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Conserved domains on  [gi|2462616741|ref|XP_054215282|]
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uncharacterized aarF domain-containing protein kinase 2 isoform X2 [Homo sapiens]

Protein Classification

protein kinase family protein( domain architecture ID 229378)

protein kinase family protein may catalyze the transfer of the gamma-phosphoryl group from ATP to substrates such as serine/threonine and/or tyrosine residues on proteins, or may be a pseudokinase

CATH:  1.10.510.10
PubMed:  16244704
SCOP:  4003661

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PKc_like super family cl21453
Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the ...
169-469 1.92e-88

Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.


The actual alignment was detected with superfamily member cd13971:

Pssm-ID: 473864 [Multi-domain]  Cd Length: 298  Bit Score: 274.48  E-value: 1.92e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 169 KLHVRVTPHPWTHTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAYantafletdsvqrlgrasclppfshtgavg 248
Cdd:cd13971     1 KLHSNAPPHSWAHTERALEAAFGKDWEDIFEEFDEEPIGSGSIAQVHRAK------------------------------ 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 249 gLRelFGYLGNGRKPpenladqsflerlllpkadlvgsnagvsraqvpghqpeatnlISVAVKVLHPGLLAQVHMDLLLM 328
Cdd:cd13971    51 -LK--PDYGGDGGGP------------------------------------------RVVAVKVLHPGVREQIERDLAIL 85
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 329 KIGSRVLGVLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVPV 408
Cdd:cd13971    86 RLFAKLLEAIPPLRWLSLPESVEQFASLMLRQLDLRVEAANLERFRENFKDRKDVSFPKPLYPLVTEEVLVETFEEGVPI 165
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 409 SSYQQAGIPVDLKRKIARLGINMLLKM----------------------------------------------------- 435
Cdd:cd13971   166 SRTVLAHGGEPLKRKLARIGLDAFLKMlfvdnfvhgdlhpgnilvrfndsnrpsllvsldargspprlvfldaglvtels 245
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462616741 436 ------------------GQRVAELILHHARAS-ECRDVEGFKTEMAMLVTQA 469
Cdd:cd13971   246 pqdrrnfidlfkavargdGYKAAELMLERSRSSqTCPDPEGFKSEMEELVNDA 298
 
Name Accession Description Interval E-value
ADCK2-like cd13971
aarF domain containing kinase 2 and similar proteins; This subfamily is composed of ...
169-469 1.92e-88

aarF domain containing kinase 2 and similar proteins; This subfamily is composed of uncharacterized ABC1 kinase-like proteins including the human protein called aarF domain containing kinase 2 (ADCK2). Eukaryotes contain at least three ABC1-like proteins; in humans, these are ADCK3 and the putative protein kinases named ADCK1 and ADCK2. Yeast Abc1p and its human homolog ADCK3 are atypical protein kinases required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Plant subfamily 10 (ABC1K10) belong to the same group of ABC1 kinases as human ADCK2. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270873 [Multi-domain]  Cd Length: 298  Bit Score: 274.48  E-value: 1.92e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 169 KLHVRVTPHPWTHTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAYantafletdsvqrlgrasclppfshtgavg 248
Cdd:cd13971     1 KLHSNAPPHSWAHTERALEAAFGKDWEDIFEEFDEEPIGSGSIAQVHRAK------------------------------ 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 249 gLRelFGYLGNGRKPpenladqsflerlllpkadlvgsnagvsraqvpghqpeatnlISVAVKVLHPGLLAQVHMDLLLM 328
Cdd:cd13971    51 -LK--PDYGGDGGGP------------------------------------------RVVAVKVLHPGVREQIERDLAIL 85
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 329 KIGSRVLGVLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVPV 408
Cdd:cd13971    86 RLFAKLLEAIPPLRWLSLPESVEQFASLMLRQLDLRVEAANLERFRENFKDRKDVSFPKPLYPLVTEEVLVETFEEGVPI 165
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 409 SSYQQAGIPVDLKRKIARLGINMLLKM----------------------------------------------------- 435
Cdd:cd13971   166 SRTVLAHGGEPLKRKLARIGLDAFLKMlfvdnfvhgdlhpgnilvrfndsnrpsllvsldargspprlvfldaglvtels 245
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462616741 436 ------------------GQRVAELILHHARAS-ECRDVEGFKTEMAMLVTQA 469
Cdd:cd13971   246 pqdrrnfidlfkavargdGYKAAELMLERSRSSqTCPDPEGFKSEMEELVNDA 298
AarF COG0661
Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme ...
142-534 2.66e-47

Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]; Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440425 [Multi-domain]  Cd Length: 487  Bit Score: 171.54  E-value: 2.66e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 142 GPTYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWTHTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAYant 221
Cdd:COG0661    63 GPTFIKLGQLLSTRPDLLPPEYAEELAKLQDRVPPFPFEEVRAVIEEELGRPLEELFAEFDPEPLAAASIGQVHRAR--- 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 222 afletdsvqrlgrasclppfshtgavgglrelfgyLGNGRKppenladqsflerlllpkadlvgsnagvsraqvpghqpe 301
Cdd:COG0661   140 -----------------------------------LKDGRE--------------------------------------- 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 302 atnlisVAVKVLHPGLLAQVHMDLLLMKIGSRVLG-VLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNV 380
Cdd:COG0661   146 ------VAVKVQRPGIEEAIEADLRILRRLARLLErLSPEGRRLDPVEVVDEFARSLLEELDYRREAANAERFRRNFADD 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 381 KAVKFPTPLRPFVTREVLVETYEESVPVSSYQQ---AGIpvDLKRkIARLGINMLLK----------------------- 434
Cdd:COG0661   220 PDVYVPKVYWELSTRRVLTMEWIDGIKISDLEAldaAGI--DRKR-LAERLVRAFLRqvfrdgffhadphpgnifvlpdg 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 435 ---------MG-------QRVAELILH-----HARASEC----------RDVEGFKTEMAMLVTQARknTITLEKLHVSS 483
Cdd:COG0661   297 rlvlldfgmVGrldpetrEGLAELLLAllnrdYDRVAEAllelgfvppdTDVDELERALRAVLEPYF--GKPLKDISFGE 374
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462616741 484 LLSSVFKLLMTHKVKLESNFASIVFAIMVLEGLGRSLDPKLDILEAARPFL 534
Cdd:COG0661   375 LLLELFELARRFPLRLPPELVLLQRTLLTLEGVGRQLDPDFDLWEVAKPFL 425
ABC1 pfam03109
ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. ...
169-436 1.88e-29

ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex and E. coli AarF is required for ubiquinone production. It has been suggested that members of the ABC1 family are novel chaperonins. These proteins are unrelated to the ABC transporter proteins.


Pssm-ID: 427143 [Multi-domain]  Cd Length: 245  Bit Score: 116.18  E-value: 1.88e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 169 KLHVRVTPHPWTHTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAyantafletdsvqRLgrasclppfsHTGAvg 248
Cdd:pfam03109   1 KLQDRAPPFPFEQAKKVIEEELGAPVEEIFAEFDEEPIAAASIAQVHRA-------------RL----------KDGE-- 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 249 glrelfgylgngrkppenladqsflerlllpkadlvgsnagvsraqvpghqpeatnliSVAVKVLHPGLLAQVHMDLLLM 328
Cdd:pfam03109  56 ----------------------------------------------------------EVAVKVQRPGVKKRIRSDLLLL 77
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 329 KIGSRVLGVL-PGIKWLslPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVP 407
Cdd:pfam03109  78 RFLAKVAKRFfPGFRRL--DWLVDEFRKSLPQELDFLREAANAEKFRENFADDPDVYVPKVYWELTTERVLTMEYVDGIK 155
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2462616741 408 VS---SYQQAGI-PVDLKRKIARLGINMLLKMG 436
Cdd:pfam03109 156 IDdldALSEAGIdRKEIARRLVELFLEQIFRDG 188
ubiB PRK04750
putative ubiquinone biosynthesis protein UbiB; Reviewed
137-429 9.83e-15

putative ubiquinone biosynthesis protein UbiB; Reviewed


Pssm-ID: 235310 [Multi-domain]  Cd Length: 537  Bit Score: 76.87  E-value: 9.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 137 ATETSGPTYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWTHTERFLRQAFG---DDWgsILSFEnREPVGSGCVAQ 213
Cdd:PRK04750   58 ALEELGPIFVKFGQMLSTRRDLFPPDIADELALLQDRVPPFDGALARAIIEKALGgpvEEW--FDDFD-IKPLASASIAQ 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 214 VYKAYantafletdsvqrlgrasclppfshtgavggLRElfgylgNGRKppenladqsflerlllpkadlvgsnagvsra 293
Cdd:PRK04750  135 VHFAR-------------------------------LKD------NGRE------------------------------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 294 qvpghqpeatnlisVAVKVLHPGLLAQVHMDLLLMKIGSRVL-GVLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEH 372
Cdd:PRK04750  147 --------------VVVKVLRPDILPVIDADLALMYRLARWVeRLLPDGRRLKPREVVAEFEKTLHDELDLMREAANASQ 212
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 373 FQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVPVS---SYQQAGIpvDLKrKIARLGI 429
Cdd:PRK04750  213 LRRNFEDSDMLYVPEVYWDYCSETVMVMERMYGIPVSdvaALRAAGT--DMK-LLAERGV 269
 
Name Accession Description Interval E-value
ADCK2-like cd13971
aarF domain containing kinase 2 and similar proteins; This subfamily is composed of ...
169-469 1.92e-88

aarF domain containing kinase 2 and similar proteins; This subfamily is composed of uncharacterized ABC1 kinase-like proteins including the human protein called aarF domain containing kinase 2 (ADCK2). Eukaryotes contain at least three ABC1-like proteins; in humans, these are ADCK3 and the putative protein kinases named ADCK1 and ADCK2. Yeast Abc1p and its human homolog ADCK3 are atypical protein kinases required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Plant subfamily 10 (ABC1K10) belong to the same group of ABC1 kinases as human ADCK2. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270873 [Multi-domain]  Cd Length: 298  Bit Score: 274.48  E-value: 1.92e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 169 KLHVRVTPHPWTHTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAYantafletdsvqrlgrasclppfshtgavg 248
Cdd:cd13971     1 KLHSNAPPHSWAHTERALEAAFGKDWEDIFEEFDEEPIGSGSIAQVHRAK------------------------------ 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 249 gLRelFGYLGNGRKPpenladqsflerlllpkadlvgsnagvsraqvpghqpeatnlISVAVKVLHPGLLAQVHMDLLLM 328
Cdd:cd13971    51 -LK--PDYGGDGGGP------------------------------------------RVVAVKVLHPGVREQIERDLAIL 85
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 329 KIGSRVLGVLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVPV 408
Cdd:cd13971    86 RLFAKLLEAIPPLRWLSLPESVEQFASLMLRQLDLRVEAANLERFRENFKDRKDVSFPKPLYPLVTEEVLVETFEEGVPI 165
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 409 SSYQQAGIPVDLKRKIARLGINMLLKM----------------------------------------------------- 435
Cdd:cd13971   166 SRTVLAHGGEPLKRKLARIGLDAFLKMlfvdnfvhgdlhpgnilvrfndsnrpsllvsldargspprlvfldaglvtels 245
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462616741 436 ------------------GQRVAELILHHARAS-ECRDVEGFKTEMAMLVTQA 469
Cdd:cd13971   246 pqdrrnfidlfkavargdGYKAAELMLERSRSSqTCPDPEGFKSEMEELVNDA 298
AarF COG0661
Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme ...
142-534 2.66e-47

Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]; Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440425 [Multi-domain]  Cd Length: 487  Bit Score: 171.54  E-value: 2.66e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 142 GPTYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWTHTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAYant 221
Cdd:COG0661    63 GPTFIKLGQLLSTRPDLLPPEYAEELAKLQDRVPPFPFEEVRAVIEEELGRPLEELFAEFDPEPLAAASIGQVHRAR--- 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 222 afletdsvqrlgrasclppfshtgavgglrelfgyLGNGRKppenladqsflerlllpkadlvgsnagvsraqvpghqpe 301
Cdd:COG0661   140 -----------------------------------LKDGRE--------------------------------------- 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 302 atnlisVAVKVLHPGLLAQVHMDLLLMKIGSRVLG-VLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNV 380
Cdd:COG0661   146 ------VAVKVQRPGIEEAIEADLRILRRLARLLErLSPEGRRLDPVEVVDEFARSLLEELDYRREAANAERFRRNFADD 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 381 KAVKFPTPLRPFVTREVLVETYEESVPVSSYQQ---AGIpvDLKRkIARLGINMLLK----------------------- 434
Cdd:COG0661   220 PDVYVPKVYWELSTRRVLTMEWIDGIKISDLEAldaAGI--DRKR-LAERLVRAFLRqvfrdgffhadphpgnifvlpdg 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 435 ---------MG-------QRVAELILH-----HARASEC----------RDVEGFKTEMAMLVTQARknTITLEKLHVSS 483
Cdd:COG0661   297 rlvlldfgmVGrldpetrEGLAELLLAllnrdYDRVAEAllelgfvppdTDVDELERALRAVLEPYF--GKPLKDISFGE 374
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462616741 484 LLSSVFKLLMTHKVKLESNFASIVFAIMVLEGLGRSLDPKLDILEAARPFL 534
Cdd:COG0661   375 LLLELFELARRFPLRLPPELVLLQRTLLTLEGVGRQLDPDFDLWEVAKPFL 425
ABC1_ADCK3-like cd05121
Activator of bc1 complex (ABC1) kinases (also called aarF domain containing kinase 3) and ...
169-435 2.45e-33

Activator of bc1 complex (ABC1) kinases (also called aarF domain containing kinase 3) and similar proteins; This family is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. Eukaryotes contain at least two more ABC1/ADCK3-like proteins: in humans, these are the putative atypical protein kinases named ADCK1 and ADCK2. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Eight of these plant ABC1 kinase subfamilies (ABC1K1-8) are specific for photosynthetic organisms. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270691 [Multi-domain]  Cd Length: 247  Bit Score: 127.23  E-value: 2.45e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 169 KLHVRVTPHPWTHTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAYantafletdsvqrlgrasclppfshtgavg 248
Cdd:cd05121     1 KLQDDVPPFPFEEVRKIIEEELGRPLEEVFAEFDPEPLAAASIAQVHRAR------------------------------ 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 249 glrelfgyLGNGRKppenladqsflerlllpkadlvgsnagvsraqvpghqpeatnlisVAVKVLHPGLLAQVHMDLLLM 328
Cdd:cd05121    51 --------LKDGRE---------------------------------------------VAVKVQRPGIEEIIEADLRIL 77
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 329 KIGSRVLG-VLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVP 407
Cdd:cd05121    78 RRLARLLErLSPLLRRLDLVAIVDEFARSLLEELDFRREARNAERFRKNLKDSPDVYVPKVYPELSTRRVLVMEYIDGVK 157
                         250       260
                  ....*....|....*....|....*...
gi 2462616741 408 VSSYQQAGIPVDLKRKIARLGINMLLKM 435
Cdd:cd05121   158 LTDLEALRAAGIDRKELARRLVDAYLKQ 185
ABC1 pfam03109
ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. ...
169-436 1.88e-29

ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex and E. coli AarF is required for ubiquinone production. It has been suggested that members of the ABC1 family are novel chaperonins. These proteins are unrelated to the ABC transporter proteins.


Pssm-ID: 427143 [Multi-domain]  Cd Length: 245  Bit Score: 116.18  E-value: 1.88e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 169 KLHVRVTPHPWTHTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAyantafletdsvqRLgrasclppfsHTGAvg 248
Cdd:pfam03109   1 KLQDRAPPFPFEQAKKVIEEELGAPVEEIFAEFDEEPIAAASIAQVHRA-------------RL----------KDGE-- 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 249 glrelfgylgngrkppenladqsflerlllpkadlvgsnagvsraqvpghqpeatnliSVAVKVLHPGLLAQVHMDLLLM 328
Cdd:pfam03109  56 ----------------------------------------------------------EVAVKVQRPGVKKRIRSDLLLL 77
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 329 KIGSRVLGVL-PGIKWLslPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVP 407
Cdd:pfam03109  78 RFLAKVAKRFfPGFRRL--DWLVDEFRKSLPQELDFLREAANAEKFRENFADDPDVYVPKVYWELTTERVLTMEYVDGIK 155
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2462616741 408 VS---SYQQAGI-PVDLKRKIARLGINMLLKMG 436
Cdd:pfam03109 156 IDdldALSEAGIdRKEIARRLVELFLEQIFRDG 188
ADCK1-like cd13969
aarF domain containing kinase 1 and similar proteins; This subfamily is composed of ...
291-446 6.21e-15

aarF domain containing kinase 1 and similar proteins; This subfamily is composed of uncharacterized ABC1 kinase-like proteins including the human protein called aarF domain containing kinase 1 (ADCK1). Eukaryotes contain at least three ABC1-like proteins: in humans, these are ADCK3 and the putative protein kinases named ADCK1 and ADCK2. Yeast Abc1p and its human homolog ADCK3 are atypical protein kinases required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Plant subfamilies 14 and 15 (ABC1K14-15) belong to the same group of ABC1 kinases as human ADCK1. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270871 [Multi-domain]  Cd Length: 253  Bit Score: 74.83  E-value: 6.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 291 SRAQVpgHQPEATNLISVAVKVLHPGLLAQVHMDLLLMKIGSRVLGVL-PGIK--WLslpeiVEEFEKLMVQQIDLRYEA 367
Cdd:cd13969    42 SLAQV--HKAKLKDGEEVAVKVQHPDLRKQFAGDLATMEFLVNLVEKLfPDFPfsWL-----VDELKKNLPKELDFLNEA 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 368 QNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEEsvpvssyqqaGIPVDLKRKIARLGIN---MLLKMGQRVAELIL 444
Cdd:cd13969   115 RNAERCAKLFKHRPDVYVPKVYWDLSSKRVLTMEFID----------GIKIDDVEALKKLGIDpkeVARLLSEAFAEMIF 184

                  ..
gi 2462616741 445 HH 446
Cdd:cd13969   185 VH 186
UbiB cd13972
Ubiquinone biosynthetic protein UbiB; UbiB is the prokaryotic homolog of yeast Abc1p and human ...
238-447 7.53e-15

Ubiquinone biosynthetic protein UbiB; UbiB is the prokaryotic homolog of yeast Abc1p and human ADCK3 (aarF domain containing kinase 3). It is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is required in the first monooxygenase step in Q biosynthesis. Mutant strains with disrupted ubiB genes lack Q and accumulate octaprenylphenol, a Q biosynthetic intermediate.


Pssm-ID: 270874 [Multi-domain]  Cd Length: 247  Bit Score: 74.16  E-value: 7.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 238 LPPFSHTGAVGGLRELFGylgngrKPPENLADqSFLERLLlpkadlvgsnAGVSRAQVpgHQPEATNLISVAVKVLHPGL 317
Cdd:cd13972     6 VPPFSGKEARAIIEAELG------KPLDALFS-DFDEEPV----------AAASIAQV--HKARLLDGREVAVKVLRPGI 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 318 LAQVHMDLLLMKIGSRVL-GVLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNVKAVKFPTPLRPFVTRE 396
Cdd:cd13972    67 EKRIERDLELLRFLARLAeRLLPEARRLRPVEVVKEFARSLLLELDLRLEAANASELRENFLDDPGFYVPEVYWELTSKN 146
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462616741 397 VLVETYEEsvpvssyqqaGIPVDLKRKIARLGINMlLKMGQRVAELILHHA 447
Cdd:cd13972   147 VLTMEWID----------GIPISDIEALDAAGIDR-KALAERLVEIFFRQV 186
ubiB PRK04750
putative ubiquinone biosynthesis protein UbiB; Reviewed
137-429 9.83e-15

putative ubiquinone biosynthesis protein UbiB; Reviewed


Pssm-ID: 235310 [Multi-domain]  Cd Length: 537  Bit Score: 76.87  E-value: 9.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 137 ATETSGPTYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWTHTERFLRQAFG---DDWgsILSFEnREPVGSGCVAQ 213
Cdd:PRK04750   58 ALEELGPIFVKFGQMLSTRRDLFPPDIADELALLQDRVPPFDGALARAIIEKALGgpvEEW--FDDFD-IKPLASASIAQ 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 214 VYKAYantafletdsvqrlgrasclppfshtgavggLRElfgylgNGRKppenladqsflerlllpkadlvgsnagvsra 293
Cdd:PRK04750  135 VHFAR-------------------------------LKD------NGRE------------------------------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 294 qvpghqpeatnlisVAVKVLHPGLLAQVHMDLLLMKIGSRVL-GVLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEH 372
Cdd:PRK04750  147 --------------VVVKVLRPDILPVIDADLALMYRLARWVeRLLPDGRRLKPREVVAEFEKTLHDELDLMREAANASQ 212
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 373 FQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVPVS---SYQQAGIpvDLKrKIARLGI 429
Cdd:PRK04750  213 LRRNFEDSDMLYVPEVYWDYCSETVMVMERMYGIPVSdvaALRAAGT--DMK-LLAERGV 269
ABC1_ADCK3 cd13970
Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3; This ...
167-427 4.47e-11

Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3; This subfamily is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Subfamily 13 (ABC1K13) of plant ABC1 kinases belongs in this subfamily with yeast Abc1p and human ADCK3. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270872 [Multi-domain]  Cd Length: 251  Bit Score: 63.30  E-value: 4.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 167 FSKLHVRVTPHPWTHTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAYantafletdsvqrlgrasclppfshtga 246
Cdd:cd13970     3 LARLRDSAPPMPWAQLEKVLEAELGEDWRELFAEFDEEPFAAASIGQVHRAT---------------------------- 54
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 247 vgglrelfgyLGNGRKppenladqsflerlllpkadlvgsnagvsraqvpghqpeatnlisVAVKVLHPGLLAQVHMDLL 326
Cdd:cd13970    55 ----------LKDGRE---------------------------------------------VAVKVQYPGVAESIDSDLN 79
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616741 327 LMKIGSRVLGVLPgiKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESV 406
Cdd:cd13970    80 NLRRLLKLTGLLP--KGLDLDALIAELREELLEECDYEREAANQRRFRELLADDPRFVVPEVIPELSTKRVLTTEFVDGV 157
                         250       260
                  ....*....|....*....|.
gi 2462616741 407 PVSSYQQAgiPVDLKRKIARL 427
Cdd:cd13970   158 PLDEAADL--SQEERNRIGEL 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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