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Conserved domains on  [gi|2462608692|ref|XP_054211514|]
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adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X4 [Homo sapiens]

Protein Classification

DMT family transporter( domain architecture ID 12093821)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others; such as yeast UDP-N-acetylglucosamine transporter YEA4 and vertebrate UDP-xylose and UDP-N-acetylglucosamine transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 82-342 6.66e-92

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


:

Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 277.64  E-value: 6.66e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608692  82 QFFICVAGVFVFYLIYGYLQELIFSVEGfKSCGWYLTLVQFAFYSIFGLIELQLI----QDKRRRIPGKTYMIIAFLTVG 157
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEP-GPFGNLLTFAQFLFYALEGLPESIDIftskFLKPRKIPLKTYVILVALFFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608692 158 TMGLSNTSLGY-LNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAAICMSLGLIWFTL-------ADSTTAPNFNLT 229
Cdd:pfam08449  80 TSVLNNEALKYdISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLfsakdkvADSVVSPNFFLI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608692 230 GVVLISLALCADAVIGNVQEKAMKLHNASNSEM-----------------------------------NPVRTYGYAFLF 274
Cdd:pfam08449 160 GIAMLSGALLLDAFLGNYQEKTYKKYGKHSKEMlfyshllslpfflllqgdlfsavqfcsqspdkavlSLPSMLFYLLLN 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462608692 275 SLTGYFGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSK 342
Cdd:pfam08449 240 VLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYSK 307
 
Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 82-342 6.66e-92

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 277.64  E-value: 6.66e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608692  82 QFFICVAGVFVFYLIYGYLQELIFSVEGfKSCGWYLTLVQFAFYSIFGLIELQLI----QDKRRRIPGKTYMIIAFLTVG 157
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEP-GPFGNLLTFAQFLFYALEGLPESIDIftskFLKPRKIPLKTYVILVALFFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608692 158 TMGLSNTSLGY-LNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAAICMSLGLIWFTL-------ADSTTAPNFNLT 229
Cdd:pfam08449  80 TSVLNNEALKYdISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLfsakdkvADSVVSPNFFLI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608692 230 GVVLISLALCADAVIGNVQEKAMKLHNASNSEM-----------------------------------NPVRTYGYAFLF 274
Cdd:pfam08449 160 GIAMLSGALLLDAFLGNYQEKTYKKYGKHSKEMlfyshllslpfflllqgdlfsavqfcsqspdkavlSLPSMLFYLLLN 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462608692 275 SLTGYFGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSK 342
Cdd:pfam08449 240 VLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYSK 307
 
Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 82-342 6.66e-92

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 277.64  E-value: 6.66e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608692  82 QFFICVAGVFVFYLIYGYLQELIFSVEGfKSCGWYLTLVQFAFYSIFGLIELQLI----QDKRRRIPGKTYMIIAFLTVG 157
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEP-GPFGNLLTFAQFLFYALEGLPESIDIftskFLKPRKIPLKTYVILVALFFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608692 158 TMGLSNTSLGY-LNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAAICMSLGLIWFTL-------ADSTTAPNFNLT 229
Cdd:pfam08449  80 TSVLNNEALKYdISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLfsakdkvADSVVSPNFFLI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608692 230 GVVLISLALCADAVIGNVQEKAMKLHNASNSEM-----------------------------------NPVRTYGYAFLF 274
Cdd:pfam08449 160 GIAMLSGALLLDAFLGNYQEKTYKKYGKHSKEMlfyshllslpfflllqgdlfsavqfcsqspdkavlSLPSMLFYLLLN 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462608692 275 SLTGYFGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSK 342
Cdd:pfam08449 240 VLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYSK 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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