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Conserved domains on  [gi|2462606086|ref|XP_054210256|]
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parkin coregulated gene protein isoform X1 [Homo sapiens]

Protein Classification

parkin coregulated gene family protein( domain architecture ID 10563193)

parkin coregulated gene (PACRG) family protein similar to human PACRG that suppresses cell death induced by the accumulation of unfolded Pael receptor (Pael-R), which is a substrate of parkin

PubMed:  18387367|12547187

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ParcG pfam10274
Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA ...
 70-204 1.20e-82

Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.


:

Pssm-ID: 431190  Cd Length: 183  Bit Score: 248.36  E-value: 1.20e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606086  70 TAFRKFYERGDFPIALEHDSKGNKIAWKVEIEKLDYHHYLPLFFDGLCEMTFPYEFFARQGIHDMLEH-GGNKILPVLPQ 148
Cdd:pfam10274   1 TSFRYVYDRGDIPCRINHGSVKNKIQWKVDPEQLDYHPYLPTFFDGLRETKHPYRFVARNGIRDLLEAeGGEKILPVLPQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462606086 149 LIIPIKNALNLRNRQVICVTLKVLQHLVVSAEMVGKALVPYYRQILPVLNIFKNMN 204
Cdd:pfam10274  81 LILPLKAALNTRDPEVFCVALKVLQLLVKSSDLIGEALVPYYRQLLPVLNLFKNKR 136
 
Name Accession Description Interval E-value
ParcG pfam10274
Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA ...
 70-204 1.20e-82

Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.


Pssm-ID: 431190  Cd Length: 183  Bit Score: 248.36  E-value: 1.20e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606086  70 TAFRKFYERGDFPIALEHDSKGNKIAWKVEIEKLDYHHYLPLFFDGLCEMTFPYEFFARQGIHDMLEH-GGNKILPVLPQ 148
Cdd:pfam10274   1 TSFRYVYDRGDIPCRINHGSVKNKIQWKVDPEQLDYHPYLPTFFDGLRETKHPYRFVARNGIRDLLEAeGGEKILPVLPQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462606086 149 LIIPIKNALNLRNRQVICVTLKVLQHLVVSAEMVGKALVPYYRQILPVLNIFKNMN 204
Cdd:pfam10274  81 LILPLKAALNTRDPEVFCVALKVLQLLVKSSDLIGEALVPYYRQLLPVLNLFKNKR 136
 
Name Accession Description Interval E-value
ParcG pfam10274
Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA ...
 70-204 1.20e-82

Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.


Pssm-ID: 431190  Cd Length: 183  Bit Score: 248.36  E-value: 1.20e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606086  70 TAFRKFYERGDFPIALEHDSKGNKIAWKVEIEKLDYHHYLPLFFDGLCEMTFPYEFFARQGIHDMLEH-GGNKILPVLPQ 148
Cdd:pfam10274   1 TSFRYVYDRGDIPCRINHGSVKNKIQWKVDPEQLDYHPYLPTFFDGLRETKHPYRFVARNGIRDLLEAeGGEKILPVLPQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462606086 149 LIIPIKNALNLRNRQVICVTLKVLQHLVVSAEMVGKALVPYYRQILPVLNIFKNMN 204
Cdd:pfam10274  81 LILPLKAALNTRDPEVFCVALKVLQLLVKSSDLIGEALVPYYRQLLPVLNLFKNKR 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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