NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462517843|ref|XP_054221182|]
View 

ankyrin repeat domain-containing protein 26 isoform X7 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 1276-1579 4.96e-166

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


:

Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 508.76  E-value: 4.96e-166
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1276 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 1355
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1356 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1435
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1436 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1515
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517843 1516 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1579
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1788-1896 2.26e-57

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


:

Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 193.73  E-value: 2.26e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1788 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1867
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 2462517843 1868 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1896
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 1.28e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 147.02  E-value: 1.28e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 2462517843  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1109-1824 1.06e-20

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.13  E-value: 1.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1109 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 1174
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1175 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQ--DGILTNHLSK 1247
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRErlQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1248 QKEIEMAQKKMNSENSHSHEEEKDLSHKN-----SMLQEEIAMLRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTI 1322
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERleealEELREELEEAEQALDAAERELAQLQARL-DSLERLQENLEGFSEGV 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1323 KQNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------D 1383
Cdd:TIGR02168  509 KALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQ 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1384 QSETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL---- 1449
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggs 665

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1450 REKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINI 1529
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1530 QDQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSR 1609
Cdd:TIGR02168  746 EER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAE 811

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1610 YRiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK---------- 1679
Cdd:TIGR02168  812 LT-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleeala 890

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1680 --NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHG----DLKTS 1753
Cdd:TIGR02168  891 llRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEalenKIEDD 966

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517843 1754 QFEMDIQINKLKHKAQAASQENL---EQFRENN--FASMKSQMElrikDLESELSKIKTSQEDFNKTELEKYKQLY 1824
Cdd:TIGR02168  967 EEEARRRLKRLENKIKELGPVNLaaiEEYEELKerYDFLTAQKE----DLTEAKETLEEAIEEIDREARERFKDTF 1038
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 1276-1579 4.96e-166

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 508.76  E-value: 4.96e-166
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1276 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 1355
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1356 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1435
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1436 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1515
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517843 1516 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1579
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1788-1896 2.26e-57

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 193.73  E-value: 2.26e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1788 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1867
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 2462517843 1868 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1896
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 1.28e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 147.02  E-value: 1.28e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 2462517843  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1109-1824 1.06e-20

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.13  E-value: 1.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1109 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 1174
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1175 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQ--DGILTNHLSK 1247
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRErlQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1248 QKEIEMAQKKMNSENSHSHEEEKDLSHKN-----SMLQEEIAMLRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTI 1322
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERleealEELREELEEAEQALDAAERELAQLQARL-DSLERLQENLEGFSEGV 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1323 KQNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------D 1383
Cdd:TIGR02168  509 KALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQ 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1384 QSETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL---- 1449
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggs 665

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1450 REKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINI 1529
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1530 QDQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSR 1609
Cdd:TIGR02168  746 EER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAE 811

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1610 YRiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK---------- 1679
Cdd:TIGR02168  812 LT-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleeala 890

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1680 --NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHG----DLKTS 1753
Cdd:TIGR02168  891 llRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEalenKIEDD 966

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517843 1754 QFEMDIQINKLKHKAQAASQENL---EQFRENN--FASMKSQMElrikDLESELSKIKTSQEDFNKTELEKYKQLY 1824
Cdd:TIGR02168  967 EEEARRRLKRLENKIKELGPVNLaaiEEYEELKerYDFLTAQKE----DLTEAKETLEEAIEEIDREARERFKDTF 1038
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-176 1.90e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.48  E-value: 1.90e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHgADPNLADvHGNTALHYAVYNEDISVAT 163
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2462517843  164 KLLLYDANIEAKN 176
Cdd:pfam12796   79 LLLEKGADINVKD 91
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1087-1823 3.72e-15

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 81.76  E-value: 3.72e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1087 LLKIQDAALSCERLL-ELKKNHCELLTVKiKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRR 1165
Cdd:pfam01576   14 LQKVKERQQKAESELkELEKKHQQLCEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESRLEEEEERSQ 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1166 NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvqerNDAQRQLSREQNARMLQDGILTNHL 1245
Cdd:pfam01576   93 QLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLL----EDQNSKLSKERKLLEERISEFTSNL 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1246 SKQKE---------------IEMAQKKMNSENSHSHEEEK---DLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfed 1307
Cdd:pfam01576  169 AEEEEkakslsklknkheamISDLEERLKKEEKGRQELEKakrKLEGESTDLQEQIAELQAQIAELRAQLAKKE------ 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1308 lkivkeknEDLQKTIKQNEETLTQTiSQYNGRLSVLTAENAMLNSKLENEKQSKER-------LEAEVESYHSRLAAAIH 1380
Cdd:pfam01576  243 --------EELQAALARLEEETAQK-NNALKKIRELEAQISELQEDLESERAARNKaekqrrdLGEELEALKTELEDTLD 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1381 DR--DQSETSKRELELA-FQRARDECSRLQDKMNFDVSNLKDNN-EILSQQLFKTESKLNSLEiefhHTRDALREKTLGL 1456
Cdd:pfam01576  314 TTaaQQELRSKREQEVTeLKKALEEETRSHEAQLQEMRQKHTQAlEELTEQLEQAKRNKANLE----KAKQALESENAEL 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1457 ERVQKDLSQ----TQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQ 1532
Cdd:pfam01576  390 QAELRTLQQakqdSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQ 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1533 FHAiVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ----SMSEASLEVTS 1608
Cdd:pfam01576  470 LQD-TQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLeedaGTLEALEEGKK 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1609 RYRINLEDETQDLKKK------LGQIRNQLQE-------AQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI- 1674
Cdd:pfam01576  549 RLQRELEALTQQLEEKaaaydkLEKTKNRLQQelddllvDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAe 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1675 ----EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQ------EMKKNV-ELEREITGFKNLLKMTRKKLNEYENgE 1743
Cdd:pfam01576  629 aearEKETRALSLARALEEALEAKEELERTNKQLRAEMEDlvsskdDVGKNVhELERSKRALEQQVEEMKTQLEELED-E 707

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1744 FSFHGDLK----------TSQFEMDIQ------------INKLKHKAQAASQEnlEQFRENNFASMKSQMELRIKDLESE 1801
Cdd:pfam01576  708 LQATEDAKlrlevnmqalKAQFERDLQardeqgeekrrqLVKQVRELEAELED--ERKQRAQAVAAKKKLELDLKELEAQ 785

                          810       820
                   ....*....|....*....|..
gi 2462517843 1802 LskiktsqEDFNKTELEKYKQL 1823
Cdd:pfam01576  786 I-------DAANKGREEAVKQL 800
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-220 1.45e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 1.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843    9 GESPLgSFARRRRSSAGGGGEPGEGAYsqPGYHVRDRDlGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLAC 88
Cdd:PHA02875    35 GISPI-KLAMKFRDSEAIKLLMKHGAI--PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLAT 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   89 ANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY 168
Cdd:PHA02875   111 ILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517843  169 DANIEAKNKD-DLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISE 220
Cdd:PHA02875   191 GANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEECTILD 243
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1087-1634 2.75e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 2.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1087 LLKIQDAALSCERL---LELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 1163
Cdd:COG1196    231 LLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1164 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQV-------VQERNDAQRQLSREQNARML 1236
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAeealleaEAELAEAEEELEELAEELLE 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1237 QDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNE 1316
Cdd:COG1196    391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE----EEEEALLELLA 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1317 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAf 1396
Cdd:COG1196    467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA- 545

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1397 qrardecSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1476
Cdd:COG1196    546 -------AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVASDLREADAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1477 Y---QNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQS---LL 1550
Cdd:COG1196    615 YyvlGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAeeeLE 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1551 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRN 1630
Cdd:COG1196    695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLER 774


                   ....
gi 2462517843 1631 QLQE 1634
Cdd:COG1196    775 EIEA 778
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1289-1858 1.72e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 69.66  E-value: 1.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1289 EIDTIKNQ--NQEKEKKCFEDLKIVKEKN----EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKE 1362
Cdd:TIGR04523   41 KLKTIKNElkNKEKELKNLDKNLNKDEEKinnsNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKN 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1363 RLEAEVESYHSRLAA--AIHDRDQSETSKRELELafqrarDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEI 1440
Cdd:TIGR04523  121 KLEVELNKLEKQKKEnkKNIDKFLTEIKKKEKEL------EKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKN 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1441 EF---HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHN 1517
Cdd:TIGR04523  195 KLlklELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQK 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1518 KADNKEKTVINIQDQFHAIVQKLQA-ESEKQslllEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADtLKK 1596
Cdd:TIGR04523  275 ELEQNNKKIKELEKQLNQLKSEISDlNNQKE----QDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQ-LKK 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1597 QSMseaslevtsryriNLEDETQDLKKKLGQIRNQLqeaqdrhteavrcaekmqdhkQKLEKDNAKLKVTVKKQMDKIEE 1676
Cdd:TIGR04523  350 ELT-------------NSESENSEKQRELEEKQNEI---------------------EKLKKENQSYKQEIKNLESQIND 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1677 LQKNLLNANLSEDEKE-QLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENgefsFHGDLKTSQF 1755
Cdd:TIGR04523  396 LESKIQNQEKLNQQKDeQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDN----TRESLETQLK 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1756 EMDIQINKLKHKAQAASQENLEQFRE-NNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLyleelkvrKSL 1834
Cdd:TIGR04523  472 VLSRSINKIKQNLEQKQKELKSKEKElKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKI--------SDL 543

                          570       580
                   ....*....|....*....|....
gi 2462517843 1835 SSKLTKTNERLAEVNTKLLVEKQQ 1858
Cdd:TIGR04523  544 EDELNKDDFELKKENLEKEIDEKN 567
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1432-1740 6.29e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 6.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1432 ESKLNSLEIEfhhTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQ 1511
Cdd:COG1196    199 ERQLEPLERQ---AEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1512 LDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSlLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELA 1591
Cdd:COG1196    276 LEELELELEEAQAEEYELLAELARLEQDIARLEERRR-ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1592 DTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQM 1671
Cdd:COG1196    355 EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE 434

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1672 DKIEELQKNLLNANLSEDEKEQ-LKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYE 1740
Cdd:COG1196    435 EEEEEEEEALEEAAEEEAELEEeEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1162-1730 1.45e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 66.63  E-value: 1.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1162 EKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQdgi 1240
Cdd:PRK03918   158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKlEKEVKELE--- 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1241 ltnhlSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQE-----KEKKCFEDLKIVKEKN 1315
Cdd:PRK03918   235 -----ELKEEIEELEKELESLEGSKRKLEEKIRE----LEERIEELKKEIEELEEKVKElkelkEKAEEYIKLSEFYEEY 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1316 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLE----------------AEVESYHSRLAA-- 1377
Cdd:PRK03918   306 LDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEeleerhelyeeakakkEELERLKKRLTGlt 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1378 ---AIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTL 1454
Cdd:PRK03918   386 pekLEKELEELEKAKEEIEEEISKITARIGELKKE----IKELKKAIEELKKA--KGKCPVCGRELTEEHRKELLEEYTA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1455 GLERVQKDLSQTqcqmKEMEQKYQNEQVKVNKYIGKQ-------------ESVEERLSQLQSENM--------LLRQQLD 1513
Cdd:PRK03918   460 ELKRIEKELKEI----EEKERKLRKELRELEKVLKKEseliklkelaeqlKELEEKLKKYNLEELekkaeeyeKLKEKLI 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1514 DAHNKADNKEKTVINIQD---QFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYEnEKAEREVVVRQLQQEL 1590
Cdd:PRK03918   536 KLKGEIKSLKKELEKLEElkkKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKEL 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1591 ADTLKKQSMSEASLEVTsryrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQ 1670
Cdd:PRK03918   615 EREEKELKKLEEELDKA-------FEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGLRAELEEL 685

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1671 MDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLK 1730
Cdd:PRK03918   686 EKRREEIKKTL------EKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYKALLK 738
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1457-1852 8.95e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 57.38  E-value: 8.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1457 ERVQKDLSQT---QCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSEnmllRQQLDDAHNKADNKEKTVINIQDQF 1533
Cdd:PRK03918   179 ERLEKFIKRTeniEELIKEKEKELEEVLREINEISSELPELREELEKLEKE----VKELEELKEEIEELEKELESLEGSK 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1534 HAIVQKLQaESEKQSLLLEERNKELISECNHLKERQyqyenEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRIN 1613
Cdd:PRK03918   255 RKLEEKIR-ELEERIEELKKEIEELEEKVKELKELK-----EKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEE 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1614 LEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANlsEDEKEQ 1693
Cdd:PRK03918   329 RIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAK--EEIEEE 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1694 LKKLMELKQSLEcNLDQEMKKNVElerEITGFKNLLKMTRKKLNEYENGEF--SFHGDLKTSQFEMDIQINKLKHKAQAA 1771
Cdd:PRK03918   407 ISKITARIGELK-KEIKELKKAIE---ELKKAKGKCPVCGRELTEEHRKELleEYTAELKRIEKELKEIEEKERKLRKEL 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1772 SQENLEQFRENNFASMKSQMELrIKDLESELSKIKTSQEDFNKTELEKYKQLYLE---ELKVRKSLSSKLTKTNERLAEV 1848
Cdd:PRK03918   483 RELEKVLKKESELIKLKELAEQ-LKELEEKLKKYNLEELEKKAEEYEKLKEKLIKlkgEIKSLKKELEKLEELKKKLAEL 561


                   ....
gi 2462517843 1849 NTKL 1852
Cdd:PRK03918   562 EKKL 565
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 82-202 7.44e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 7.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   82 TALHLACANGHPEVVTLLVDRKCQLN------VCDNENRTALMK--------AVQCQEEKCATILLEHGADPNLADVHGN 147
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517843  148 TALHYAVYNEDISVATK----LLLYDANIEA------KNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd22192    171 TVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQKR 235
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 82-202 1.14e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.46  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   82 TALHLACANGHPEVVTLLVDRKCQLNV---CD-------------NENRTALMKAVQcqEEKCATILLEHGADPNLADVH 145
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGASVPAracGDffvksqgvdsfyhGESPLNAAACLG--SPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517843  146 GNTALHYAVYNEDISVATK---------LLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:TIGR00870  208 GNTLLHLLVMENEFKAEYEelscqmynfALSLLDKLrdskeleVILNHQGLTPLKLAAKEGRIVLFRLKLAIK 280
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 79-108 8.30e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 8.30e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 2462517843    79 MNRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 1544-1741 1.39e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 42.05  E-value: 1.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1544 SEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQeLADTLkKQSMSEASLEVTSRYRiNLEDETQDLKK 1623
Cdd:cd00176     17 SEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNE-LGEQL-IEEGHPDAEEIQERLE-ELNQRWEELRE 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1624 KLGQIRNQLQEAQDRHT---EAVRCAEKMQDHKQKLEK-DNAKLKVTVKKQMDKIEELQKNLLNAnlsedeKEQLKKLME 1699
Cdd:cd00176     94 LAEERRQRLEEALDLQQffrDADDLEQWLEEKEAALASeDLGKDLESVEELLKKHKELEEELEAH------EPRLKSLNE 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2462517843 1700 LKQSL--ECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEN 1741
Cdd:cd00176    168 LAEELleEGHPDADEEIEEKLEELNERWEELLELAEERQKKLEE 211
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 1276-1579 4.96e-166

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 508.76  E-value: 4.96e-166
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1276 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 1355
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1356 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1435
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1436 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1515
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517843 1516 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1579
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1788-1896 2.26e-57

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 193.73  E-value: 2.26e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1788 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1867
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 2462517843 1868 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1896
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 1.28e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 147.02  E-value: 1.28e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 2462517843  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-218 1.16e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.94  E-value: 1.16e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   50 IHKAASAGNVAKVQqiLLLRKNG-LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKC 128
Cdd:COG0666     91 LHAAARNGDLEIVK--LLLEAGAdVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  129 ATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAV 208
Cdd:COG0666    169 VKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAK 248

                          170
                   ....*....|
gi 2462517843  209 DKLESSHQLI 218
Cdd:COG0666    249 DKDGLTALLL 258
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-210 2.75e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.45  E-value: 2.75e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   50 IHKAASAGNVAKVQqilLLRKNG--LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEK 127
Cdd:COG0666    124 LHLAAYNGNLEIVK---LLLEAGadVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLE 200

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  128 CATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNA 207
Cdd:COG0666    201 IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAA 280


                   ...
gi 2462517843  208 VDK 210
Cdd:COG0666    281 ALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 1.85e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 117.36  E-value: 1.85e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666     98 GDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177


                   ....*..
gi 2462517843  204 NVNAVDK 210
Cdd:COG0666    178 DVNARDN 184
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1109-1824 1.06e-20

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.13  E-value: 1.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1109 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 1174
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1175 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQ--DGILTNHLSK 1247
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRErlQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1248 QKEIEMAQKKMNSENSHSHEEEKDLSHKN-----SMLQEEIAMLRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTI 1322
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERleealEELREELEEAEQALDAAERELAQLQARL-DSLERLQENLEGFSEGV 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1323 KQNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------D 1383
Cdd:TIGR02168  509 KALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQ 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1384 QSETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL---- 1449
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggs 665

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1450 REKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINI 1529
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1530 QDQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSR 1609
Cdd:TIGR02168  746 EER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAE 811

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1610 YRiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK---------- 1679
Cdd:TIGR02168  812 LT-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleeala 890

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1680 --NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHG----DLKTS 1753
Cdd:TIGR02168  891 llRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEalenKIEDD 966

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517843 1754 QFEMDIQINKLKHKAQAASQENL---EQFRENN--FASMKSQMElrikDLESELSKIKTSQEDFNKTELEKYKQLY 1824
Cdd:TIGR02168  967 EEEARRRLKRLENKIKELGPVNLaaiEEYEELKerYDFLTAQKE----DLTEAKETLEEAIEEIDREARERFKDTF 1038
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-176 1.90e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.48  E-value: 1.90e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHgADPNLADvHGNTALHYAVYNEDISVAT 163
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2462517843  164 KLLLYDANIEAKN 176
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
50-143 6.92e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 85.94  E-value: 6.92e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDrKCQLNVCDNeNRTALMKAVQCQEEKCA 129
Cdd:pfam12796    1 LHLAAKNGNLELVKL-LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 2462517843  130 TILLEHGADPNLAD 143
Cdd:pfam12796   78 KLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-183 1.54e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.17  E-value: 1.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   50 IHKAASAGNVAKVQqiLLLrKNG--LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEK 127
Cdd:COG0666    157 LHLAAANGNLEIVK--LLL-EAGadVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517843  128 CATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPL 183
Cdd:COG0666    234 IVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-210 5.44e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.55  E-value: 5.44e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   65 ILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADV 144
Cdd:COG0666      6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517843  145 HGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDK 210
Cdd:COG0666     86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDN 151
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1102-1894 1.18e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.65  E-value: 1.18e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1102 ELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRK 1181
Cdd:TIGR02168  221 ELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1182 EEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLsreqnarmlqDGILTNHLSKQKEIEMAQKKMnsE 1261
Cdd:TIGR02168  301 EQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKL----------EELKEELESLEAELEELEAEL--E 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1262 NSHSHEEEKDLSHKNsmLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQKTIKQNEETLTqtisqyNGRLS 1341
Cdd:TIGR02168  369 ELESRLEELEEQLET--LRSKVAQLELQIASLNNEIERLEAR----LERLEDRRERLQQEIEELLKKLE------EAELK 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1342 VLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQsetSKRELELAFQRARDECSRLQDKMNF--DVSNLKD 1419
Cdd:TIGR02168  437 ELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDA---AERELAQLQARLDSLERLQENLEGFseGVKALLK 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1420 NNEILSQ------QLFKTESKLnsleiefhhtRDALrEKTLGlERVQKDLSQT-QCQMKEMEQKYQNEQVKVN----KYI 1488
Cdd:TIGR02168  514 NQSGLSGilgvlsELISVDEGY----------EAAI-EAALG-GRLQAVVVENlNAAKKAIAFLKQNELGRVTflplDSI 581

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1489 GKQESVEERLSQLQSENMLLRQQLDdaHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNkeLISECNHLKER 1568
Cdd:TIGR02168  582 KGTEIQGNDREILKNIEGFLGVAKD--LVKFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRPGYR--IVTLDGDLVRP 657

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1569 QYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEK 1648
Cdd:TIGR02168  658 GGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLAR 737

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1649 MQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNL 1728
Cdd:TIGR02168  738 LEAEVEQLEERIAQLSKELTELEAEIEELEERL------EEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAE 811

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1729 LKMTRKKLNEYENGefsfhgdLKTSQFEMDIQINKLKHKAQAASQENLEQfrENNFASMkSQMELRIKDLESEL---SKI 1805
Cdd:TIGR02168  812 LTLLNEEAANLRER-------LESLERRIAATERRLEDLEEQIEELSEDI--ESLAAEI-EELEELIEELESELealLNE 881

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1806 KTSQEDFNKTELEKYKQLYLEELKVRKSLSS---KLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLNN 1882
Cdd:TIGR02168  882 RASLEEALALLRSELEELSEELRELESKRSElrrELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALEN 961

                          810
                   ....*....|..
gi 2462517843 1883 SLDLNRKLIPRE 1894
Cdd:TIGR02168  962 KIEDDEEEARRR 973
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1115-1822 1.50e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.26  E-value: 1.50e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1115 IKKMEDKVNVLQRELSET---KEIKSQLEhqkvEWERELCSLRFslNQEEEKRrnadtlyEKIREQLRRKEEQYRKEVEV 1191
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAeryKELKAELR----ELELALLVLRL--EELREEL-------EELQEELKEAEEELEELTAE 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1192 KQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGiLTNHLSKQKEIEMAQKKMNSENSHSHEEEK 1270
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRlEQQKQILRER-LANLERQLEELEAQLEELESKLDELAEELA 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1271 DLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKK---CFEDLKIVKEKNEDLQKTIKQNEETLTQ---TISQYNGRLSVLT 1344
Cdd:TIGR02168  341 ELEEKLEELKEELESLEAELEELEAELEELESRleeLEEQLETLRSKVAQLELQIASLNNEIERleaRLERLEDRRERLQ 420

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1345 AENAMLNSKLENEKQSK-----ERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFdVSNLKD 1419
Cdd:TIGR02168  421 QEIEELLKKLEEAELKElqaelEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDS-LERLQE 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1420 NNEILSQ---QLFKTESKLNSLE------IEFHHTRDALREKTLGlERVQKDLSQT-QCQMKEMEQKYQNEQVKVN---- 1485
Cdd:TIGR02168  500 NLEGFSEgvkALLKNQSGLSGILgvlselISVDEGYEAAIEAALG-GRLQAVVVENlNAAKKAIAFLKQNELGRVTflpl 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1486 KYIGKQESVEERLSQLQSENMLLRQQLDdaHNKADNKEKTVINIQDQFHAIVQKLQ------------------------ 1541
Cdd:TIGR02168  579 DSIKGTEIQGNDREILKNIEGFLGVAKD--LVKFDPKLRKALSYLLGGVLVVDDLDnalelakklrpgyrivtldgdlvr 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1542 --------AESEKQSLL--------LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLE 1605
Cdd:TIGR02168  657 pggvitggSAKTNSSILerrreieeLEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLA 736

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1606 VTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnan 1685
Cdd:TIGR02168  737 RLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAEL---- 812

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1686 lsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREItgfknllkmtrKKLNEYENGEFSFHGDLKTSQFEMDIQINKLK 1765
Cdd:TIGR02168  813 --TLLNEEAANLRERLESLERRIAATERRLEDLEEQI-----------EELSEDIESLAAEIEELEELIEELESELEALL 879

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517843 1766 hKAQAASQENLEQFRENNFASMKSQ--MELRIKDLESELSKIKTSQEDFNkTELEKYKQ 1822
Cdd:TIGR02168  880 -NERASLEEALALLRSELEELSEELreLESKRSELRRELEELREKLAQLE-LRLEGLEV 936
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1087-1823 3.72e-15

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 81.76  E-value: 3.72e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1087 LLKIQDAALSCERLL-ELKKNHCELLTVKiKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRR 1165
Cdd:pfam01576   14 LQKVKERQQKAESELkELEKKHQQLCEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESRLEEEEERSQ 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1166 NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvqerNDAQRQLSREQNARMLQDGILTNHL 1245
Cdd:pfam01576   93 QLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLL----EDQNSKLSKERKLLEERISEFTSNL 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1246 SKQKE---------------IEMAQKKMNSENSHSHEEEK---DLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfed 1307
Cdd:pfam01576  169 AEEEEkakslsklknkheamISDLEERLKKEEKGRQELEKakrKLEGESTDLQEQIAELQAQIAELRAQLAKKE------ 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1308 lkivkeknEDLQKTIKQNEETLTQTiSQYNGRLSVLTAENAMLNSKLENEKQSKER-------LEAEVESYHSRLAAAIH 1380
Cdd:pfam01576  243 --------EELQAALARLEEETAQK-NNALKKIRELEAQISELQEDLESERAARNKaekqrrdLGEELEALKTELEDTLD 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1381 DR--DQSETSKRELELA-FQRARDECSRLQDKMNFDVSNLKDNN-EILSQQLFKTESKLNSLEiefhHTRDALREKTLGL 1456
Cdd:pfam01576  314 TTaaQQELRSKREQEVTeLKKALEEETRSHEAQLQEMRQKHTQAlEELTEQLEQAKRNKANLE----KAKQALESENAEL 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1457 ERVQKDLSQ----TQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQ 1532
Cdd:pfam01576  390 QAELRTLQQakqdSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQ 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1533 FHAiVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ----SMSEASLEVTS 1608
Cdd:pfam01576  470 LQD-TQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLeedaGTLEALEEGKK 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1609 RYRINLEDETQDLKKK------LGQIRNQLQE-------AQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI- 1674
Cdd:pfam01576  549 RLQRELEALTQQLEEKaaaydkLEKTKNRLQQelddllvDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAe 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1675 ----EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQ------EMKKNV-ELEREITGFKNLLKMTRKKLNEYENgE 1743
Cdd:pfam01576  629 aearEKETRALSLARALEEALEAKEELERTNKQLRAEMEDlvsskdDVGKNVhELERSKRALEQQVEEMKTQLEELED-E 707

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1744 FSFHGDLK----------TSQFEMDIQ------------INKLKHKAQAASQEnlEQFRENNFASMKSQMELRIKDLESE 1801
Cdd:pfam01576  708 LQATEDAKlrlevnmqalKAQFERDLQardeqgeekrrqLVKQVRELEAELED--ERKQRAQAVAAKKKLELDLKELEAQ 785

                          810       820
                   ....*....|....*....|..
gi 2462517843 1802 LskiktsqEDFNKTELEKYKQL 1823
Cdd:pfam01576  786 I-------DAANKGREEAVKQL 800
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1125-1822 1.37e-13

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 76.55  E-value: 1.37e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1125 LQRELSETKEIKSQLEhqKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLrrKEEQYRKEVEVKQQLELSLQTLEM 1204
Cdd:TIGR00618  158 LKAKSKEKKELLMNLF--PLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLC--TPCMPDTYHERKQVLEKELKHLRE 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1205 ELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGI------LTNHLSKQKEIEMA------------------------ 1254
Cdd:TIGR00618  234 ALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIeelraqEAVLEETQERINRArkaaplaahikavtqieqqaqrih 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1255 ---QKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQ 1331
Cdd:TIGR00618  314 telQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQ 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1332 TISQYNGRLSVLTAENAM---LNSKLENEKQSKERLEAEVE---SYHSRLAAAIHDRDQSET-SKRELELAFQRARDECS 1404
Cdd:TIGR00618  394 KLQSLCKELDILQREQATidtRTSAFRDLQGQLAHAKKQQElqqRYAELCAAAITCTAQCEKlEKIHLQESAQSLKEREQ 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1405 RLQDKMNF--DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREktlglervqkdLSQTQCQMKEMEQKYQNEQV 1482
Cdd:TIGR00618  474 QLQTKEQIhlQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDN-----------PGPLTRRMQRGEQTYAQLET 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1483 KVNKYIGKQESVEERLSQLQSENMLLRQQLdDAHNKADNKEKTVINIQDQFHAIVQKL---QAESEKQSLLLEERNKELI 1559
Cdd:TIGR00618  543 SEEDVYHQLTSERKQRASLKEQMQEIQQSF-SILTQCDNRSKEDIPNLQNITVRLQDLtekLSEAEDMLACEQHALLRKL 621

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1560 SECNHlKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTS------RYRINLEDETQDLKKKLGQIRNQLQ 1633
Cdd:TIGR00618  622 QPEQD-LQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVlpkellASRQLALQKMQSEKEQLTYWKEMLA 700

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1634 EAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD-------KIEELQKNLLNANLSEDEKEQLKKLMELK--QSL 1704
Cdd:TIGR00618  701 QCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDalnqslkELMHQARTVLKARTEAHFNNNEEVTAALQtgAEL 780

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1705 ECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEnGEFSFHGDLKTSQFEMDIQINKLKHKAQAASQENLEQFREN-N 1783
Cdd:TIGR00618  781 SHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDE-DILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECsK 859

                          730       740       750
                   ....*....|....*....|....*....|....*....
gi 2462517843 1784 FASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQ 1822
Cdd:TIGR00618  860 QLAQLTQEQAKIIQLSDKLNGINQIKIQFDGDALIKFLH 898
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-220 1.45e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 1.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843    9 GESPLgSFARRRRSSAGGGGEPGEGAYsqPGYHVRDRDlGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLAC 88
Cdd:PHA02875    35 GISPI-KLAMKFRDSEAIKLLMKHGAI--PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLAT 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   89 ANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY 168
Cdd:PHA02875   111 ILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517843  169 DANIEAKNKD-DLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISE 220
Cdd:PHA02875   191 GANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEECTILD 243
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 843-1634 1.51e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 73.17  E-value: 1.51e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  843 SANNYKSMEPELENVRSSpprgdRTSKVSLKEELQQDMQRFKNEIGMLKVEFQALEKEKVQLQKEVEeerkkhrnnemEV 922
Cdd:TIGR02168  230 LVLRLEELREELEELQEE-----LKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELY-----------AL 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  923 SANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKEN---KEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKA 999
Cdd:TIGR02168  294 ANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDelaEELAELEEKLEELKEELESLEAELEELEAELEELESR 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1000 SlltgGLLQVDDDSSLSEIDEdegrptkkTSNEKNKVKNQIQSMDD-VDDLTQSSETASEDcelphssyknfmllIEQLG 1078
Cdd:TIGR02168  374 L----EELEEQLETLRSKVAQ--------LELQIASLNNEIERLEArLERLEDRRERLQQE--------------IEELL 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1079 MEckdsvslLKIQDAALSCERLLELKKnhcelltvKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLN 1158
Cdd:TIGR02168  428 KK-------LEEAELKELQAELEELEE--------ELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLD 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1159 QEEEKRRNADTLYEKIREQLRRK----------------EEQYRKEVEVkqQLELSLQTLEMElrtvksNLNQVVQ---- 1218
Cdd:TIGR02168  493 SLERLQENLEGFSEGVKALLKNQsglsgilgvlselisvDEGYEAAIEA--ALGGRLQAVVVE------NLNAAKKaiaf 564

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1219 -ERNDAQRQL-------------SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEkDLSHKNSMLQEEIA 1284
Cdd:TIGR02168  565 lKQNELGRVTflpldsikgteiqGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVD-DLDNALELAKKLRP 643

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1285 MLR---LEIDTIKN---------------QNQEKE-KKCFEDLKIVKEKNEDLQKTIKQNEETLtqtiSQYNGRLSVLTA 1345
Cdd:TIGR02168  644 GYRivtLDGDLVRPggvitggsaktnssiLERRREiEELEEKIEELEEKIAELEKALAELRKEL----EELEEELEQLRK 719

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1346 ENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNfdvsNLKDNNEILS 1425
Cdd:TIGR02168  720 ELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIE----ELEAQIEQLK 795

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1426 QQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSEn 1505
Cdd:TIGR02168  796 EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE- 874

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1506 mllrqqLDDAHNKADNKEKTVINIQDQFHAIVQKLQAesekqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQ 1585
Cdd:TIGR02168  875 ------LEALLNERASLEEALALLRSELEELSEELRE--------LESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*....
gi 2462517843 1586 LQQELADTLkkqsmsEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQE 1634
Cdd:TIGR02168  941 LQERLSEEY------SLTLEEAEALENKIEDDEEEARRRLKRLENKIKE 983
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1087-1634 2.75e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 2.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1087 LLKIQDAALSCERL---LELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 1163
Cdd:COG1196    231 LLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1164 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQV-------VQERNDAQRQLSREQNARML 1236
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAeealleaEAELAEAEEELEELAEELLE 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1237 QDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNE 1316
Cdd:COG1196    391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE----EEEEALLELLA 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1317 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAf 1396
Cdd:COG1196    467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA- 545

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1397 qrardecSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1476
Cdd:COG1196    546 -------AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVASDLREADAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1477 Y---QNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQS---LL 1550
Cdd:COG1196    615 YyvlGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAeeeLE 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1551 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRN 1630
Cdd:COG1196    695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLER 774


                   ....
gi 2462517843 1631 QLQE 1634
Cdd:COG1196    775 EIEA 778
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 54-210 1.17e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.92  E-value: 1.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   54 ASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACAN--GHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI 131
Cdd:PHA03100    80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  132 ------------------LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQ 193
Cdd:PHA03100   160 kllidkgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                          170
                   ....*....|....*..
gi 2462517843  194 MVEFLIKKKANVNAVDK 210
Cdd:PHA03100   240 IFKLLLNNGPSIKTIIE 256
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1289-1858 1.72e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 69.66  E-value: 1.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1289 EIDTIKNQ--NQEKEKKCFEDLKIVKEKN----EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKE 1362
Cdd:TIGR04523   41 KLKTIKNElkNKEKELKNLDKNLNKDEEKinnsNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKN 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1363 RLEAEVESYHSRLAA--AIHDRDQSETSKRELELafqrarDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEI 1440
Cdd:TIGR04523  121 KLEVELNKLEKQKKEnkKNIDKFLTEIKKKEKEL------EKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKN 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1441 EF---HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHN 1517
Cdd:TIGR04523  195 KLlklELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQK 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1518 KADNKEKTVINIQDQFHAIVQKLQA-ESEKQslllEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADtLKK 1596
Cdd:TIGR04523  275 ELEQNNKKIKELEKQLNQLKSEISDlNNQKE----QDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQ-LKK 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1597 QSMseaslevtsryriNLEDETQDLKKKLGQIRNQLqeaqdrhteavrcaekmqdhkQKLEKDNAKLKVTVKKQMDKIEE 1676
Cdd:TIGR04523  350 ELT-------------NSESENSEKQRELEEKQNEI---------------------EKLKKENQSYKQEIKNLESQIND 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1677 LQKNLLNANLSEDEKE-QLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENgefsFHGDLKTSQF 1755
Cdd:TIGR04523  396 LESKIQNQEKLNQQKDeQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDN----TRESLETQLK 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1756 EMDIQINKLKHKAQAASQENLEQFRE-NNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLyleelkvrKSL 1834
Cdd:TIGR04523  472 VLSRSINKIKQNLEQKQKELKSKEKElKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKI--------SDL 543

                          570       580
                   ....*....|....*....|....
gi 2462517843 1835 SSKLTKTNERLAEVNTKLLVEKQQ 1858
Cdd:TIGR04523  544 EDELNKDDFELKKENLEKEIDEKN 567
PHA03095 PHA03095
ankyrin-like protein; Provisional
 94-212 2.49e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   94 EVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI---LLEHGADPNLADVHGNTALHYAVYNED-ISVATKLLLYD 169
Cdd:PHA03095    28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAG 107

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2462517843  170 ANIEAKNKDDLTPLLLAVSGK--KQQMVEFLIKKKANVNAVDKLE 212
Cdd:PHA03095   108 ADVNAKDKVGRTPLHVYLSGFniNPKVIRLLLRKGADVNALDLYG 152
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1103-1539 3.58e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 68.51  E-value: 3.58e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1103 LKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE 1182
Cdd:TIGR04523  194 NKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1183 EQYRKEVEVKQQLELSLQTLEMEL------------RTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGIL-------- 1241
Cdd:TIGR04523  274 KELEQNNKKIKELEKQLNQLKSEIsdlnnqkeqdwnKELKSELKNQEKKLEEIQNQISQnNKIISQLNEQISqlkkeltn 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1242 --TNHLSKQKEIEMAQKKMNSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQ 1319
Cdd:TIGR04523  354 seSENSEKQRELEEKQNEIEKLK----KENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ----IKKLQQEKELLE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1320 KTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE---TSKRELELAF 1396
Cdd:TIGR04523  426 KEIER----LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQkelKSKEKELKKL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1397 QRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE-----IEFHHTRDALREKTLG-------LERVQKDLS 1464
Cdd:TIGR04523  502 NEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEdelnkDDFELKKENLEKEIDEknkeieeLKQTQKSLK 581

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517843 1465 QTQCQMKEMEQKYQNEQVKVNK----YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK 1539
Cdd:TIGR04523  582 KKQEEKQELIDQKEKEKKDLIKeieeKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNK 660
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1110-1852 4.08e-11

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 68.71  E-value: 4.08e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1110 LLTVKIKKMEDKVNVLQRELSET-KEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE----EQ 1184
Cdd:pfam12128  262 HLHFGYKSDETLIASRQEERQETsAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLdadiET 341

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1185 YRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvQERNDAQRQLSREQNARMLQDgiLTNHLSKQKEIEMAQKKmnsensh 1264
Cdd:pfam12128  342 AAADQEQLPSWQSELENLEERLKALTGKHQDV-TAKYNRRRSKIKEQNNRDIAG--IKDKLAKIREARDRQLA------- 411

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1265 shEEEKDLSHKNSMLQEEIAMLRLEIdtikNQNQEKEKKCFEDLKIvkeknedLQKTIKQNEETLTQTisqyngrlsvlt 1344
Cdd:pfam12128  412 --VAEDDLQALESELREQLEAGKLEF----NEEEYRLKSRLGELKL-------RLNQATATPELLLQL------------ 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1345 aenAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQdkmnfdvsnlkdnneil 1424
Cdd:pfam12128  467 ---ENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELE----------------- 526

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1425 sQQLFKTESKLnsleIEFHHTRDALREKTLG-------LERVQKDLSQTQCQMKEMEQKY----QNEQVKVNKYIGKQES 1493
Cdd:pfam12128  527 -LQLFPQAGTL----LHFLRKEAPDWEQSIGkvispelLHRTDLDPEVWDGSVGGELNLYgvklDLKRIDVPEWAASEEE 601

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1494 VEERLSQLQSEnmllrqqLDDAHNKADNKEKTVINIQDQfhaiVQKLQAESEKQSLLLEERnkelisecnhlKERQYQYE 1573
Cdd:pfam12128  602 LRERLDKAEEA-------LQSAREKQAAAEEQLVQANGE----LEKASREETFARTALKNA-----------RLDLRRLF 659

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1574 NEkaerevvvrqlQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKK--LGQIRNQLQEAQDRHTEAVRCAEKMQD 1651
Cdd:pfam12128  660 DE-----------KQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQawLEEQKEQKREARTEKQAYWQVVEGALD 728

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1652 HKQ-KLEKDNAKLKVTVKKQMDKIEELQKNLLnANLSEDEkeqlKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLK 1730
Cdd:pfam12128  729 AQLaLLKAAIAARRSGAKAELKALETWYKRDL-ASLGVDP----DVIAKLKREIR-TLERKIERIAVRRQEVLRYFDWYQ 802

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1731 MTRKKLNEYENGEFSfhgDLKTSQFEMDIQINKLkhkaQAASQENLEQFRENNFASMKSQMEL--RIKDLESELSKIKTS 1808
Cdd:pfam12128  803 ETWLQRRPRLATQLS---NIERAISELQQQLARL----IADTKLRRAKLEMERKASEKQQVRLseNLRGLRCEMSKLATL 875

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*...
gi 2462517843 1809 QEDFNKTELE---KYKQLYLEELK-VRKSLSSKLTKTNERLAEVNTKL 1852
Cdd:pfam12128  876 KEDANSEQAQgsiGERLAQLEDLKlKRDYLSESVKKYVEHFKNVIADH 923
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1432-1740 6.29e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 6.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1432 ESKLNSLEIEfhhTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQ 1511
Cdd:COG1196    199 ERQLEPLERQ---AEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1512 LDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSlLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELA 1591
Cdd:COG1196    276 LEELELELEEAQAEEYELLAELARLEQDIARLEERRR-ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1592 DTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQM 1671
Cdd:COG1196    355 EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE 434

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1672 DKIEELQKNLLNANLSEDEKEQ-LKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYE 1740
Cdd:COG1196    435 EEEEEEEEALEEAAEEEAELEEeEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1074-1637 1.08e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 67.07  E-value: 1.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1074 IEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKS----QLEHQKVEWERE 1149
Cdd:pfam15921  278 VEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEdkieELEKQLVLANSE 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1150 LCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL---------------------ELSLQTLEMELRT 1208
Cdd:pfam15921  358 LTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLwdrdtgnsitidhlrrelddrNMEVQRLEALLKA 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1209 VKSNlnqvVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI------EMAQKKMNSENShsheeEKDLSHKNSMLQE- 1281
Cdd:pfam15921  438 MKSE----CQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMlrkvveELTAKKMTLESS-----ERTVSDLTASLQEk 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1282 ---------EIAMLRLEIDT-------IKNQN---QEKEKKCfEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSV 1342
Cdd:pfam15921  509 eraieatnaEITKLRSRVDLklqelqhLKNEGdhlRNVQTEC-EALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGA 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1343 LTAENAMLNSK-------------LENEKQSKER-LEAEV---ESYHSRLAAAIHDRDQS----ETSKRELELAFQRARD 1401
Cdd:pfam15921  588 MQVEKAQLEKEindrrlelqefkiLKDKKDAKIReLEARVsdlELEKVKLVNAGSERLRAvkdiKQERDQLLNEVKTSRN 667

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1402 ECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR----------------EKTLGLERVQKDLSQ 1465
Cdd:pfam15921  668 ELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKsmegsdghamkvamgmQKQITAKRGQIDALQ 747

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1466 TQCQMKEMEQKYQNEQV-----KVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQF---HAIV 1537
Cdd:pfam15921  748 SKIQFLEEAMTNANKEKhflkeEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFaecQDII 827

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1538 QKLQAESEKQSLLLEERNKEL----ISECNHLKERQYQYENEKAEREVVVRQlqQELADTLKKQSMSEASLEvtsryrin 1613
Cdd:pfam15921  828 QRQEQESVRLKLQHTLDVKELqgpgYTSNSSMKPRLLQPASFTRTHSNVPSS--QSTASFLSHHSRKTNALK-------- 897

                          650       660
                   ....*....|....*....|....
gi 2462517843 1614 lEDETQDLKKKLGQIRNQLQEAQD 1637
Cdd:pfam15921  898 -EDPTRDLKQLLQELRSVINEEPT 920
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1179-1602 1.12e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 67.02  E-value: 1.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1179 RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSReqnarmlqdgiltnhlsKQKEIEMAQKKM 1258
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGE-----------------IEKEIEQLEQEE 732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1259 NSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNEDLqktikqneetltqtisqyng 1338
Cdd:TIGR02169  733 EKLK----ERLEELEEDLSSLEQEIENVKSELKELEARIEELE----EDLHKLEEALNDL-------------------- 784

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1339 rlsvltaENAMLNSKLENEKQSKErleaEVESYHSRLAAAIHDRDQsETSKRELELAFqrARDECSRLQDKMNfdvsNLK 1418
Cdd:TIGR02169  785 -------EARLSHSRIPEIQAELS----KLEEEVSRIEARLREIEQ-KLNRLTLEKEY--LEKEIQELQEQRI----DLK 846

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1419 DNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERL 1498
Cdd:TIGR02169  847 EQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKL 926

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1499 SQLQSENmllrQQLDDAhNKADNKEKTVINIQDQFHAIVQKLQAESEKqsllLEERNKELISECNHLKERQYQYENEKAE 1578
Cdd:TIGR02169  927 EALEEEL----SEIEDP-KGEDEEIPEEELSLEDVQAELQRVEEEIRA----LEPVNMLAIQEYEEVLKRLDELKEKRAK 997

                          410       420
                   ....*....|....*....|....*.
gi 2462517843 1579 REVVVRQLQQELA--DTLKKQSMSEA 1602
Cdd:TIGR02169  998 LEEERKAILERIEeyEKKKREVFMEA 1023
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 75-209 1.26e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 66.06  E-value: 1.26e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   75 DRDKMNrTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAV 154
Cdd:PHA02878   164 DRHKGN-TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV 242

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517843  155 -YNEDISVATKLLLYDANIEAKNK-DDLTPLLLAVsgKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA02878   243 gYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADINSLN 297
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1162-1730 1.45e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 66.63  E-value: 1.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1162 EKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQdgi 1240
Cdd:PRK03918   158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKlEKEVKELE--- 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1241 ltnhlSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQE-----KEKKCFEDLKIVKEKN 1315
Cdd:PRK03918   235 -----ELKEEIEELEKELESLEGSKRKLEEKIRE----LEERIEELKKEIEELEEKVKElkelkEKAEEYIKLSEFYEEY 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1316 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLE----------------AEVESYHSRLAA-- 1377
Cdd:PRK03918   306 LDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEeleerhelyeeakakkEELERLKKRLTGlt 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1378 ---AIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTL 1454
Cdd:PRK03918   386 pekLEKELEELEKAKEEIEEEISKITARIGELKKE----IKELKKAIEELKKA--KGKCPVCGRELTEEHRKELLEEYTA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1455 GLERVQKDLSQTqcqmKEMEQKYQNEQVKVNKYIGKQ-------------ESVEERLSQLQSENM--------LLRQQLD 1513
Cdd:PRK03918   460 ELKRIEKELKEI----EEKERKLRKELRELEKVLKKEseliklkelaeqlKELEEKLKKYNLEELekkaeeyeKLKEKLI 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1514 DAHNKADNKEKTVINIQD---QFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYEnEKAEREVVVRQLQQEL 1590
Cdd:PRK03918   536 KLKGEIKSLKKELEKLEElkkKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKEL 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1591 ADTLKKQSMSEASLEVTsryrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQ 1670
Cdd:PRK03918   615 EREEKELKKLEEELDKA-------FEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGLRAELEEL 685

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1671 MDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLK 1730
Cdd:PRK03918   686 EKRREEIKKTL------EKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYKALLK 738
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 66-280 1.79e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.43  E-value: 1.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   66 LLLRKNGLNDRDKMNRTALHLAcANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVH 145
Cdd:PLN03192   512 LLGDNGGEHDDPNMASNLLTVA-STGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDAN 590

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  146 GNTAL-------HYAVYN------------------------EDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQM 194
Cdd:PLN03192   591 GNTALwnaisakHHKIFRilyhfasisdphaagdllctaakrNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDM 670

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  195 VEFLIKKKANVNAVDKLES-SHQLISEYKEERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSwpTSDDEdlnfdtKNV 273
Cdd:PLN03192   671 VRLLIMNGADVDKANTDDDfSPTELRELLQKRELGHSITIVDSVPADEPDLGRDGGSRPGRLQG--TSSDN------QCR 742


                   ....*..
gi 2462517843  274 PKPSLAK 280
Cdd:PLN03192   743 PRVSIYK 749
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1161-1722 2.13e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.11  E-value: 2.13e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1161 EEKRRNADTL---------YEKIREQLRRKEEQYRkeVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQ 1231
Cdd:COG1196    196 GELERQLEPLerqaekaerYRELKEELKELEAELL--LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1232 NARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcFEDLKIV 1311
Cdd:COG1196    274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE-LEEAEEE 352

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1312 KEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRE 1391
Cdd:COG1196    353 LEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAE 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1392 LELAFQRARDECSRLQDKMNfDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMK 1471
Cdd:COG1196    433 LEEEEEEEEEALEEAAEEEA-ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK 511

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1472 EMEQKyqNEQVKVNKYIGKQESVEERLSQLQSEnmLLRQQLDDAHNKADNKEKTVINIQDQFHA----------IVQKLQ 1541
Cdd:COG1196    512 AALLL--AGLRGLAGAVAVLIGVEAAYEAALEA--ALAAALQNIVVEDDEVAAAAIEYLKAAKAgratflpldkIRARAA 587

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1542 AESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVV----------RQLQQELADTLKKQSMSEASLEVTSRYR 1611
Cdd:COG1196    588 LAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAarleaalrraVTLAGRLREVTLEGEGGSAGGSLTGGSR 667

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1612 INLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEK 1691
Cdd:COG1196    668 RELLAALLEAEAELEELAERLAEEELELEEALL-AEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEE 746

                          570       580       590
                   ....*....|....*....|....*....|..
gi 2462517843 1692 EQLKKLMELKQSLEcNLDqEMKKNVE-LEREI 1722
Cdd:COG1196    747 LLEEEALEELPEPP-DLE-ELERELErLEREI 776
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1161-1862 2.23e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 66.15  E-value: 2.23e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1161 EEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL-------------ELSLQTLEMELRTVKSNLNQVVQERNDaqrQL 1227
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELklkeqakkaleyyQLKEKLELEEEYLLYLDYLKLNEERID---LL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1228 SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENShshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFED 1307
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEE---KEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKES 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1308 LKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLnSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSET 1387
Cdd:pfam02463  320 EKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELE-KLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELE 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1388 ----SKRELELAFQRARDECSRLQDKMNFDVSNLKDNNE-ILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKD 1462
Cdd:pfam02463  399 lkseEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEEsIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQ 478

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1463 LSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQ----QLDDAHNKADNKEKTVINIQDQFHAIVQ 1538
Cdd:pfam02463  479 LVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISahgrLGDLGVAVENYKVAISTAVIVEVSATAD 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1539 KLQAESEKQsLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDET 1618
Cdd:pfam02463  559 EVEERQKLV-RALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKL 637

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1619 QDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLeKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLM 1698
Cdd:pfam02463  638 KESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKEL-LEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLK 716

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1699 ELKQSLECNLDQEMKKNVELEREI-TGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKAQAASQENLE 1777
Cdd:pfam02463  717 LEAEELLADRVQEAQDKINEELKLlKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKL 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1778 QFRENNFASMKSQMELRIKDLESELSKIktSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQ 1857
Cdd:pfam02463  797 KAQEEELRALEEELKEEAELLEEEQLLI--EQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLL 874


                   ....*
gi 2462517843 1858 QSRSL 1862
Cdd:pfam02463  875 KEEEL 879
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1174-1862 2.76e-10

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 65.51  E-value: 2.76e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1174 IREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDaqrqLSREQNARMLQDGILTNHLSKQKEiem 1253
Cdd:pfam05483   97 IEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKD----LIKENNATRHLCNLLKETCARSAE--- 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1254 AQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDtikNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 1333
Cdd:pfam05483  170 KTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAE---NARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLL 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1334 SQYNGRlsvltaENAM--LNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMN 1411
Cdd:pfam05483  247 IQITEK------ENKMkdLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQ 320

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1412 F---DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALrEKTLGLERVQKDLSQTQCQMKEME-QKYQNEQVKVNKY 1487
Cdd:pfam05483  321 IatkTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSL-EELLRTEQQRLEKNEDQLKIITMElQKKSSELEEMTKF 399

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1488 IGKQESVEERLSQLQSENMLLRQQLDDAHNKADN--------------KEKTVINIQDQFHAI----------VQKLQAE 1543
Cdd:pfam05483  400 KNNKEVELEELKKILAEDEKLLDEKKQFEKIAEElkgkeqelifllqaREKEIHDLEIQLTAIktseehylkeVEDLKTE 479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1544 SEKQSLlleeRNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKK 1623
Cdd:pfam05483  480 LEKEKL----KNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVRE 555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1624 KLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKlekdnaklkvTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQS 1703
Cdd:pfam05483  556 EFIQKGDEVKCKLDKSEENARSIEYEVLKKEK----------QMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGS 625

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1704 lecnldQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKAQAAS--QENLEQFRE 1781
Cdd:pfam05483  626 ------AENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVklQKEIDKRCQ 699

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1782 NNFASMKSQMELRikdlESELSKIKTSQEdfnkTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRS 1861
Cdd:pfam05483  700 HKIAEMVALMEKH----KHQYDKIIEERD----SELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEK 771


                   .
gi 2462517843 1862 L 1862
Cdd:pfam05483  772 L 772
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1022-1814 2.97e-10

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 65.84  E-value: 2.97e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1022 EGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFM---------LLIEQLGMECKDSVSLLKIQD 1092
Cdd:TIGR00606  167 EGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVQEHQMELKYLKQYKekaceirdqITSKEAQLESSREIVKSYENE 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1093 AALSCERLLELKKNhcellTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEwerELCSLRFSLNQEEEKRRNADTLYE 1172
Cdd:TIGR00606  247 LDPLKNRLKEIEHN-----LSKIMKLDNEIKALKSRKKQMEKDNSELELKMEK---VFQGTDEQLNDLYHNHQRTVREKE 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1173 KIREQLRRKEEQYRKEVEvkqqlELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI- 1251
Cdd:TIGR00606  319 RELVDCQRELEKLNKERR-----LLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIk 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1252 ---EMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEI----DTIKNQNQEKEKKCfEDLKIVKEKNEDLQ---KT 1321
Cdd:TIGR00606  394 nfhTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKkglgRTIELKKEILEKKQ-EELKFVIKELQQLEgssDR 472

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1322 IKQNEETLTQTISQYNgrlsvLTAENAMLNSKLENEKqSKERLEAEVESYHSRLAAAIHDRDQSETSKRELEL------- 1394
Cdd:TIGR00606  473 ILELDQELRKAERELS-----KAEKNSLTETLKKEVK-SLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMltkdkmd 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1395 AFQRARDECSRLQDKMNFDVS-------------NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQK 1461
Cdd:TIGR00606  547 KDEQIRKIKSRHSDELTSLLGyfpnkkqledwlhSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYED 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1462 DLSQTqCQMKEMEQKYQNEQVKVNK-------YIGKQESVEERLSQLQSEN----------MLLRQQLDDAHNKADNKEK 1524
Cdd:TIGR00606  627 KLFDV-CGSQDEESDLERLKEEIEKsskqramLAGATAVYSQFITQLTDENqsccpvcqrvFQTEAELQEFISDLQSKLR 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1525 TVINIQDQFHAIVQKLQAESEKQSLLLEERNKEL---ISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSE 1601
Cdd:TIGR00606  706 LAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIdlkEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAK 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1602 ASL-EVTSRYRinLEDETQDLKKKLGQIRNQLQEAQ-DRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK 1679
Cdd:TIGR00606  786 VCLtDVTIMER--FQMELKDVERKIAQQAAKLQGSDlDRTVQQVN--QEKQEKQHELDTVVSKIELNRKLIQDQQEQIQH 861

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1680 NLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKN--LLKMTRKKLNEYENGEFSFHGDLKTSQFEM 1757
Cdd:TIGR00606  862 LKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEqdSPLETFLEKDQQEKEELISSKETSNKKAQD 941

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517843 1758 DIQINKLKHKAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNK 1814
Cdd:TIGR00606  942 KVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNAQLEECEKHQEKINE 998
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1176-1866 3.31e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 65.47  E-value: 3.31e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1176 EQLRRKEEQYRKEVEvkqQLELSLQTLEMELRTVKSNLNQVVQERNDAQR--QLSREqnarmLQDGILTNHLsKQKEIEM 1253
Cdd:TIGR02169  166 AEFDRKKEKALEELE---EVEENIERLDLIIDEKRQQLERLRREREKAERyqALLKE-----KREYEGYELL-KEKEALE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1254 AQKKmnsenshshEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 1333
Cdd:TIGR02169  237 RQKE---------AIERQLAS----LEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEI 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1334 SQ-------YNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAI----HDRDQSETSKRELE---LAFQRA 1399
Cdd:TIGR02169  304 ASlersiaeKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTeeyaELKEELEDLRAELEevdKEFAET 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1400 RDECSRLQDKM----------NFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQ 1469
Cdd:TIGR02169  384 RDELKDYREKLeklkreinelKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAAD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1470 MKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHN-----KADN-------------KEKTVINIQ- 1530
Cdd:TIGR02169  464 LSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAveevlKASIqgvhgtvaqlgsvGERYATAIEv 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1531 ---DQFHAIVQKLQAESEKQSLLLEERN------------------KELISECNHLK--------ERQYQ---------- 1571
Cdd:TIGR02169  544 aagNRLNNVVVEDDAVAKEAIELLKRRKagratflplnkmrderrdLSILSEDGVIGfavdlvefDPKYEpafkyvfgdt 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1572 --YENEKAEREVVVR----QLQQELADtlKKQSMS----------------EASLEVTSRYRINLEDETQDLKKKLGQIR 1629
Cdd:TIGR02169  624 lvVEDIEAARRLMGKyrmvTLEGELFE--KSGAMTggsraprggilfsrsePAELQRLRERLEGLKRELSSLQSELRRIE 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1630 NQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLECNLD 1709
Cdd:TIGR02169  702 NRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEI------ENVKSELKELEARIEELEEDLH 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1710 QEMKKNVELEREITGFKnlLKMTRKKLNEYEngefSFHGDLKTSQFEMDIQINKLKHKAQAASQENLEQFRENNfasmks 1789
Cdd:TIGR02169  776 KLEEALNDLEARLSHSR--IPEIQAELSKLE----EEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRI------ 843

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1790 QMELRIKDLESELSKIKTSQEDFNkTELEKYkQLYLEEL--------KVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRS 1861
Cdd:TIGR02169  844 DLKEQIKSIEKEIENLNGKKEELE-EELEEL-EAALRDLesrlgdlkKERDELEAQLRELERKIEELEAQIEKKRKRLSE 921


                   ....*
gi 2462517843 1862 LFTTL 1866
Cdd:TIGR02169  922 LKAKL 926
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 889-1759 6.30e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 64.61  E-value: 6.30e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  889 MLKVEFQALEKEKVQLQKEVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSgETDHQQFPRKENKEYASS 968
Cdd:pfam02463  202 LKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEK-EEEKLAQVLKENKEEEKE 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  969 GPALQMKEVKSTEKEKRTSKEsvnspvfgkasLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDD 1048
Cdd:pfam02463  281 KKLQEEELKLLAKEEEELKSE-----------LLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEI 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1049 LTQSSETASEDCELphssyknfmLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKnhcELLTVKIKKMEDKVNVLQRE 1128
Cdd:pfam02463  350 KREAEEEEEEELEK---------LQEKLEQLEEELLAKKKLESERLSSAAKLKEEEL---ELKSEEEKEAQLLLELARQL 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1129 LSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRT 1208
Cdd:pfam02463  418 EDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEE 497

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1209 VKSNLnQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRL 1288
Cdd:pfam02463  498 RSQKE-SKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLG 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1289 EIDTIknqnQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTqtisqyngrlsvltaenAMLNSKLENEKQSKERLEAEV 1368
Cdd:pfam02463  577 ARKLR----LLIPKLKLPLKSIAVLEIDPILNLAQLDKATLE-----------------ADEDDKRAKVVEGILKDTELT 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1369 ESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdvsNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDA 1448
Cdd:pfam02463  636 KLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELL------EIQELQEKAESELAKEEILRRQLEIKKKEQREK 709

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1449 LREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGK-QESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVI 1527
Cdd:pfam02463  710 EELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEeEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVE 789

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1528 NIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEA----- 1602
Cdd:pfam02463  790 EEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITkeell 869

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1603 SLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV-------RCAEKMQDHKQKLEKDNAKLK------VTVKK 1669
Cdd:pfam02463  870 QELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNlleekenEIEERIKEEAEILLKYEEEPEellleeADEKE 949

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1670 QMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECN---LDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSF 1746
Cdd:pfam02463  950 KEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEeryNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLELFVSI 1029

                          890
                   ....*....|...
gi 2462517843 1747 HGDLKTSQFEMDI 1759
Cdd:pfam02463 1030 NKGWNKVFFYLEL 1042
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 39-214 8.39e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.93  E-value: 8.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   39 GYHVRDRDLGK---IHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGH-PEVVTLLVDRKCQLNVCDNENR 114
Cdd:PHA02876   263 GFSVNSIDDCKntpLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYI 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  115 TALMKAVQCQEEKCATI-LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQ 193
Cdd:PHA02876   343 TPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPY 422

                          170       180
                   ....*....|....*....|..
gi 2462517843  194 M-VEFLIKKKANVNAVDKLESS 214
Cdd:PHA02876   423 MsVKTLIDRGANVNSKNKDLST 444
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 125-210 1.24e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 62.98  E-value: 1.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  125 EEKCATILLEHGADPNLADVH-GNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:PHA02878   146 EAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225


                   ....*..
gi 2462517843  204 NVNAVDK 210
Cdd:PHA02878   226 STDARDK 232
PHA03095 PHA03095
ankyrin-like protein; Provisional
 55-179 1.74e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.35  E-value: 1.74e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   55 SAGNVAKVqqILLLRKNG--LNDRDKMNRTALHL-ACANGHPEVVTLLVDRKCQLNVCDNENRTALMK--AVQCQEEKCA 129
Cdd:PHA03095    58 SSEKVKDI--VRLLLEAGadVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVI 135

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462517843  130 TILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDD 179
Cdd:PHA03095   136 RLLLRKGADVNALDLYGMTPLAVLLKSRNANVELLRLLIDAGADVYAVDD 185
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1116-1935 3.24e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 62.30  E-value: 3.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1116 KKMEDKVNVLQRELSETKEIKSQLEHQKVEwERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL 1195
Cdd:pfam02463  177 KLIEETENLAELIIDLEELKLQELKLKEQA-KKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIES 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1196 ELSLQTLEMELrTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHK 1275
Cdd:pfam02463  256 SKQEIEKEEEK-LAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEK 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1276 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEknEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 1355
Cdd:pfam02463  335 EEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLE--EELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLE 412

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1356 NEKQSKERLEAEVESYHSRLAAAIHDRDQSET--SKRELELAFQRARDECSRLQDKMNFDvsnLKDNNEILSQQLFKTES 1433
Cdd:pfam02463  413 LARQLEDLLKEEKKEELEILEEEEESIELKQGklTEEKEELEKQELKLLKDELELKKSED---LLKETQLVKLQEQLELL 489

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1434 KLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQneQVKVNKYIGKQESVEERLSQLQSENMLLRQQLD 1513
Cdd:pfam02463  490 LSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDL--GVAVENYKVAISTAVIVEVSATADEVEERQKLV 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1514 DAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADT 1593
Cdd:pfam02463  568 RALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESG 647

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1594 LKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQdrhTEAVRCAEKMQDHKQKLEKDNAKLKvtvKKQMDK 1673
Cdd:pfam02463  648 LRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELA---KEEILRRQLEIKKKEQREKEELKKL---KLEAEE 721

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1674 IEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEfsFHGDLKTS 1753
Cdd:pfam02463  722 LLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEE--KEEKLKAQ 799

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1754 QFEMDIQINKLKHKAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKS 1833
Cdd:pfam02463  800 EEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEEL 879

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1834 LSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLNNSLDLNRKLIPRENLVISTSNPRASNNSMENY 1913
Cdd:pfam02463  880 EEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEE 959

                          810       820
                   ....*....|....*....|..
gi 2462517843 1914 LSKMQQELEKNITRELKEAAAE 1935
Cdd:pfam02463  960 ERNKRLLLAKEELGKVNLMAIE 981
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1176-1771 3.51e-09

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 62.11  E-value: 3.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1176 EQLRRKEEQYRKEVEVKQQLELSLQTLEmelrtvkSNLNQVVQERNDAQRQL---------SREQNARMLQ-----DGIL 1241
Cdd:pfam01576    5 EEMQAKEEELQKVKERQQKAESELKELE-------KKHQQLCEEKNALQEQLqaetelcaeAEEMRARLAArkqelEEIL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1242 TNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKnsMLQEEIAMLRLEIDtiKNQNQEKEKKCFEDLKIVKEKNEDLQKT 1321
Cdd:pfam01576   78 HELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQ--LDEEEAARQKLQLE--KVTTEAKIKKLEEDILLLEDQNSKLSKE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1322 IKQNEEtltqtisqyngRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARD 1401
Cdd:pfam01576  154 RKLLEE-----------RISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQE 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1402 ECSRLQDKMnfdvsnlkdnnEILSQQLFKTESKLNSLEiefhhtrDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQ 1481
Cdd:pfam01576  223 QIAELQAQI-----------AELRAQLAKKEEELQAAL-------ARLEEETAQKNNALKKIRELEAQISELQEDLESER 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1482 VKVNKYIGKQESVEERLSQLQSEnmlLRQQLDDAHNKAD---NKEKTVIN----IQDQFHAIVQKLQAESEKQSLLLEER 1554
Cdd:pfam01576  285 AARNKAEKQRRDLGEELEALKTE---LEDTLDTTAAQQElrsKREQEVTElkkaLEEETRSHEAQLQEMRQKHTQALEEL 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1555 NKELisecNHLKERQYQYENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSRyRINLEDETQDLKKKLGQIRNQLQE 1634
Cdd:pfam01576  362 TEQL----EQAKRNKANLEKAKQALESENAELQAEL------RTLQQAKQDSEHK-RKKLEGQLQELQARLSESERQRAE 430

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1635 AQDRHTEAVRCAEKMQDHKQKLEKDNAKLK---VTVKKQMDKIEELQKNLLNANLSEDEKeqLKKLMELKQSLECNLDQE 1711
Cdd:pfam01576  431 LAEKLSKLQSELESVSSLLNEAEGKNIKLSkdvSSLESQLQDTQELLQEETRQKLNLSTR--LRQLEDERNSLQEQLEEE 508

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1712 MKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKAQAA 1771
Cdd:pfam01576  509 EEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAY 568
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 50-211 3.60e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 62.00  E-value: 3.60e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   50 IHKAASAGNvAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNvcdnENRTALMKAVQCQEEKCA 129
Cdd:PHA02876   182 IHYAAERGN-AKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNIN----KNDLSLLKAIRNEDLETS 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  130 TILLEHGADPNLADVHGNTALHYAVYNEDIS-VATKLLLYDANIEAKNKDDLTPL-LLAVSGKKQQMVEFLIKKKANVNA 207
Cdd:PHA02876   257 LLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNA 336


                   ....
gi 2462517843  208 VDKL 211
Cdd:PHA02876   337 ADRL 340
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 50-214 4.70e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 60.83  E-value: 4.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   50 IHKAASAGNVAKVQQILllrKNG--LNDRDKMNRTALHLACANGH-----PEVVTLLVDRKCQLNVCDNENRTALMKAVQ 122
Cdd:PHA03100    39 LYLAKEARNIDVVKILL---DNGadINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAIS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  123 CQEEKCATI--LLEHGADPNLADVHGNTALHYAV---------------YNEDISVATK---LLLYDANIEAKNKDDLTP 182
Cdd:PHA03100   116 KKSNSYSIVeyLLDNGANVNIKNSDGENLLHLYLesnkidlkilkllidKGVDINAKNRvnyLLSYGVPINIKDVYGFTP 195

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2462517843  183 LLLAVSGKKQQMVEFLIKKKANVNAVDKLESS 214
Cdd:PHA03100   196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227
PHA03095 PHA03095
ankyrin-like protein; Provisional
 50-209 4.79e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.19  E-value: 4.79e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   50 IHKAASAGNVAKVQQiLLLRKNG-LNDRDKMNRTALH--LACANGHPEVVTLLVDRKCQLNVCDNENRT---ALMKAVQC 123
Cdd:PHA03095    87 LHLYLYNATTLDVIK-LLIKAGAdVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTplaVLLKSRNA 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  124 QEE----------------------------------KCATILLEHGADPNLADVHGNTALHYAVYNEDI--SVATKLLL 167
Cdd:PHA03095   166 NVEllrllidagadvyavddrfrsllhhhlqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSCkrSLVLPLLI 245

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2462517843  168 YDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA03095   246 AGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1306-1848 6.76e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 61.23  E-value: 6.76e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1306 EDLKIVKEKNEDLQKTIKQNEETLTQTISqyngRLSVLTAENAMLNSKLENEKQSKERLEAEVEsyhsRLAAAIHDRDQS 1385
Cdd:PRK03918   179 ERLEKFIKRTENIEELIKEKEKELEEVLR----EINEISSELPELREELEKLEKEVKELEELKE----EIEELEKELESL 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1386 ETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEIlsQQLFKTESKLNSLEIEFhhtRDALREKTLGLERVQKDLSQ 1465
Cdd:PRK03918   251 EGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKEL--KEKAEEYIKLSEFYEEY---LDELREIEKRLSRLEEEING 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1466 TQCQMKEMEQKyqneQVKVNKYIGKQESVEERLSQLQSENMLLrqqlDDAHNKADNKEKTVINIQDQfhaIVQKLQAESE 1545
Cdd:PRK03918   326 IEERIKELEEK----EERLEELKKKLKELEKRLEELEERHELY----EEAKAKKEELERLKKRLTGL---TPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1546 KqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ----------QELADTLKKQSMSEASLEVTsryriNLE 1615
Cdd:PRK03918   395 E----LEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKkakgkcpvcgRELTEEHRKELLEEYTAELK-----RIE 465

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1616 DETQDLKKKLGQIRNQLQE------AQDRHTEAVRCAEKMQDHKQKLEKDN-------AKLKVTVKKQMDKIEELQKNLl 1682
Cdd:PRK03918   466 KELKEIEEKERKLRKELRElekvlkKESELIKLKELAEQLKELEEKLKKYNleelekkAEEYEKLKEKLIKLKGEIKSL- 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1683 nanlsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREIT--GFKNL--LKMTRKKLNEYENGEFSfhgdLKTSQFEMD 1758
Cdd:PRK03918   545 -----KKELEKLEELKKKLAELEKKLDELEEELAELLKELEelGFESVeeLEERLKELEPFYNEYLE----LKDAEKELE 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1759 IQINKLKhkaqaASQENLEQFRENnfasmksqMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKL 1838
Cdd:PRK03918   616 REEKELK-----KLEEELDKAFEE--------LAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAEL 682

                          570
                   ....*....|
gi 2462517843 1839 TKTNERLAEV 1848
Cdd:PRK03918   683 EELEKRREEI 692
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 129-282 1.01e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.30  E-value: 1.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  129 ATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVeflikkkanvnav 208
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV------------- 164

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517843  209 dklesshQLISEYKEEripkHSSQNSNSVDESsedslsrLSGKPGVDDSWPTSDDEDlnfDTKNVPKPSLAKLM 282
Cdd:PTZ00322   165 -------QLLSRHSQC----HFELGANAKPDS-------FTGKPPSLEDSPISSHHP---DFSAVPQPMMGSLI 217
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1092-1642 1.12e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 60.44  E-value: 1.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1092 DAALSCERLLELKKNHCELLTVKIKKMEDK-----VNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRN 1166
Cdd:PRK02224   173 DARLGVERVLSDQRGSLDQLKAQIEEKEEKdlherLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1167 ADTLYEKIRE------QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTvKSNLNQVVQERNDAQRQ-LSREQNArmLQDG 1239
Cdd:PRK02224   253 LETLEAEIEDlretiaETEREREELAEEVRDLRERLEELEEERDDLLA-EAGLDDADAEAVEARREeLEDRDEE--LRDR 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1240 ILtnhlskqkEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKnqnqekekkcfEDLKIVKEKNEDLQ 1319
Cdd:PRK02224   330 LE--------ECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAR-----------EAVEDRREEIEELE 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1320 KTIKQNEETLTQTISQYNGrlsvLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA---------------IHDR-- 1382
Cdd:PRK02224   391 EEIEELRERFGDAPVDLGN----AEDFLEELREERDELREREAELEATLRTARERVEEAealleagkcpecgqpVEGSph 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1383 ----DQSETSKRELELAFQRARDECSRLQDKMNfdvsnlkdnneiLSQQLFKTESKLNSLE---------IEFHHTRDAL 1449
Cdd:PRK02224   467 vetiEEDRERVEELEAELEDLEEEVEEVEERLE------------RAEDLVEAEDRIERLEerredleelIAERRETIEE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1450 REKTLGLERVQKDLSQTQCQMK-----EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSenmlLRQQLDDAHNKADN--- 1521
Cdd:PRK02224   535 KRERAEELRERAAELEAEAEEKreaaaEAEEEAEEAREEVAELNSKLAELKERIESLER----IRTLLAAIADAEDEier 610

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1522 ---KEKTVINIQDQFHaivQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAERevvVRQLQQELADTLKKQS 1598
Cdd:PRK02224   611 lreKREALAELNDERR---ERLAEKRERKRELEAEFDEARIEEAREDKERAEEYLEQVEEK---LDELREERDDLQAEIG 684

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....
gi 2462517843 1599 MSEASLEvtsryrinledETQDLKKKLGQIRNQLQEAQDRHTEA 1642
Cdd:PRK02224   685 AVENELE-----------ELEELRERREALENRVEALEALYDEA 717
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 73-218 5.37e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 57.67  E-value: 5.37e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   73 LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHY 152
Cdd:PHA02874   117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517843  153 AVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSgKKQQMVEFLIKKKA-NVNAVDKLESSHQLI 218
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII-HNRSAIELLINNASiNDQDIDGSTPLHHAI 262
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 1146-1720 5.70e-08

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 58.22  E-value: 5.70e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1146 WERELCS-------------LRFS--LNQEEEkrrnadtLYEKIREQLRRKEEQYR--KEVEVKQQLELSLQTLEME--- 1205
Cdd:pfam07111   35 WEQDVSGdgqgpgrrgrsleLEGSqaLSQQAE-------LISRQLQELRRLEEEVRllRETSLQQKMRLEAQAMELDala 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1206 ------------LRT-------VKSNLNQVVQERNDAQRQLSREQNARMLQ--DGILTNHLSKQKEIEmaqKKMNSENSH 1264
Cdd:pfam07111  108 vaekagqaeaegLRAalagaemVRKNLEEGSQRELEEIQRLHQEQLSSLTQahEEALSSLTSKAEGLE---KSLNSLETK 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1265 SHEEEKDLshknSMLQEEIAMLRLEIDTIKnQNQEKEKKCFEDLK-----------------IVKEKNEDLQKTIKQNEE 1327
Cdd:pfam07111  185 RAGEAKQL----AEAQKEAELLRKQLSKTQ-EELEAQVTLVESLRkyvgeqvppevhsqtweLERQELLDTMQHLQEDRA 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1328 TLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAE--------VESYHSRLAAAIHDRDQSETSKRElelAFQRA 1399
Cdd:pfam07111  260 DLQATVELLQVRVQSLTHMLALQEEELTRKIQPSDSLEPEfpkkcrslLNRWREKVFALMVQLKAQDLEHRD---SVKQL 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1400 RDECSRLQDKmnfdVSNLKDNNEILSQQLFKTESKL-------NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKE 1472
Cdd:pfam07111  337 RGQVAELQEQ----VTSQSQEQAILQRALQDKAAEVevermsaKGLQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSS 412

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1473 MEQKYQNEQVKVNKYIGKQESVEERLSQlqsenmllrqqlddahnkADNKEKTVINIQDQFHAIVQkLQAESEKQSLLLE 1552
Cdd:pfam07111  413 TQIWLETTMTRVEQAVARIPSLSNRLSY------------------AVRKVHTIKGLMARKVALAQ-LRQESCPPPPPAP 473

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1553 ERNKELISECNHLKERQYQYEnekAEREVVVRQLQQELAdtlKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQL 1632
Cdd:pfam07111  474 PVDADLSLELEQLREERNRLD---AELQLSAHLIQQEVG---RAREQGEAERQQLSEVAQQLEQELQRAQESLASVGQQL 547

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1633 QEAQDRHTEAVRCA--------EKMQDHKQKLEKDNAKLKVTVKKQMDKIEElqknllnaNLSEDEKEQLKKLMELKQsL 1704
Cdd:pfam07111  548 EVARQGQQESTEEAaslrqeltQQQEIYGQALQEKVAEVETRLREQLSDTKR--------RLNEARREQAKAVVSLRQ-I 618

                          650
                   ....*....|....*.
gi 2462517843 1705 ECNLDQEMKKNVELER 1720
Cdd:pfam07111  619 QHRATQEKERNQELRR 634
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1112-1756 7.57e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 57.75  E-value: 7.57e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1112 TVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEV 1191
Cdd:TIGR00606  397 TLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILEL 476

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1192 KQQLELSLQTL---------------EMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIemaqK 1256
Cdd:TIGR00606  477 DQELRKAERELskaeknsltetlkkeVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQI----R 552

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1257 KMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIdtikNQNQEKekkcFEDLKIVKEKNEDLQKTIKQNEETLTQTISQY 1336
Cdd:TIGR00606  553 KIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEI----NQTRDR----LAKLNKELASLEQNKNHINNELESKEEQLSSY 624

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1337 NGRL----SVLTAENAMLNSKLENEKQSKER--LEAEVESYHSRLAAAIH---------DRD-QSETSKRELELAFQRAR 1400
Cdd:TIGR00606  625 EDKLfdvcGSQDEESDLERLKEEIEKSSKQRamLAGATAVYSQFITQLTDenqsccpvcQRVfQTEAELQEFISDLQSKL 704

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1401 DECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNE 1480
Cdd:TIGR00606  705 RLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESA 784

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1481 QV------KVNKYIGKQESVEERLSQLQSEN-----MLLRQQLDDAHNKADNKEKTVIniqdQFHAIVQKLQAESEKQSL 1549
Cdd:TIGR00606  785 KVcltdvtIMERFQMELKDVERKIAQQAAKLqgsdlDRTVQQVNQEKQEKQHELDTVV----SKIELNRKLIQDQQEQIQ 860

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1550 LLEERNKELISECNHLKE---RQYQYENEKAEREVVVRQLQQELAD---------TLKKQSMSEASLEVTSRYRIN--LE 1615
Cdd:TIGR00606  861 HLKSKTNELKSEKLQIGTnlqRRQQFEEQLVELSTEVQSLIREIKDakeqdspleTFLEKDQQEKEELISSKETSNkkAQ 940

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1616 DETQDLKKKLGQ-------IRNQLQEAQDRH--------TEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKN 1680
Cdd:TIGR00606  941 DKVNDIKEKVKNihgymkdIENKIQDGKDDYlkqketelNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDN 1020

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517843 1681 LLNANLSEDEKEQLKKLME-LKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFE 1756
Cdd:TIGR00606 1021 LTLRKRENELKEVEEELKQhLKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFR 1097
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1098-1710 7.67e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 57.77  E-value: 7.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1098 ERLLELKKNHCELLTVKIKKMEDKVNVLQRELSE-TKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIRE 1176
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEElNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1177 QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQL-SREQNARMLQDgiltNHLSKQKEIEMAQ 1255
Cdd:TIGR02169  323 RLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELeEVDKEFAETRD----ELKDYREKLEKLK 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1256 KKMNSenshsheeekdLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNEDLQKTIKQNEETLTQTI-- 1333
Cdd:TIGR02169  399 REINE-----------LKRELDRLQEELQRLSEELADLNAAIAGIE----AKINELEEEKEDKALEIKKQEWKLEQLAad 463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1334 -SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVE-------------------------------SYHSRLAAAIHD 1381
Cdd:TIGR02169  464 lSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARaseervrggraveevlkasiqgvhgtvaqlgSVGERYATAIEV 543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1382 R----------DQSETSKRELELAFQR------------ARDECSRLQ------------DKMNFD-------------- 1413
Cdd:TIGR02169  544 AagnrlnnvvvEDDAVAKEAIELLKRRkagratflplnkMRDERRDLSilsedgvigfavDLVEFDpkyepafkyvfgdt 623

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1414 --VSNL-------------------------------------------KDNNEILSQQLFKTESKLNSLEIEFHHTRDA 1448
Cdd:TIGR02169  624 lvVEDIeaarrlmgkyrmvtlegelfeksgamtggsraprggilfsrsePAELQRLRERLEGLKRELSSLQSELRRIENR 703

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1449 LREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQvkvnkyiGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVIN 1528
Cdd:TIGR02169  704 LDELSQELSDASRKIGEIEKEIEQLEQEEEKLK-------ERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHK 776

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1529 IQDQFHAIVQKLqaesekqsllLEERNKELISECNHLKErqyqyenEKAEREVVVRQLQQELAD-TLKKQSMSEAslevt 1607
Cdd:TIGR02169  777 LEEALNDLEARL----------SHSRIPEIQAELSKLEE-------EVSRIEARLREIEQKLNRlTLEKEYLEKE----- 834

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1608 sryRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS 1687
Cdd:TIGR02169  835 ---IQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQ 911

                          730       740
                   ....*....|....*....|....
gi 2462517843 1688 -EDEKEQLKKLMELKQSLECNLDQ 1710
Cdd:TIGR02169  912 iEKKRKRLSELKAKLEALEEELSE 935
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1108-1721 8.14e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 57.42  E-value: 8.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1108 CELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFslnQEEEKRRNADTLYEKIREQLRRKEEQYRK 1187
Cdd:pfam05483  157 CNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRV---QAENARLEMHFKLKEDHEKIQHLEEEYKK 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1188 EVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNarmLQDGILTNHLSKQKEIEMAQKKMNSENSHSHE 1267
Cdd:pfam05483  234 EINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTK---LQDENLKELIEKKDHLTKELEDIKMSLQRSMS 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1268 EEKDLSHKNSMLQEEIAMLRLEidtiKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAEN 1347
Cdd:pfam05483  311 TQKALEEDLQIATKTICQLTEE----KEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMEL 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1348 AMLNSKLENEKQSKERLEAEVESYHSRLA---AAIHDRDQSET-------SKRELELAFQRARDECSRLQdkmnFDVSNL 1417
Cdd:pfam05483  387 QKKSSELEEMTKFKNNKEVELEELKKILAedeKLLDEKKQFEKiaeelkgKEQELIFLLQAREKEIHDLE----IQLTAI 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1418 KDNNEILSQQL--FKTE---SKLNSLEIEFHHTRDALREK---------TLGLERVQKDLSQTQCQMKEMEQKYQNEQVK 1483
Cdd:pfam05483  463 KTSEEHYLKEVedLKTElekEKLKNIELTAHCDKLLLENKeltqeasdmTLELKKHQEDIINCKKQEERMLKQIENLEEK 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1484 VNKYIGKQESVEERLSQLQSEnmlLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK---LQAESEKQSLLLEernkELIS 1560
Cdd:pfam05483  543 EMNLRDELESVREEFIQKGDE---VKCKLDKSEENARSIEYEVLKKEKQMKILENKcnnLKKQIENKNKNIE----ELHQ 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1561 ECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSmseaslEVTSRYRINLEDETQDLKKKLGQIrnqlQEAQDRHT 1640
Cdd:pfam05483  616 ENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFE------EIIDNYQKEIEDKKISEEKLLEEV----EKAKAIAD 685

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1641 EAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI-EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELE 1719
Cdd:pfam05483  686 EAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIiEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIE 765


                   ..
gi 2462517843 1720 RE 1721
Cdd:pfam05483  766 KE 767
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-210 8.84e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.66  E-value: 8.84e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462517843  150 LHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIkKKANVNAVDK 210
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDN 60
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1457-1852 8.95e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 57.38  E-value: 8.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1457 ERVQKDLSQT---QCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSEnmllRQQLDDAHNKADNKEKTVINIQDQF 1533
Cdd:PRK03918   179 ERLEKFIKRTeniEELIKEKEKELEEVLREINEISSELPELREELEKLEKE----VKELEELKEEIEELEKELESLEGSK 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1534 HAIVQKLQaESEKQSLLLEERNKELISECNHLKERQyqyenEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRIN 1613
Cdd:PRK03918   255 RKLEEKIR-ELEERIEELKKEIEELEEKVKELKELK-----EKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEE 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1614 LEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANlsEDEKEQ 1693
Cdd:PRK03918   329 RIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAK--EEIEEE 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1694 LKKLMELKQSLEcNLDQEMKKNVElerEITGFKNLLKMTRKKLNEYENGEF--SFHGDLKTSQFEMDIQINKLKHKAQAA 1771
Cdd:PRK03918   407 ISKITARIGELK-KEIKELKKAIE---ELKKAKGKCPVCGRELTEEHRKELleEYTAELKRIEKELKEIEEKERKLRKEL 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1772 SQENLEQFRENNFASMKSQMELrIKDLESELSKIKTSQEDFNKTELEKYKQLYLE---ELKVRKSLSSKLTKTNERLAEV 1848
Cdd:PRK03918   483 RELEKVLKKESELIKLKELAEQ-LKELEEKLKKYNLEELEKKAEEYEKLKEKLIKlkgEIKSLKKELEKLEELKKKLAEL 561


                   ....
gi 2462517843 1849 NTKL 1852
Cdd:PRK03918   562 EKKL 565
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1203-1852 1.75e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 56.77  E-value: 1.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1203 EMELRTVKSNLNQVVQER--NDAQRQLSREQNARMLQDgiltnhlskqkeIEMAQKKMNsenshsheeekdLSHKNSMLQ 1280
Cdd:pfam12128  192 EGKFRDVKSMIVAILEDDgvVPPKSRLNRQQVEHWIRD------------IQAIAGIMK------------IRPEFTKLQ 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1281 EEIAMLR---LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLEN- 1356
Cdd:pfam12128  248 QEFNTLEsaeLRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEAl 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1357 EKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDecsrLQDKMNFDVSNLK-DNNEILSqqlfkteskl 1435
Cdd:pfam12128  328 EDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQD----VTAKYNRRRSKIKeQNNRDIA---------- 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1436 nsleiEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERL----SQLQSENMLLRQQ 1511
Cdd:pfam12128  394 -----GIKDKLAKIREARDRQLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGELKLrlnqATATPELLLQLEN 468

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1512 LDDAHNKADNKektviniQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQyqyeNEKAEREVVVRQLQQELA 1591
Cdd:pfam12128  469 FDERIERAREE-------QEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQ----SALDELELQLFPQAGTLL 537

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1592 DTLKKQS--MSEASLEVTSR---YRINLEDETQDLKKK----LGQIRNQLQEAQdrHTEAVrcaekmqDHKQKLEKDNAK 1662
Cdd:pfam12128  538 HFLRKEApdWEQSIGKVISPellHRTDLDPEVWDGSVGgelnLYGVKLDLKRID--VPEWA-------ASEEELRERLDK 608

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1663 LKVTVKKQMDKIEELQKNLLNANLSEDEkeQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENg 1742
Cdd:pfam12128  609 AEEALQSAREKQAAAEEQLVQANGELEK--ASREETFARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANERLN- 685

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1743 efsfhgdlktsqfEMDIQINKLKHKAQAASQENLEQFRENNFASMKSQMELrIKDLESELSKIKT---SQEDFNKTELEK 1819
Cdd:pfam12128  686 -------------SLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVV-EGALDAQLALLKAaiaARRSGAKAELKA 751

                          650       660       670
                   ....*....|....*....|....*....|...
gi 2462517843 1820 YKQLYLEELKVRKSLSSKLTKTNERLAEVNTKL 1852
Cdd:pfam12128  752 LETWYKRDLASLGVDPDVIAKLKREIRTLERKI 784
Ank_4 pfam13637
Ankyrin repeats (many copies);
113-166 2.85e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 2.85e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462517843  113 NRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLL 166
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1176-1660 3.09e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.54  E-value: 3.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1176 EQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDgiLTNHL-SKQKEIEMA 1254
Cdd:COG4717     74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEA--LEAELaELPERLEEL 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1255 QKKMnsenshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQTIS 1334
Cdd:COG4717    152 EERL--------EELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDL---AEELEELQQRLAELEEELEEAQE 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1335 QYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESyhSRLAAAIHDRDQSETSKRELELAFQRA--------RDECSRL 1406
Cdd:COG4717    221 ELEELEEELEQLENELEAAALEERLKEARLLLLIAA--ALLALLGLGGSLLSLILTIAGVLFLVLgllallflLLAREKA 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1407 QDKMNFDVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNK 1486
Cdd:COG4717    299 SLGKEAEELQALPALEELEEE--ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALL 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1487 YIGKQESVEErlsqlqsenmlLRQQLdDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLlleernkelisecNHLK 1566
Cdd:COG4717    377 AEAGVEDEEE-----------LRAAL-EQAEEYQELKEELEELEEQLEELLGELEELLEALDE-------------EELE 431

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1567 ERQYQYENEKAEREVVVRQLQQELADTlkkqsmsEASLEVTSRyrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCA 1646
Cdd:COG4717    432 EELEELEEELEELEEELEELREELAEL-------EAELEQLEE-----DGELAELLQELEELKAELRELAEEWAALKLAL 499

                          490
                   ....*....|....
gi 2462517843 1647 EKMQDHKQKLEKDN 1660
Cdd:COG4717    500 ELLEEAREEYREER 513
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1083-1799 6.94e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 54.74  E-value: 6.94e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1083 DSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEW---EREL--------- 1150
Cdd:pfam15921  208 DSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQlisEHEVeitglteka 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1151 -------CSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEV-EVKQQLELSLQTLEMELRTVKSNLNQVVQERNd 1222
Cdd:pfam15921  288 ssarsqaNSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELrEAKRMYEDKIEELEKQLVLANSELTEARTERD- 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1223 aqrQLSREQnarmlqdGILTNHLSKqkeIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDT---------- 1292
Cdd:pfam15921  367 ---QFSQES-------GNLDDQLQK---LLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDrnmevqrlea 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1293 -IKNQNQEKEKKCFEDLKIVKEKNEDLQKT------IKQNEETLTQTISQYNG-RLSVLTAENAM--LNSKLENEKQSKE 1362
Cdd:pfam15921  434 lLKAMKSECQGQMERQMAAIQGKNESLEKVssltaqLESTKEMLRKVVEELTAkKMTLESSERTVsdLTASLQEKERAIE 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1363 RLEAEVESYHSRLAAAIHDRDQSETSKRELelafQRARDECSRLQDKMnfdvSNLKDNNEILSQQLfkteskLNSLEIEF 1442
Cdd:pfam15921  514 ATNAEITKLRSRVDLKLQELQHLKNEGDHL----RNVQTECEALKLQM----AEKDKVIEILRQQI------ENMTQLVG 579

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1443 HHTRdalrekTLGLERVQKdlSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRqqlddahNKADNK 1522
Cdd:pfam15921  580 QHGR------TAGAMQVEK--AQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLV-------NAGSER 644

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1523 EKTVINIQdqfhaivqklqaeSEKQSLLLEERNKEliSECNHLKErqyqyenekaEREVVVRQLQQEladtlkkqsmSEA 1602
Cdd:pfam15921  645 LRAVKDIK-------------QERDQLLNEVKTSR--NELNSLSE----------DYEVLKRNFRNK----------SEE 689

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1603 SLEVTSRYRINLEDETQDLKkklgQIRNQLQEAQDRHTEAVRCAEKMQdhKQKLEKdnaklKVTVKKQMDKIEELQKNLL 1682
Cdd:pfam15921  690 METTTNKLKMQLKSAQSELE----QTRNTLKSMEGSDGHAMKVAMGMQ--KQITAK-----RGQIDALQSKIQFLEEAMT 758

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1683 NANlseDEKEQLKKlmelkqsLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEyengefsfhgdlKTSQFEMDIQin 1762
Cdd:pfam15921  759 NAN---KEKHFLKE-------EKNKLSQELSTVATEKNKMAGELEVLRSQERRLKE------------KVANMEVALD-- 814

                          730       740       750
                   ....*....|....*....|....*....|....*..
gi 2462517843 1763 klKHKAQAASQENLEQFRENNFASMKSQMELRIKDLE 1799
Cdd:pfam15921  815 --KASLQFAECQDIIQRQEQESVRLKLQHTLDVKELQ 849
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1126-1739 7.19e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 54.26  E-value: 7.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1126 QRELSETKEIKSQLEHQkvewERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEME 1205
Cdd:TIGR04523   36 KQLEKKLKTIKNELKNK----EKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1206 LRTVKSNLNQVVQERNDAQRQLsreQNARMLQDGILTNHLSKQKEIEmaqkKMNSENSHSHEEEKDLSHKNSMLQEEIAM 1285
Cdd:TIGR04523  112 IKNDKEQKNKLEVELNKLEKQK---KENKKNIDKFLTEIKKKEKELE----KLNNKYNDLKKQKEELENELNLLEKEKLN 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1286 LRLEIDTIKNQNQEKEKKCFeDLKIVKEKNEDLQKTI---KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKE 1362
Cdd:TIGR04523  185 IQKNIDKIKNKLLKLELLLS-NLKKKIQKNKSLESQIselKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQN 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1363 RLEaevesyhSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLkdnneiLSQQLFKTESKLNSLEIEF 1442
Cdd:TIGR04523  264 KIK-------KQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKE------LKSELKNQEKKLEEIQNQI 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1443 HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNK 1522
Cdd:TIGR04523  331 SQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQK 410

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1523 EKTVINIQDQFHAI---VQKLQAESEKQSLL---LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKK 1596
Cdd:TIGR04523  411 DEQIKKLQQEKELLekeIERLKETIIKNNSEikdLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKE 490

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1597 QSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKL--EKDNAKLKVTVKKQMDKI 1674
Cdd:TIGR04523  491 LKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDdfELKKENLEKEIDEKNKEI 570

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517843 1675 EEL---QKNLLNANLS--------EDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEY 1739
Cdd:TIGR04523  571 EELkqtQKSLKKKQEEkqelidqkEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQE 646
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1375-1638 9.00e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 9.00e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1375 LAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTL 1454
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKE----EKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1455 GLERVQKDLSQTQCQMKEMEQKYQNeqvkvnkyIGKQESVEERLSQLQSENMLLRQQLDDAHNKADnkektviniQDQFH 1534
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYR--------LGRQPPLALLLSPEDFLDAVRRLQYLKYLAPAR---------REQAE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1535 AIVQKLQAESEKQSLLLEERnKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSmseaslevtsryriNL 1614
Cdd:COG4942    154 ELRADLAELAALRAELEAER-AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELA--------------EL 218

                          250       260
                   ....*....|....*....|....
gi 2462517843 1615 EDETQDLKKKLGQIRNQLQEAQDR 1638
Cdd:COG4942    219 QQEAEELEALIARLEAEAAAAAER 242
Ank_5 pfam13857
Ankyrin repeats (many copies);
132-186 9.18e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 9.18e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517843  132 LLEHG-ADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLA 186
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 66-210 1.02e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 1.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   66 LLLRK-NGLNDRDKMNRTALHLACANGHP--EVVTLLVDRKCQLNVCDNENRTAL-MKAVQCQeekCATI----LLEHGA 137
Cdd:PHA03095   172 LLIDAgADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLhSMATGSS---CKRSlvlpLLIAGI 248

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517843  138 DPNLADVHGNTALHYA-VYNEDISVAtKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDK 210
Cdd:PHA03095   249 SINARNRYGQTPLHYAaVFNNPRACR-RLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1147-1378 1.25e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.84  E-value: 1.25e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1147 ERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYrkevevkQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQ 1226
Cdd:COG4942     26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRI-------AALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1227 LSREQN--ARMLQDgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKD-LSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKK 1303
Cdd:COG4942     99 LEAQKEelAELLRA------LYRLGRQPPLALLLSPEDFLDAVRRLQyLKYLAPARREQAEELRADLAELAALRAELEAE 172

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517843 1304 cFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA 1378
Cdd:COG4942    173 -RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 121-292 1.40e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  121 VQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIK 200
Cdd:PHA02876   153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  201 KKANVNAVDkLESSHQLISEYKEERIPKHSSQNS-NSVDESSEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLA 279
Cdd:PHA02876   233 NRSNINKND-LSLLKAIRNEDLETSLLLYDAGFSvNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPL 311

                          170
                   ....*....|...
gi 2462517843  280 KLMTASQQSRKNL 292
Cdd:PHA02876   312 YLMAKNGYDTENI 324
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1105-1331 1.92e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 53.14  E-value: 1.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1105 KNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQ 1184
Cdd:TIGR02168  795 KEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE 874

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1185 YRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLS--REQNARM-LQDGILTNHLSKQKEIEMAQKKMNSE 1261
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEelREKLAQLeLRLEGLEVRIDNLQERLSEEYSLTLE 954

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517843 1262 NSHSHEEEKDLSHKNsmLQEEIAMLRLEIDTIKNQNQ------EKEKKCFEDLKivKEKnEDLQKTIKQNEETLTQ 1331
Cdd:TIGR02168  955 EAEALENKIEDDEEE--ARRRLKRLENKIKELGPVNLaaieeyEELKERYDFLT--AQK-EDLTEAKETLEEAIEE 1025
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1172-1861 2.02e-06

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 53.16  E-value: 2.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1172 EKIREQLRRKEEQYR--KEVEVKQQLELSLQTLEMELRTVKSNLN-QVVQERNDAQRQLSREQnarmLQDGILTNHLSKQ 1248
Cdd:COG5022    826 IKREKKLRETEEVEFslKAEVLIQKFGRSLKAKKRFSLLKKETIYlQSAQRVELAERQLQELK----IDVKSISSLKLVN 901

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1249 KEIEmaqkKMNSENSHSheEEKDLSHKNSMLQEEIAMLR---LEID-----TIKNQNQEKEKKCFEDLKIVKEKNEDLQK 1320
Cdd:COG5022    902 LELE----SEIIELKKS--LSSDLIENLEFKTELIARLKkllNNIDleegpSIEYVKLPELNKLHEVESKLKETSEEYED 975

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1321 TIKQNEETltqtISQYNGRLSVLTAENAMLNSKLENEK--QSKERLEAEVESYHSRLAAAIH-DRDQSETSKRELELAFQ 1397
Cdd:COG5022    976 LLKKSTIL----VREGNKANSELKNFKKELAELSKQYGalQESTKQLKELPVEVAELQSASKiISSESTELSILKPLQKL 1051

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1398 RARDECSRLQDKMNF-DVSNLKDNNEILSQQLF---KTESKLNSLEIefhhtrDALREKTLGLERVQKDLSQTQCQMKem 1473
Cdd:COG5022   1052 KGLLLLENNQLQARYkALKLRRENSLLDDKQLYqleSTENLLKTINV------KDLEVTNRNLVKPANVLQFIVAQMI-- 1123

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1474 eqKYQNEQVK---VNKYIGKQESVEERLSQLQSEnmllrqqLDDAHNKADNKEKTVIniqDQFHAIVQKlqaeSEKQSLL 1550
Cdd:COG5022   1124 --KLNLLQEIskfLSQLVNTLEPVFQKLSVLQLE-------LDGLFWEANLEALPSP---PPFAALSEK----RLYQSAL 1187

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1551 LEERNKELISECNHLKER---QYQYENEKAEREVVVRQLQQELAD-TLKKQSMSEASlevtsrYRINLEDETQDLKK-KL 1625
Cdd:COG5022   1188 YDEKSKLSSSEVNDLKNEliaLFSKIFSGWPRGDKLKKLISEGWVpTEYSTSLKGFN------NLNKKFDTPASMSNeKL 1261

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1626 GQIRNQLQeaqdrhteAVRCAEKMQDHKqklekdnakLKVTVKKQMDKIEELQKNLLNANLSEdekeqlkklMELKQSLE 1705
Cdd:COG5022   1262 LSLLNSID--------NLLSSYKLEEEV---------LPATINSLLQYINVGLFNALRTKASS---------LRWKSATE 1315

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1706 CNLDQEMKKNVELEREI----TGFKNLLKMTR-KKLNEYENGEFSFHGDLKTSQFemDIQINKLKHKAQAASQEN--LEQ 1778
Cdd:COG5022   1316 VNYNSEELDDWCREFEIsdvdEELEELIQAVKvLQLLKDDLNKLDELLDACYSLN--PAEIQNLKSRYDPADKENnlPKE 1393

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1779 FRENnfasmksqmelrikdLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQ 1858
Cdd:COG5022   1394 ILKK---------------IEALLIKQELQLSLEGKDETEVHLSEIFSEEKSLISLDRNSIYKEEVLSSLSALLTKEKIA 1458


                   ...
gi 2462517843 1859 SRS 1861
Cdd:COG5022   1459 LLD 1461
Ank_5 pfam13857
Ankyrin repeats (many copies);
68-117 2.09e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 2.09e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517843   68 LRKNG---LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTAL 117
Cdd:pfam13857    1 LLEHGpidLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1537-1852 2.55e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 52.75  E-value: 2.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1537 VQKLQAESEK----QSLLLEERNKELISECNHLKErqyqYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRI 1612
Cdd:TIGR02168  202 LKSLERQAEKaeryKELKAELRELELALLVLRLEE----LREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVS 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1613 NLEDETQDLKKKLGQIRNQLQEAQDRhteavrcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnaNLSEDEKE 1692
Cdd:TIGR02168  278 ELEEEIEELQKELYALANEISRLEQQ-------KQILRERLANLERQLEELEAQLEELESKLDELAEEL---AELEEKLE 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1693 QLKKlmelkqslecnldqemkknvelerEITGFKNLLKMTRKKLNEYENGE---FSFHGDLKTSQFEMDIQINKLKHKAQ 1769
Cdd:TIGR02168  348 ELKE------------------------ELESLEAELEELEAELEELESRLeelEEQLETLRSKVAQLELQIASLNNEIE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1770 AA------SQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKsLSSKLTKTNE 1843
Cdd:TIGR02168  404 RLearlerLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEE-AEQALDAAER 482


                   ....*....
gi 2462517843 1844 RLAEVNTKL 1852
Cdd:TIGR02168  483 ELAQLQARL 491
Ank_4 pfam13637
Ankyrin repeats (many copies);
50-100 2.97e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 2.97e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517843   50 IHKAASAGNVAKVQqilLLRKNG--LNDRDKMNRTALHLACANGHPEVVTLLV 100
Cdd:pfam13637    5 LHAAAASGHLELLR---LLLEKGadINAVDGNGETALHFAASNGNVEVLKLLL 54
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1245-1837 3.20e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.42  E-value: 3.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1245 LSKQKEIEMAQKKMNSENSHSHEEEKD--------LSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNE 1316
Cdd:pfam05483   41 FQKLNFLPMLEQVANSGDCHYQEGLKDsdfensegLSRLYSKLYKEAEKIKKWKVSIEAELKQKENKLQENRKIIEAQRK 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1317 DLQKTIKQNEET---LTQTISQ-------------YNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIH 1380
Cdd:pfam05483  121 AIQELQFENEKVslkLEEEIQEnkdlikennatrhLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFE 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1381 D-RDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERV 1459
Cdd:pfam05483  201 ElRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQ 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1460 QKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLsQLQSENMLLRQQLDDAHNKADNKEKT-------------- 1525
Cdd:pfam05483  281 DENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDL-QIATKTICQLTEEKEAQMEELNKAKAahsfvvtefeattc 359

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1526 ------------VINIQDQFHAIVQKLQAE-SEKQSLLLEERNKEL-ISECNHLKERQYQYENEKAEREVVVRQLQ---Q 1588
Cdd:pfam05483  360 sleellrteqqrLEKNEDQLKIITMELQKKsSELEEMTKFKNNKEVeLEELKKILAEDEKLLDEKKQFEKIAEELKgkeQ 439

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1589 ELADTLKKQSMSEASLEVTSRYRINLEdetQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVK 1668
Cdd:pfam05483  440 ELIFLLQAREKEIHDLEIQLTAIKTSE---EHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELK 516

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1669 KQMDKI-------EELQKNLLNANLSE----DEKEQLKK-LMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKL 1736
Cdd:pfam05483  517 KHQEDIinckkqeERMLKQIENLEEKEmnlrDELESVREeFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKC 596

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1737 NEYENgefsfHGDLKTSQFEMDIQINKLKHKAQAASQENLEQFR------ENNFASMKSQMELRIKDLESELSKIKTSQE 1810
Cdd:pfam05483  597 NNLKK-----QIENKNKNIEELHQENKALKKKGSAENKQLNAYEikvnklELELASAKQKFEEIIDNYQKEIEDKKISEE 671

                          650       660
                   ....*....|....*....|....*..
gi 2462517843 1811 DFNKtELEKYKQLYLEELKVRKSLSSK 1837
Cdd:pfam05483  672 KLLE-EVEKAKAIADEAVKLQKEIDKR 697
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 56-237 5.54e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.12  E-value: 5.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   56 AGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQ------------- 122
Cdd:PHA02874    11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKigahdiikllidn 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  123 ----------CQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQ 192
Cdd:PHA02874    91 gvdtsilpipCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2462517843  193 QMVEFLIKKKANVNAVD-KLESSHQLISEYKEERIPKHSSQNSNSV 237
Cdd:PHA02874   171 DIIKLLLEKGAYANVKDnNGESPLHNAAEYGDYACIKLLIDHGNHI 216
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1633-1842 7.27e-06

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 51.08  E-value: 7.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1633 QEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQM----DKIEELQKNLlNANLSEDEKEQLKKLMELKQslecnL 1708
Cdd:PRK05771    39 ELSNERLRKLRSLLTKLSEALDKLRSYLPKLNPLREEKKkvsvKSLEELIKDV-EEELEKIEKEIKELEEEISE-----L 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1709 DQEMKKNVELEREITGFKNLlKMTRKKLNEYENGEFSFhGDLKTSQFEMDIQ---------INKLKHK-------AQAAS 1772
Cdd:PRK05771   113 ENEIKELEQEIERLEPWGNF-DLDLSLLLGFKYVSVFV-GTVPEDKLEELKLesdvenveyISTDKGYvyvvvvvLKELS 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1773 QENLEQFRENNFASMK-----------SQMELRIKDLESELSKIKTSQEDFNKtELEKYKQLYLEEL---KVRKSLSSKL 1838
Cdd:PRK05771   191 DEVEEELKKLGFERLEleeegtpseliREIKEELEEIEKERESLLEELKELAK-KYLEELLALYEYLeieLERAEALSKF 269


                   ....
gi 2462517843 1839 TKTN 1842
Cdd:PRK05771   270 LKTD 273
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 82-202 7.44e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 7.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   82 TALHLACANGHPEVVTLLVDRKCQLN------VCDNENRTALMK--------AVQCQEEKCATILLEHGADPNLADVHGN 147
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517843  148 TALHYAVYNEDISVATK----LLLYDANIEA------KNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd22192    171 TVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQKR 235
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 82-202 1.14e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.46  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   82 TALHLACANGHPEVVTLLVDRKCQLNV---CD-------------NENRTALMKAVQcqEEKCATILLEHGADPNLADVH 145
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGASVPAracGDffvksqgvdsfyhGESPLNAAACLG--SPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517843  146 GNTALHYAVYNEDISVATK---------LLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:TIGR00870  208 GNTLLHLLVMENEFKAEYEelscqmynfALSLLDKLrdskeleVILNHQGLTPLKLAAKEGRIVLFRLKLAIK 280
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1038-1642 1.39e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.30  E-value: 1.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1038 NQIQSMDDVDDLTqssetasedcELphssYKNFML-------LIEQLgmecKDSVSLLK-----IQDAALSCERLLELKK 1105
Cdd:COG4913    198 HKTQSFKPIGDLD----------DF----VREYMLeepdtfeAADAL----VEHFDDLEraheaLEDAREQIELLEPIRE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1106 NHcelltVKIKKMEDKVNVLQRELSETKEIKSQLEHQkvEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQY 1185
Cdd:COG4913    260 LA-----ERYAAARERLAELEYLRAALRLWFAQRRLE--LLEAELEELRAELARLEAELERLEARLDALREELDELEAQI 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1186 RK-EVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAqrQLSREQNARMLQDgiltnhlsKQKEIEMAQKKMNSENSH 1264
Cdd:COG4913    333 RGnGGDRLEQLEREIERLERELEERERRRARLEALLAAL--GLPLPASAEEFAA--------LRAEAAALLEALEEELEA 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1265 SHEEEKDLSHKNSMLQEEIAMLRLEIDTIKN------QNQEK-----EKKC---FEDLKI------VKEKNEDLQKTI-- 1322
Cdd:COG4913    403 LEEALAEAEAALRDLRRELRELEAEIASLERrksnipARLLAlrdalAEALgldEAELPFvgelieVRPEEERWRGAIer 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1323 ------------KQNEETLTQTISQYNGRLSVLTaenamlnSKLENEKQSKERLEAEVESYHSRLAAAIHD-RD--QSET 1387
Cdd:COG4913    483 vlggfaltllvpPEHYAAALRWVNRLHLRGRLVY-------ERVRTGLPDPERPRLDPDSLAGKLDFKPHPfRAwlEAEL 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1388 SKR------ELELAFQRAR----DECsrlQDKMNFDVSNLKDNNEILSQQL--FKTESKLNSLEIEfhhtRDALREKtlg 1455
Cdd:COG4913    556 GRRfdyvcvDSPEELRRHPraitRAG---QVKGNGTRHEKDDRRRIRSRYVlgFDNRAKLAALEAE----LAELEEE--- 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1456 LERVQKDLSQTQCQMKEMEQK---------YQNEQVKVnkyigkqESVEERLSQLQSEnmllRQQLDDAHNKadnkektV 1526
Cdd:COG4913    626 LAEAEERLEALEAELDALQERrealqrlaeYSWDEIDV-------ASAEREIAELEAE----LERLDASSDD-------L 687

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1527 INIQDQFHAIVQKLQaESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEaslEV 1606
Cdd:COG4913    688 AALEEQLEELEAELE-ELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGD---AV 763

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 2462517843 1607 TSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1642
Cdd:COG4913    764 ERELRENLEERIDALRARLNRAEEELERAMRAFNRE 799
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 41-209 1.84e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.58  E-value: 1.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   41 HVRDRDLGK-IHKAASAGNVAKVQQILLLRKNgLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMK 119
Cdd:PHA02874   118 NIKDAELKTfLHYAIKKGDLESIKMLFEYGAD-VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  120 AVQCQEEKCATILLEHGADPNLADVHGNTALHYAV-YNEDisvATKLLLYDANIEAKNKDDLTPLLLAVSGK-KQQMVEF 197
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIiHNRS---AIELLINNASINDQDIDGSTPLHHAINPPcDIDIIDI 273

                          170
                   ....*....|..
gi 2462517843  198 LIKKKANVNAVD 209
Cdd:PHA02874   274 LLYHKADISIKD 285
Ank_4 pfam13637
Ankyrin repeats (many copies);
146-199 1.92e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 1.92e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462517843  146 GNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLI 199
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1491-1795 1.92e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 49.63  E-value: 1.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1491 QESVEERLSQLQSENMLLR----QQLDDAHNKADNKEKTVINiqdqfhAIVQKLQAESEKQSLLLE----ERNKELISE- 1561
Cdd:COG3206     80 DSPLETQIEILKSRPVLERvvdkLNLDEDPLGEEASREAAIE------RLRKNLTVEPVKGSNVIEisytSPDPELAAAv 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1562 CNHLKE--RQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEvtsRYR-----INLEDETQDLKKKLGQIRNQLQE 1634
Cdd:COG3206    154 ANALAEayLEQNLELRREEARKALEFLEEQLPELRKELEEAEAALE---EFRqknglVDLSEEAKLLLQQLSELESQLAE 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1635 AQDRHTEAVRCAEKMQDHKQKLEKDNAKLK--VTVKKQMDKIEELQKNLlnANLSE---DEKEQLKKLMELKQSLECNLD 1709
Cdd:COG3206    231 ARAELAEAEARLAALRAQLGSGPDALPELLqsPVIQQLRAQLAELEAEL--AELSArytPNHPDVIALRAQIAALRAQLQ 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1710 QEMKKN-VELEREITGFKNLLKMTRKKLNEYENgefsfhgdlKTSQF-EMDIQINKLKHKAQAAsQENLEQFrennfasM 1787
Cdd:COG3206    309 QEAQRIlASLEAELEALQAREASLQAQLAQLEA---------RLAELpELEAELRRLEREVEVA-RELYESL-------L 371


                   ....*...
gi 2462517843 1788 KSQMELRI 1795
Cdd:COG3206    372 QRLEEARL 379
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 51-179 2.03e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 2.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   51 HKAASAGNVAKvqQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLlvdrkcqlnvcdnenrtalmkavqcqeekcat 130
Cdd:PTZ00322    88 QLAASGDAVGA--RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRV-------------------------------- 133

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462517843  131 iLLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY---DANIEAKNKDD 179
Cdd:PTZ00322   134 -LLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHsqcHFELGANAKPD 184
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1250-1867 2.71e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 49.35  E-value: 2.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1250 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTI------KNQNQEKEKKCFE----DLKIVKEKNEDLQ 1319
Cdd:pfam15921   86 QVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMadirrrESQSQEDLRNQLQntvhELEAAKCLKEDML 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1320 KTIKQNEETLTQTISQYNGRL----SVLT-----------AENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD-RD 1383
Cdd:pfam15921  166 EDSNTQIEQLRKMMLSHEGVLqeirSILVdfeeasgkkiyEHDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPvED 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1384 QSETSKRE----LELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLnslEIEFHHTRDALREKTLGLERV 1459
Cdd:pfam15921  246 QLEALKSEsqnkIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQL---EIIQEQARNQNSMYMRQLSDL 322

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1460 QKDLSQTQCQMKEMEQKYqneqvkvnkyigkqesvEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK 1539
Cdd:pfam15921  323 ESTVSQLRSELREAKRMY-----------------EDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLAD 385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1540 LQaESEKQSLLLEERNKELISE-------CNHLKeRQYQYENEKAER-EVVVRQLQQELADTLKKQSMS----EASLEVT 1607
Cdd:pfam15921  386 LH-KREKELSLEKEQNKRLWDRdtgnsitIDHLR-RELDDRNMEVQRlEALLKAMKSECQGQMERQMAAiqgkNESLEKV 463

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1608 SRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKnllnanlS 1687
Cdd:pfam15921  464 SSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQH-------L 536

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1688 EDEKEQLKKLMELKQSLECNLdQEMKKNVELEREitGFKNLLKMTRKklneyengefsfHGDLKTSqfemdIQInklkHK 1767
Cdd:pfam15921  537 KNEGDHLRNVQTECEALKLQM-AEKDKVIEILRQ--QIENMTQLVGQ------------HGRTAGA-----MQV----EK 592

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1768 AQAASQENLEQFRENNFASMKSQMELRIKDLESELSkiktsqedfnktelekykQLYLEELKVRKSLSSKLTKTNErLAE 1847
Cdd:pfam15921  593 AQLEKEINDRRLELQEFKILKDKKDAKIRELEARVS------------------DLELEKVKLVNAGSERLRAVKD-IKQ 653

                          650       660
                   ....*....|....*....|
gi 2462517843 1848 VNTKLLVEKQQSRSLFTTLT 1867
Cdd:pfam15921  654 ERDQLLNEVKTSRNELNSLS 673
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1089-1633 3.35e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 48.95  E-value: 3.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1089 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEhQKVEWERElcslrfSLNQEEEKRRNAD 1168
Cdd:pfam05483  223 KIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLE-EKTKLQDE------NLKELIEKKDHLT 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1169 TLYEKIREQLRRKEEqyrkevevkqqlelSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNAR-MLQDGILTNHLSK 1247
Cdd:pfam05483  296 KELEDIKMSLQRSMS--------------TQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHsFVVTEFEATTCSL 361

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1248 QKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAML---RLEIDTIKNQNQEKEKKCFEdlkivKEKNEDLQKTIKQ 1324
Cdd:pfam05483  362 EELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKnnkEVELEELKKILAEDEKLLDE-----KKQFEKIAEELKG 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1325 NEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELelaFQRARDECS 1404
Cdd:pfam05483  437 KEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKEL---TQEASDMTL 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1405 RLQDKMNfDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREK----TLGLERVQKDLSQTQCQMKEMEQKYQNE 1480
Cdd:pfam05483  514 ELKKHQE-DIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKgdevKCKLDKSEENARSIEYEVLKKEKQMKIL 592

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1481 QVKVNKYIGKQESVEERLSQLQSENMLLR-------QQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAE------SEKQ 1547
Cdd:pfam05483  593 ENKCNNLKKQIENKNKNIEELHQENKALKkkgsaenKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEiedkkiSEEK 672

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1548 SLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASL-----EVTSRYRINLEDETQDLK 1622
Cdd:pfam05483  673 LLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLyknkeQEQSSAKAALEIELSNIK 752

                          570
                   ....*....|.
gi 2462517843 1623 KKLGQIRNQLQ 1633
Cdd:pfam05483  753 AELLSLKKQLE 763
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1089-1370 3.83e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.90  E-value: 3.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1089 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAD 1168
Cdd:TIGR02168  716 QLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLK 795

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1169 TLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR--------EQNARMLQDGI 1240
Cdd:TIGR02168  796 EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlaaeieelEELIEELESEL 875

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1241 ltNHLSKQK------------EIEMAQKKMNSENSHSHEEEKDLSHKNSML---QEEIAMLRLEIDTIKNQNQEKEKKCF 1305
Cdd:TIGR02168  876 --EALLNERasleealallrsELEELSEELRELESKRSELRRELEELREKLaqlELRLEGLEVRIDNLQERLSEEYSLTL 953

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517843 1306 EDLKIVKEKNEDLQKTIKQNEETLTQTI--------------SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVES 1370
Cdd:TIGR02168  954 EEAEALENKIEDDEEEARRRLKRLENKIkelgpvnlaaieeyEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARE 1032
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1072-1553 3.86e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.61  E-value: 3.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1072 LLIEQLGmecKDSVSLLKIQDaalsceRLLELKKNHCELLTVKIKKMEDKvnvlQRELSETKEIKSQLEHQKVEWERELC 1151
Cdd:COG4717     46 MLLERLE---KEADELFKPQG------RKPELNLKELKELEEELKEAEEK----EEEYAELQEELEELEEELEELEAELE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1152 SLRFSLNQEEEKRRNADTL--YEKIREQLRRKEEQYRkevEVKQQLElSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR 1229
Cdd:COG4717    113 ELREELEKLEKLLQLLPLYqeLEALEAELAELPERLE---ELEERLE-ELRELEEELEELEAELAELQEELEELLEQLSL 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1230 EQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEE------------IAMLRLEIDTIKNQN 1297
Cdd:COG4717    189 ATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALeerlkearllllIAAALLALLGLGGSL 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1298 QEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAA 1377
Cdd:COG4717    269 LSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEE 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1378 AIHDRDQSETSKRELELafQRARDECSRLQDKmnFDVSNLKDNNEILSQ--QLFKTESKLNSLEIEFHHTRDALRE--KT 1453
Cdd:COG4717    349 LQELLREAEELEEELQL--EELEQEIAALLAE--AGVEDEEELRAALEQaeEYQELKEELEELEEQLEELLGELEEllEA 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1454 LGLERVQKDLSQTQCQMKEMEQKYQNEQvkvnkyiGKQESVEERLSQLQSENML--LRQQLDDAHNKADNKEKTVINIQD 1531
Cdd:COG4717    425 LDEEELEEELEELEEELEELEEELEELR-------EELAELEAELEQLEEDGELaeLLQELEELKAELRELAEEWAALKL 497

                          490       500
                   ....*....|....*....|...
gi 2462517843 1532 QFHAIVQKLQ-AESEKQSLLLEE 1553
Cdd:COG4717    498 ALELLEEAREeYREERLPPVLER 520
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1175-1806 4.84e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 48.66  E-value: 4.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1175 REQLRRKEE---------QYRKEVEVKQQLELSLQTLEMELRTvksnlnqvvqerndaqrqlSREQNARMLQDGILTNHL 1245
Cdd:pfam10174   43 KERALRKEEaarisvlkeQYRVTQEENQHLQLTIQALQDELRA-------------------QRDLNQLLQQDFTTSPVD 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1246 SKQKEiemAQKKMNSEN-SHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNedLQKTIKQ 1324
Cdd:pfam10174  104 GEDKF---STPELTEENfRRLQSEHERQAKELFLLRKTLEEMELRIETQKQTLGARDESIKKLLEMLQSKG--LPKKSGE 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1325 NEETLTQTISQYNGRLS---VLTAENAMLNSKLENEKQSKERLE---AEVESYHSRLAAAIHDRDQSETSKRELELAFQr 1398
Cdd:pfam10174  179 EDWERTRRIAEAEMQLGhleVLLDQKEKENIHLREELHRRNQLQpdpAKTKALQTVIEMKDTKISSLERNIRDLEDEVQ- 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1399 ardecsrlQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIefhhtrdalrektlglERVQKDLSQTQCQMKEMEQKYQ 1478
Cdd:pfam10174  258 --------MLKTNGLLHTEDREEEIKQMEVYKSHSKFMKNKI----------------DQLKQELSKKESELLALQTKLE 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1479 ---NEQVKVNKYIGK-QESV---EERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQ----FHAI----------- 1536
Cdd:pfam10174  314 tltNQNSDCKQHIEVlKESLtakEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEkstlAGEIrdlkdmldvke 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1537 --VQKLQAESEKQSLLLEERNKELISecnhLKERQYQYENEKAEREVVVRQLQQELADtlkKQSMSEASLEVTSRYRINL 1614
Cdd:pfam10174  394 rkINVLQKKIENLQEQLRDKDKQLAG----LKERVKSLQTDSSNTDTALTTLEEALSE---KERIIERLKEQREREDRER 466

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1615 EDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAK-------LKVTVKKQMDKIEELQKNLLNANLS 1687
Cdd:pfam10174  467 LEELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKkdsklksLEIAVEQKKEECSKLENQLKKAHNA 546

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1688 EDEK----EQLKKLMELKQSLECNLDQEMKKNVELEREITGFK---NLLKMTRKKLNEYENGEFSFHGDlktsQFEMDIQ 1760
Cdd:pfam10174  547 EEAVrtnpEINDRIRLLEQEVARYKEESGKAQAEVERLLGILReveNEKNDKDKKIAELESLTLRQMKE----QNKKVAN 622

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*.
gi 2462517843 1761 INKLKHKAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIK 1806
Cdd:pfam10174  623 IKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQLEELMGALEKTR 668
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1116-1540 4.97e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 48.53  E-value: 4.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1116 KKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAdtlyEKIREQLRRKEEQYRKEVEvkqQL 1195
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEI----EKEIEQLEQEEEKLKERLE---EL 742

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1196 ELSLQTLEmelrtvksnlnqvvQERNDAQRQLsrEQNARMLQDgiltnhlsKQKEIEMAQKKMNS-ENSHSHEEEKDLSH 1274
Cdd:TIGR02169  743 EEDLSSLE--------------QEIENVKSEL--KELEARIEE--------LEEDLHKLEEALNDlEARLSHSRIPEIQA 798

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1275 KNSMLQEEIAMLRLEIDTI-KNQNQEKEKKCFEDLKI--VKEKNEDLQKTIKQNEETLtqtisqyngrlsvltaenAMLN 1351
Cdd:TIGR02169  799 ELSKLEEEVSRIEARLREIeQKLNRLTLEKEYLEKEIqeLQEQRIDLKEQIKSIEKEI------------------ENLN 860

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1352 SKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELelafQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKT 1431
Cdd:TIGR02169  861 GKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLREL----ERKIEELEAQIEKKRKRLSELKAKLEALEEELSEI 936

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1432 ESKLNSLEIEfhhtrdalREKTLGLERVQKDLSQTQCQMKEMEQkyqneqvkVN-KYIGKQESVEERLSQLQSENMLL-- 1508
Cdd:TIGR02169  937 EDPKGEDEEI--------PEEELSLEDVQAELQRVEEEIRALEP--------VNmLAIQEYEEVLKRLDELKEKRAKLee 1000

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 2462517843 1509 -RQQLDDAHNKADNKEKTV-----INIQDQFHAIVQKL 1540
Cdd:TIGR02169 1001 eRKAILERIEEYEKKKREVfmeafEAINENFNEIFAEL 1038
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1086-1697 5.00e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 48.43  E-value: 5.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1086 SLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKsQLEHQKVEWERELCSLRFSLNQEEEKRR 1165
Cdd:TIGR00618  332 AHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIH-TLQQQKTTLTQKLQSLCKELDILQREQA 410

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1166 NADTlyekirEQLRRKEEQYRKeVEVKQQLELSLQTLEMeLRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHL 1245
Cdd:TIGR00618  411 TIDT------RTSAFRDLQGQL-AHAKKQQELQQRYAEL-CAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIH 482

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1246 SKQKEI-EMAQKKMNSENSHSHEEEKDLSHKNSMLQEEI-------AMLRLEIDTIKNQNQEK--EKKCFEDLKIVKEKN 1315
Cdd:TIGR00618  483 LQETRKkAVVLARLLELQEEPCPLCGSCIHPNPARQDIDnpgpltrRMQRGEQTYAQLETSEEdvYHQLTSERKQRASLK 562

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1316 EDLQKtIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSET----SKRE 1391
Cdd:TIGR00618  563 EQMQE-IQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHlqqcSQEL 641

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1392 LELAFQRARDECSRLQDKMNFDVSNLKDnneilsQQLFKTESKLNSLeiefhhtrDALREKTLGLERVQKDLSQTQCQMK 1471
Cdd:TIGR00618  642 ALKLTALHALQLTLTQERVREHALSIRV------LPKELLASRQLAL--------QKMQSEKEQLTYWKEMLAQCQTLLR 707

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1472 EMEQKYQNEQVKVNKYigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQ-FHAIVQKLQAESEKQSLL 1550
Cdd:TIGR00618  708 ELETHIEEYDREFNEI---ENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNnNEEVTAALQTGAELSHLA 784

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1551 --LEERNKELISECNHLKERQYQYENEKAE----REVVVRQLQQELADTLKKqsmseaslevtsryrinLEDETQdlkkK 1624
Cdd:TIGR00618  785 aeIQFFNRLREEDTHLLKTLEAEIGQEIPSdediLNLQCETLVQEEEQFLSR-----------------LEEKSA----T 843

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517843 1625 LGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKL 1697
Cdd:TIGR00618  844 LGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQIKIQFDGDALIKFLHEITLYANVRLANQSEGRF 916
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1362-1847 5.61e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 48.50  E-value: 5.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1362 ERLEAEVESYHSRLAAAIHDRDQSETSKR--ELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTEsKLNSLE 1439
Cdd:PRK02224   179 ERVLSDQRGSLDQLKAQIEEKEEKDLHERlnGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERRE-ELETLE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1440 IEFhhtrDALREKTLGLERVQKDLSQT----QCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1515
Cdd:PRK02224   258 AEI----EDLRETIAETEREREELAEEvrdlRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEEC 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1516 HNKADNKEKtviniqdqfhaivqklQAESEKQSLL-LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTL 1594
Cdd:PRK02224   334 RVAAQAHNE----------------EAESLREDADdLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELR 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1595 KKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVR------CAEKMQDHKQKLEKDnaklkvTVK 1668
Cdd:PRK02224   398 ERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEAlleagkCPECGQPVEGSPHVE------TIE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1669 KQMDKIEELqknllnanlsEDEKEQLK-KLMELKQSLEcnldqEMKKNVELEREITGFKNLLKMTRKKLNEYENGEfsfh 1747
Cdd:PRK02224   472 EDRERVEEL----------EAELEDLEeEVEEVEERLE-----RAEDLVEAEDRIERLEERREDLEELIAERRETI---- 532

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1748 gDLKTSQFEmdiQINKLKHKAQAASQENLEQFRENNFASMKSQMElrIKDLESELSKIKTSQEDFNK-----TELEKYKQ 1822
Cdd:PRK02224   533 -EEKRERAE---ELRERAAELEAEAEEKREAAAEAEEEAEEAREE--VAELNSKLAELKERIESLERirtllAAIADAED 606

                          490       500
                   ....*....|....*....|....*.
gi 2462517843 1823 lYLEELK-VRKSLSSKLTKTNERLAE 1847
Cdd:PRK02224   607 -EIERLReKREALAELNDERRERLAE 631
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1584-1804 5.93e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 5.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1584 RQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKL 1663
Cdd:COG4942     23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1664 KVTVKKQMDKIEEL-QKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENG 1742
Cdd:COG4942    103 KEELAELLRALYRLgRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAE 182

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462517843 1743 EFSFHGDLKTSQFEMDIQINKLKHKAQAASQEnLEQFRENnfasmKSQMELRIKDLESELSK 1804
Cdd:COG4942    183 LEEERAALEALKAERQKLLARLEKELAELAAE-LAELQQE-----AEELEALIARLEAEAAA 238
PRK11281 PRK11281
mechanosensitive channel MscK;
1311-1515 6.07e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 48.37  E-value: 6.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1311 VKEKNEDLQKTIKQneetLTQTISQYNGRLSVLTAEN-------------AMLNSKLENEKQSKERLEAEVESYHSRLAA 1377
Cdd:PRK11281    78 QKEETEQLKQQLAQ----APAKLRQAQAELEALKDDNdeetretlstlslRQLESRLAQTLDQLQNAQNDLAEYNSQLVS 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1378 AihdRDQSETSKRELELAFQRArdecsrlqDKMNFDVSNLKDNNEILS---QQLFKTESKLNSLEIEFHHT--------- 1445
Cdd:PRK11281   154 L---QTQPERAQAALYANSQRL--------QQIRNLLKGGKVGGKALRpsqRVLLQAEQALLNAQNDLQRKslegntqlq 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1446 ------RDALREKTLGLERV---------QKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQ---------- 1500
Cdd:PRK11281   223 dllqkqRDYLTARIQRLEHQlqllqeainSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQrllkatekln 302

                          250
                   ....*....|....*.
gi 2462517843 1501 -LQSENMLLRQQLDDA 1515
Cdd:PRK11281   303 tLTQQNLRVKNWLDRL 318
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1096-1703 7.26e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 47.89  E-value: 7.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1096 SCERLLELKknHCELLTvkiKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRfslnqEEEKRRNADTlyekir 1175
Cdd:pfam10174  159 SIKKLLEML--QSKGLP---KKSGEEDWERTRRIAEAEMQLGHLEVLLDQKEKENIHLR-----EELHRRNQLQ------ 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1176 eQLRRKEEQYRKEVEVKQ----QLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSreqnarmlqdgILTNHlSKQKEI 1251
Cdd:pfam10174  223 -PDPAKTKALQTVIEMKDtkisSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQME-----------VYKSH-SKFMKN 289

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1252 EMAQKKmnsenshsheeeKDLSHKNSmlqeEIAMLRLEIDTIKNQNQEKekkcfedlkivkeknedlqktiKQNEETLTQ 1331
Cdd:pfam10174  290 KIDQLK------------QELSKKES----ELLALQTKLETLTNQNSDC----------------------KQHIEVLKE 331

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1332 TISQYNGRLSVLTAENAMLNSKLEnEKQS----KERLEAEVESYHSRLAAAIHD-RDQSETSKRELELAFQRARDECSRL 1406
Cdd:pfam10174  332 SLTAKEQRAAILQTEVDALRLRLE-EKESflnkKTKQLQDLTEEKSTLAGEIRDlKDMLDVKERKINVLQKKIENLQEQL 410

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1407 QDKmNFDVSNLKDNNEILSQQLFKTESKLNSLEiefhhtrDALREKTLGLERVQKDLSQTQCQMKE----MEQKYQNEQV 1482
Cdd:pfam10174  411 RDK-DKQLAGLKERVKSLQTDSSNTDTALTTLE-------EALSEKERIIERLKEQREREDRERLEelesLKKENKDLKE 482

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1483 KVNKYIGKQESVEERLSQLQSENmllrQQLDDAHNKADNKEKTV-INIQDQFHAiVQKLQAESEK-QSLLLEERNKELIS 1560
Cdd:pfam10174  483 KVSALQPELTEKESSLIDLKEHA----SSLASSGLKKDSKLKSLeIAVEQKKEE-CSKLENQLKKaHNAEEAVRTNPEIN 557

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1561 ECNHLKERQYQY---ENEKAEREV-----VVRQLQQELADTLKK----QSMSEASLEVTSRYRINLEDETQDLKKKLGQi 1628
Cdd:pfam10174  558 DRIRLLEQEVARykeESGKAQAEVerllgILREVENEKNDKDKKiaelESLTLRQMKEQNKKVANIKHGQQEMKKKGAQ- 636

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1629 rnQLQEAQDRHTEAVRCAEKMQ---------DHKQKLEKDNAKLKVTV-----------------KKQMDKIEELQKNLL 1682
Cdd:pfam10174  637 --LLEEARRREDNLADNSQQLQleelmgaleKTRQELDATKARLSSTQqslaekdghltnlraerRKQLEEILEMKQEAL 714

                          650       660
                   ....*....|....*....|.
gi 2462517843 1683 NANLSedEKEQLKKLMELKQS 1703
Cdd:pfam10174  715 LAAIS--EKDANIALLELSSS 733
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1098-1546 7.62e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 47.75  E-value: 7.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1098 ERLLELKKNHCELltVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQ 1177
Cdd:PRK03918   273 KEIEELEEKVKEL--KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKEL 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1178 LRRKEEqyrkevevkqqLELSLQTLEmELRTVKSNLNQVVQERNDaqrqLSREQNARMLQDgiltnhLSKQK-EIEMAQK 1256
Cdd:PRK03918   351 EKRLEE-----------LEERHELYE-EAKAKKEELERLKKRLTG----LTPEKLEKELEE------LEKAKeEIEEEIS 408

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1257 KMNSENSHSHEEEKDLSHKNSMLQ-------------------EEIAMLRLEIDTIKNQNQEKEKKcFEDLKIVKEKNED 1317
Cdd:PRK03918   409 KITARIGELKKEIKELKKAIEELKkakgkcpvcgrelteehrkELLEEYTAELKRIEKELKEIEEK-ERKLRKELRELEK 487

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1318 L---QKTIKQNEETLTQtISQYNGRLSVLTAENamLNSKLENEKQSKERLeAEVESYHSRLAAAIHDRDQSETSKRELEL 1394
Cdd:PRK03918   488 VlkkESELIKLKELAEQ-LKELEEKLKKYNLEE--LEKKAEEYEKLKEKL-IKLKGEIKSLKKELEKLEELKKKLAELEK 563

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1395 AFQRARDECSRLQDKM-NFDVSNLKDNNEILSQ---------QLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLS 1464
Cdd:PRK03918   564 KLDELEEELAELLKELeELGFESVEELEERLKElepfyneylELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLE 643

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1465 QTQCQMKEMEQKYQNEqvkvnkyigKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIvQKLQAES 1544
Cdd:PRK03918   644 ELRKELEELEKKYSEE---------EYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER-EKAKKEL 713


                   ..
gi 2462517843 1545 EK 1546
Cdd:PRK03918   714 EK 715
PTZ00121 PTZ00121
MAEBL; Provisional
 1099-1819 9.58e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.83  E-value: 9.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1099 RLLELKKNHCELLTVKIKKMEDkVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLY---EKIR 1175
Cdd:PTZ00121  1213 KAEEARKAEDAKKAEAVKKAEE-AKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKkaeEKKK 1291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1176 EQLRRKEEQYRKEVEVKQQLElslqtlemELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQ 1255
Cdd:PTZ00121  1292 ADEAKKAEEKKKADEAKKKAE--------EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAE 1363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1256 KKMNSENSHSHEEEKDLSHKNSMLQEeiamlRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTIKQNEEtltqtisq 1335
Cdd:PTZ00121  1364 EKAEAAEKKKEEAKKKADAAKKKAEE-----KKKADEAKKKAEEDKKKA-DELKKAAAAKKKADEAKKKAEE-------- 1429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1336 yngrlsVLTAENAmlNSKLENEKQSKE-RLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDV 1414
Cdd:PTZ00121  1430 ------KKKADEA--KKKAEEAKKADEaKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADE 1501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1415 SNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKV---NKYIGKQ 1491
Cdd:PTZ00121  1502 AKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKaeeDKNMALR 1581

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1492 ESVEERLSQLQSENMLLRQQLDDAHNKADNKEKtviniqdqfhAIVQKLQAESEKQSLllEERNKELISECNHLKERQYQ 1571
Cdd:PTZ00121  1582 KAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKK----------AEEAKIKAEELKKAE--EEKKKVEQLKKKEAEEKKKA 1649

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1572 YENEKAEREVVVRQLQQELADTLKKQSMSEA-SLEVTSRYRINLEDETQDLKKKLGQIRNQLQEaQDRHTEAVRCAEKMQ 1650
Cdd:PTZ00121  1650 EELKKAEEENKIKAAEEAKKAEEDKKKAEEAkKAEEDEKKAAEALKKEAEEAKKAEELKKKEAE-EKKKAEELKKAEEEN 1728

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1651 DHKQKLEKDNAKlKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQE-MKKNVELEREI----TGF 1725
Cdd:PTZ00121  1729 KIKAEEAKKEAE-EDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEdEKRRMEVDKKIkdifDNF 1807

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1726 KNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKI 1805
Cdd:PTZ00121  1808 ANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEA 1887

                          730
                   ....*....|....
gi 2462517843 1806 KTSqEDFNKTELEK 1819
Cdd:PTZ00121  1888 DEI-EKIDKDDIER 1900
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1129-1860 1.09e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 47.35  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1129 LSETKEIKSQLEH-----QKVEWERELCSLRFSLNQEEEKRRNADTLYEK-------IREQLRRKEEQYRKEVEVKQQLE 1196
Cdd:TIGR00606  165 LSEGKALKQKFDEifsatRYIKALETLRQVRQTQGQKVQEHQMELKYLKQykekaceIRDQITSKEAQLESSREIVKSYE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1197 LSLQTLEMELRTVKSNLNQVVQERND----AQRQLSREQNARMLQ--------------DGILTNHLSKQKEIEMAQKKM 1258
Cdd:TIGR00606  245 NELDPLKNRLKEIEHNLSKIMKLDNEikalKSRKKQMEKDNSELElkmekvfqgtdeqlNDLYHNHQRTVREKERELVDC 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1259 NSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEK----------------EKKCFEDLKI------VKEKNE 1316
Cdd:TIGR00606  325 QRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARdsliqslatrleldgfERGPFSERQIknfhtlVIERQE 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1317 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEkqsKERLEAEVEsyhsRLAAAIHDRDQSETSKR---ELE 1393
Cdd:TIGR00606  405 DEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELK---KEILEKKQE----ELKFVIKELQQLEGSSDrilELD 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1394 LAFQRARDECSRLQDKMNfdvsnlkdnneilSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEM 1473
Cdd:TIGR00606  478 QELRKAERELSKAEKNSL-------------TETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDK 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1474 EQKYQneQVKVNKYIGKQESVEerlsqlQSENMLLRQQLDDAHNKADNKektvINIQDQFHAIVQKLQAESEKQSLLLEE 1553
Cdd:TIGR00606  545 MDKDE--QIRKIKSRHSDELTS------LLGYFPNKKQLEDWLHSKSKE----INQTRDRLAKLNKELASLEQNKNHINN 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1554 RNKELISECNHLKERQYQYENEKAErEVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQD---LKKKLGQIRN 1630
Cdd:TIGR00606  613 ELESKEEQLSSYEDKLFDVCGSQDE-ESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSccpVCQRVFQTEA 691

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1631 QLQEAQDRHTEAVRCA----EKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNL-----LNANLSEDEKEqLKKLMELK 1701
Cdd:TIGR00606  692 ELQEFISDLQSKLRLApdklKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIpelrnKLQKVNRDIQR-LKNDIEEQ 770

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1702 QSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHG-DLKTSQFEMDIQINKLKHKAQAASQE-----N 1775
Cdd:TIGR00606  771 ETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGsDLDRTVQQVNQEKQEKQHELDTVVSKielnrK 850

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1776 LEQFRENNFASMKSQM-ELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLV 1854
Cdd:TIGR00606  851 LIQDQQEQIQHLKSKTnELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELIS 930


                   ....*.
gi 2462517843 1855 EKQQSR 1860
Cdd:TIGR00606  931 SKETSN 936
Ank_5 pfam13857
Ankyrin repeats (many copies);
98-153 1.09e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 1.09e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517843   98 LLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYA 153
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1552-1860 1.12e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 47.37  E-value: 1.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1552 EERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ 1631
Cdd:PRK03918   164 YKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEEL 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1632 LQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVtVKKQMDKIEELQ-KNLLNANLSEDEKEQLKKLMELKQSLEC---- 1706
Cdd:PRK03918   244 EKELESLEGSKRKLEEKIRELEERIEELKKEIEE-LEEKVKELKELKeKAEEYIKLSEFYEEYLDELREIEKRLSRleee 322

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1707 --NLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHgDLKTSQFEMD--------IQINKLKHKAQAASQENL 1776
Cdd:PRK03918   323 inGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYE-EAKAKKEELErlkkrltgLTPEKLEKELEELEKAKE 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1777 EQFRE-NNFASMKSQMELRIKDLESELSKIKTSQ-----------EDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNER 1844
Cdd:PRK03918   402 EIEEEiSKITARIGELKKEIKELKKAIEELKKAKgkcpvcgreltEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKE 481

                          330
                   ....*....|....*.
gi 2462517843 1845 LAEVNTKLLVEKQQSR 1860
Cdd:PRK03918   482 LRELEKVLKKESELIK 497
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1114-1473 1.20e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.22  E-value: 1.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1114 KIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTlyekiREQLRRKEEQYRkevevkq 1193
Cdd:COG4913    611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASA-----EREIAELEAELE------- 678

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1194 QLELS---LQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARmlqdgiltnhlsKQKEIEMAQKKMNSENSHSHEEEK 1270
Cdd:COG4913    679 RLDASsddLAALEEQLEELEAELEELEEELDELKGEIGRLEKEL------------EQAEEELDELQDRLEAAEDLARLE 746

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1271 DLSHKNSMLQEEIAmlrleidtiknqnQEKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAE---- 1346
Cdd:COG4913    747 LRALLEERFAAALG-------------DAVERELRENL---EERIDALRARLNRAEEELERAMRAFNREWPAETADldad 810

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1347 -------NAMLNsKLENekqskERLEAevesYHSRLAAAIHdrDQSETSKRELELAFQRARDECSRlqdkmnfdvsNLKD 1419
Cdd:COG4913    811 leslpeyLALLD-RLEE-----DGLPE----YEERFKELLN--ENSIEFVADLLSKLRRAIREIKE----------RIDP 868

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462517843 1420 NNEILSQQLFKTESKLnSLEI------EFHHTRDALREKTLGLERVQKDLSQTQC-QMKEM 1473
Cdd:COG4913    869 LNDSLKRIPFGPGRYL-RLEArprpdpEVREFRQELRAVTSGASLFDEELSEARFaALKRL 928
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1404-1867 1.82e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 46.68  E-value: 1.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1404 SRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEI---EFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNE 1480
Cdd:COG4717     49 ERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEkeeEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLL 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1481 QvkvnkYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEktviNIQDQFHAIVQKLQAESEKQSLLLEERNKELIS 1560
Cdd:COG4717    129 P-----LYQELEALEAELAELPERLEELEERLEELRELEEELE----ELEAELAELQEELEELLEQLSLATEEELQDLAE 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1561 ECNHLKERQYQYENEKAEREVVVRQLQQELaDTLKKQSMSEASLEVTSRYRINLEDET---------------------- 1618
Cdd:COG4717    200 ELEELQQRLAELEEELEEAQEELEELEEEL-EQLENELEAAALEERLKEARLLLLIAAallallglggsllsliltiagv 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1619 ------------QDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKnlLNANL 1686
Cdd:COG4717    279 lflvlgllallfLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQE--LLREA 356

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1687 SEDEKE-QLKKLMELKQSL----ECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSqfEMDIQI 1761
Cdd:COG4717    357 EELEEElQLEELEQEIAALlaeaGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEE--ELEEEL 434

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1762 NKLKHKAQAASQEnLEQFRENnfasmKSQMELRIKDLES--ELSKIKTSQEdfnkTELEKYKQLyLEELKVRKSLSSKLT 1839
Cdd:COG4717    435 EELEEELEELEEE-LEELREE-----LAELEAELEQLEEdgELAELLQELE----ELKAELREL-AEEWAALKLALELLE 503

                          490       500       510
                   ....*....|....*....|....*....|...
gi 2462517843 1840 KT-----NERLAEVNtkllvekQQSRSLFTTLT 1867
Cdd:COG4717    504 EAreeyrEERLPPVL-------ERASEYFSRLT 529
PRK12704 PRK12704
phosphodiesterase; Provisional
 1571-1699 1.83e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 46.31  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1571 QYENEKAEREVVVRQLQQElADTLKKQSMSEASLEVtSRYRINLEDETQDLKKKLGQIRNQLQ---EAQDRHTEAVrcaE 1647
Cdd:PRK12704    32 KIKEAEEEAKRILEEAKKE-AEAIKKEALLEAKEEI-HKLRNEFEKELRERRNELQKLEKRLLqkeENLDRKLELL---E 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462517843 1648 KMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLN-----ANLSEDE-KEQLKKLME 1699
Cdd:PRK12704   107 KREEELEKKEKELEQKQQELEKKEEELEELIEEQLQeleriSGLTAEEaKEILLEKVE 164
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 81-111 1.87e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 1.87e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462517843   81 RTALHLACA-NGHPEVVTLLVDRKCQLNVCDN 111
Cdd:pfam00023    3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
Rabaptin pfam03528
Rabaptin;
1492-1845 1.93e-04

Rabaptin;


Pssm-ID: 367545 [Multi-domain]  Cd Length: 486  Bit Score: 46.25  E-value: 1.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1492 ESVEERLSQLQSEN---MLLRQQLDDAHNKADNKektviniqdqFHAIVQKLQAESEKQSLLLEERNKELISECNHLKER 1568
Cdd:pfam03528    4 EDLQQRVAELEKENaefYRLKQQLEAEFNQKRAK----------FKELYLAKEEDLKRQNAVLQEAQVELDALQNQLALA 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1569 QYQYENEKAeREVVVRQLQQELADTLKKQ----------SMSEASLEVTSRYRINLEDE-------TQDLKKKLGQIRNQ 1631
Cdd:pfam03528   74 RAEMENIKA-VATVSENTKQEAIDEVKSQwqeevaslqaIMKETVREYEVQFHRRLEQEraqwnqyRESAEREIADLRRR 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1632 LQEAQDRhteavrcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEKEQLK--KLMELKQSLE---- 1705
Cdd:pfam03528  153 LSEGQEE--------ENLEDEMKKAQEDAEKLRSVVMPMEKEIAALKAKLTEA---EDKIKELEasKMKELNHYLEaeks 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1706 CNLDQEMKKNVelereITGFKNLLKMTRKKLNEyengefSFHGDLKTSQFEMDiQINKLKHKAQAASQENLEQFR--ENN 1783
Cdd:pfam03528  222 CRTDLEMYVAV-----LNTQKSVLQEDAEKLRK------ELHEVCHLLEQERQ-QHNQLKHTWQKANDQFLESQRllMRD 289

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462517843 1784 FASMKSQM---------ELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERL 1845
Cdd:pfam03528  290 MQRMESVLtseqlrqveEIKKKDQEEHKRARTHKEKETLKSDREHTVSIHAVFSPAGVETSAPLSNVEEQI 360
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 81-202 2.22e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 46.03  E-value: 2.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   81 RTALHLACANGHPEVVTLLVDRKC--QLNVCDNENRTA-----------LMKAVQCQEEKCATILLEHGADP---NLADV 144
Cdd:cd21882     74 QTALHIAIENRNLNLVRLLVENGAdvSARATGRFFRKSpgnlfyfgelpLSLAACTNQEEIVRLLLENGAQPaalEAQDS 153

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517843  145 HGNTALHYAVYNED---------ISVATKLLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd21882    154 LGNTVLHALVLQADntpensafvCQMYNLLLSYGAHLdptqqleEIPNHQGLTPLKLAAVEGKIVMFQHILQRE 227
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1474-1693 2.60e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 2.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1474 EQKYQNEQVKVNKYIGKQESVEERLSQLQsenmllrQQLDDAHNKADNKEKTVINIQDQfhaiVQKLQAESEKQSLLLEE 1553
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQ-------AELEELNEEYNELQAELEALQAE----IDKLQAEIAEAEAEIEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1554 RNKELisecnhlKER-QYQYENEKA-----------------EREVVVRQLQQELADTLKKQSMSEASLEvtsRYRINLE 1615
Cdd:COG3883     84 RREEL-------GERaRALYRSGGSvsyldvllgsesfsdflDRLSALSKIADADADLLEELKADKAELE---AKKAELE 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462517843 1616 DETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQ 1693
Cdd:COG3883    154 AKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1266-1815 3.26e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 3.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1266 HEEEKDLSHKNSMLQEEIAMLRLEIDTIK-NQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNG----RL 1340
Cdd:COG4913    261 AERYAAARERLAELEYLRAALRLWFAQRRlELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGnggdRL 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1341 SVLTAEnamlnskLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDN 1420
Cdd:COG4913    341 EQLERE-------IERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAA 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1421 NEILSQQLFKTESKLNSLE-------IEFHHTRDALREKtLGLERVQ----KDLsqtqCQMKEMEQKYQNeqvKVNKYIG 1489
Cdd:COG4913    414 LRDLRRELRELEAEIASLErrksnipARLLALRDALAEA-LGLDEAElpfvGEL----IEVRPEEERWRG---AIERVLG 485

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1490 KQesveeRLSqlqsenMLLRQQLDDAHNKA--DNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL 1565
Cdd:COG4913    486 GF-----ALT------LLVPPEHYAAALRWvnRLHLRGRLVYERVRTGLPDPERPRLDPDSLAgkLDFKPHPFRAWLEAE 554

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1566 KERQYQYEneKAEREvvvrqlqQELADTlkKQSMSEASL--EVTSRYRINLEDET-------QDLKKKLGQIRNQLQEAQ 1636
Cdd:COG4913    555 LGRRFDYV--CVDSP-------EELRRH--PRAITRAGQvkGNGTRHEKDDRRRIrsryvlgFDNRAKLAALEAELAELE 623

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1637 DRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD---------KIEELQKNLLNANLSEDE----KEQLKKLMELKQS 1703
Cdd:COG4913    624 EELAEAEERLEALEAELDALQERREALQRLAEYSWDeidvasaerEIAELEAELERLDASSDDlaalEEQLEELEAELEE 703

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1704 LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHgdlkTSQFEmdiqinklKHKAQAASQENLEQFREnN 1783
Cdd:COG4913    704 LEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLEL----RALLE--------ERFAAALGDAVERELRE-N 770

                          570       580       590
                   ....*....|....*....|....*....|..
gi 2462517843 1784 FASMKSQMELRIKDLESELSKIktsQEDFNKT 1815
Cdd:COG4913    771 LEERIDALRARLNRAEEELERA---MRAFNRE 799
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1462-1642 3.68e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.21  E-value: 3.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1462 DLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQ 1541
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALY 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1542 AESEKQSLL---------------------LEERNKELISEcnhLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMS 1600
Cdd:COG3883     97 RSGGSVSYLdvllgsesfsdfldrlsalskIADADADLLEE---LKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2462517843 1601 EASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1642
Cdd:COG3883    174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1120-1346 4.73e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 45.43  E-value: 4.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1120 DKVNVLQRELSETKEIKSQLE----HQKV--EWERELCSLRFSLNQEEEKRRNadtlyekIREQLRRKE-EQyrKEVEVK 1192
Cdd:PRK10929    45 EIVEALQSALNWLEERKGSLErakqYQQVidNFPKLSAELRQQLNNERDEPRS-------VPPNMSTDAlEQ--EILQVS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1193 QQL-ELS--LQTLEMELRTVKSNLNQVVQERNDAQRQLSreQNARMLQdgILTNHLSKQKEIEMAQKKMNSENSHSHEEE 1269
Cdd:PRK10929   116 SQLlEKSrqAQQEQDRAREISDSLSQLPQQQTEARRQLN--EIERRLQ--TLGTPNTPLAQAQLTALQAESAALKALVDE 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1270 KDLSHKNSMLQEEIAMLRLEI----------------DTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTI----KQNEEtL 1329
Cdd:PRK10929   192 LELAQLSANNRQELARLRSELakkrsqqldaylqalrNQLNSQRQREAERALESTELLAEQSGDLPKSIvaqfKINRE-L 270

                          250
                   ....*....|....*..
gi 2462517843 1330 TQTISQYNGRLSVLTAE 1346
Cdd:PRK10929   271 SQALNQQAQRMDLIASQ 287
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1280-1504 6.67e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 6.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1280 QEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQKTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQ 1359
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKE----LAALKKEEKALLKQLAA----LERRIAALARRIRALEQELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1360 SKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE 1439
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELE 170

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517843 1440 IEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSE 1504
Cdd:COG4942    171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1401-1568 7.33e-04

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 44.69  E-value: 7.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1401 DE-CSRLqdKMNfdvsnlkdnNEILSQQLFKTESKLNSLEIEfhhtRDAL-REKTLG----LERVQKDLSQTQCQMKEME 1474
Cdd:COG0542    396 DEaAARV--RME---------IDSKPEELDELERRLEQLEIE----KEALkKEQDEAsferLAELRDELAELEEELEALK 460

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1475 QKYQNEQVKVNKYIGKQESVEERLSQLQSenmlLRQQLDDAHNKADNKEKTVINI--QDQFHAIV--------QKLQaES 1544
Cdd:COG0542    461 ARWEAEKELIEEIQELKEELEQRYGKIPE----LEKELAELEEELAELAPLLREEvtEEDIAEVVsrwtgipvGKLL-EG 535

                          170       180
                   ....*....|....*....|....*
gi 2462517843 1545 EKQSLL-LEErnkelisecnHLKER 1568
Cdd:COG0542    536 EREKLLnLEE----------ELHER 550
PRK11281 PRK11281
mechanosensitive channel MscK;
1114-1472 8.16e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.52  E-value: 8.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1114 KIKKMEDKVNVLQRELSETKEIKSQLEHQKveweRELCSLRFSLNQEEEKRRNADTLYEKIREQLrrkeeqyrkEVEVKQ 1193
Cdd:PRK11281    50 KQKLLEAEDKLVQQDLEQTLALLDKIDRQK----EETEQLKQQLAQAPAKLRQAQAELEALKDDN---------DEETRE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1194 QLE-LSLQTLEmelrtvkSNLNQVVQERNDAQRQLSrEQNARMlqdgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKDL 1272
Cdd:PRK11281   117 TLStLSLRQLE-------SRLAQTLDQLQNAQNDLA-EYNSQL---------VSLQTQPERAQAALYANSQRLQQIRNLL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1273 SH----KNSMLQEEIAMLRLEIDTIKNQNqekekkcfedlkivkekneDLQKTIKQNEETLTQTisqYNGRLSVLTAENA 1348
Cdd:PRK11281   180 KGgkvgGKALRPSQRVLLQAEQALLNAQN-------------------DLQRKSLEGNTQLQDL---LQKQRDYLTARIQ 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1349 mlnsklenekqskeRLEAEVESyhsrLAAAIHDR--DQSETSKRELElafqrARDECSRLQDkmNFDVSNLKDNNEILSQ 1426
Cdd:PRK11281   238 --------------RLEHQLQL----LQEAINSKrlTLSEKTVQEAQ-----SQDEAARIQA--NPLVAQELEINLQLSQ 292

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 2462517843 1427 QLFKTESKLNSLeiefhhTRDALREKTLgLERvqkdLSQTQCQMKE 1472
Cdd:PRK11281   293 RLLKATEKLNTL------TQQNLRVKNW-LDR----LTQSERNIKE 327
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 79-108 8.30e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 8.30e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 2462517843    79 MNRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 80-108 8.82e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 8.82e-04
                           10        20
                   ....*....|....*....|....*....
gi 2462517843   80 NRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 1351-1697 1.13e-03

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 43.98  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1351 NSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMnfdVSNLKDNNEILSQQLFK 1430
Cdd:pfam09731  121 KSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKA---TDSALQKAEALAEKLKE 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1431 TESKLNSLEIEfhhtrdALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYigkQESVEErlsqlqsENMLLRQ 1510
Cdd:pfam09731  198 VINLAKQSEEE------AAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQY---KELVAS-------ERIVFQQ 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1511 QLDDAHN------KADNKEKTviniqDQFHAIVQKLQAEsekqsllLEERNKELIsecnHLKERqyqyENEKAEREVVVR 1584
Cdd:pfam09731  262 ELVSIFPdiipvlKEDNLLSN-----DDLNSLIAHAHRE-------IDQLSKKLA----ELKKR----EEKHIERALEKQ 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1585 QLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKL-GQIRNQLQEAQDRHTEAVRCAEK----------MQDHK 1653
Cdd:pfam09731  322 KEELDKLAEELSARLEEVRAADEAQLRLEFEREREEIRESYeEKLRTELERQAEAHEEHLKDVLVeqeielqrefLQDIK 401

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 2462517843 1654 QKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKL 1697
Cdd:pfam09731  402 EKVEEERAGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQL 445
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 1264-1582 1.22e-03

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 43.52  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1264 HSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKivkeKNEDLQKTIKQNEETltqtISQYNGRLSVL 1343
Cdd:pfam19220   45 QAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVA----RLAKLEAALREAEAA----KEELRIELRDK 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1344 TAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQ---DKMNFDVSNLKDN 1420
Cdd:pfam19220  117 TAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQalsEEQAAELAELTRR 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1421 NEILSQQLFKTESKLNSLEIEFHHTRdALREK----------TLGLER----------------VQKDLSQTQCQMKEME 1474
Cdd:pfam19220  197 LAELETQLDATRARLRALEGQLAAEQ-AERERaeaqleeaveAHRAERaslrmklealtaraaaTEQLLAEARNQLRDRD 275

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1475 QKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAH-------------NKA--------DNKEKTVINIQDQf 1533
Cdd:pfam19220  276 EAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQraraeleeraemlTKAlaakdaalERAEERIASLSDR- 354

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 2462517843 1534 haiVQKLQAESEKQSLLLEERNKELISEcnhlkerqyqYENEKAEREVV 1582
Cdd:pfam19220  355 ---IAELTKRFEVERAALEQANRRLKEE----------LQRERAERALA 390
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 145-177 1.35e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 1.35e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462517843  145 HGNTALHYAVYNE-DISVATKLLLYDANIEAKNK 177
Cdd:pfam00023    1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1363-1852 1.37e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.01  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1363 RLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMnfdvsnlkdnneilsqqlfKTESKLNSleiEF 1442
Cdd:pfam01576    2 RQEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQL-------------------QAETELCA---EA 59

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1443 HHTRDALREKTLGLERVqkdlsqtqcqMKEMEQKYQNEqvkvnkyigkqesvEERLSQLQSENMLLRQQLDDAHNKADNK 1522
Cdd:pfam01576   60 EEMRARLAARKQELEEI----------LHELESRLEEE--------------EERSQQLQNEKKKMQQHIQDLEEQLDEE 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1523 EktviniqdqfhAIVQKLQAES----------EKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQ---- 1588
Cdd:pfam01576  116 E-----------AARQKLQLEKvtteakikklEEDILLLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKlknk 184

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1589 ------ELADTLKKQSMSEASLEVTSRyriNLEDETQDLKKKLGQIRNQLQEAQdrhTEAVRCAEKMQDHKQKLEKDNAK 1662
Cdd:pfam01576  185 heamisDLEERLKKEEKGRQELEKAKR---KLEGESTDLQEQIAELQAQIAELR---AQLAKKEEELQAALARLEEETAQ 258

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1663 LKVTVKKQ---MDKIEELQKNLLNANLSEDEKEQLKK-----LMELKQSLECNLD-----QEMKKNVELEreitgfknlL 1729
Cdd:pfam01576  259 KNNALKKIrelEAQISELQEDLESERAARNKAEKQRRdlgeeLEALKTELEDTLDttaaqQELRSKREQE---------V 329

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1730 KMTRKKLNEyengefsfhgdlKTSQFEMDIQINKLKHKAQAAS-QENLEQFREN--NFASMKSQMELRIKDLESELSKIK 1806
Cdd:pfam01576  330 TELKKALEE------------ETRSHEAQLQEMRQKHTQALEElTEQLEQAKRNkaNLEKAKQALESENAELQAELRTLQ 397

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 2462517843 1807 TSQEDfnkTELEKYKQ-LYLEELKVRKSLSSKL-TKTNERLAEVNTKL 1852
Cdd:pfam01576  398 QAKQD---SEHKRKKLeGQLQELQARLSESERQrAELAEKLSKLQSEL 442
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 1544-1741 1.39e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 42.05  E-value: 1.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1544 SEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQeLADTLkKQSMSEASLEVTSRYRiNLEDETQDLKK 1623
Cdd:cd00176     17 SEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNE-LGEQL-IEEGHPDAEEIQERLE-ELNQRWEELRE 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1624 KLGQIRNQLQEAQDRHT---EAVRCAEKMQDHKQKLEK-DNAKLKVTVKKQMDKIEELQKNLLNAnlsedeKEQLKKLME 1699
Cdd:cd00176     94 LAEERRQRLEEALDLQQffrDADDLEQWLEEKEAALASeDLGKDLESVEELLKKHKELEEELEAH------EPRLKSLNE 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2462517843 1700 LKQSL--ECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEN 1741
Cdd:cd00176    168 LAEELleEGHPDADEEIEEKLEELNERWEELLELAEERQKKLEE 211
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 75-203 1.58e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 41.02  E-value: 1.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   75 DRDKMNRTALHLACANGhpEVVTLLVDRkcqlNVCDNENRTALMK----AVQC-----------QEEKCaTILLEHGADP 139
Cdd:PHA02736    12 EPDIEGENILHYLCRNG--GVTDLLAFK----NAISDENRYLVLEynrhGKQCvhivsnpdkadPQEKL-KLLMEWGADI 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517843  140 NLAD-VHGNTALHYAVYNEDISVATKLLLY-DANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:PHA02736    85 NGKErVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1424-1642 1.64e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1424 LSQQLFKTESKLNSLEIEFhhtrDALREKtlgLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKyigKQESVEERLSQLQS 1503
Cdd:COG3883     28 LQAELEAAQAELDALQAEL----EELNEE---YNELQAELEALQAEIDKLQAEIAEAEAEIEE---RREELGERARALYR 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1504 E-------NMLLRQQ-LDDAHNKADNKEKtvinIQDQFHAIV---QKLQAESEKQSLLLEERNKELISECNHLKERQYQY 1572
Cdd:COG3883     98 SggsvsylDVLLGSEsFSDFLDRLSALSK----IADADADLLeelKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1573 ENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1642
Cdd:COG3883    174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 243
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1404-1701 1.78e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 1.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1404 SRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVK 1483
Cdd:COG4372     30 SEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEE 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1484 VNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECN 1563
Cdd:COG4372    110 AEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELL 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1564 HLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV 1643
Cdd:COG4372    190 KEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILV 269

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462517843 1644 RCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELK 1701
Cdd:COG4372    270 EKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKK 327
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 178-210 1.85e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 1.85e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462517843  178 DDLTPLLLAV-SGKKQQMVEFLIKKKANVNAVDK 210
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 79-215 1.92e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.06  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   79 MNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNED 158
Cdd:PHA02875     1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  159 ISVATKLLLYDANI-EAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA--NVNAVDKLESSH 215
Cdd:PHA02875    81 VKAVEELLDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGAdpDIPNTDKFSPLH 140
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1153-1364 2.41e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.70  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1153 LRFSLNQEEEKRRNADTLYEK----IREQLRRKE---EQYRKE-------------VEVKQQLELSLQTLEMELRTVKSN 1212
Cdd:COG3206    162 LEQNLELRREEARKALEFLEEqlpeLRKELEEAEaalEEFRQKnglvdlseeakllLQQLSELESQLAEARAELAEAEAR 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1213 LNQVvqernDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHeeekdlshknsmlqEEIAMLRLEIDT 1292
Cdd:COG3206    242 LAAL-----RAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNH--------------PDVIALRAQIAA 302

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462517843 1293 IKNQNQEKEKKCFEDLKIVKEknedlqkTIKQNEETLTQTISQYNGRLSVLTAENAMLNSkLENEKQSKERL 1364
Cdd:COG3206    303 LRAQLQQEAQRILASLEAELE-------ALQAREASLQAQLAQLEARLAELPELEAELRR-LEREVEVAREL 366
CEP63 pfam17045
Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole ...
 1128-1408 3.08e-03

Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole activity.


Pssm-ID: 465338 [Multi-domain]  Cd Length: 264  Bit Score: 41.73  E-value: 3.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1128 ELSE-TKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAdtlyekiREQLRRKEeqyrKEVEVKQQLELSLQTLEMEL 1206
Cdd:pfam17045    7 ELQElMKQIDIMVAHKKSEWEGQTRALETRLDIREEELLSA-------RNTLERKH----KEIGLLRQQLEELEKGKQEL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1207 rTVKSNlnqvvQERNDAQRQLSReqnarmlqdgiLTNHLSKqkeIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAML 1286
Cdd:pfam17045   76 -VAKYE-----QQLQKLQEELSK-----------LKRSYEK---LQRKQLKEAREEAKSREEDRSELSRLNGKLEEFRQK 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1287 RLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQneetltqtiSQYNGRLSVLTA---ENAMLNSKLENEKQSKER 1363
Cdd:pfam17045  136 SLEWEQQRLQYQQQVASLEAQRKALAEQSSLIQSAAYQ---------VQLEGRKQCLEAsqsEIQRLRSKLERAQDSLCA 206

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 2462517843 1364 LEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQD 1408
Cdd:pfam17045  207 QELELERLRMRVSELGDSNRKLLEEQQRLLEELRMSQRQLQVLQN 251
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1027-1669 3.32e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.73  E-value: 3.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1027 KKTSNEKNKVKNQIQSMDDVDDLTQSSETASedcelphssyknfmllieqlGMECKDSVSLLKIQdaalscerllelkkn 1106
Cdd:TIGR01612 1139 KKSENYIDEIKAQINDLEDVADKAISNDDPE--------------------EIEKKIENIVTKID--------------- 1183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1107 hcelltvKIKKMEDKVNVLQRELSETKEIKSQLEHQK---VEWERELCSLrFSLNQEEEKRRNADTL-----YEKIREQL 1178
Cdd:TIGR01612 1184 -------KKKNIYDEIKKLLNEIAEIEKDKTSLEEVKginLSYGKNLGKL-FLEKIDEEKKKSEHMIkameaYIEDLDEI 1255

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1179 RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSnlNQVVQERNDAQRQLSREQNARMLQDgiltnhLSKQKEIEMAQKKM 1258
Cdd:TIGR01612 1256 KEKSPEIENEMGIEMDIKAEMETFNISHDDDKD--HHIISKKHDENISDIREKSLKIIED------FSEESDINDIKKEL 1327

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1259 NSENSHSHEEEKDLSHKNSMLQEEIAMLRL-EIDTIKNQNQEKEKKCFEDLKIVK---EKNEDLQKTIKQNE--ETLTQT 1332
Cdd:TIGR01612 1328 QKNLLDAQKHNSDINLYLNEIANIYNILKLnKIKKIIDEVKEYTKEIEENNKNIKdelDKSEKLIKKIKDDInlEECKSK 1407

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1333 ISQyngrlsvlTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRA----RDECSRLQD 1408
Cdd:TIGR01612 1408 IES--------TLDDKDIDECIKKIKELKNHILSEESNIDTYFKNADENNENVLLLFKNIEMADNKSqhilKIKKDNATN 1479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1409 KMNFDVSNLKDNNEilSQQLFKTESKLNSLEIEfhhtrdalREKTLgLERVQKDLSQTQCQMKEMEQKYQNEQVKV---- 1484
Cdd:TIGR01612 1480 DHDFNINELKEHID--KSKGCKDEADKNAKAIE--------KNKEL-FEQYKKDVTELLNKYSALAIKNKFAKTKKdsei 1548

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1485 ---------NKYIGKQESVEERLSQLQSENMllrqQLDDAHNKADNKEKTVINIQdqfhaivqkLQAESEKQSLLLEERN 1555
Cdd:TIGR01612 1549 iikeikdahKKFILEAEKSEQKIKEIKKEKF----RIEDDAAKNDKSNKAAIDIQ---------LSLENFENKFLKISDI 1615

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1556 KELISECnhLKERQyqyENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLED---ETQDLKKKLGQIRNQL 1632
Cdd:TIGR01612 1616 KKKINDC--LKETE---SIEKKISSFSIDSQDTELKENGDNLNSLQEFLESLKDQKKNIEDkkkELDELDSEIEKIEIDV 1690

                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 2462517843 1633 QEAQDRHTEAV--RCAEKMQDHKQKLEKDNAKLKVTVKK 1669
Cdd:TIGR01612 1691 DQHKKNYEIGIieKIKEIAIANKEEIESIKELIEPTIEN 1729
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1139-1369 3.45e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 3.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1139 LEHQKVEWERelcslrfslnQEEEKrrnadtlYEKI-REQLRRKEEQYRKEVEVKQQLELSLQTLEMELR---TVKSNLN 1214
Cdd:pfam17380  278 VQHQKAVSER----------QQQEK-------FEKMeQERLRQEKEEKAREVERRRKLEEAEKARQAEMDrqaAIYAEQE 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1215 QVVQERN---DAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHShEEEKDLSHKNSMLQEE----IAMLR 1287
Cdd:pfam17380  341 RMAMERErelERIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKNERV-RQELEAARKVKILEEErqrkIQQQK 419

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1288 LEIDTIKNQNQEKEKkcfEDLKIVKEKNEDLQKTIKQNEETLTQTISqyngRLSVLTAENAmlNSKLENEKQSKERLEAE 1367
Cdd:pfam17380  420 VEMEQIRAEQEEARQ---REVRRLEEERAREMERVRLEEQERQQQVE----RLRQQEEERK--RKKLELEKEKRDRKRAE 490


                   ..
gi 2462517843 1368 VE 1369
Cdd:pfam17380  491 EQ 492
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1202-1525 3.77e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 42.35  E-value: 3.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1202 LEMELRTVKSNLN----QVVQERNDAQRQLSR----EQNARMLQDGI-----LTNHLSKQKEIEMAQKKMNSENSHSHEE 1268
Cdd:PRK10929    28 ITQELEQAKAAKTpaqaEIVEALQSALNWLEErkgsLERAKQYQQVIdnfpkLSAELRQQLNNERDEPRSVPPNMSTDAL 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1269 EKDLSHKNSMLQEEIAMLrleidtikNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLtQTISQYN-----GRLSVL 1343
Cdd:PRK10929   108 EQEILQVSSQLLEKSRQA--------QQEQDRAREISDSLSQLPQQQTEARRQLNEIERRL-QTLGTPNtplaqAQLTAL 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1344 TAENAMLNSKLE---------NEKQSKERLEAEV-ESYHSRLAAAIHD-RDQ-SETSKRELELAFQRARDECSRLQDKMN 1411
Cdd:PRK10929   179 QAESAALKALVDelelaqlsaNNRQELARLRSELaKKRSQQLDAYLQAlRNQlNSQRQREAERALESTELLAEQSGDLPK 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1412 FDVSNLKDNNEI---LSQQ------LFKTESKLNSLEIEFHHTRDALREKT--LGLERVQKDLSQTQ-CQMKEMEqKYQn 1479
Cdd:PRK10929   259 SIVAQFKINRELsqaLNQQaqrmdlIASQQRQAASQTLQVRQALNTLREQSqwLGVSNALGEALRAQvARLPEMP-KPQ- 336

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 2462517843 1480 eQVKvnkyigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKT 1525
Cdd:PRK10929   337 -QLD-------TEMAQLRVQRLRYEDLLNKQPQLRQIRQADGQPLT 374
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1335-1738 3.84e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 42.25  E-value: 3.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1335 QYNGRLSVLTAE--------NAMLNSKLENEKQskERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRL 1406
Cdd:COG3096    317 ELSARESDLEQDyqaasdhlNLVQTALRQQEKI--ERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSL 394

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1407 QdkmnfdvSNLKDNNEILSQQlfKTESklnsleIEFHHTRDALREktlglervqkdlSQTQCQMKEMEQkyqnEQVKvnk 1486
Cdd:COG3096    395 K-------SQLADYQQALDVQ--QTRA------IQYQQAVQALEK------------ARALCGLPDLTP----ENAE--- 440

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1487 yiGKQESVEERLSQLQSENMLLRQQL---DDAHNKADNKEKTVINIQDQfhaiVQKLQAESEKQSLLLEERnkelisECN 1563
Cdd:COG3096    441 --DYLAAFRAKEQQATEEVLELEQKLsvaDAARRQFEKAYELVCKIAGE----VERSQAWQTARELLRRYR------SQQ 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1564 HLKERQYQYENEKAEREVVVRQLQ--QELADTLKKQSmseaSLEVTSryRINLEDEtqdlkkklgqiRNQLQEAQDRHTE 1641
Cdd:COG3096    509 ALAQRLQQLRAQLAELEQRLRQQQnaERLLEEFCQRI----GQQLDA--AEELEEL-----------LAELEAQLEELEE 571

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1642 AVR-CAEKMQDHKQKLEKDNAKLKvTVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMElkqslecnLDQEMKKNVELER 1720
Cdd:COG3096    572 QAAeAVEQRSELRQQLEQLRARIK-ELAARAPAWLAAQDAL--ERLREQSGEALADSQE--------VTAAMQQLLERER 640

                          410
                   ....*....|....*...
gi 2462517843 1721 EITGFKNLLKMTRKKLNE 1738
Cdd:COG3096    641 EATVERDELAARKQALES 658
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1355-1634 4.02e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 4.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1355 ENEKQSKERLEAEVESYHSRLAAAIH---DRDQSETSKRELELAFQRARD-ECSRLQDKMNFDVSNLKDNNEIlsQQLFK 1430
Cdd:pfam17380  322 EKARQAEMDRQAAIYAEQERMAMERErelERIRQEERKRELERIRQEEIAmEISRMRELERLQMERQQKNERV--RQELE 399

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1431 TESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVnkyigkqesvEERLSQLQSEnmLLRQ 1510
Cdd:pfam17380  400 AARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRL----------EEQERQQQVE--RLRQ 467

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1511 QLDDAHNKADNKEKTVIN---IQDQFHAIVQKlQAESEKQSLLlEERNKELISEcNHLKERQYQ-YENEKAEREVVVRQL 1586
Cdd:pfam17380  468 QEEERKRKKLELEKEKRDrkrAEEQRRKILEK-ELEERKQAMI-EEERKRKLLE-KEMEERQKAiYEEERRREAEEERRK 544

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 2462517843 1587 QQELADTLK-KQSMSEASLEvtsRYRINLEDETQDLKKKLGQIRNQLQE 1634
Cdd:pfam17380  545 QQEMEERRRiQEQMRKATEE---RSRLEAMEREREMMRQIVESEKARAE 590
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1161-1885 4.03e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.35  E-value: 4.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1161 EEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQlELSLQTLEMELRT---VKSNLNQVVQERNDAQRQLSREQNARMLQ 1237
Cdd:TIGR01612  699 DDLKSKIDKEYDKIQNMETATVELHLSNIENKKN-ELLDIIVEIKKHIhgeINKDLNKILEDFKNKEKELSNKINDYAKE 777

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1238 DGILTNHLSKQKEIEmaqkkmnsenshsheeekdlSHKNSmlqeeiamlRLEIDTIKNqnqekekkcfEDLKIVKEKNED 1317
Cdd:TIGR01612  778 KDELNKYKSKISEIK--------------------NHYND---------QINIDNIKD----------EDAKQNYDKSKE 818

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1318 LQKTIKQNEETLTQTISQY-NGRLSVLTAENAMLNskLENekQSKERLEAEVESYhsrlaAAIHDRDQSETSKRELELAF 1396
Cdd:TIGR01612  819 YIKTISIKEDEIFKIINEMkFMKDDFLNKVDKFIN--FEN--NCKEKIDSEHEQF-----AELTNKIKAEISDDKLNDYE 889

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1397 QRARDECSRLQDKMNF------DVSNLKDNNEIL------SQQLFKTESKLNSLEIEFHHTRDALREKTLgLERVQKDLS 1464
Cdd:TIGR01612  890 KKFNDSKSLINEINKSieeeyqNINTLKKVDEYIkicentKESIEKFHNKQNILKEILNKNIDTIKESNL-IEKSYKDKF 968

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1465 QTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQS------ENMLLRQ------QLDDAHNKADNKEKTVINIQDQ 1532
Cdd:TIGR01612  969 DNTLIDKINELDKAFKDASLNDYEAKNNELIKYFNDLKAnlgknkENMLYHQfdekekATNDIEQKIEDANKNIPNIEIA 1048

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1533 FHAIVQKLQAESEKQ-SLLLEERNKELISEC-------NHLKERQYQYENEKAEREVVVRqlqqeLADTLKKQSMSEASL 1604
Cdd:TIGR01612 1049 IHTSIYNIIDEIEKEiGKNIELLNKEILEEAeinitnfNEIKEKLKHYNFDDFGKEENIK-----YADEINKIKDDIKNL 1123

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1605 EVTSRYRINledETQDLKKKLGQIRNQLQeAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNA 1684
Cdd:TIGR01612 1124 DQKIDHHIK---ALEEIKKKSENYIDEIK-AQINDLEDVADKAISNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNEI 1199

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1685 NLSEDEKEQLKKLMELKQSLECNL--------DQEMKKNVELEREITGFKNLLKMTRKKLNEYENgEFSFHGDLKTSQFE 1756
Cdd:TIGR01612 1200 AEIEKDKTSLEEVKGINLSYGKNLgklflekiDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIEN-EMGIEMDIKAEMET 1278

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1757 MDIQINKLK--HKAQAASQENLEQFRENNFA-----SMKSQMELRIKDLESELSKIKTSQEDFNKTeLEKYKQLY-LEEL 1828
Cdd:TIGR01612 1279 FNISHDDDKdhHIISKKHDENISDIREKSLKiiedfSEESDINDIKKELQKNLLDAQKHNSDINLY-LNEIANIYnILKL 1357

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517843 1829 KVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEpPCVGNLNNSLD 1885
Cdd:TIGR01612 1358 NKIKKIIDEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDINLE-ECKSKIESTLD 1413
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 145-174 4.12e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 4.12e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2462517843   145 HGNTALHYAVYNEDISVATKLLLYDANIEA 174
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1456-1638 4.34e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.93  E-value: 4.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1456 LERVQKDLSQTQCQMKEMEQKYQNEQVKvnkyiGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTViniqDQFHA 1535
Cdd:COG3206    184 LPELRKELEEAEAALEEFRQKNGLVDLS-----EEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQL----GSGPD 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1536 IVQKLQAESEKQSLLleERNKELISECNHLKERqYQYENEKaerevvVRQLQQELADtLKKQSMSEAslevtSRYRINLE 1615
Cdd:COG3206    255 ALPELLQSPVIQQLR--AQLAELEAELAELSAR-YTPNHPD------VIALRAQIAA-LRAQLQQEA-----QRILASLE 319

                          170       180
                   ....*....|....*....|...
gi 2462517843 1616 DETQDLKKKLGQIRNQLQEAQDR 1638
Cdd:COG3206    320 AELEALQAREASLQAQLAQLEAR 342
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1277-1868 4.34e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 42.04  E-value: 4.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1277 SMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNE--ETLTQTISQYNGRLSVLTAENAMLNSKL 1354
Cdd:pfam05557   12 SQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEkrEAEAEEALREQAELNRLKKKYLEALNKK 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1355 ENEKQSKerlEAEVESYHSRLAAAIHDRdQSETSKRELELAFQRARDECSR----LQDKMNFDVSNLKDNNEILSQQLFK 1430
Cdd:pfam05557   92 LNEKESQ---LADAREVISCLKNELSEL-RRQIQRAELELQSTNSELEELQerldLLKAKASEAEQLRQNLEKQQSSLAE 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1431 TESKLNSLEIEFH-HTRDALrektlglerVQKDLSQTQCQMKEMEqkyqneqvkvnKYIGKQESVEERLSQLQSENMLLR 1509
Cdd:pfam05557  168 AEQRIKELEFEIQsQEQDSE---------IVKNSKSELARIPELE-----------KELERLREHNKHLNENIENKLLLK 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1510 QQLDDAHNKADNKEKT---VINIQDQFHAIVQKLQA-ESEKQSLLLE--------ERNKELISECNHLKERQYQYENEKA 1577
Cdd:pfam05557  228 EEVEDLKRKLEREEKYreeAATLELEKEKLEQELQSwVKLAQDTGLNlrspedlsRRIEQLQQREIVLKEENSSLTSSAR 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1578 EREVVVRQLQQELADTLKKqsmseaslevtsryrinledeTQDLKKKLGQIRNQLQEAQDRhteavrcaekmqdhkqkle 1657
Cdd:pfam05557  308 QLEKARRELEQELAQYLKK---------------------IEDLNKKLKRHKALVRRLQRR------------------- 347

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1658 kdnaklKVTVKKQMDKIEELQKN----LLNANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVE-LEREITGFKNLLKMT 1732
Cdd:pfam05557  348 ------VLLLTKERDGYRAILESydkeLTMSNYSPQLLERIEEAEDMTQKMQ-AHNEEMEAQLSvAEEELGGYKQQAQTL 420

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1733 RKKLNEYENGEfsFHGDLKTSQFEMDIqinkLKHKAQAASQENLEQFRENNfaSMKSQMELRIKDLESELSKIKTSQEDF 1812
Cdd:pfam05557  421 ERELQALRQQE--SLADPSYSKEEVDS----LRRKLETLELERQRLREQKN--ELEMELERRCLQGDYDPKKTKVLHLSM 492

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517843 1813 NKTelekykqlyLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTT 1868
Cdd:pfam05557  493 NPA---------AEAYQQRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRLPETTST 539
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 50-224 4.47e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.79  E-value: 4.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNEnrTALMKAVQCQEEKCA 129
Cdd:PHA02878    41 LHQAVEARNLDVVKS-LLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTL--VAIKDAFNNRNVEIF 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  130 TILLEHGADPN--LADVHGNTALHYAVYNEDIsvaTKLLL-YDANIEAKNKDDL-TPLLLAVSGKKQQMVEFLIKKKANV 205
Cdd:PHA02878   118 KIILTNRYKNIqtIDLVYIDKKSKDDIIEAEI---TKLLLsYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANV 194

                          170       180
                   ....*....|....*....|.
gi 2462517843  206 NAVDKLESS--HQLISEYKEE 224
Cdd:PHA02878   195 NIPDKTNNSplHHAVKHYNKP 215
PHA02946 PHA02946
ankyin-like protein; Provisional
 96-215 4.82e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.58  E-value: 4.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   96 VTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNED--ISVATKLLLYDANIE 173
Cdd:PHA02946    55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKIN 134

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2462517843  174 AKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSH 215
Cdd:PHA02946   135 NSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKFGKNH 176
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 877-1852 5.04e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.08  E-value: 5.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  877 QQDMQRFKNEIGMLKVEFQALEKEKVQLQK----------EVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQK 946
Cdd:pfam01576   18 KERQQKAESELKELEKKHQQLCEEKNALQEqlqaetelcaEAEEMRARLAARKQELEEILHELESRLEEEEERSQQLQNE 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843  947 RKSGETDHQQFPRKENKEYASSgPALQMKEVKSTEKEKRTSK-----ESVNSPVFGKASLLTGGLLQVddDSSLSEIDEd 1021
Cdd:pfam01576   98 KKKMQQHIQDLEEQLDEEEAAR-QKLQLEKVTTEAKIKKLEEdilllEDQNSKLSKERKLLEERISEF--TSNLAEEEE- 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1022 egrptKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGmECKDSVSLLKIQDAALSCERL- 1100
Cdd:pfam01576  174 -----KAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIA-ELQAQIAELRAQLAKKEEELQa 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1101 ----LELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNqeeekrrnaDTLYEKIRE 1176
Cdd:pfam01576  248 alarLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELE---------DTLDTTAAQ 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1177 Q-LRRKEEQyrkEV-EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR------------EQNARMLQDGILT 1242
Cdd:pfam01576  319 QeLRSKREQ---EVtELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRnkanlekakqalESENAELQAELRT 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1243 NHLSKQkEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTI 1322
Cdd:pfam01576  396 LQQAKQ-DSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQ 474

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1323 KQNEETLTQTISqYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDE 1402
Cdd:pfam01576  475 ELLQEETRQKLN-LSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRE 553

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1403 CsrlqdkmnfdvsnlkdnnEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQV 1482
Cdd:pfam01576  554 L------------------EALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKA 615

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1483 KVNKYigkqesVEERlsqlqsenmllrqqlDDAHNKADNKEKTVINIQdqfHAIVQKLQAESEkqsllLEERNKELISEC 1562
Cdd:pfam01576  616 ISARY------AEER---------------DRAEAEAREKETRALSLA---RALEEALEAKEE-----LERTNKQLRAEM 666

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1563 NHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKkklGQIRNQLQeAQDRHTEA 1642
Cdd:pfam01576  667 EDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALK---AQFERDLQ-ARDEQGEE 742

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1643 VRCAEKMQDHKQKLEKDNAK----LKVTVKKQMD-KIEELQKNLLNANLSEDEK-EQLKKLMELKQSLECNLDQEMKKNV 1716
Cdd:pfam01576  743 KRRQLVKQVRELEAELEDERkqraQAVAAKKKLElDLKELEAQIDAANKGREEAvKQLKKLQAQMKDLQRELEEARASRD 822

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1717 ELereitgfKNLLKMTRKKLNEYENGEFSFHGDLKTSQfemdiqinKLKHKAQAASQENLEQFRENN-----FASMKSQM 1791
Cdd:pfam01576  823 EI-------LAQSKESEKKLKNLEAELLQLQEDLAASE--------RARRQAQQERDELADEIASGAsgksaLQDEKRRL 887

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517843 1792 ELRIKDLESELSKIKTSQEDFNktelEKYKQLYLE------ELKVRKSLSSKLTKTNERLAEVNTKL 1852
Cdd:pfam01576  888 EARIAQLEEELEEEQSNTELLN----DRLRKSTLQveqlttELAAERSTSQKSESARQQLERQNKEL 950
PRK09039 PRK09039
peptidoglycan -binding protein;
1329-1439 5.14e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 41.49  E-value: 5.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1329 LTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELElafqRARDECSRLQD 1408
Cdd:PRK09039    44 LSREISGKDSALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRLQALLAELA----GAGAAAEGRAG 119

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2462517843 1409 KMNFDVSNLKDNN-------EILSQQLFKTESKLNSLE 1439
Cdd:PRK09039   120 ELAQELDSEKQVSaralaqvELLNQQIAALRRQLAALE 157
PTZ00121 PTZ00121
MAEBL; Provisional
 1469-1862 5.15e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 5.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1469 QMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAeSEKQS 1548
Cdd:PTZ00121  1288 EKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEA-AEEKA 1366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1549 LLLEERNKELISECNHLKERQYqyENEKAEREVVVRQLQQELADTLKKQSMSEASLEvTSRYRINLEDETQDLKKKLGQI 1628
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAAKKKAE--EKKKADEAKKKAEEDKKKADELKKAAAAKKKAD-EAKKKAEEKKKADEAKKKAEEA 1443

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1629 RnQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD----KIEELQKNLLNANLSEDEK---EQLKKLMELK 1701
Cdd:PTZ00121  1444 K-KADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADeakkKAEEAKKKADEAKKAAEAKkkaDEAKKAEEAK 1522

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1702 QSLECNLDQEMKKNVELER--EITGFKNLlkmtrKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKAQAASQENLEQF 1779
Cdd:PTZ00121  1523 KADEAKKAEEAKKADEAKKaeEKKKADEL-----KKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEV 1597

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1780 RENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQS 1859
Cdd:PTZ00121  1598 MKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKA 1677


                   ...
gi 2462517843 1860 RSL 1862
Cdd:PTZ00121  1678 EEA 1680
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1111-1650 5.53e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 41.70  E-value: 5.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1111 LTVKIKKMEDKVNVLQRELSETKEIKSQLEH-------QKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEE 1183
Cdd:pfam01576  487 LSTRLRQLEDERNSLQEQLEEEEEAKRNVERqlstlqaQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAA 566

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1184 QYRKEVEVKQQLELSLQTLEMEL---RTVKSNL------------------NQVVQERNDAQRQlSREQNARMLQ-DGIL 1241
Cdd:pfam01576  567 AYDKLEKTKNRLQQELDDLLVDLdhqRQLVSNLekkqkkfdqmlaeekaisARYAEERDRAEAE-AREKETRALSlARAL 645

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1242 TNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEK--KCFEDLKIVKEKNedLQ 1319
Cdd:pfam01576  646 EEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDelQATEDAKLRLEVN--MQ 723

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1320 KTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQ-------SKERLEAEVESYHSRLAAAIHDRDQSETSKREL 1392
Cdd:pfam01576  724 ALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKqraqavaAKKKLELDLKELEAQIDAANKGREEAVKQLKKL 803

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1393 ELA---FQRARDECSRLQDkmnfdvsnlkdnnEILSQQLfKTESKLNSLEIEFHHtrdaLREKTLGLERVQKdlsQTQCQ 1469
Cdd:pfam01576  804 QAQmkdLQRELEEARASRD-------------EILAQSK-ESEKKLKNLEAELLQ----LQEDLAASERARR---QAQQE 862

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1470 MKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSEnmllrqqLDDAHNKADNKEKTVINIQDQFHAIVQKLQAE------ 1543
Cdd:pfam01576  863 RDELADEIASGASGKSALQDEKRRLEARIAQLEEE-------LEEEQSNTELLNDRLRKSTLQVEQLTTELAAErstsqk 935

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1544 SEKQSLLLEERNKELISECNHLKER-QYQYENEKAEREVVVRQLQQELADTLKKQSMS------------EASLEVTSRY 1610
Cdd:pfam01576  936 SESARQQLERQNKELKAKLQEMEGTvKSKFKSSIAALEAKIAQLEEQLEQESRERQAAnklvrrtekklkEVLLQVEDER 1015

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|..
gi 2462517843 1611 RI--NLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQ 1650
Cdd:pfam01576 1016 RHadQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQ 1057
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1275-1658 5.98e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 5.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1275 KNSMLQEEIAMLRLEIDTIKNQNQEkekkcFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAM--LNS 1352
Cdd:COG4717     65 KPELNLKELKELEEELKEAEEKEEE-----YAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELeaLEA 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1353 KLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTE 1432
Cdd:COG4717    140 ELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQ 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1433 SKLNSLEIEFHHTRDALREKTLgLERVQK-----------------------------------------DLSQTQCQMK 1471
Cdd:COG4717    220 EELEELEEELEQLENELEAAAL-EERLKEarlllliaaallallglggsllsliltiagvlflvlgllalLFLLLAREKA 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1472 EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIvqKLQAESEKQSLLL 1551
Cdd:COG4717    299 SLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL--QLEELEQEIAALL 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1552 EERNKELISECNHLKERQYQYENEKAEREVVVRQLQQ------ELADTLKKQSMSEASLEVTSRYRiNLEDETQDLKKKL 1625
Cdd:COG4717    377 AEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEEllgeleELLEALDEEELEEELEELEEELE-ELEEELEELREEL 455

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2462517843 1626 GQIRNQLQEAQDRHteavRCAEKMQDHKQKLEK 1658
Cdd:COG4717    456 AELEAELEQLEEDG----ELAELLQELEELKAE 484
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
 1111-1331 6.45e-03

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 41.43  E-value: 6.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1111 LTVKIKKMEDKVNVLQRE----LSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYR 1186
Cdd:pfam15964  408 LSQNVAQLEAQVEKVTREknslVSQLEEAQKQLASQEMDVTKVCGEMRYQLNQTKMKKDEAEKEHREYRTKTGRQLEIKD 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1187 KEVEvKQQLELSLQTLEME-------------------LRTVKSNLNQVVQERNDAQRQLSREQNARMLQdgiltnhlSK 1247
Cdd:pfam15964  488 QEIE-KLGLELSESKQRLEqaqqdaarareeclkltelLGESEHQLHLTRLEKESIQQSFSNEAKAQALQ--------AQ 558

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1248 QKEIEMAQKKMNSENSHS---HEEEKDLSHKNSM---LQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKT 1321
Cdd:pfam15964  559 QREQELTQKMQQMEAQHDktvNEQYSLLTSQNTFiakLKEECCTLAKKLEEITQKSRSEVEQLSQEKEYLQDRLEKLQKR 638

                          250
                   ....*....|
gi 2462517843 1322 IKQNEETLTQ 1331
Cdd:pfam15964  639 NEELEEQCVQ 648
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 95-209 6.91e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.20  E-value: 6.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843   95 VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIea 174
Cdd:PHA02876   160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI-- 237

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462517843  175 kNKDDLTpLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA02876   238 -NKNDLS-LLKAIRNEDLETSLLLYDAGFSVNSID 270
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1098-1301 7.09e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 7.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1098 ERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRfslnQEEEKRRNADTLYEKIREQ 1177
Cdd:pfam17380  410 ERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQVERLR----QQEEERKRKKLELEKEKRD 485

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1178 LRRKEEQYRKEVEvkQQLELSLQTLEMELRTVKsnlnQVVQERNDAQRQLSREQNARMLQDgiltnhlSKQKEIEMAQKK 1257
Cdd:pfam17380  486 RKRAEEQRRKILE--KELEERKQAMIEEERKRK----LLEKEMEERQKAIYEEERRREAEE-------ERRKQQEMEERR 552

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2462517843 1258 MNSENSHSHEEEKDlshKNSMLQEEIAMLRleiDTIKNQNQEKE 1301
Cdd:pfam17380  553 RIQEQMRKATEERS---RLEAMEREREMMR---QIVESEKARAE 590
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1423-1644 7.45e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 7.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1423 ILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQ 1502
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1503 SENMLLRQQLDD-----------AHNKADNKEKTVINIQDQFHAIVQKLQAeSEKQSLLLEERNKELISECNHLKERQYQ 1571
Cdd:COG4942     90 KEIAELRAELEAqkeelaellraLYRLGRQPPLALLLSPEDFLDAVRRLQY-LKYLAPARREQAEELRADLAELAALRAE 168

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517843 1572 YENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVR 1644
Cdd:COG4942    169 LEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
PRK11281 PRK11281
mechanosensitive channel MscK;
1451-1681 8.04e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.44  E-value: 8.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1451 EKTLGL----ERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGK-QESVEERLSQL---QSENML--LRQQLDDAHNKAD 1520
Cdd:PRK11281    66 EQTLALldkiDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDnDEETRETLSTLslrQLESRLaqTLDQLQNAQNDLA 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1521 NKEKTVINIQDQFHAiVQKLQAESEKQSLLLEER-NKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSM 1599
Cdd:PRK11281   146 EYNSQLVSLQTQPER-AQAALYANSQRLQQIRNLlKGGKVGGKALRPSQRVLLQAEQALLNAQNDLQRKSLEGNTQLQDL 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1600 SEASLEVTSRYRINLEDETQDLK-----KKLGQIRNQLQEAQdrhteAVRCAEKMQDH---KQKLEKdNAKLKVTVKKQM 1671
Cdd:PRK11281   225 LQKQRDYLTARIQRLEHQLQLLQeainsKRLTLSEKTVQEAQ-----SQDEAARIQANplvAQELEI-NLQLSQRLLKAT 298

                          250
                   ....*....|.
gi 2462517843 1672 DKIEEL-QKNL 1681
Cdd:PRK11281   299 EKLNTLtQQNL 309
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1381-1734 8.64e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 41.03  E-value: 8.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1381 DRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKD----------NNEILSQQLFKTESKLNSLEIEFHHTRDALR 1450
Cdd:pfam07888   67 DREQWERQRRELESRVAELKEELRQSREKHEELEEKYKElsasseelseEKDALLAQRAAHEARIRELEEDIKTLTQRVL 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1451 EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKvnkyigkqesveerLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQ 1530
Cdd:pfam07888  147 ERETELERMKERAKKAGAQRKEEEAERKQLQAK--------------LQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQ 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1531 DQFHAIVQKLQAESEKqslllEERNKELISECNHLKERQyqyenekAEREVVVRQLQQELADTLKKQSMSEASLevtsrY 1610
Cdd:pfam07888  213 DTITTLTQKLTTAHRK-----EAENEALLEELRSLQERL-------NASERKVEGLGEELSSMAAQRDRTQAEL-----H 275

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1611 RINLEdetqdlkkkLGQIRNQLQEAqdrhteavrcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAN--LSE 1688
Cdd:pfam07888  276 QARLQ---------AAQLTLQLADA----------SLALREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEerLQE 336

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 2462517843 1689 DEKEQLKKLMELKQSLECNLDQEMkknvELEREITGFKNLLKMTRK 1734
Cdd:pfam07888  337 ERMEREKLEVELGREKDCNRVQLS----ESRRELQELKASLRVAQK 378
PTZ00121 PTZ00121
MAEBL; Provisional
 1116-1434 8.82e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 8.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1116 KKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKR-----RNADTLYEKIREQLRRKEEQYRKEVE 1190
Cdd:PTZ00121  1627 KAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKkaeeaKKAEEDEKKAAEALKKEAEEAKKAEE 1706

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1191 VKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARmlqdgiltnhlskqKEIEMAQKKMNSENSHSHEEEK 1270
Cdd:PTZ00121  1707 LKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAK--------------KDEEEKKKIAHLKKEEEKKAEE 1772

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1271 DLSHKNSMLQEEiamLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQyngrlsVLTAENAML 1350
Cdd:PTZ00121  1773 IRKEKEAVIEEE---LDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKE------VADSKNMQL 1843

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1351 NS--KLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDvsnlKDNNEILSQQL 1428
Cdd:PTZ00121  1844 EEadAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREIPNNNMA----GKNNDIIDDKL 1919


                   ....*.
gi 2462517843 1429 FKTESK 1434
Cdd:PTZ00121  1920 DKDEYI 1925
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 1175-1303 9.18e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 39.50  E-value: 9.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1175 REQLRRKEEQYRkevevkqQLELSLQTLEMELRTVKSNLNQVVQ--------ERNDAQRQLSREQNarMLQDgiltnhls 1246
Cdd:pfam15619   73 RERLRRLQEKER-------DLERKLKEKEAELLRLRDQLKRLEKlsedknlaEREELQKKLEQLEA--KLED-------- 135

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462517843 1247 KQKEIEMAQKKM-NSENSHSHEEEKDLShKNSMLQEEIAMLRLEIDTIKNQNQEKEKK 1303
Cdd:pfam15619  136 KDEKIQDLERKLeLENKSFRRQLAAEKK-KHKEAQEEVKILQEEIERLQQKLKEKERE 192
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 1615-1738 9.19e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 40.43  E-value: 9.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1615 EDETQDLKKKL-GQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKvTVKKQMD-------------KIEELQKN 1680
Cdd:cd22656    109 DEELEEAKKTIkALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALE-TLEKALKdlltdeggaiarkEIKDLQKE 187

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462517843 1681 LLNANlsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNE 1738
Cdd:cd22656    188 LEKLN--EEYAAKLKAKIDELKALIADDEAKLAAALRLIADLTAADTDLDNLLALIGP 243
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1415-1882 9.70e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 40.86  E-value: 9.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1415 SNLKDNNEILSQQ-------LFKTESKLNSLEIEFHHTRDALREKTlGLERVQKDLSQTQCQMKEMEQKYQNEQ------ 1481
Cdd:pfam05483  106 NKLQENRKIIEAQrkaiqelQFENEKVSLKLEEEIQENKDLIKENN-ATRHLCNLLKETCARSAEKTKKYEYEReetrqv 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1482 -VKVNKYIGKQESVEERLsQLQSENMLLRQ--QLDDAHNKADNKE----KTVINIQDQFHAIVQKLQAESEKQS----LL 1550
Cdd:pfam05483  185 yMDLNNNIEKMILAFEEL-RVQAENARLEMhfKLKEDHEKIQHLEeeykKEINDKEKQVSLLLIQITEKENKMKdltfLL 263

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1551 LEERNK-ELISECNHLKERQYQYENEKAEREVV-VRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQI 1628
Cdd:pfam05483  264 EESRDKaNQLEEKTKLQDENLKELIEKKDHLTKeLEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKA 343

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1629 RNQLQ-EAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECN 1707
Cdd:pfam05483  344 KAAHSfVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDE 423

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1708 LDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSfhgdLKTSQFEMDIQINKLKHKAQAASQENLEqfrennFASM 1787
Cdd:pfam05483  424 KKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTA----IKTSEEHYLKEVEDLKTELEKEKLKNIE------LTAH 493

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517843 1788 KSQMELRIKDLESELS----KIKTSQEDFNKTE------LEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQ 1857
Cdd:pfam05483  494 CDKLLLENKELTQEASdmtlELKKHQEDIINCKkqeermLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEE 573

                          490       500
                   ....*....|....*....|....*
gi 2462517843 1858 QSRSLFTTLTTRPVMEPPCVGNLNN 1882
Cdd:pfam05483  574 NARSIEYEVLKKEKQMKILENKCNN 598
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH