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Conserved domains on  [gi|2462624216|ref|XP_054218719|]
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ran-binding protein 6 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 361-470 4.58e-38

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


:

Pssm-ID: 465881  Cd Length: 110  Bit Score: 136.85  E-value: 4.58e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624216 361 VLSEIMNSFAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSD 440
Cdd:pfam18829   1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462624216 441 ILHSLFSTYKEKILPWFEQLLPLIVNLICS 470
Cdd:pfam18829  81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
Importin_rep_5 super family cl40106
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 601-648 5.20e-06

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.


The actual alignment was detected with superfamily member pfam18816:

Pssm-ID: 465877  Cd Length: 52  Bit Score: 44.01  E-value: 5.20e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462624216 601 DKEEAIQTLSFLCDLIESNHPVVIgpnnSNLPKIISIIAEGKINETIN 648
Cdd:pfam18816   1 DEEAAPFAYRFLAELIEQNHPAVT----SQIPKVVDSVVQALEHKSLS 44
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
8-218 4.09e-04

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 43.77  E-value: 4.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624216   8 HPRVRAAACTTLGQMATDFAP------NFQKKFHETVIAALLRTMENQGNQ-RVQSHAASALIIFIEDCPKSllvlyVDS 80
Cdd:COG5215   463 CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNEsNLRVSLFSALGTLILICPDA-----VSD 537

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624216  81 MVKNLHSVLVIKLQELIR-NGTKLALE----------QLVTTIASVADTIEEKFVPYYDIFMPSLKHIVELAVQkelKLL 149
Cdd:COG5215   538 ILAGFYDYTSKKLDECISvLGQILATEdqllveelqsNYIGVLEAIIRTRRRDIEDVEDQLMELFIRILESTKP---TTA 614

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462624216 150 RGKTIECISHIGLAVGkEKFMQDASNVMQLLLKtqsDLNnmEDDDPQTSYMVSAWARMCKILGKDFQQY 218
Cdd:COG5215   615 FGDVYTAISALSTSLE-ERFEQYASKFIPYLTR---ALN--CTDRFVLNSAVGLVGDLANTLGTDFNIY 677
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 515-575 5.42e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


:

Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.42  E-value: 5.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462624216 515 PEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLVKVIKCANSKTKKNVIAtencisAIGKI 575
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAW------ALGRL 55
 
Name Accession Description Interval E-value
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 361-470 4.58e-38

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


Pssm-ID: 465881  Cd Length: 110  Bit Score: 136.85  E-value: 4.58e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624216 361 VLSEIMNSFAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSD 440
Cdd:pfam18829   1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462624216 441 ILHSLFSTYKEKILPWFEQLLPLIVNLICS 470
Cdd:pfam18829  81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
Importin_rep_5 pfam18816
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 601-648 5.20e-06

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.


Pssm-ID: 465877  Cd Length: 52  Bit Score: 44.01  E-value: 5.20e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462624216 601 DKEEAIQTLSFLCDLIESNHPVVIgpnnSNLPKIISIIAEGKINETIN 648
Cdd:pfam18816   1 DEEAAPFAYRFLAELIEQNHPAVT----SQIPKVVDSVVQALEHKSLS 44
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
8-218 4.09e-04

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 43.77  E-value: 4.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624216   8 HPRVRAAACTTLGQMATDFAP------NFQKKFHETVIAALLRTMENQGNQ-RVQSHAASALIIFIEDCPKSllvlyVDS 80
Cdd:COG5215   463 CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNEsNLRVSLFSALGTLILICPDA-----VSD 537

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624216  81 MVKNLHSVLVIKLQELIR-NGTKLALE----------QLVTTIASVADTIEEKFVPYYDIFMPSLKHIVELAVQkelKLL 149
Cdd:COG5215   538 ILAGFYDYTSKKLDECISvLGQILATEdqllveelqsNYIGVLEAIIRTRRRDIEDVEDQLMELFIRILESTKP---TTA 614

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462624216 150 RGKTIECISHIGLAVGkEKFMQDASNVMQLLLKtqsDLNnmEDDDPQTSYMVSAWARMCKILGKDFQQY 218
Cdd:COG5215   615 FGDVYTAISALSTSLE-ERFEQYASKFIPYLTR---ALN--CTDRFVLNSAVGLVGDLANTLGTDFNIY 677
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 5-62 4.27e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 39.63  E-value: 4.27e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624216   5 QDPHPRVRAAACTTLGQMATdfapnfqkkfhETVIAALLRTMENQGNQRVQSHAASAL 62
Cdd:pfam13646  41 KDEDPAVRRAAAEALGKIGD-----------PEALPALLELLRDDDDDVVRAAAAEAL 87
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 515-575 5.42e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.42  E-value: 5.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462624216 515 PEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLVKVIKCANSKTKKNVIAtencisAIGKI 575
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAW------ALGRL 55
 
Name Accession Description Interval E-value
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 361-470 4.58e-38

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


Pssm-ID: 465881  Cd Length: 110  Bit Score: 136.85  E-value: 4.58e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624216 361 VLSEIMNSFAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSD 440
Cdd:pfam18829   1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462624216 441 ILHSLFSTYKEKILPWFEQLLPLIVNLICS 470
Cdd:pfam18829  81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
Importin_rep_5 pfam18816
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 601-648 5.20e-06

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.


Pssm-ID: 465877  Cd Length: 52  Bit Score: 44.01  E-value: 5.20e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462624216 601 DKEEAIQTLSFLCDLIESNHPVVIgpnnSNLPKIISIIAEGKINETIN 648
Cdd:pfam18816   1 DEEAAPFAYRFLAELIEQNHPAVT----SQIPKVVDSVVQALEHKSLS 44
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
8-218 4.09e-04

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 43.77  E-value: 4.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624216   8 HPRVRAAACTTLGQMATDFAP------NFQKKFHETVIAALLRTMENQGNQ-RVQSHAASALIIFIEDCPKSllvlyVDS 80
Cdd:COG5215   463 CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNEsNLRVSLFSALGTLILICPDA-----VSD 537

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624216  81 MVKNLHSVLVIKLQELIR-NGTKLALE----------QLVTTIASVADTIEEKFVPYYDIFMPSLKHIVELAVQkelKLL 149
Cdd:COG5215   538 ILAGFYDYTSKKLDECISvLGQILATEdqllveelqsNYIGVLEAIIRTRRRDIEDVEDQLMELFIRILESTKP---TTA 614

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462624216 150 RGKTIECISHIGLAVGkEKFMQDASNVMQLLLKtqsDLNnmEDDDPQTSYMVSAWARMCKILGKDFQQY 218
Cdd:COG5215   615 FGDVYTAISALSTSLE-ERFEQYASKFIPYLTR---ALN--CTDRFVLNSAVGLVGDLANTLGTDFNIY 677
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 5-62 4.27e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 39.63  E-value: 4.27e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624216   5 QDPHPRVRAAACTTLGQMATdfapnfqkkfhETVIAALLRTMENQGNQRVQSHAASAL 62
Cdd:pfam13646  41 KDEDPAVRRAAAEALGKIGD-----------PEALPALLELLRDDDDDVVRAAAAEAL 87
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 3-62 1.70e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 38.09  E-value: 1.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624216   3 ISQDPHPRVRAAACTTLGQMAtdfapnfqkkfHETVIAALLRTMENQgNQRVQSHAASAL 62
Cdd:pfam13646   8 LLRDPDPEVRAAAIRALGRIG-----------DPEAVPALLELLKDE-DPAVRRAAAEAL 55
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 9-62 3.45e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.19  E-value: 3.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462624216   9 PRVRAAACTTLGQMAtDFAPNFQKKFHETVIAALLRTMENqGNQRVQSHAASAL 62
Cdd:pfam13513   1 WRVREAAALALGSLA-EGGPDLLAPAVPELLPALLPLLND-DSDLVREAAAWAL 52
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 515-575 5.42e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.42  E-value: 5.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462624216 515 PEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLVKVIKCANSKTKKNVIAtencisAIGKI 575
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAW------ALGRL 55
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 505-531 6.37e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 34.81  E-value: 6.37e-03
                          10        20
                  ....*....|....*....|....*...
gi 2462624216 505 PMLLNM-RDNNPEVRQAAAYGLGVMAQF 531
Cdd:pfam02985   3 PLLLKLlNDPSPEVREAAAEALGELAEV 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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