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Conserved domains on  [gi|2462620852|ref|XP_054217103|]
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thyroglobulin isoform X6 [Homo sapiens]

Protein Classification

TY and COesterase domain-containing protein( domain architecture ID 10828663)

protein containing domains TY, Ephrin_rec_like, and COesterase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
2124-2645 3.12e-175

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 548.83  E-value: 3.12e-175
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2124 SVPSVPISThGRLLGRSQAIQVGtswKQVDQFLGVPYAAPPLAERRFQAPEPL-NWTGSWDASKPRASCWQPGTRTSTSP 2202
Cdd:pfam00135    1 DSPVVTTSL-GRVRGKRLKVDGG---KPVYAFLGIPYAEPPVGELRFQPPEPPePWTGVRDATKFGPRCPQNGDLTSPGS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2203 ---GVSEDCLYLNVFIPQNVAPNA---SVLVFFHNTMDREESegWPAIDGSFLAAVGNLIVVTASYRVGVFGFLSSGSGE 2276
Cdd:pfam00135   77 sglEGSEDCLYLNVYTPKELKENKnklPVMVWIHGGGFMFGS--GSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTGDDE 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2277 VSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARAtnSQLFRRAVLMGGSALSPAAVISHERa 2356
Cdd:pfam00135  155 APGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLS--KGLFHRAILMSGSALSPWAIQSNAR- 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2357 qQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLL-AVSGPFHYWGPVIDGHFLREPPARALKRSLRVEVDLLI 2435
Cdd:pfam00135  232 -QRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLvYGSVPFVPFGPVVDGDFLPEHPEELLKSGNFPKVPLLI 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2436 GSSQDDGLINRA------KAVKQFEESQGRTSSKTAFYQALqnslggEDSDARVEAAATWYYSLEHSTDDYASFSRALEN 2509
Cdd:pfam00135  311 GVTKDEGLLFAAyildnvDILKALEEKLLRSLLIDLLYLLL------VDLPEEISAALREEYLDWGDRDDPETSRRALVE 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2510 ATRDYFIICPIIDMASAWAKRaRGNVFMYH---------APENYG--HGSlellaDVQFALGLPFYPAYEgqFSLEEKSL 2578
Cdd:pfam00135  385 LLTDYLFNCPVIRFADLHASR-GTPVYMYSfdyrgsslrYPKWVGvdHGD-----ELPYVFGTPFVGALL--FTEEDEKL 456

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462620852 2579 SLKIMQYFSHFIRSGNPNYpyefsrkvPTFATPWPDFVPraggENYKEFSELLPNR--QGLKKADCSFW 2645
Cdd:pfam00135  457 SRKMMTYWTNFAKTGNPNG--------PEGLPKWPPYTD----ENGQYLSIDLEPRvkQGLKAERCAFW 513
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 95-160 8.67e-22

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 90.99  E-value: 8.67e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852   95 FCQLQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRC 160
Cdd:cd00191      1 PCERERASALESLAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 300-358 7.69e-19

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 82.51  E-value: 7.69e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852  300 KCEVERFTATS------FGHPYVPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSC 358
Cdd:cd00191      1 PCERERASALEslagpkLSGLYVPQCDEDGNYEPVQCHGStGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 662-724 1.68e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 81.58  E-value: 1.68e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462620852  662 CEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPK 724
Cdd:pfam00086    1 CERERARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGStgYCWCVDPEGQEIPGTRTRGGDPD 65
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1149-1210 3.07e-18

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 80.97  E-value: 3.07e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852 1149 CNVLKSGVLSRRVSPG----YVPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPAC 1210
Cdd:cd00191      2 CERERASALESLAGPKlsglYVPQCD-EDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 599-658 6.72e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 80.04  E-value: 6.72e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462620852  599 METVLSSQTCEQTPERLFVPSCTTEGSYEDVQCFS--GECWCVNSWGKELPGSRVRGGQPRC 658
Cdd:pfam00086    5 RARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGstGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 33-92 1.81e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 78.66  E-value: 1.81e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852   33 PCELQRETAFLKQA------DYVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVAC 92
Cdd:cd00191      1 PCERERASALESLAgpklsgLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1004-1073 5.28e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 77.50  E-value: 5.28e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 1004 FYQRRRFSPDDSAgaSALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARslQIPQC 1073
Cdd:cd00191      1 PCERERASALESL--AGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRG--GPPNC 66
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
 1392-1437 7.67e-15

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


:

Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 70.46  E-value: 7.67e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462620852 1392 GSYSQDE--ECIPCPVGFYQEQAGSLACVPCPVGRTTISAGAFSQTHC 1437
Cdd:pfam07699    1 GTYSNTGlePCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1447-1494 2.82e-08

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


:

Pssm-ID: 214561  Cd Length: 46  Bit Score: 51.99  E-value: 2.82e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 2462620852  1447 GLQCDQNGQYRASQKDRGSGKAFCVDGEGRRLPWweTEAPLEDSQCLM 1494
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPG--TRTEGGDPDCPS 46
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1077-1145 4.40e-05

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 43.61  E-value: 4.40e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462620852 1077 CEKSRTSGLLSSwkqarsqENPSPKDLFVPACLETGEYARLQ--ASGAGTWCVDPAsGEELrPGSSS---SAQC 1145
Cdd:cd00191      2 CERERASALESL-------AGPKLSGLYVPQCDEDGNYEPVQchGSTGYCWCVDPD-GEEI-PGTRTrggPPNC 66
TY super family cl00150
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 892-922 1.05e-03

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


The actual alignment was detected with superfamily member smart00211:

Pssm-ID: 469630  Cd Length: 46  Bit Score: 38.90  E-value: 1.05e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2462620852   892 HFDLRNCWCVDEAGQELEGMRSEPSKlPTCP 922
Cdd:smart00211   16 DGSSGQCWCVDATGREIPGTRTEGGD-PDCP 45
TY super family cl00150
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 730-776 4.06e-03

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


The actual alignment was detected with superfamily member pfam00086:

Pssm-ID: 469630  Cd Length: 66  Bit Score: 38.05  E-value: 4.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2462620852  730 CQLQSEQAflrtvqaLLSNSSMLPtLSDTYIPQCSTDGQWRQVQCNG 776
Cdd:pfam00086    1 CERERARA-------LEQAASGRP-ASGLYIPNCDEDGFYKPVQCHG 39
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
2124-2645 3.12e-175

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 548.83  E-value: 3.12e-175
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2124 SVPSVPISThGRLLGRSQAIQVGtswKQVDQFLGVPYAAPPLAERRFQAPEPL-NWTGSWDASKPRASCWQPGTRTSTSP 2202
Cdd:pfam00135    1 DSPVVTTSL-GRVRGKRLKVDGG---KPVYAFLGIPYAEPPVGELRFQPPEPPePWTGVRDATKFGPRCPQNGDLTSPGS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2203 ---GVSEDCLYLNVFIPQNVAPNA---SVLVFFHNTMDREESegWPAIDGSFLAAVGNLIVVTASYRVGVFGFLSSGSGE 2276
Cdd:pfam00135   77 sglEGSEDCLYLNVYTPKELKENKnklPVMVWIHGGGFMFGS--GSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTGDDE 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2277 VSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARAtnSQLFRRAVLMGGSALSPAAVISHERa 2356
Cdd:pfam00135  155 APGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLS--KGLFHRAILMSGSALSPWAIQSNAR- 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2357 qQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLL-AVSGPFHYWGPVIDGHFLREPPARALKRSLRVEVDLLI 2435
Cdd:pfam00135  232 -QRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLvYGSVPFVPFGPVVDGDFLPEHPEELLKSGNFPKVPLLI 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2436 GSSQDDGLINRA------KAVKQFEESQGRTSSKTAFYQALqnslggEDSDARVEAAATWYYSLEHSTDDYASFSRALEN 2509
Cdd:pfam00135  311 GVTKDEGLLFAAyildnvDILKALEEKLLRSLLIDLLYLLL------VDLPEEISAALREEYLDWGDRDDPETSRRALVE 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2510 ATRDYFIICPIIDMASAWAKRaRGNVFMYH---------APENYG--HGSlellaDVQFALGLPFYPAYEgqFSLEEKSL 2578
Cdd:pfam00135  385 LLTDYLFNCPVIRFADLHASR-GTPVYMYSfdyrgsslrYPKWVGvdHGD-----ELPYVFGTPFVGALL--FTEEDEKL 456

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462620852 2579 SLKIMQYFSHFIRSGNPNYpyefsrkvPTFATPWPDFVPraggENYKEFSELLPNR--QGLKKADCSFW 2645
Cdd:pfam00135  457 SRKMMTYWTNFAKTGNPNG--------PEGLPKWPPYTD----ENGQYLSIDLEPRvkQGLKAERCAFW 513
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
2132-2620 1.14e-94

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 316.83  E-value: 1.14e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2132 THGRLLGRSQAiqvgtswkQVDQFLGVPYAAPPLAERRFQAPEPL-NWTGSWDASKPRASCWQPGTRTST--SPGVSEDC 2208
Cdd:COG2272     18 EAGRVRGVVEG--------GVRVFLGIPYAAPPVGELRWRAPQPVePWTGVRDATEFGPACPQPPRPGDPggPAPGSEDC 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2209 LYLNVFIPqNVAPNAS--VLVFFH---NTMdreeseGWPAI---DGSFLAAVGnLIVVTASYRVGVFGF-----LSSGSG 2275
Cdd:COG2272     90 LYLNVWTP-ALAAGAKlpVMVWIHgggFVS------GSGSEplyDGAALARRG-VVVVTINYRLGALGFlalpaLSGESY 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2276 EVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLA---AdrGGADVASihLLTARATNSqLFRRAVLMGGSALSPAaviS 2352
Cdd:COG2272    162 GASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFgesA--GAASVAA--LLASPLAKG-LFHRAIAQSGAGLSVL---T 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2353 HERAQQQAIALAKEVSCPMSSsqevVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLRVEVD 2432
Cdd:COG2272    234 LAEAEAVGAAFAAALGVAPAT----LAALRALPAEELLAAQAALAAEGPGGLPFGPVVDGDVLPEDPLEAFAAGRAADVP 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2433 LLIGSSQDDGLINRAKAVKQFEESQGRtssktafYQALQNSLGGEDSDARVEAaatwyyslehstddY--ASFSRALENA 2510
Cdd:COG2272    310 LLIGTNRDEGRLFAALLGDLGPLTAAD-------YRAALRRRFGDDADEVLAA--------------YpaASPAEALAAL 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2511 TRDYFIICPIIDMASAWAkRARGNVFMY---HAPENYG-------HGslellADVQFALGLPFYPAYEGqFSLEEKSLSL 2580
Cdd:COG2272    369 ATDRVFRCPARRLAEAHA-AAGAPVYLYrfdWRSPPLRgfglgafHG-----AELPFVFGNLDAPALTG-LTPADRALSD 441

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 2462620852 2581 KIMQYFSHFIRSGNPNYPYefsrkvptfATPWPDFVPRAG 2620
Cdd:COG2272    442 QMQAYWVNFARTGDPNGPG---------LPEWPAYDPEDR 472
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 2152-2624 1.81e-92

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 310.42  E-value: 1.81e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2152 VDQFLGVPYAAPPLAERRFQAPEPLN-WTGSWDASKPRASC-----WQPGTRTSTSPGvSEDCLYLNVFIPQNVAPNAS- 2224
Cdd:cd00312     17 VYSFLGIPYAEPPVGDLRFKEPQPYEpWSDVLDATSYPPSCmqwdqLGGGLWNAKLPG-SEDCLYLNVYTPKNTKPGNSl 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2225 -VLVFFHntmdreeSEGW----PAIDG--SFLAAVGNLIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALTWVQTHI 2297
Cdd:cd00312     96 pVMVWIH-------GGGFmfgsGSLYPgdGLAREGDNVIVVSINYRLGVLGFLSTGDIELPGNYGLKDQRLALKWVQDNI 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2298 RGFGGDPRRVSLAADRGGAdvASIHLLTARATNSQLFRRAVLMGGSALSPAAVisHERAQQQAIALAKEVSCPMSSSQEV 2377
Cdd:cd00312    169 AAFGGDPDSVTIFGESAGG--ASVSLLLLSPDSKGLFHRAISQSGSALSPWAI--QENARGRAKRLARLLGCNDTSSAEL 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2378 VSCLRQKPANVLNDAQTKLLAVSG-PFHYWGPVIDGHFLREPPARALKRSLRVEVDLLIGSSQDDGLINRAKAVKQFEES 2456
Cdd:cd00312    245 LDCLRSKSAEELLDATRKLLLFSYsPFLPFGPVVDGDFIPDDPEELIKEGKFAKVPLIIGVTKDEGGYFAAMLLNFDAKL 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2457 QGRTSskTAFYQALQNSLGGEDsDARVEAAATWYY-SLEHSTDDYASFSRALEnatrDYFIICPIIDMASAWAKRARGNV 2535
Cdd:cd00312    325 IIETN--DRWLELLPYLLFYAD-DALADKVLEKYPgDVDDSVESRKNLSDMLT----DLLFKCPARYFLAQHRKAGGSPV 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2536 FMYH-----------APENYG--HGSlellaDVQFALGLPFypaYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNypYEFS 2602
Cdd:cd00312    398 YAYVfdhrsslsvgrWPPWLGtvHGD-----EIFFVFGNPL---LKEGLREEEEKLSRTMMKYWANFAKTGNPN--TEGN 467

                          490       500
                   ....*....|....*....|..
gi 2462620852 2603 RKVptfatpWPDFVprAGGENY 2624
Cdd:cd00312    468 LVV------WPAYT--SESEKY 481
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 95-160 8.67e-22

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 90.99  E-value: 8.67e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852   95 FCQLQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRC 160
Cdd:cd00191      1 PCERERASALESLAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 96-160 7.01e-19

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 82.74  E-value: 7.01e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852   96 CQLQKQQILLS-GYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRC 160
Cdd:pfam00086    1 CERERARALEQaASGRPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 300-358 7.69e-19

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 82.51  E-value: 7.69e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852  300 KCEVERFTATS------FGHPYVPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSC 358
Cdd:cd00191      1 PCERERASALEslagpkLSGLYVPQCDEDGNYEPVQCHGStGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 662-724 1.68e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 81.58  E-value: 1.68e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462620852  662 CEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPK 724
Cdd:pfam00086    1 CERERARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGStgYCWCVDPEGQEIPGTRTRGGDPD 65
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1149-1210 3.07e-18

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 80.97  E-value: 3.07e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852 1149 CNVLKSGVLSRRVSPG----YVPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPAC 1210
Cdd:cd00191      2 CERERASALESLAGPKlsglYVPQCD-EDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 599-658 6.72e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 80.04  E-value: 6.72e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462620852  599 METVLSSQTCEQTPERLFVPSCTTEGSYEDVQCFS--GECWCVNSWGKELPGSRVRGGQPRC 658
Cdd:pfam00086    5 RARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGstGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 33-92 1.81e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 78.66  E-value: 1.81e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852   33 PCELQRETAFLKQA------DYVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVAC 92
Cdd:cd00191      1 PCERERASALESLAgpklsgLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 612-658 2.07e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 78.66  E-value: 2.07e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462620852  612 PERLFVPSCTTEGSYEDVQCFS--GECWCVNSWGKELPGSRVRGGQPRC 658
Cdd:cd00191     18 LSGLYVPQCDEDGNYEPVQCHGstGYCWCVDPDGEEIPGTRTRGGPPNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 662-724 3.87e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 77.89  E-value: 3.87e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462620852  662 CEKQRARMQSLMgSQPAGSTLFVPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPK 724
Cdd:cd00191      2 CERERASALESL-AGPKLSGLYVPQCDEDGNYEPVQCHGStgYCWCVDPDGEEIPGTRTRGGPPN 65
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1004-1073 5.28e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 77.50  E-value: 5.28e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 1004 FYQRRRFSPDDSAgaSALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARslQIPQC 1073
Cdd:cd00191      1 PCERERASALESL--AGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRG--GPPNC 66
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
 1392-1437 7.67e-15

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 70.46  E-value: 7.67e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462620852 1392 GSYSQDE--ECIPCPVGFYQEQAGSLACVPCPVGRTTISAGAFSQTHC 1437
Cdd:pfam07699    1 GTYSNTGlePCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 1151-1210 9.50e-15

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 70.79  E-value: 9.50e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 1151 VLKSGVLSRRVSPGYVPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPAC 1210
Cdd:pfam00086    8 ALEQAASGRPASGLYIPNCD-EDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGDPDC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 1024-1073 1.24e-14

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 70.41  E-value: 1.24e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462620852 1024 SGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSlqIPQC 1073
Cdd:pfam00086   19 SGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGG--DPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 117-162 4.15e-14

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 68.56  E-value: 4.15e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462620852   117 LPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPR 162
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGGDPDCPS 46
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 301-358 4.75e-14

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 68.87  E-value: 4.75e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852  301 CEVERFTA---TSFGHP----YVPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSC 358
Cdd:pfam00086    1 CERERARAleqAASGRPasglYIPNCDEDGFYKPVQCHGStGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1166-1212 5.61e-14

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 68.17  E-value: 5.61e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 2462620852  1166 VPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPACES 1212
Cdd:smart00211    1 IPQCD-EDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGGDPDCPS 46
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 34-92 7.68e-13

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 65.40  E-value: 7.68e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852   34 CELQRETAFLKQAD-------YVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVAC 92
Cdd:pfam00086    1 CERERARALEQAASgrpasglYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 316-360 1.03e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 64.32  E-value: 1.03e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462620852   316 VPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSCAE 360
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSsGQCWCVDATGREIPGTRTEGGDPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 49-94 1.18e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 64.32  E-value: 1.18e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462620852    49 VPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVACLS 94
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGGDPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1028-1075 1.54e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 63.94  E-value: 1.54e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 2462620852  1028 MPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSlqIPQCPT 1075
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGG--DPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 617-660 3.08e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 63.17  E-value: 3.08e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462620852   617 VPSCTTEGSYEDVQCF--SGECWCVNSWGKELPGSRVRGGQPRCPT 660
Cdd:smart00211    1 IPQCDEDGNYEPVQCDgsSGQCWCVDATGREIPGTRTEGGDPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 684-728 5.49e-11

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 59.70  E-value: 5.49e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 2462620852   684 VPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPkKCPT 728
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSsgQCWCVDATGREIPGTRTEGGDP-DCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1447-1494 2.82e-08

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 51.99  E-value: 2.82e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 2462620852  1447 GLQCDQNGQYRASQKDRGSGKAFCVDGEGRRLPWweTEAPLEDSQCLM 1494
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPG--TRTEGGDPDCPS 46
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1077-1145 4.40e-05

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 43.61  E-value: 4.40e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462620852 1077 CEKSRTSGLLSSwkqarsqENPSPKDLFVPACLETGEYARLQ--ASGAGTWCVDPAsGEELrPGSSS---SAQC 1145
Cdd:cd00191      2 CERERASALESL-------AGPKLSGLYVPQCDEDGNYEPVQchGSTGYCWCVDPD-GEEI-PGTRTrggPPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 892-922 1.05e-03

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 38.90  E-value: 1.05e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2462620852   892 HFDLRNCWCVDEAGQELEGMRSEPSKlPTCP 922
Cdd:smart00211   16 DGSSGQCWCVDATGREIPGTRTEGGD-PDCP 45
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 730-776 4.06e-03

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 38.05  E-value: 4.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2462620852  730 CQLQSEQAflrtvqaLLSNSSMLPtLSDTYIPQCSTDGQWRQVQCNG 776
Cdd:pfam00086    1 CERERARA-------LEQAASGRP-ASGLYIPNCDEDGFYKPVQCHG 39
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 1449-1479 4.14e-03

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 38.05  E-value: 4.14e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2462620852 1449 QCDQNGQYRASQKDRGSGKAFCVDGEGRRLP 1479
Cdd:pfam00086   25 NCDEDGFYKPVQCHGSTGYCWCVDPEGQEIP 55
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 729-776 4.42e-03

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 37.83  E-value: 4.42e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462620852  729 PCQLQSEQAFLRTVQALLSNSsmlptlsdtYIPQCSTDGQWRQVQCNG 776
Cdd:cd00191      1 PCERERASALESLAGPKLSGL---------YVPQCDEDGNYEPVQCHG 39
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 892-921 6.61e-03

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 37.44  E-value: 6.61e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462620852  892 HFDLRNCWCVDEAGQELEGMRSEPSKlPTC 921
Cdd:cd00191     38 HGSTGYCWCVDPDGEEIPGTRTRGGP-PNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1449-1492 7.09e-03

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 37.44  E-value: 7.09e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462620852 1449 QCDQNGQYRASQKDRGSGKAFCVDGEGRRLPwwETEAPLEDSQC 1492
Cdd:cd00191     25 QCDEDGNYEPVQCHGSTGYCWCVDPDGEEIP--GTRTRGGPPNC 66
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
2124-2645 3.12e-175

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 548.83  E-value: 3.12e-175
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2124 SVPSVPISThGRLLGRSQAIQVGtswKQVDQFLGVPYAAPPLAERRFQAPEPL-NWTGSWDASKPRASCWQPGTRTSTSP 2202
Cdd:pfam00135    1 DSPVVTTSL-GRVRGKRLKVDGG---KPVYAFLGIPYAEPPVGELRFQPPEPPePWTGVRDATKFGPRCPQNGDLTSPGS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2203 ---GVSEDCLYLNVFIPQNVAPNA---SVLVFFHNTMDREESegWPAIDGSFLAAVGNLIVVTASYRVGVFGFLSSGSGE 2276
Cdd:pfam00135   77 sglEGSEDCLYLNVYTPKELKENKnklPVMVWIHGGGFMFGS--GSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTGDDE 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2277 VSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARAtnSQLFRRAVLMGGSALSPAAVISHERa 2356
Cdd:pfam00135  155 APGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLS--KGLFHRAILMSGSALSPWAIQSNAR- 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2357 qQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLL-AVSGPFHYWGPVIDGHFLREPPARALKRSLRVEVDLLI 2435
Cdd:pfam00135  232 -QRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLvYGSVPFVPFGPVVDGDFLPEHPEELLKSGNFPKVPLLI 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2436 GSSQDDGLINRA------KAVKQFEESQGRTSSKTAFYQALqnslggEDSDARVEAAATWYYSLEHSTDDYASFSRALEN 2509
Cdd:pfam00135  311 GVTKDEGLLFAAyildnvDILKALEEKLLRSLLIDLLYLLL------VDLPEEISAALREEYLDWGDRDDPETSRRALVE 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2510 ATRDYFIICPIIDMASAWAKRaRGNVFMYH---------APENYG--HGSlellaDVQFALGLPFYPAYEgqFSLEEKSL 2578
Cdd:pfam00135  385 LLTDYLFNCPVIRFADLHASR-GTPVYMYSfdyrgsslrYPKWVGvdHGD-----ELPYVFGTPFVGALL--FTEEDEKL 456

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462620852 2579 SLKIMQYFSHFIRSGNPNYpyefsrkvPTFATPWPDFVPraggENYKEFSELLPNR--QGLKKADCSFW 2645
Cdd:pfam00135  457 SRKMMTYWTNFAKTGNPNG--------PEGLPKWPPYTD----ENGQYLSIDLEPRvkQGLKAERCAFW 513
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
2132-2620 1.14e-94

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 316.83  E-value: 1.14e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2132 THGRLLGRSQAiqvgtswkQVDQFLGVPYAAPPLAERRFQAPEPL-NWTGSWDASKPRASCWQPGTRTST--SPGVSEDC 2208
Cdd:COG2272     18 EAGRVRGVVEG--------GVRVFLGIPYAAPPVGELRWRAPQPVePWTGVRDATEFGPACPQPPRPGDPggPAPGSEDC 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2209 LYLNVFIPqNVAPNAS--VLVFFH---NTMdreeseGWPAI---DGSFLAAVGnLIVVTASYRVGVFGF-----LSSGSG 2275
Cdd:COG2272     90 LYLNVWTP-ALAAGAKlpVMVWIHgggFVS------GSGSEplyDGAALARRG-VVVVTINYRLGALGFlalpaLSGESY 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2276 EVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLA---AdrGGADVASihLLTARATNSqLFRRAVLMGGSALSPAaviS 2352
Cdd:COG2272    162 GASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFgesA--GAASVAA--LLASPLAKG-LFHRAIAQSGAGLSVL---T 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2353 HERAQQQAIALAKEVSCPMSSsqevVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLRVEVD 2432
Cdd:COG2272    234 LAEAEAVGAAFAAALGVAPAT----LAALRALPAEELLAAQAALAAEGPGGLPFGPVVDGDVLPEDPLEAFAAGRAADVP 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2433 LLIGSSQDDGLINRAKAVKQFEESQGRtssktafYQALQNSLGGEDSDARVEAaatwyyslehstddY--ASFSRALENA 2510
Cdd:COG2272    310 LLIGTNRDEGRLFAALLGDLGPLTAAD-------YRAALRRRFGDDADEVLAA--------------YpaASPAEALAAL 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2511 TRDYFIICPIIDMASAWAkRARGNVFMY---HAPENYG-------HGslellADVQFALGLPFYPAYEGqFSLEEKSLSL 2580
Cdd:COG2272    369 ATDRVFRCPARRLAEAHA-AAGAPVYLYrfdWRSPPLRgfglgafHG-----AELPFVFGNLDAPALTG-LTPADRALSD 441

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 2462620852 2581 KIMQYFSHFIRSGNPNYPYefsrkvptfATPWPDFVPRAG 2620
Cdd:COG2272    442 QMQAYWVNFARTGDPNGPG---------LPEWPAYDPEDR 472
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 2152-2624 1.81e-92

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 310.42  E-value: 1.81e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2152 VDQFLGVPYAAPPLAERRFQAPEPLN-WTGSWDASKPRASC-----WQPGTRTSTSPGvSEDCLYLNVFIPQNVAPNAS- 2224
Cdd:cd00312     17 VYSFLGIPYAEPPVGDLRFKEPQPYEpWSDVLDATSYPPSCmqwdqLGGGLWNAKLPG-SEDCLYLNVYTPKNTKPGNSl 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2225 -VLVFFHntmdreeSEGW----PAIDG--SFLAAVGNLIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALTWVQTHI 2297
Cdd:cd00312     96 pVMVWIH-------GGGFmfgsGSLYPgdGLAREGDNVIVVSINYRLGVLGFLSTGDIELPGNYGLKDQRLALKWVQDNI 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2298 RGFGGDPRRVSLAADRGGAdvASIHLLTARATNSQLFRRAVLMGGSALSPAAVisHERAQQQAIALAKEVSCPMSSSQEV 2377
Cdd:cd00312    169 AAFGGDPDSVTIFGESAGG--ASVSLLLLSPDSKGLFHRAISQSGSALSPWAI--QENARGRAKRLARLLGCNDTSSAEL 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2378 VSCLRQKPANVLNDAQTKLLAVSG-PFHYWGPVIDGHFLREPPARALKRSLRVEVDLLIGSSQDDGLINRAKAVKQFEES 2456
Cdd:cd00312    245 LDCLRSKSAEELLDATRKLLLFSYsPFLPFGPVVDGDFIPDDPEELIKEGKFAKVPLIIGVTKDEGGYFAAMLLNFDAKL 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2457 QGRTSskTAFYQALQNSLGGEDsDARVEAAATWYY-SLEHSTDDYASFSRALEnatrDYFIICPIIDMASAWAKRARGNV 2535
Cdd:cd00312    325 IIETN--DRWLELLPYLLFYAD-DALADKVLEKYPgDVDDSVESRKNLSDMLT----DLLFKCPARYFLAQHRKAGGSPV 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2536 FMYH-----------APENYG--HGSlellaDVQFALGLPFypaYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNypYEFS 2602
Cdd:cd00312    398 YAYVfdhrsslsvgrWPPWLGtvHGD-----EIFFVFGNPL---LKEGLREEEEKLSRTMMKYWANFAKTGNPN--TEGN 467

                          490       500
                   ....*....|....*....|..
gi 2462620852 2603 RKVptfatpWPDFVprAGGENY 2624
Cdd:cd00312    468 LVV------WPAYT--SESEKY 481
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 95-160 8.67e-22

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 90.99  E-value: 8.67e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852   95 FCQLQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRC 160
Cdd:cd00191      1 PCERERASALESLAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 96-160 7.01e-19

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 82.74  E-value: 7.01e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852   96 CQLQKQQILLS-GYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRC 160
Cdd:pfam00086    1 CERERARALEQaASGRPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 300-358 7.69e-19

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 82.51  E-value: 7.69e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852  300 KCEVERFTATS------FGHPYVPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSC 358
Cdd:cd00191      1 PCERERASALEslagpkLSGLYVPQCDEDGNYEPVQCHGStGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 662-724 1.68e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 81.58  E-value: 1.68e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462620852  662 CEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPK 724
Cdd:pfam00086    1 CERERARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGStgYCWCVDPEGQEIPGTRTRGGDPD 65
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1149-1210 3.07e-18

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 80.97  E-value: 3.07e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852 1149 CNVLKSGVLSRRVSPG----YVPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPAC 1210
Cdd:cd00191      2 CERERASALESLAGPKlsglYVPQCD-EDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 599-658 6.72e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 80.04  E-value: 6.72e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462620852  599 METVLSSQTCEQTPERLFVPSCTTEGSYEDVQCFS--GECWCVNSWGKELPGSRVRGGQPRC 658
Cdd:pfam00086    5 RARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGstGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 33-92 1.81e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 78.66  E-value: 1.81e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852   33 PCELQRETAFLKQA------DYVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVAC 92
Cdd:cd00191      1 PCERERASALESLAgpklsgLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 612-658 2.07e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 78.66  E-value: 2.07e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462620852  612 PERLFVPSCTTEGSYEDVQCFS--GECWCVNSWGKELPGSRVRGGQPRC 658
Cdd:cd00191     18 LSGLYVPQCDEDGNYEPVQCHGstGYCWCVDPDGEEIPGTRTRGGPPNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 662-724 3.87e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 77.89  E-value: 3.87e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462620852  662 CEKQRARMQSLMgSQPAGSTLFVPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPK 724
Cdd:cd00191      2 CERERASALESL-AGPKLSGLYVPQCDEDGNYEPVQCHGStgYCWCVDPDGEEIPGTRTRGGPPN 65
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1004-1073 5.28e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 77.50  E-value: 5.28e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 1004 FYQRRRFSPDDSAgaSALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARslQIPQC 1073
Cdd:cd00191      1 PCERERASALESL--AGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRG--GPPNC 66
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
 1392-1437 7.67e-15

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 70.46  E-value: 7.67e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462620852 1392 GSYSQDE--ECIPCPVGFYQEQAGSLACVPCPVGRTTISAGAFSQTHC 1437
Cdd:pfam07699    1 GTYSNTGlePCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 1151-1210 9.50e-15

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 70.79  E-value: 9.50e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 1151 VLKSGVLSRRVSPGYVPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPAC 1210
Cdd:pfam00086    8 ALEQAASGRPASGLYIPNCD-EDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGDPDC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 1024-1073 1.24e-14

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 70.41  E-value: 1.24e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462620852 1024 SGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSlqIPQC 1073
Cdd:pfam00086   19 SGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGG--DPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 117-162 4.15e-14

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 68.56  E-value: 4.15e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462620852   117 LPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPR 162
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGGDPDCPS 46
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 301-358 4.75e-14

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 68.87  E-value: 4.75e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852  301 CEVERFTA---TSFGHP----YVPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSC 358
Cdd:pfam00086    1 CERERARAleqAASGRPasglYIPNCDEDGFYKPVQCHGStGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1166-1212 5.61e-14

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 68.17  E-value: 5.61e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 2462620852  1166 VPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPACES 1212
Cdd:smart00211    1 IPQCD-EDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGGDPDCPS 46
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 34-92 7.68e-13

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 65.40  E-value: 7.68e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620852   34 CELQRETAFLKQAD-------YVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVAC 92
Cdd:pfam00086    1 CERERARALEQAASgrpasglYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 316-360 1.03e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 64.32  E-value: 1.03e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462620852   316 VPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSCAE 360
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSsGQCWCVDATGREIPGTRTEGGDPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 49-94 1.18e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 64.32  E-value: 1.18e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462620852    49 VPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVACLS 94
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGGDPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1028-1075 1.54e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 63.94  E-value: 1.54e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 2462620852  1028 MPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSlqIPQCPT 1075
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGG--DPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 617-660 3.08e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 63.17  E-value: 3.08e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462620852   617 VPSCTTEGSYEDVQCF--SGECWCVNSWGKELPGSRVRGGQPRCPT 660
Cdd:smart00211    1 IPQCDEDGNYEPVQCDgsSGQCWCVDATGREIPGTRTEGGDPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 684-728 5.49e-11

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 59.70  E-value: 5.49e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 2462620852   684 VPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPkKCPT 728
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSsgQCWCVDATGREIPGTRTEGGDP-DCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1447-1494 2.82e-08

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 51.99  E-value: 2.82e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 2462620852  1447 GLQCDQNGQYRASQKDRGSGKAFCVDGEGRRLPWweTEAPLEDSQCLM 1494
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPG--TRTEGGDPDCPS 46
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
2213-2348 5.73e-07

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 52.57  E-value: 5.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620852 2213 VFIPQNVAPNASVLVFFH---------NTMDREesegwpaidGSFLAAVGNLIVVTASYRVgvfgflssgSGEVSGNWGL 2283
Cdd:COG0657      3 VYRPAGAKGPLPVVVYFHgggwvsgskDTHDPL---------ARRLAARAGAAVVSVDYRL---------APEHPFPAAL 64

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462620852 2284 LDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGS---ALSPA 2348
Cdd:COG0657     65 EDAYAALRWLRANAAELGIDPDRIAVAGDSAGGHLAAALALRARDRGGPRPAAQVLIYPVldlTASPL 132
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1077-1145 4.40e-05

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 43.61  E-value: 4.40e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462620852 1077 CEKSRTSGLLSSwkqarsqENPSPKDLFVPACLETGEYARLQ--ASGAGTWCVDPAsGEELrPGSSS---SAQC 1145
Cdd:cd00191      2 CERERASALESL-------AGPKLSGLYVPQCDEDGNYEPVQchGSTGYCWCVDPD-GEEI-PGTRTrggPPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 892-922 1.05e-03

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 38.90  E-value: 1.05e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2462620852   892 HFDLRNCWCVDEAGQELEGMRSEPSKlPTCP 922
Cdd:smart00211   16 DGSSGQCWCVDATGREIPGTRTEGGD-PDCP 45
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 730-776 4.06e-03

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 38.05  E-value: 4.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2462620852  730 CQLQSEQAflrtvqaLLSNSSMLPtLSDTYIPQCSTDGQWRQVQCNG 776
Cdd:pfam00086    1 CERERARA-------LEQAASGRP-ASGLYIPNCDEDGFYKPVQCHG 39
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 1449-1479 4.14e-03

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 38.05  E-value: 4.14e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2462620852 1449 QCDQNGQYRASQKDRGSGKAFCVDGEGRRLP 1479
Cdd:pfam00086   25 NCDEDGFYKPVQCHGSTGYCWCVDPEGQEIP 55
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 729-776 4.42e-03

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 37.83  E-value: 4.42e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462620852  729 PCQLQSEQAFLRTVQALLSNSsmlptlsdtYIPQCSTDGQWRQVQCNG 776
Cdd:cd00191      1 PCERERASALESLAGPKLSGL---------YVPQCDEDGNYEPVQCHG 39
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 892-921 6.61e-03

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 37.44  E-value: 6.61e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462620852  892 HFDLRNCWCVDEAGQELEGMRSEPSKlPTC 921
Cdd:cd00191     38 HGSTGYCWCVDPDGEEIPGTRTRGGP-PNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1449-1492 7.09e-03

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 37.44  E-value: 7.09e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462620852 1449 QCDQNGQYRASQKDRGSGKAFCVDGEGRRLPwwETEAPLEDSQC 1492
Cdd:cd00191     25 QCDEDGNYEPVQCHGSTGYCWCVDPDGEEIP--GTRTRGGPPNC 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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