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Conserved domains on  [gi|2462606921|ref|XP_054210659|]
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centrosomal protein of 162 kDa isoform X4 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000095)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 656-928 3.52e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.29  E-value: 3.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  656 KQQEK---------ELFKLNQDNYI-----LQAKLSSFEET-NKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGY 720
Cdd:TIGR02168  207 RQAEKaerykelkaELRELELALLVlrleeLREELEELQEElKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEEL 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  721 QQENERLYNQVKDLQEQNKKNEERMfkenQSLFSEVASLKEQMHKSRflSQVVEDSEptrnqNFTDLLAELRMAQKEKDS 800
Cdd:TIGR02168  287 QKELYALANEISRLEQQKQILRERL----ANLERQLEELEAQLEELE--SKLDELAE-----ELAELEEKLEELKEELES 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  801 LLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAyVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDA--LR 878
Cdd:TIGR02168  356 LEAELEELEAELEELESRLEELEEQLETLRSKVA-QLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLeeAE 434

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462606921  879 LREANEEIEKLKLEIEKLKAESGNpSIRQKIRLKDKAADAK-KIQDLERQV 928
Cdd:TIGR02168  435 LKELQAELEELEEELEELQEELER-LEEALEELREELEEAEqALDAAEREL 484
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 656-928 3.52e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.29  E-value: 3.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  656 KQQEK---------ELFKLNQDNYI-----LQAKLSSFEET-NKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGY 720
Cdd:TIGR02168  207 RQAEKaerykelkaELRELELALLVlrleeLREELEELQEElKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEEL 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  721 QQENERLYNQVKDLQEQNKKNEERMfkenQSLFSEVASLKEQMHKSRflSQVVEDSEptrnqNFTDLLAELRMAQKEKDS 800
Cdd:TIGR02168  287 QKELYALANEISRLEQQKQILRERL----ANLERQLEELEAQLEELE--SKLDELAE-----ELAELEEKLEELKEELES 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  801 LLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAyVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDA--LR 878
Cdd:TIGR02168  356 LEAELEELEAELEELESRLEELEEQLETLRSKVA-QLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLeeAE 434

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462606921  879 LREANEEIEKLKLEIEKLKAESGNpSIRQKIRLKDKAADAK-KIQDLERQV 928
Cdd:TIGR02168  435 LKELQAELEELEEELEELQEELER-LEEALEELREELEEAEqALDAAEREL 484
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
668-894 5.61e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 53.48  E-value: 5.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 668 DNYILQAKLSSFEETNKKQRWLhfgeaadpvtGEKLKQIQKEIQEQETLLQGYQQENerlynQVKDLQEQNKKNEERMFK 747
Cdd:COG3206   159 EAYLEQNLELRREEARKALEFL----------EEQLPELRKELEEAEAALEEFRQKN-----GLVDLSEEAKLLLQQLSE 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 748 ENQSLFSEVASLKEQMHKSRFLSQVVEDSEPT-----RNQNFTDLLAELRMAQKEKDSLLE-------DIKRLKQDKQAL 815
Cdd:COG3206   224 LESQLAEARAELAEAEARLAALRAQLGSGPDAlpellQSPVIQQLRAQLAELEAELAELSArytpnhpDVIALRAQIAAL 303

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462606921 816 EvdfEKMKKERDQAKDQIayvtgeklyeikileethKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIE 894
Cdd:COG3206   304 R---AQLQQEAQRILASL------------------EAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVE 361
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
701-910 2.13e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 48.52  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 701 EKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEErMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTR 780
Cdd:PRK03918  518 EELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAE-LEKKLDELEEELAELLKELEELGFESVEELEERLKE 596

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 781 NQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYV----TGEKLYEIKILEETHKQEIS 856
Cdd:PRK03918  597 LEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELekkySEEEYEELREEYLELSRELA 676

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462606921 857 RLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKL-KAESGNPSIRQKIR 910
Cdd:PRK03918  677 GLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLeKALERVEELREKVK 731
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 710-931 2.88e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 710 IQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLfSEVASLKEQMHKSRFLSQVVEDSEPTRNqnftdlLA 789
Cdd:pfam17380 377 MRELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQK-VEMEQIRAEQEEARQREVRRLEEERARE------ME 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 790 ELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIK--ILEETHKQEIsrLQKRLQwyaE 867
Cdd:pfam17380 450 RVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKqaMIEEERKRKL--LEKEME---E 524

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462606921 868 NQELLDKDALRlREANEEIEKlKLEIEKLKaesgnpSIRQKIRLKDKAADAKKIQDLERQVCVQ 931
Cdd:pfam17380 525 RQKAIYEEERR-REAEEERRK-QQEMEERR------RIQEQMRKATEERSRLEAMEREREMMRQ 580
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 656-928 3.52e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.29  E-value: 3.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  656 KQQEK---------ELFKLNQDNYI-----LQAKLSSFEET-NKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGY 720
Cdd:TIGR02168  207 RQAEKaerykelkaELRELELALLVlrleeLREELEELQEElKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEEL 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  721 QQENERLYNQVKDLQEQNKKNEERMfkenQSLFSEVASLKEQMHKSRflSQVVEDSEptrnqNFTDLLAELRMAQKEKDS 800
Cdd:TIGR02168  287 QKELYALANEISRLEQQKQILRERL----ANLERQLEELEAQLEELE--SKLDELAE-----ELAELEEKLEELKEELES 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  801 LLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAyVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDA--LR 878
Cdd:TIGR02168  356 LEAELEELEAELEELESRLEELEEQLETLRSKVA-QLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLeeAE 434

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462606921  879 LREANEEIEKLKLEIEKLKAESGNpSIRQKIRLKDKAADAK-KIQDLERQV 928
Cdd:TIGR02168  435 LKELQAELEELEEELEELQEELER-LEEALEELREELEEAEqALDAAEREL 484
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 657-897 3.83e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 54.30  E-value: 3.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  657 QQEKELFKLNQDNYILQAKLSS-FEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEqetLLQGYQQENERLYNQVKDLQ 735
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSlQSELRRIENRLDELSQELSDASRKIGEIEKEIEQ---LEQEEEKLKERLEELEEDLS 747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  736 --EQNKKNEERMFKENQSlfsEVASLKEQMHKSRFLSQVVEDSE-PTRNQNFTDLLAELRMAQKEKDSLLEDI----KRL 808
Cdd:TIGR02169  748 slEQEIENVKSELKELEA---RIEELEEDLHKLEEALNDLEARLsHSRIPEIQAELSKLEEEVSRIEARLREIeqklNRL 824

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  809 KQDKQALEVDFEKMKKERDQAKDQIAYVtGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALR----LREANE 884
Cdd:TIGR02169  825 TLEKEYLEKEIQELQEQRIDLKEQIKSI-EKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDEleaqLRELER 903

                          250
                   ....*....|...
gi 2462606921  885 EIEKLKLEIEKLK 897
Cdd:TIGR02169  904 KIEELEAQIEKKR 916
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
668-894 5.61e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 53.48  E-value: 5.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 668 DNYILQAKLSSFEETNKKQRWLhfgeaadpvtGEKLKQIQKEIQEQETLLQGYQQENerlynQVKDLQEQNKKNEERMFK 747
Cdd:COG3206   159 EAYLEQNLELRREEARKALEFL----------EEQLPELRKELEEAEAALEEFRQKN-----GLVDLSEEAKLLLQQLSE 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 748 ENQSLFSEVASLKEQMHKSRFLSQVVEDSEPT-----RNQNFTDLLAELRMAQKEKDSLLE-------DIKRLKQDKQAL 815
Cdd:COG3206   224 LESQLAEARAELAEAEARLAALRAQLGSGPDAlpellQSPVIQQLRAQLAELEAELAELSArytpnhpDVIALRAQIAAL 303

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462606921 816 EvdfEKMKKERDQAKDQIayvtgeklyeikileethKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIE 894
Cdd:COG3206   304 R---AQLQQEAQRILASL------------------EAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVE 361
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 701-928 1.00e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 52.75  E-value: 1.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  701 EKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQeqnkkneermfKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTR 780
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAELRKELEELEEELEQLR-----------KELEELSRQISALRKDLARLEAEVEQLEERIAQL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  781 NQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYV------TGEKLYEIKILEETHKQE 854
Cdd:TIGR02168  753 SKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELraeltlLNEEAANLRERLESLERR 832

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462606921  855 ISRLQKRLQWYAE----NQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQV 928
Cdd:TIGR02168  833 IAATERRLEDLEEqieeLSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKR 910
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 617-899 1.05e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.63  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 617 KRVQEAEDKWRGAQALIEQIKATfSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLssfEETNKKQRwlhfgeaad 696
Cdd:COG1196   225 LEAELLLLKLRELEAELEELEAE-LEELEAELEELEAELAELEAELEELRLELEELELEL---EEAQAEEY--------- 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 697 pVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMfkenQSLFSEVASLKEQMHKSRFLSQVVEDS 776
Cdd:COG1196   292 -ELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEEL----EELEEELEEAEEELEEAEAELAEAEEA 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 777 EPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAyvtgEKLYEIKILEETHKQEIS 856
Cdd:COG1196   367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELE----ELEEALAELEEEEEEEEE 442

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2462606921 857 RLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAE 899
Cdd:COG1196   443 ALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEE 485
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
700-902 8.46e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.91  E-value: 8.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  700 GEKLKQIQKEIQEQETLLQGYQ-QENERLYNQVKDLQEQNKKneermfkenqslfsEVASLKEQMHKSRflsqvvedsep 778
Cdd:COG4913    261 AERYAAARERLAELEYLRAALRlWFAQRRLELLEAELEELRA--------------ELARLEAELERLE----------- 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  779 trnQNFTDLLAELRMAQKEKDSL-LEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISR 857
Cdd:COG4913    316 ---ARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAAL 392

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2462606921  858 LQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGN 902
Cdd:COG4913    393 LEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSN 437
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 613-911 1.14e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 613 LLMFKRVQEAEDKWRGAQALIEQIKAtfsekekelenkleeLKKQQEKELFKLNQDnyilqaklssfEETNKKQrwlhfg 692
Cdd:COG4942     9 LLLALAAAAQADAAAEAEAELEQLQQ---------------EIAELEKELAALKKE-----------EKALLKQ------ 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 693 eaadpvtgekLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMfKENQSLFSEVASLKEQMHKSRFLSQV 772
Cdd:COG4942    57 ----------LAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL-EAQKEELAELLRALYRLGRQPPLALL 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 773 VEDSEPTRNQNFTDLLAELRMAQKEkdsLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAyvtgEKLYEIKILEETHK 852
Cdd:COG4942   126 LSPEDFLDAVRRLQYLKYLAPARRE---QAEELRADLAELAALRAELEAERAELEALLAELE----EERAALEALKAERQ 198

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462606921 853 QEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRL 911
Cdd:COG4942   199 KLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKGKLPW 257
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 611-899 1.76e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 48.91  E-value: 1.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  611 KKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKElENKLEELKKQQEKELFKLNQDNYI-LQAKLSSFEetnkkqrwl 689
Cdd:TIGR02169  231 EKEALERQKEAIERQLASLEEELEKLTEEISELEKR-LEEIEQLLEELNKKIKDLGEEEQLrVKEKIGELE--------- 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  690 hfgeaadpVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFL 769
Cdd:TIGR02169  301 --------AEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAE 372

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  770 SQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKlyEIKILE- 848
Cdd:TIGR02169  373 LEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEK--EDKALEi 450

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462606921  849 ETHKQEISRLQKRLQwyAENQELLDKDAlRLREANEEIEKLKLEIEKLKAE 899
Cdd:TIGR02169  451 KKQEWKLEQLAADLS--KYEQELYDLKE-EYDRVEKELSKLQRELAEAEAQ 498
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
701-910 2.13e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 48.52  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 701 EKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEErMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTR 780
Cdd:PRK03918  518 EELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAE-LEKKLDELEEELAELLKELEELGFESVEELEERLKE 596

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 781 NQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYV----TGEKLYEIKILEETHKQEIS 856
Cdd:PRK03918  597 LEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELekkySEEEYEELREEYLELSRELA 676

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462606921 857 RLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKL-KAESGNPSIRQKIR 910
Cdd:PRK03918  677 GLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLeKALERVEELREKVK 731
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 701-862 2.36e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.84  E-value: 2.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 701 EKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEErmfkenqslfsEVASLKEQMHKSRFLSQVVEDseptr 780
Cdd:COG1579    24 HRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLEL-----------EIEEVEARIKKYEEQLGNVRN----- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 781 NQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGE---KLYEIKILEETHKQEISR 857
Cdd:COG1579    88 NKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAEldeELAELEAELEELEAEREE 167


                  ....*
gi 2462606921 858 LQKRL 862
Cdd:COG1579   168 LAAKI 172
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
696-927 2.44e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 48.37  E-value: 2.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  696 DPVTGEKLKQIQKEIQEqetlLQGYQQENERLYNQVKDLQEQNKKNEERmfkenQSLFSEVASLKEQMHKSRFLsqvved 775
Cdd:COG4913    220 EPDTFEAADALVEHFDD----LERAHEALEDAREQIELLEPIRELAERY-----AAARERLAELEYLRAALRLW------ 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  776 septRNQNFTDLLaelrmaQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEI 855
Cdd:COG4913    285 ----FAQRRLELL------EAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLEREL 354

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462606921  856 SRLQKRLQWYaenQELLDKDALRLREANEEIEKLKLEIEKLKAESGnpsiRQKIRLKDKAADAK-KIQDLERQ 927
Cdd:COG4913    355 EERERRRARL---EALLAALGLPLPASAEEFAALRAEAAALLEALE----EELEALEEALAEAEaALRDLRRE 420
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
695-889 3.83e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.60  E-value: 3.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  695 ADPVTG----EKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQnkKNEERMFKENQSLFSEVASLKEQMH-KSRFL 769
Cdd:COG4913    600 SRYVLGfdnrAKLAALEAELAELEEELAEAEERLEALEAELDALQER--REALQRLAEYSWDEIDVASAEREIAeLEAEL 677

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  770 SQVVEDseptrNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQI-AYVTGEKLYEIKILE 848
Cdd:COG4913    678 ERLDAS-----SDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLeAAEDLARLELRALLE 752

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 2462606921  849 ETHKQEI-SRLQKRL-QWYAENQELLDKdalRLREANEEIEKL 889
Cdd:COG4913    753 ERFAAALgDAVERELrENLEERIDALRA---RLNRAEEELERA 792
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 695-904 4.41e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.75  E-value: 4.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 695 ADP---VTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERM-------------FKENQSLFSEVA- 757
Cdd:COG3883    14 ADPqiqAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIdklqaeiaeaeaeIEERREELGERAr 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 758 SLKEQMHKSRFLSQVVEdseptrNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVt 837
Cdd:COG3883    94 ALYRSGGSVSYLDVLLG------SESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAEL- 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462606921 838 geklyeikileETHKQEISRLQkrlqwyAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPS 904
Cdd:COG3883   167 -----------EAAKAELEAQQ------AEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAA 216
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 607-899 5.30e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.36  E-value: 5.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  607 ENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKekelenkleelkkqqEKELFKLNQDNYILQAKLSSFEETNKKQ 686
Cdd:TIGR02168  243 ELQEELKEAEEELEELTAELQELEEKLEELRLEVSEL---------------EEEIEELQKELYALANEISRLEQQKQIL 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  687 RwlhfgeaadpvtgEKLKQIQKEIQEQETLLQGYQQENERLynqvkdlqeqnKKNEERMFKENQSLFSEVASLKEQMHKS 766
Cdd:TIGR02168  308 R-------------ERLANLERQLEELEAQLEELESKLDEL-----------AEELAELEEKLEELKEELESLEAELEEL 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  767 RFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVtgeKLYEIKI 846
Cdd:TIGR02168  364 EAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEA---ELKELQA 440

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462606921  847 LEETHKQEISRLQKRLQWYAENQELLDKdalRLREANEEIEKLKLEIEKLKAE 899
Cdd:TIGR02168  441 ELEELEEELEELQEELERLEEALEELRE---ELEEAEQALDAAERELAQLQAR 490
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 656-899 5.44e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.36  E-value: 5.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  656 KQQEKELFKLNQDNYILQaklssfEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQ 735
Cdd:TIGR02168  694 AELEKALAELRKELEELE------EELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELE 767

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  736 EQNKKNEE---RMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDK 812
Cdd:TIGR02168  768 ERLEEAEEelaEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQI 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  813 QALEVDFEKMKKERDQAKDQIAYVTgEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLR----EANEEIEK 888
Cdd:TIGR02168  848 EELSEDIESLAAEIEELEELIEELE-SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRreleELREKLAQ 926

                          250
                   ....*....|.
gi 2462606921  889 LKLEIEKLKAE 899
Cdd:TIGR02168  927 LELRLEGLEVR 937
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 701-919 9.11e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.60  E-value: 9.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  701 EKLKQIQKEIQEQETLLQGYQQE----NERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKsrflsqvVEDS 776
Cdd:TIGR02169  237 RQKEAIERQLASLEEELEKLTEEiselEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIAS-------LERS 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  777 EPTRNQNFTDLLAELRMAQKEKDSLLEDIkrlkqdkQALEVDFEKMKKERDQAKDqiayvtgeklyEIKILEETHKQEIS 856
Cdd:TIGR02169  310 IAEKERELEDAEERLAKLEAEIDKLLAEI-------EELEREIEEERKRRDKLTE-----------EYAELKEELEDLRA 371

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462606921  857 RLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKiRLKDKAADAK 919
Cdd:TIGR02169  372 ELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELA-DLNAAIAGIE 433
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
786-928 1.50e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.68  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  786 DLLAELRMAQKEKDSLLEDIKRLKQDKQALEvdfekmkkERDQAKDQIAYVTGEklyEIKIleETHKQEISRLQKRLqwy 865
Cdd:COG4913    614 ALEAELAELEEELAEAEERLEALEAELDALQ--------ERREALQRLAEYSWD---EIDV--ASAEREIAELEAEL--- 677

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462606921  866 aenqELLDKDALRLREANEEIEKLKLEIEKLKAESGNpSIRQKIRLKDKAADAKK-IQDLERQV 928
Cdd:COG4913    678 ----ERLDASSDDLAALEEQLEELEAELEELEEELDE-LKGEIGRLEKELEQAEEeLDELQDRL 736
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
788-928 3.50e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.37  E-value: 3.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 788 LAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIayvtgeKLYEIKILEETHKQEISRLQKRLQWYAE 867
Cdd:COG4717    73 LKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREEL------EKLEKLLQLLPLYQELEALEAELAELPE 146

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462606921 868 NQELLDKDALRLREANEEIEKLKLEIEKLKAEsgnpsiRQKIRLKDKAADAKKIQDLERQV 928
Cdd:COG4717   147 RLEELEERLEELRELEEELEELEAELAELQEE------LEELLEQLSLATEEELQDLAEEL 201
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
701-899 3.78e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.28  E-value: 3.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 701 EKLKQIQKEIQEQETLLQGYQQENErlynQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKsrfLSQVVEDSEPTR 780
Cdd:PRK03918  165 KNLGEVIKEIKRRIERLEKFIKRTE----NIEELIKEKEKELEEVLREINEISSELPELREELEK---LEKEVKELEELK 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 781 NqnftdllaELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVT-----GEKLYEIKILEETHKQEI 855
Cdd:PRK03918  238 E--------EIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKelkekAEEYIKLSEFYEEYLDEL 309

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2462606921 856 SRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAE 899
Cdd:PRK03918  310 REIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKR 353
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
786-898 4.41e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 44.08  E-value: 4.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 786 DLLAELRMAQKEKDSLLEDIKRLKQDKQALEvdfEKMKKERDQAKDQIayvtgEKLYEIKILEEthkqEISRLQKRLqwy 865
Cdd:COG2433   417 RLEEQVERLEAEVEELEAELEEKDERIERLE---RELSEARSEERREI-----RKDREISRLDR----EIERLEREL--- 481

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462606921 866 aenqelldkdalrlREANEEIEKLKLEIEKLKA 898
Cdd:COG2433   482 --------------EEERERIEELKRKLERLKE 500
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 784-927 4.56e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 44.29  E-value: 4.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  784 FTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKE-------RDQAKDQIAYVTGEKLYEIKILEETHKQEIS 856
Cdd:TIGR02169  225 GYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRleeieqlLEELNKKIKDLGEEEQLRVKEKIGELEAEIA 304

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462606921  857 RLQKRLQWYAENQELLDKdalRLREANEEIEKLKLEIEKLKAESGNPSIRqKIRLKDKAADAKKIQDLERQ 927
Cdd:TIGR02169  305 SLERSIAEKERELEDAEE---RLAKLEAEIDKLLAEIEELEREIEEERKR-RDKLTEEYAELKEELEDLRA 371
PRK12704 PRK12704
phosphodiesterase; Provisional
 789-899 4.65e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.00  E-value: 4.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 789 AELRMAQKEKDSLLEDIKR----LKQDKQaLEVDfEKMKKERDQAKDQIAyvtgEKLYEIKILEETHKQEISRLQKRLQW 864
Cdd:PRK12704   31 AKIKEAEEEAKRILEEAKKeaeaIKKEAL-LEAK-EEIHKLRNEFEKELR----ERRNELQKLEKRLLQKEENLDRKLEL 104

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462606921 865 YAENQELLDKDALRLREANEEIEKLKLEIEKLKAE 899
Cdd:PRK12704  105 LEKREEELEKKEKELEQKQQELEKKEEELEELIEE 139
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 653-928 5.01e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.16  E-value: 5.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 653 ELKKQQEK-ELFKLNQDNY-ILQAKLSSFEETNKKQRWLHFGEAADpVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQ 730
Cdd:COG1196   204 PLERQAEKaERYRELKEELkELEAELLLLKLRELEAELEELEAELE-ELEAELEELEAELAELEAELEELRLELEELELE 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 731 VKDLQ----------EQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDS 800
Cdd:COG1196   283 LEEAQaeeyellaelARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 801 LLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAyvtgEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLR 880
Cdd:COG1196   363 AEEALLEAEAELAEAEEELEELAEELLEALRAAA----ELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEE 438

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2462606921 881 EANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQV 928
Cdd:COG1196   439 EEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
699-891 1.63e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.06  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 699 TGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKneermFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEP 778
Cdd:COG4717    62 QGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEE-----LEELEAELEELREELEKLEKLLQLLPLYQELEA 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 779 TRNQ--NFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEIS 856
Cdd:COG4717   137 LEAElaELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELE 216

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2462606921 857 RLQKRLQWYAENQELLDKDALRLrEANEEIEKLKL 891
Cdd:COG4717   217 EAQEELEELEEELEQLENELEAA-ALEERLKEARL 250
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 701-899 1.71e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 42.31  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 701 EKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNeermFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTR 780
Cdd:TIGR04523 342 EQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSY----KQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKL 417

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 781 NQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQK 860
Cdd:TIGR04523 418 QQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKE 497

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462606921 861 RLQWYAENQELLDKdalrLREANEEIEKLKLEIEKLKAE 899
Cdd:TIGR04523 498 LKKLNEEKKELEEK----VKDLTKKISSLKEKIEKLESE 532
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
657-863 2.21e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 657 QQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAAdpvtgEKLKQIQKEIQEQET--LLQGYQQENERLYNQ--VK 732
Cdd:COG4717   308 QALPALEELEEEELEELLAALGLPPDLSPEELLELLDRI-----EELQELLREAEELEEelQLEELEQEIAALLAEagVE 382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 733 DLQEQNKKNEErmFKENQSLFSEVASLKEQM--HKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQ 810
Cdd:COG4717   383 DEEELRAALEQ--AEEYQELKEELEELEEQLeeLLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEA 460

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462606921 811 DKQALEVD--FEKMKKERDQAKDQIAYVTgEKLYEIKILEETHKQEISRLQKRLQ 863
Cdd:COG4717   461 ELEQLEEDgeLAELLQELEELKAELRELA-EEWAALKLALELLEEAREEYREERL 514
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 710-931 2.88e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 710 IQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLfSEVASLKEQMHKSRFLSQVVEDSEPTRNqnftdlLA 789
Cdd:pfam17380 377 MRELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQK-VEMEQIRAEQEEARQREVRRLEEERARE------ME 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 790 ELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIK--ILEETHKQEIsrLQKRLQwyaE 867
Cdd:pfam17380 450 RVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKqaMIEEERKRKL--LEKEME---E 524

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462606921 868 NQELLDKDALRlREANEEIEKlKLEIEKLKaesgnpSIRQKIRLKDKAADAKKIQDLERQVCVQ 931
Cdd:pfam17380 525 RQKAIYEEERR-REAEEERRK-QQEMEERR------RIQEQMRKATEERSRLEAMEREREMMRQ 580
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
700-825 3.44e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 3.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  700 GEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERmFKENQSlfsEVASLKEQMHKSRFLSQvvedsept 779
Cdd:COG4913    337 GDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEE-FAALRA---EAAALLEALEEELEALE-------- 404

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462606921  780 rnQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKE 825
Cdd:COG4913    405 --EALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDA 448
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 786-899 3.59e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.91  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 786 DLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILE-ETHKQEISRLQKRLQw 864
Cdd:COG1579    35 ELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKEYEALQKEiESLKRRISDLEDEIL- 113

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462606921 865 yaENQELLDKDALRLREANEEIEKLKLEIEKLKAE 899
Cdd:COG1579   114 --ELMERIEELEEELAELEAELAELEAELEEKKAE 146
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 707-899 6.03e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 40.30  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 707 QKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEqmhksRFLSQVVEDseptrnqnFTD 786
Cdd:PRK05771   38 EELSNERLRKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIKDVE-----EELEKIEKE--------IKE 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 787 LLAELRMAQKEKDSLLEDIKRLKQDKqALEVDFEKMKKER-----------DQAKDQIAYVTGEKLYEIKILEET----- 850
Cdd:PRK05771  105 LEEEISELENEIKELEQEIERLEPWG-NFDLDLSLLLGFKyvsvfvgtvpeDKLEELKLESDVENVEYISTDKGYvyvvv 183

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462606921 851 -----HKQEISRLQKRLQWYAEN-------QELLDKDALRLREANEEIEKLKLEIEKLKAE 899
Cdd:PRK05771  184 vvlkeLSDEVEEELKKLGFERLEleeegtpSELIREIKEELEEIEKERESLLEELKELAKK 244
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 711-826 7.26e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 39.88  E-value: 7.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 711 QEQETLLQGYQQENERLYNQVKDLQEQNKK-NEERMfkENQSLFSEVASLKEqmhksrflSQVVEDSEPTRNqnFTDLLA 789
Cdd:pfam07888 304 QERETLQQSAEADKDRIEKLSAELQRLEERlQEERM--EREKLEVELGREKD--------CNRVQLSESRRE--LQELKA 371

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462606921 790 ELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKER 826
Cdd:pfam07888 372 SLRVAQKEKEQLQAEKQELLEYIRQLEQRLETVADAK 408
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 701-881 8.40e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 39.88  E-value: 8.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 701 EKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMfkenQSLFSEVASLKEQMHKSRFLSQVVEDSEPTR 780
Cdd:pfam07888  38 ECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRV----AELKEELRQSREKHEELEEKYKELSASSEEL 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921 781 NQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEEThKQEISRLQK 860
Cdd:pfam07888 114 SEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQT-EEELRSLSK 192

                         170       180
                  ....*....|....*....|.
gi 2462606921 861 RLQWYAENQELLDKDALRLRE 881
Cdd:pfam07888 193 EFQELRNSLAQRDTQVLQLQD 213
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 617-889 8.65e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.05  E-value: 8.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  617 KRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKqQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAAD 696
Cdd:TIGR02169  723 KEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKE-LEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELS 801

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  697 PVTgEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMfkenQSLFSEVASLKEQMHKsrfLSQVVEDS 776
Cdd:TIGR02169  802 KLE-EEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQI----KSIEKEIENLNGKKEE---LEEELEEL 873

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606921  777 EptrnqnftdllAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIayvtGEKLYEIKILEETHKqEIS 856
Cdd:TIGR02169  874 E-----------AALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRL----SELKAKLEALEEELS-EIE 937

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2462606921  857 RLQKRLQWYAENQELLDKDALRLREANEEIEKL 889
Cdd:TIGR02169  938 DPKGEDEEIPEEELSLEDVQAELQRVEEEIRAL 970
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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