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Conserved domains on  [gi|2462620066|ref|XP_054216745|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X2 [Homo sapiens]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10168517)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-166 1.46e-33

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 118.11  E-value: 1.46e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620066  63 LFFFENYTGVQILLYGDLPK-NKENIIYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYV 141
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100
                  ....*....|....*....|....*
gi 2462620066 142 KRSAKFNEKEMRNKLQSYVDAGTPN 166
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPF 105
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-166 1.46e-33

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 118.11  E-value: 1.46e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620066  63 LFFFENYTGVQILLYGDLPK-NKENIIYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYV 141
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100
                  ....*....|....*....|....*
gi 2462620066 142 KRSAKFNEKEMRNKLQSYVDAGTPN 166
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPF 105
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 13-165 7.74e-15

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 71.27  E-value: 7.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620066  13 RYLLPSVVLLGTAPTYVLAWGvwrLLSAFLPaRFYQALDDR-----LYCVYQSMVLFFFENYTGVQILLYGDLPKNKENI 87
Cdd:PLN02510   19 RGLICLLVLLSTAFMMLVYLA---PVSAVLL-RLFSVHYSRkatsfFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERV 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462620066  88 IYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYVDAGTP 165
Cdd:PLN02510   95 LLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDP 172
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 87-162 2.59e-11

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 58.14  E-value: 2.59e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620066   87 IIYLANHQSTVDWIVadILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSakfNEKEMRNKLQSYVDA 162
Cdd:smart00563   1 ALVVANHQSFLDPLV--LSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRS---NGRKARAALREAVEL 71
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 36-165 1.18e-07

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 50.01  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620066  36 RLLSAFLPARFYQALddRLYCvyqSMVLFFFenYTGVQILLYGDLPKNKeNIIYLANHQSTVDWIVAdILAIRQnalgHV 115
Cdd:COG0204     2 RSLFLLLRRFRYRLV--RLWA---RLLLRLL--GVRVRVEGLENLPADG-PVLIVANHQSWLDILLL-LAALPR----PV 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462620066 116 RYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYVDAGTP 165
Cdd:COG0204    69 RFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAALRALRQAVEALKAGES 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 83-157 6.83e-05

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 41.11  E-value: 6.83e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620066  83 NKENIIYLANHQSTVDWIVADILAIRQNALghVRYVLKEGLKWLPLYGcYFAQHGG-IYVKRSakfNEKEMRNKLQ 157
Cdd:pfam01553  12 RGGPAIVVANHQSYLDVLLLSLALYKRGRP--LVFVAKKELFDIPLVG-WLMRLLGcIFIDRK---NRKDAAGTLE 81
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-166 1.46e-33

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 118.11  E-value: 1.46e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620066  63 LFFFENYTGVQILLYGDLPK-NKENIIYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYV 141
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100
                  ....*....|....*....|....*
gi 2462620066 142 KRSAKFNEKEMRNKLQSYVDAGTPN 166
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPF 105
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 13-165 7.74e-15

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 71.27  E-value: 7.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620066  13 RYLLPSVVLLGTAPTYVLAWGvwrLLSAFLPaRFYQALDDR-----LYCVYQSMVLFFFENYTGVQILLYGDLPKNKENI 87
Cdd:PLN02510   19 RGLICLLVLLSTAFMMLVYLA---PVSAVLL-RLFSVHYSRkatsfFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERV 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462620066  88 IYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYVDAGTP 165
Cdd:PLN02510   95 LLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDP 172
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 87-162 2.59e-11

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 58.14  E-value: 2.59e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620066   87 IIYLANHQSTVDWIVadILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSakfNEKEMRNKLQSYVDA 162
Cdd:smart00563   1 ALVVANHQSFLDPLV--LSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRS---NGRKARAALREAVEL 71
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 63-161 4.66e-10

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 57.83  E-value: 4.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620066  63 LFFFENYTGVQILLYGDLPK----NKENIIYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYG--CYFAQH 136
Cdd:PLN02380   58 IWLVDWWAGVKVQLYADEETfelmGKEHALVISNHRSDIDWLVGWILAQRSGCLGSALAVMKKSSKFLPVIGwsMWFSEY 137

                          90       100
                  ....*....|....*....|....*
gi 2462620066 137 ggIYVKRSAKFNEKEMRNKLQSYVD 161
Cdd:PLN02380  138 --VFLERSWAKDENTLKSGFQRLKD 160
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 36-165 1.18e-07

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 50.01  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620066  36 RLLSAFLPARFYQALddRLYCvyqSMVLFFFenYTGVQILLYGDLPKNKeNIIYLANHQSTVDWIVAdILAIRQnalgHV 115
Cdd:COG0204     2 RSLFLLLRRFRYRLV--RLWA---RLLLRLL--GVRVRVEGLENLPADG-PVLIVANHQSWLDILLL-LAALPR----PV 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462620066 116 RYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYVDAGTP 165
Cdd:COG0204    69 RFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAALRALRQAVEALKAGES 118
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 82-163 1.69e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 46.11  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620066  82 KNKENI------IYLANHQSTVDWIVadILAIrqnALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNK 155
Cdd:cd07989    15 EGLENLppkgpvIIVANHQSYLDPLV--LGAA---LPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGRSAREALRE 89


                  ....*...
gi 2462620066 156 LQSYVDAG 163
Cdd:cd07989    90 AIEALKEG 97
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 83-157 6.83e-05

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 41.11  E-value: 6.83e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462620066  83 NKENIIYLANHQSTVDWIVADILAIRQNALghVRYVLKEGLKWLPLYGcYFAQHGG-IYVKRSakfNEKEMRNKLQ 157
Cdd:pfam01553  12 RGGPAIVVANHQSYLDVLLLSLALYKRGRP--LVFVAKKELFDIPLVG-WLMRLLGcIFIDRK---NRKDAAGTLE 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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