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Conserved domains on  [gi|2462610766|ref|XP_054212491|]
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dysbindin isoform X3 [Homo sapiens]

Protein Classification

Dysbindin domain-containing protein( domain architecture ID 10517140)

Dysbindin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dysbindin pfam04440
Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa ...
 19-163 7.56e-72

Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. Genetic variation in the human dysbindin gene is also thought to be associated with Schizophrenia.


:

Pssm-ID: 461312  Cd Length: 143  Bit Score: 213.95  E-value: 7.56e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610766  19 AEHAQKVLEMEHTQQMKLKERQKFFEEAFQQDMEQYLSTGYLQIAERREPIGSMSSMEVNVDMLEQMDLMDISDQEALDV 98
Cdd:pfam04440   1 AEHAQKVLEMEHTQQLKLKERQKFFEEAFQQDMEQYLSTGYLQITERRQPLGSVSSMEVNVDLLDQMELTDMSDQEALDV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462610766  99 FLNSGGEENTVLSPALGPESStCQNEITLQVPNPSELRAKPPSSSSTCTDSAtRDISEGGESPVV 163
Cdd:pfam04440  81 FADSDGEENALESPAGLPRSS-CQNEISLRVPSWTETRAEQPSESSPCTDPE-TENSDGGDDPLV 143
 
Name Accession Description Interval E-value
Dysbindin pfam04440
Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa ...
 19-163 7.56e-72

Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. Genetic variation in the human dysbindin gene is also thought to be associated with Schizophrenia.


Pssm-ID: 461312  Cd Length: 143  Bit Score: 213.95  E-value: 7.56e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610766  19 AEHAQKVLEMEHTQQMKLKERQKFFEEAFQQDMEQYLSTGYLQIAERREPIGSMSSMEVNVDMLEQMDLMDISDQEALDV 98
Cdd:pfam04440   1 AEHAQKVLEMEHTQQLKLKERQKFFEEAFQQDMEQYLSTGYLQITERRQPLGSVSSMEVNVDLLDQMELTDMSDQEALDV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462610766  99 FLNSGGEENTVLSPALGPESStCQNEITLQVPNPSELRAKPPSSSSTCTDSAtRDISEGGESPVV 163
Cdd:pfam04440  81 FADSDGEENALESPAGLPRSS-CQNEISLRVPSWTETRAEQPSESSPCTDPE-TENSDGGDDPLV 143
 
Name Accession Description Interval E-value
Dysbindin pfam04440
Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa ...
 19-163 7.56e-72

Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. Genetic variation in the human dysbindin gene is also thought to be associated with Schizophrenia.


Pssm-ID: 461312  Cd Length: 143  Bit Score: 213.95  E-value: 7.56e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610766  19 AEHAQKVLEMEHTQQMKLKERQKFFEEAFQQDMEQYLSTGYLQIAERREPIGSMSSMEVNVDMLEQMDLMDISDQEALDV 98
Cdd:pfam04440   1 AEHAQKVLEMEHTQQLKLKERQKFFEEAFQQDMEQYLSTGYLQITERRQPLGSVSSMEVNVDLLDQMELTDMSDQEALDV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462610766  99 FLNSGGEENTVLSPALGPESStCQNEITLQVPNPSELRAKPPSSSSTCTDSAtRDISEGGESPVV 163
Cdd:pfam04440  81 FADSDGEENALESPAGLPRSS-CQNEISLRVPSWTETRAEQPSESSPCTDPE-TENSDGGDDPLV 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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