NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462518498|ref|XP_054221503|]
View 

trans-acting T-cell-specific transcription factor GATA-3 isoform X1 [Homo sapiens]

Protein Classification

trans-acting T-cell-specific transcription factor GATA-3( domain architecture ID 13285435)

trans-acting T-cell-specific transcription factor GATA-3 acts as a transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes

Gene Symbol:  GATA3
Gene Ontology:  GO:0003700|GO:0008270|GO:0043565|GO:0050852
PubMed:  31574210

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 317-367 1.57e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.65  E-value: 1.57e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462518498 317 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNINRPLTMKKEG-IQTRNR 367
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 263-313 2.58e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.18  E-value: 2.58e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462518498 263 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 313
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
PHA03377 super family cl31823
EBNA-3C; Provisional
 1-261 2.96e-04

EBNA-3C; Provisional


The actual alignment was detected with superfamily member PHA03377:

Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 43.50  E-value: 2.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498    1 MEVTADQPRWVSHHHPavLNGQHPDTHHPGLSHSYMDAaqyplPEEVDVLFNIDGQGNHVPPYYG-NSVRATVQRYP--- 76
Cdd:PHA03377   693 VDAGRAQPSEESHLSS--MSPTQPISHEEQPRYEDPDD-----PLDLSLHPDQAPPPSHQAPYSGhEEPQAQQAPYPgyw 765

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498   77 --------------PTHHGSQVCRPPLLHGslPWLDGGKALGSHHTASPWNLSPfsktsIHHGSPGPLSVYPPASSSSLS 142
Cdd:PHA03377   766 eprppqapylgyqePQAQGVQVSSYPGYAG--PWGLRAQHPRYRHSWAYWSQYP-----GHGHPQGPWAPRPPHLPPQWD 838

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498  143 G--GHASPHLFTFPPTPPKDVSPDPSLS---------TPGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMtALGGA 211
Cdd:PHA03377   839 GsaGHGQDQVSQFPHLQSETGPPRLQLSqvpqlpysqTLVSSSAPSWSSPQPRAPIRPIPTRFPPPPMPLQDSM-AVGCD 917

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462518498  212 SSSTHHPITtypPYVPEYSSGLFPPSSLLGGSPtgfgckSRPKARSSTEG 261
Cdd:PHA03377   918 SSGTACPSM---PFASDYSQGAFTPLDINAQTP------KRPRVEESSHG 958
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 317-367 1.57e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.65  E-value: 1.57e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462518498 317 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNINRPLTMKKEG-IQTRNR 367
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 263-313 2.58e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.18  E-value: 2.58e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462518498 263 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 313
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
313-362 2.56e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 75.53  E-value: 2.56e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462518498  313 RAGTSCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNI-NRPLTMKKEGI 362
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
260-307 6.64e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 68.60  E-value: 6.64e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462518498  260 EGRECVNCGATSTPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 307
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 318-349 4.92e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 4.92e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462518498 318 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLH 349
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKK 33
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 264-298 5.54e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 5.54e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462518498 264 CVNCGATSTPLWRRDGTGHY-LCNACGLYHKMNGQN 298
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
208-342 4.71e-08

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 55.26  E-value: 4.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498 208 LGGASSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSPTgfgcksrpKARSSTEGRECVNCGATSTPLWRRD-----GTGH 282
Cdd:COG5641   113 SNAASPSTNYTDESNQQFSSYNTTLNPGGTSSLNPNNN--------QSDNSNQPHVCSNCKTTSTPLWRRAssessLPGN 184

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462518498 283 YLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTT-TTLWRRNANGDPVCNAC 342
Cdd:COG5641   185 NLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTESIGNSSASKLTK 245
PHA03377 PHA03377
EBNA-3C; Provisional
 1-261 2.96e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 43.50  E-value: 2.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498    1 MEVTADQPRWVSHHHPavLNGQHPDTHHPGLSHSYMDAaqyplPEEVDVLFNIDGQGNHVPPYYG-NSVRATVQRYP--- 76
Cdd:PHA03377   693 VDAGRAQPSEESHLSS--MSPTQPISHEEQPRYEDPDD-----PLDLSLHPDQAPPPSHQAPYSGhEEPQAQQAPYPgyw 765

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498   77 --------------PTHHGSQVCRPPLLHGslPWLDGGKALGSHHTASPWNLSPfsktsIHHGSPGPLSVYPPASSSSLS 142
Cdd:PHA03377   766 eprppqapylgyqePQAQGVQVSSYPGYAG--PWGLRAQHPRYRHSWAYWSQYP-----GHGHPQGPWAPRPPHLPPQWD 838

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498  143 G--GHASPHLFTFPPTPPKDVSPDPSLS---------TPGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMtALGGA 211
Cdd:PHA03377   839 GsaGHGQDQVSQFPHLQSETGPPRLQLSqvpqlpysqTLVSSSAPSWSSPQPRAPIRPIPTRFPPPPMPLQDSM-AVGCD 917

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462518498  212 SSSTHHPITtypPYVPEYSSGLFPPSSLLGGSPtgfgckSRPKARSSTEG 261
Cdd:PHA03377   918 SSGTACPSM---PFASDYSQGAFTPLDINAQTP------KRPRVEESSHG 958
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 76-224 9.67e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.59  E-value: 9.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498  76 PPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPP 155
Cdd:pfam03154 257 PPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQS 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498 156 TPPKDVSP-----------DPSLSTPGSAGSARQDEKECLKYQVPLPDSMklesSHSRGSMTALGGASS-STHHPITTYP 223
Cdd:pfam03154 337 QQPPREQPlppaplsmphiKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQM----NSNLPPPPALKPLSSlSTHHPPSAHP 412


                  .
gi 2462518498 224 P 224
Cdd:pfam03154 413 P 413
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 317-367 1.57e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.65  E-value: 1.57e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462518498 317 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNINRPLTMKKEG-IQTRNR 367
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 263-313 2.58e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.18  E-value: 2.58e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462518498 263 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 313
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
313-362 2.56e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 75.53  E-value: 2.56e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462518498  313 RAGTSCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNI-NRPLTMKKEGI 362
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
260-307 6.64e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 68.60  E-value: 6.64e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462518498  260 EGRECVNCGATSTPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 307
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 318-349 4.92e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 4.92e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462518498 318 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLH 349
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKK 33
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 264-298 5.54e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 5.54e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462518498 264 CVNCGATSTPLWRRDGTGHY-LCNACGLYHKMNGQN 298
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
208-342 4.71e-08

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 55.26  E-value: 4.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498 208 LGGASSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSPTgfgcksrpKARSSTEGRECVNCGATSTPLWRRD-----GTGH 282
Cdd:COG5641   113 SNAASPSTNYTDESNQQFSSYNTTLNPGGTSSLNPNNN--------QSDNSNQPHVCSNCKTTSTPLWRRAssessLPGN 184

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462518498 283 YLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTT-TTLWRRNANGDPVCNAC 342
Cdd:COG5641   185 NLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTESIGNSSASKLTK 245
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
266-430 1.88e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 53.34  E-value: 1.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498 266 NCGATSTPLWRR-DGTGHYLCNACGLYHKMNGQNRPLikPKRRLSAARRAGTSCANCQTTTTTLWRRNANGdpvCNACGL 344
Cdd:COG5641   303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKILSPPTT---SNSPGA 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498 345 YYKLHNINRPLTMKKEGIQTRnrkmsskskkckkvhdsledfPKNSSFNPAALSRHMSSLSHISPFShSSHMLTTPTPMH 424
Cdd:COG5641   378 QVKLPNQTRSTGATKKKITRR---------------------RMNSGKIPALSSSMKNPVPKEFSPL-IPQSTESETPSQ 435


                  ....*.
gi 2462518498 425 PPSSLS 430
Cdd:COG5641   436 SKSSLT 441
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
317-367 2.97e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 52.57  E-value: 2.97e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462518498 317 SCANCQTTTTTLWRR-----NANGDPVCNACGLYYKLHNINR-PLTMKKEGIQTRNR 367
Cdd:COG5641   160 VCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRSS 216
PHA03377 PHA03377
EBNA-3C; Provisional
 1-261 2.96e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 43.50  E-value: 2.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498    1 MEVTADQPRWVSHHHPavLNGQHPDTHHPGLSHSYMDAaqyplPEEVDVLFNIDGQGNHVPPYYG-NSVRATVQRYP--- 76
Cdd:PHA03377   693 VDAGRAQPSEESHLSS--MSPTQPISHEEQPRYEDPDD-----PLDLSLHPDQAPPPSHQAPYSGhEEPQAQQAPYPgyw 765

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498   77 --------------PTHHGSQVCRPPLLHGslPWLDGGKALGSHHTASPWNLSPfsktsIHHGSPGPLSVYPPASSSSLS 142
Cdd:PHA03377   766 eprppqapylgyqePQAQGVQVSSYPGYAG--PWGLRAQHPRYRHSWAYWSQYP-----GHGHPQGPWAPRPPHLPPQWD 838

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498  143 G--GHASPHLFTFPPTPPKDVSPDPSLS---------TPGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMtALGGA 211
Cdd:PHA03377   839 GsaGHGQDQVSQFPHLQSETGPPRLQLSqvpqlpysqTLVSSSAPSWSSPQPRAPIRPIPTRFPPPPMPLQDSM-AVGCD 917

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462518498  212 SSSTHHPITtypPYVPEYSSGLFPPSSLLGGSPtgfgckSRPKARSSTEG 261
Cdd:PHA03377   918 SSGTACPSM---PFASDYSQGAFTPLDINAQTP------KRPRVEESSHG 958
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 76-224 9.67e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.59  E-value: 9.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498  76 PPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPP 155
Cdd:pfam03154 257 PPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQS 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518498 156 TPPKDVSP-----------DPSLSTPGSAGSARQDEKECLKYQVPLPDSMklesSHSRGSMTALGGASS-STHHPITTYP 223
Cdd:pfam03154 337 QQPPREQPlppaplsmphiKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQM----NSNLPPPPALKPLSSlSTHHPPSAHP 412


                  .
gi 2462518498 224 P 224
Cdd:pfam03154 413 P 413
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH