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Conserved domains on  [gi|2462626412|ref|XP_054219765|]
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DDB1- and CUL4-associated factor 10 isoform X5 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-348 1.23e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 1.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412   9 VLTVACEQTEVLLFDpISSKHIKTLSEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGHTSWVKNIE 87
Cdd:COG2319    92 LLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVA 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412  88 YDTNTRLLVTSGFDGNVIIWDTnryTEDGCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILHDLDltkslevgsyp 167
Cdd:COG2319   170 FSPDGKLLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLWDLA----------- 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 168 ilrarrttsssgvsprnslevvTPEVLGE-SDHGNCITSLQLHPKGwATLLrcsSNSDDEEcTCVYEFQEGAPVRpvspr 246
Cdd:COG2319   235 ----------------------TGKLLRTlTGHSGSVRSVAFSPDG-RLLA---SGSADGT-VRLWDLATGELLR----- 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 247 cslRLTHyieeanvGRGYIKELCFSPDGRMI-SSPHGYGIRLLgfdkqcselvdclpkEASPLRVIRSLYSHNDVVLTTK 325
Cdd:COG2319   283 ---TLTG-------HSGGVNSVAFSPDGKLLaSGSDDGTVRLW---------------DLATGKLLRTLTGHTGAVRSVA 337

                         330       340
                  ....*....|....*....|...
gi 2462626412 326 FSPTHCQIASGCLSGRVSLYQPK 348
Cdd:COG2319   338 FSPDGKTLASGSDDGTVRLWDLA 360
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-348 1.23e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 1.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412   9 VLTVACEQTEVLLFDpISSKHIKTLSEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGHTSWVKNIE 87
Cdd:COG2319    92 LLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVA 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412  88 YDTNTRLLVTSGFDGNVIIWDTnryTEDGCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILHDLDltkslevgsyp 167
Cdd:COG2319   170 FSPDGKLLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLWDLA----------- 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 168 ilrarrttsssgvsprnslevvTPEVLGE-SDHGNCITSLQLHPKGwATLLrcsSNSDDEEcTCVYEFQEGAPVRpvspr 246
Cdd:COG2319   235 ----------------------TGKLLRTlTGHSGSVRSVAFSPDG-RLLA---SGSADGT-VRLWDLATGELLR----- 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 247 cslRLTHyieeanvGRGYIKELCFSPDGRMI-SSPHGYGIRLLgfdkqcselvdclpkEASPLRVIRSLYSHNDVVLTTK 325
Cdd:COG2319   283 ---TLTG-------HSGGVNSVAFSPDGKLLaSGSDDGTVRLW---------------DLATGKLLRTLTGHTGAVRSVA 337

                         330       340
                  ....*....|....*....|...
gi 2462626412 326 FSPTHCQIASGCLSGRVSLYQPK 348
Cdd:COG2319   338 FSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-346 5.51e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 5.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412   6 HRSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGHTSWVK 84
Cdd:cd00200    20 DGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLET-GECVRTLTGHTSYVS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412  85 NIEYDTNTRLLVTSGFDGNVIIWDTNRYTEDGCPHkkfFHTRFLMRMRLTPDcsKMLISTSSgyllilhdLDLTKSLEVG 164
Cdd:cd00200    98 SVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR---GHTDWVNSVAFSPD--GTFVASSS--------QDGTIKLWDL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 165 SYPILRARRTtsssgvsprnslevvtpevlgesDHGNCITSLQLHPKGwATLLRCSSNSddeeCTCVYEFQEGAPVrpvs 244
Cdd:cd00200   165 RTGKCVATLT-----------------------GHTGEVNSVAFSPDG-EKLLSSSSDG----TIKLWDLSTGKCL---- 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 245 prCSLRlTHyieeanvgRGYIKELCFSPDGRMISSPHGYG-IRLlgFDKQCSELVDCLPkeasplrvirslySHNDVVLT 323
Cdd:cd00200   213 --GTLR-GH--------ENGVNSVAFSPDGYLLASGSEDGtIRV--WDLRTGECVQTLS-------------GHTNSVTS 266

                         330       340
                  ....*....|....*....|...
gi 2462626412 324 TKFSPTHCQIASGCLSGRVSLYQ 346
Cdd:cd00200   267 LAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 71-108 6.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 6.61e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462626412   71 TKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 108
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
70-108 2.01e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.01e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462626412  70 NTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 108
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 51-108 6.55e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 6.55e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462626412  51 LFATCSDDTTIALWDLRKLNTKV-------CTLHGHTSWVKNIEYD-TNTRLLVTSGFDGNVIIWD 108
Cdd:PTZ00420   89 ILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWD 154
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-348 1.23e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 1.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412   9 VLTVACEQTEVLLFDpISSKHIKTLSEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGHTSWVKNIE 87
Cdd:COG2319    92 LLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVA 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412  88 YDTNTRLLVTSGFDGNVIIWDTnryTEDGCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILHDLDltkslevgsyp 167
Cdd:COG2319   170 FSPDGKLLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLWDLA----------- 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 168 ilrarrttsssgvsprnslevvTPEVLGE-SDHGNCITSLQLHPKGwATLLrcsSNSDDEEcTCVYEFQEGAPVRpvspr 246
Cdd:COG2319   235 ----------------------TGKLLRTlTGHSGSVRSVAFSPDG-RLLA---SGSADGT-VRLWDLATGELLR----- 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 247 cslRLTHyieeanvGRGYIKELCFSPDGRMI-SSPHGYGIRLLgfdkqcselvdclpkEASPLRVIRSLYSHNDVVLTTK 325
Cdd:COG2319   283 ---TLTG-------HSGGVNSVAFSPDGKLLaSGSDDGTVRLW---------------DLATGKLLRTLTGHTGAVRSVA 337

                         330       340
                  ....*....|....*....|...
gi 2462626412 326 FSPTHCQIASGCLSGRVSLYQPK 348
Cdd:COG2319   338 FSPDGKTLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
10-277 2.30e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.35  E-value: 2.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412  10 LTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGHTSWVKNIEY 88
Cdd:COG2319   177 LASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAF 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412  89 DTNTRLLVTSGFDGNVIIWDTNRYTedgCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILHDLDltkslevgsypi 168
Cdd:COG2319   255 SPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLA------------ 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 169 lrarrttsssgvsprnslevvTPEVLGE-SDHGNCITSLQLHPKGwATLLrcsSNSDDEEcTCVYEFQEGAPVRPVSprc 247
Cdd:COG2319   319 ---------------------TGKLLRTlTGHTGAVRSVAFSPDG-KTLA---SGSDDGT-VRLWDLATGELLRTLT--- 369

                         250       260       270
                  ....*....|....*....|....*....|
gi 2462626412 248 slrlTHyieeanvgRGYIKELCFSPDGRMI 277
Cdd:COG2319   370 ----GH--------TGAVTSVAFSPDGRTL 387
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-346 5.51e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 5.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412   6 HRSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGHTSWVK 84
Cdd:cd00200    20 DGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLET-GECVRTLTGHTSYVS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412  85 NIEYDTNTRLLVTSGFDGNVIIWDTNRYTEDGCPHkkfFHTRFLMRMRLTPDcsKMLISTSSgyllilhdLDLTKSLEVG 164
Cdd:cd00200    98 SVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR---GHTDWVNSVAFSPD--GTFVASSS--------QDGTIKLWDL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 165 SYPILRARRTtsssgvsprnslevvtpevlgesDHGNCITSLQLHPKGwATLLRCSSNSddeeCTCVYEFQEGAPVrpvs 244
Cdd:cd00200   165 RTGKCVATLT-----------------------GHTGEVNSVAFSPDG-EKLLSSSSDG----TIKLWDLSTGKCL---- 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 245 prCSLRlTHyieeanvgRGYIKELCFSPDGRMISSPHGYG-IRLlgFDKQCSELVDCLPkeasplrvirslySHNDVVLT 323
Cdd:cd00200   213 --GTLR-GH--------ENGVNSVAFSPDGYLLASGSEDGtIRV--WDLRTGECVQTLS-------------GHTNSVTS 266

                         330       340
                  ....*....|....*....|...
gi 2462626412 324 TKFSPTHCQIASGCLSGRVSLYQ 346
Cdd:cd00200   267 LAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-163 1.08e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 1.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412   1 MLSRSHRSVLTVACEQTeVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGH 79
Cdd:cd00200    58 AASADGTYLASGSSDKT-IRLWDLETGECVRTL-TGHTSYVSSVAFSpDGRILSSSSRDKTIKVWDVET-GKCLTTLRGH 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412  80 TSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNrytedGCPHKKFF--HTRFLMRMRLTPDcSKMLISTSSGYLLILHDLDL 157
Cdd:cd00200   135 TDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLtgHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLST 208


                  ....*.
gi 2462626412 158 TKSLEV 163
Cdd:cd00200   209 GKCLGT 214
WD40 COG2319
WD40 repeat [General function prediction only];
9-110 1.95e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 1.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412   9 VLTVACEQTEVLLFDPISSKHIKTLSeAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGHTSWVKNIE 87
Cdd:COG2319   302 LLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLAT-GELLRTLTGHTGAVTSVA 379

                          90       100
                  ....*....|....*....|...
gi 2462626412  88 YDTNTRLLVTSGFDGNVIIWDTN 110
Cdd:COG2319   380 FSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
2-348 7.11e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 7.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412   2 LSRSHRSVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLFATCSDDTTIALWDLRkLNTKVCTLHGHTS 81
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAA-AGALLATLLGHTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412  82 WVKNIEYDTNTRLLVTSGFDGNVIIWDTNRyteDGCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILHDLD---LT 158
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLAT---GLLLRTLTGHTGAVRSVAFSPD-GKTLASGSADGTVRLWDLAtgkLL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 159 KSLEVGSYPILRArrTTSSSG-----VSPRNSL---EVVTPEVLGE-SDHGNCITSLQLHPKGwaTLLrcSSNSDDEECT 229
Cdd:COG2319   156 RTLTGHSGAVTSV--AFSPDGkllasGSDDGTVrlwDLATGKLLRTlTGHTGAVRSVAFSPDG--KLL--ASGSADGTVR 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 230 cVYEFQEGAPVRpvsprcslRLTHYieeanvgRGYIKELCFSPDGRMISSPHGYG-IRLlgFDkqcselvdclpkeASPL 308
Cdd:COG2319   230 -LWDLATGKLLR--------TLTGH-------SGSVRSVAFSPDGRLLASGSADGtVRL--WD-------------LATG 278

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2462626412 309 RVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPK 348
Cdd:COG2319   279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-348 3.02e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 3.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412  37 HEDCVNNIRFL-DNRLFATCSDDTTIALWDLrKLNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTnrytED 115
Cdd:cd00200     8 HTGGVTCVAFSpDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL----ET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 116 GCPHKKFF-HTRFLMRMRLTPDcSKMLISTSSGYLLILHDLDltkslevgsypilrarrttsssgvsprnslevvtpevl 194
Cdd:cd00200    83 GECVRTLTgHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVE-------------------------------------- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462626412 195 gesdHGNCITSLQLHpkgwatllrcssnsddeectcvyefqegapvrpvsprcslrlthyieeanvgRGYIKELCFSPDG 274
Cdd:cd00200   124 ----TGKCLTTLRGH----------------------------------------------------TDWVNSVAFSPDG 147

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462626412 275 RMISSPHGYG-IRLlgFDkqcselvdclpkeASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPK 348
Cdd:cd00200   148 TFVASSSQDGtIKL--WD-------------LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 71-108 6.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 6.61e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462626412   71 TKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 108
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
70-108 2.01e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.01e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462626412  70 NTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 108
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 51-108 6.55e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 6.55e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462626412  51 LFATCSDDTTIALWDLRKLNTKV-------CTLHGHTSWVKNIEYD-TNTRLLVTSGFDGNVIIWD 108
Cdd:PTZ00420   89 ILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWD 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 26-65 6.38e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 6.38e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462626412   26 SSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWD 65
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
27-65 2.81e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.81e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462626412  27 SKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWD 65
Cdd:pfam00400   1 GKLLKTL-EGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 307-345 8.10e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 8.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462626412  307 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 345
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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