT 190

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

865-905

5.77e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 35.98 E-value: 5.77e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462525224  865 DYIYWTDWNLH-SIERADKTSGRNRTLIQGHLDFVMDILVFH 905
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

216-254

7.38e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 35.98 E-value: 7.38e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462525224  216 QKLYWADAKLSF-IHRANLDGSFRQKVVEGSLTHPFALTL 254
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAV 40

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

239-273

7.95e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 35.66 E-value: 7.95e-03

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2462525224   239 QKVVEGSLTHP--FALTLSGDTLYWTDWQTRSIHACN 273
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37

NHL_PKND_like