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Conserved domains on  [gi|2462603590|ref|XP_054209081|]
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zinc finger protein 62 homolog isoform X5 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
363-776 7.01e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 7.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 363 KPYECDECGKAFRNSSGLIVHKRIHTGEKPYKCDVCGKAFSYSSGLA--VHKSIHPGKKAHEC-KECGKSFSYNSLLLQH 439
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 440 RTIHTGERPYVCDVCGKTFRNNAGLKVHRRLHTGEKPYKCDVCGKAYISR----SSLKNHKGIHLGEKPYKCSYCE---- 511
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnSLHPPLPANSLSKDPSSNLSLLissn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 512 KSFNYSSALEQHKRIHTREKPFGCDECGKaFRNNSGLKVHKRIHTGERPYKCEecgkayislssliNHKSVHPGEKPFKC 591
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQ-------------SPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 592 DECEKAFITYRTLTNHKKVHLGE-------KPYKCDVCEKSFNYTSLLSQHRR--VHTRE--KPYECD--RCEKVFRNNS 658
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRND 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 659 SLKVHKRIHTGERPYEC--DVCGKAYI------SHSSLINHKSTHPGRTPHTCDECGKAFFSSR-TLISHKRVHLGEKP- 728
Cdd:COG5048   338 ALKRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSNSCIRNFKRDsNLSLHIITHLSFRPy 417

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 2462603590 729 -FKCVECGKSFSYSSLLSQHKRIHTGEKPYVCDRCGKAFRNSSGLTVHK 776
Cdd:COG5048   418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-552 2.79e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 125 TSYPSLQQKTNAVKKLHKCDECGKSFKYNSRLVQHKIMHTGEKRYECDDCGGT--FRSSSSLRVHKRIHTGEKPYKCEEC 202
Cdd:COG5048    18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 203 GKAYMSY--SSLINHKSTHS--GEKNCKCDECGKSFNYSSVLDQHKRIHTGEKPYECGECGKAFRNSSGLRVHKRIHtge 278
Cdd:COG5048    98 LPLSNSKasSSSLSSSSSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN--- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 279 kpyecdICGKTFSNSSGLRVHKRIHTGEKPYECDECGKAFITCRTLLNHKSIHFGDKPYKCDECEKSFNYSSLLIQHKVI 358
Cdd:COG5048   175 ------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 359 HTGEKPYECDECGKAFRNSSGLIVHKRIHTGE-------KPYKCDVCGKAFSYSSGLAVHK--SIHPGK--KAHECKE-- 425
Cdd:COG5048   249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYsl 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 426 CGKSFSYNSLLLQHRTIHTGERPYVC--DVCGKTFR-----NNAGLKVHRRLHTGEKPYKCDV--CGKAYISRSSLKNHK 496
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHI 408

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462603590 497 GIHLGEKP--YKCSYCEKSFNYSSALEQHKRIHTREKPFGCDECGKAFRNNSGLKVHK 552
Cdd:COG5048   409 ITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
363-776 7.01e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 7.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 363 KPYECDECGKAFRNSSGLIVHKRIHTGEKPYKCDVCGKAFSYSSGLA--VHKSIHPGKKAHEC-KECGKSFSYNSLLLQH 439
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 440 RTIHTGERPYVCDVCGKTFRNNAGLKVHRRLHTGEKPYKCDVCGKAYISR----SSLKNHKGIHLGEKPYKCSYCE---- 511
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnSLHPPLPANSLSKDPSSNLSLLissn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 512 KSFNYSSALEQHKRIHTREKPFGCDECGKaFRNNSGLKVHKRIHTGERPYKCEecgkayislssliNHKSVHPGEKPFKC 591
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQ-------------SPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 592 DECEKAFITYRTLTNHKKVHLGE-------KPYKCDVCEKSFNYTSLLSQHRR--VHTRE--KPYECD--RCEKVFRNNS 658
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRND 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 659 SLKVHKRIHTGERPYEC--DVCGKAYI------SHSSLINHKSTHPGRTPHTCDECGKAFFSSR-TLISHKRVHLGEKP- 728
Cdd:COG5048   338 ALKRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSNSCIRNFKRDsNLSLHIITHLSFRPy 417

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 2462603590 729 -FKCVECGKSFSYSSLLSQHKRIHTGEKPYVCDRCGKAFRNSSGLTVHK 776
Cdd:COG5048   418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-552 2.79e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 125 TSYPSLQQKTNAVKKLHKCDECGKSFKYNSRLVQHKIMHTGEKRYECDDCGGT--FRSSSSLRVHKRIHTGEKPYKCEEC 202
Cdd:COG5048    18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 203 GKAYMSY--SSLINHKSTHS--GEKNCKCDECGKSFNYSSVLDQHKRIHTGEKPYECGECGKAFRNSSGLRVHKRIHtge 278
Cdd:COG5048    98 LPLSNSKasSSSLSSSSSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN--- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 279 kpyecdICGKTFSNSSGLRVHKRIHTGEKPYECDECGKAFITCRTLLNHKSIHFGDKPYKCDECEKSFNYSSLLIQHKVI 358
Cdd:COG5048   175 ------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 359 HTGEKPYECDECGKAFRNSSGLIVHKRIHTGE-------KPYKCDVCGKAFSYSSGLAVHK--SIHPGK--KAHECKE-- 425
Cdd:COG5048   249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYsl 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 426 CGKSFSYNSLLLQHRTIHTGERPYVC--DVCGKTFR-----NNAGLKVHRRLHTGEKPYKCDV--CGKAYISRSSLKNHK 496
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHI 408

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462603590 497 GIHLGEKP--YKCSYCEKSFNYSSALEQHKRIHTREKPFGCDECGKAFRNNSGLKVHK 552
Cdd:COG5048   409 ITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 503-551 2.49e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.23  E-value: 2.49e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462603590 503 KPYkCSYCEKSFNYSSALEQHKRIHTrekpFGCDECGKAFRNNSGLKVH 551
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-320 2.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.66e-04
                          10        20
                  ....*....|....*....|....*
gi 2462603590 296 LRVHKRIHTGEKPYECDECGKAFIT 320
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
380-404 7.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.03e-04
                          10        20
                  ....*....|....*....|....*
gi 2462603590 380 LIVHKRIHTGEKPYKCDVCGKAFSY 404
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
363-776 7.01e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 7.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 363 KPYECDECGKAFRNSSGLIVHKRIHTGEKPYKCDVCGKAFSYSSGLA--VHKSIHPGKKAHEC-KECGKSFSYNSLLLQH 439
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 440 RTIHTGERPYVCDVCGKTFRNNAGLKVHRRLHTGEKPYKCDVCGKAYISR----SSLKNHKGIHLGEKPYKCSYCE---- 511
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnSLHPPLPANSLSKDPSSNLSLLissn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 512 KSFNYSSALEQHKRIHTREKPFGCDECGKaFRNNSGLKVHKRIHTGERPYKCEecgkayislssliNHKSVHPGEKPFKC 591
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQ-------------SPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 592 DECEKAFITYRTLTNHKKVHLGE-------KPYKCDVCEKSFNYTSLLSQHRR--VHTRE--KPYECD--RCEKVFRNNS 658
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRND 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 659 SLKVHKRIHTGERPYEC--DVCGKAYI------SHSSLINHKSTHPGRTPHTCDECGKAFFSSR-TLISHKRVHLGEKP- 728
Cdd:COG5048   338 ALKRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSNSCIRNFKRDsNLSLHIITHLSFRPy 417

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 2462603590 729 -FKCVECGKSFSYSSLLSQHKRIHTGEKPYVCDRCGKAFRNSSGLTVHK 776
Cdd:COG5048   418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-552 2.79e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 125 TSYPSLQQKTNAVKKLHKCDECGKSFKYNSRLVQHKIMHTGEKRYECDDCGGT--FRSSSSLRVHKRIHTGEKPYKCEEC 202
Cdd:COG5048    18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 203 GKAYMSY--SSLINHKSTHS--GEKNCKCDECGKSFNYSSVLDQHKRIHTGEKPYECGECGKAFRNSSGLRVHKRIHtge 278
Cdd:COG5048    98 LPLSNSKasSSSLSSSSSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN--- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 279 kpyecdICGKTFSNSSGLRVHKRIHTGEKPYECDECGKAFITCRTLLNHKSIHFGDKPYKCDECEKSFNYSSLLIQHKVI 358
Cdd:COG5048   175 ------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 359 HTGEKPYECDECGKAFRNSSGLIVHKRIHTGE-------KPYKCDVCGKAFSYSSGLAVHK--SIHPGK--KAHECKE-- 425
Cdd:COG5048   249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYsl 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 426 CGKSFSYNSLLLQHRTIHTGERPYVC--DVCGKTFR-----NNAGLKVHRRLHTGEKPYKCDV--CGKAYISRSSLKNHK 496
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHI 408

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462603590 497 GIHLGEKP--YKCSYCEKSFNYSSALEQHKRIHTREKPFGCDECGKAFRNNSGLKVHK 552
Cdd:COG5048   409 ITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
279-665 2.92e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 279 KPYECDICGKTFSNSSGLRVHKRIHTGEKPYECDECGKAFITCRTLLNHKSI------------------HFGDKPYKCD 340
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLrthhnnpsdlnskslplsNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 341 ECEKSFNYSSLLIQHKVIHTGEKPYECDECGKAFRNSSGLIVHKRIHTGEK-------PYKCDVCGKAFSYSSGLAVHKS 413
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 414 IHPGKKAHECKECGKSFSYNSLLLQHRTIHTGERPYVCDVCgkTFRNNAGLKVHRRLHTGEKPYK--CDVCGKAYISRSS 491
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSssASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 492 LKNHKGIHLGE-------KPYKCSYCEKSFNYSSALEQHKR--IHTRE--KPFGCDE--CGKAFRNNSGLKVHKRIHTGE 558
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 559 RPYKC--EECGKAYISLSSLINHKSVHP-----GEKPFKCD--ECEKAFITYRTLTNHKKVHLGEKP--YKCDVCEKSFN 627
Cdd:COG5048   350 SPAKEklLNSSSKFSPLLNNEPPQSLQQykdlkNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2462603590 628 YTSLLSQHRRVHTREKPYECdRCEKVFRNNSSLKVHKR 665
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 389-468 5.39e-09

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 59.35  E-value: 5.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 389 GEKPYKCDV--CGKAFSYSSGLAVHKsihpgKKAHeckeCGKSFSYNSLLLQHRTIHTGERPYVCDVCGKTFRNNAGLKV 466
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHM-----LHGH----QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462603590 467 HR 468
Cdd:COG5189   417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-610 8.50e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 8.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 195 KPYKCEECGKAYMSYSSLINHKSTHSGEKNCKC--DECGKSFNYSSVLDQHKRIHTGEKPYECgeCGKAFRNSSGLRVHK 272
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 273 RIHTGEKPYECDIC-GKTFSNSSGLRVHKRIHTGEKPYECDECGKAFITCRTLLNHKSIHfgDKPYKCdECEKSFNYSSL 351
Cdd:COG5048   110 LSSSSSNSNDNNLLsSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP--PLPANS-LSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 352 LIQHKVIHTGEKPYECDECGKAFRNSSGLIVHKRIHTgEKPYKCDVCGKAFSYSSGLAVHKSIHPGKKAHECKECGKSFS 431
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 432 YNSLLLQHRTIHTGER-------PYVCDVCGKTFRNNAGLKVHRR--LHTGE--KPYKCDV--CGKAYISRSSLKNHKGI 498
Cdd:COG5048   266 PTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 499 HLGEKPYKCSYCEKSFNYSSAL-------EQHKRIHTREKPFGCD--ECGKAFRNNSGLKVHKRIHTGERP--YKCEECG 567
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 2462603590 568 KAYISLSSLINHKSVHPGEKPFKCdECEKAFITYRTLTNHKKV 610
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 468-552 9.76e-09

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 58.19  E-value: 9.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 468 RRLHT-GEKPYKCDV--CGKAYISRSSLKNHKgihlgekpyKCSYCEKSFNYSSALEQHKRIHTREKPFGCDECGKAFRN 544
Cdd:COG5189   340 RMLKVkDGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKN 410


                  ....*...
gi 2462603590 545 NSGLKVHK 552
Cdd:COG5189   411 LNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 445-497 3.41e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.10  E-value: 3.41e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462603590 445 GERPYVCDV--CGKTFRNNAGLKVHRrLH--------------------TGEKPYKCDVCGKAYISRSSLKNHKG 497
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHM-LHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 249-300 2.66e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 2.66e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462603590 249 GEKPYECG--ECGKAFRNSSGLRVHKR-------------------IHTGEKPYECDICGKTFSNSSGLRVHK 300
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 193-272 6.51e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 6.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603590 193 GEKPYKCE--ECGKAYMSYSSLINHKsthsgekncKCDECGKSFNYSSVLDQHKRIHTGEKPYECGECGKAFRNSSGLRV 270
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462603590 271 HK 272
Cdd:COG5189   417 HR 418
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 503-551 2.49e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.23  E-value: 2.49e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462603590 503 KPYkCSYCEKSFNYSSALEQHKRIHTrekpFGCDECGKAFRNNSGLKVH 551
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-320 2.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.66e-04
                          10        20
                  ....*....|....*....|....*
gi 2462603590 296 LRVHKRIHTGEKPYECDECGKAFIT 320
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-292 5.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.04e-04
                          10        20
                  ....*....|....*....|....*
gi 2462603590 268 LRVHKRIHTGEKPYECDICGKTFSN 292
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
380-404 7.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.03e-04
                          10        20
                  ....*....|....*....|....*
gi 2462603590 380 LIVHKRIHTGEKPYKCDVCGKAFSY 404
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-264 9.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 9.08e-04
                          10        20
                  ....*....|....*....|....*
gi 2462603590 240 LDQHKRIHTGEKPYECGECGKAFRN 264
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 612-664 9.86e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 9.86e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462603590 612 LGEKPYKCDV--CEKSFNYTSLLSQHRR-------------------VHTREKPYECDRCEKVFRNNSSLKVHK 664
Cdd:COG5189   345 KDGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
183-206 1.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....
gi 2462603590 183 SLRVHKRIHTGEKPYKCEECGKAY 206
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
548-572 1.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.67e-03
                          10        20
                  ....*....|....*....|....*
gi 2462603590 548 LKVHKRIHTGERPYKCEECGKAYIS 572
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
659-684 1.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.90e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462603590 659 SLKVHKRIHTGERPYECDVCGKAYIS 684
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
744-768 3.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.55e-03
                          10        20
                  ....*....|....*....|....*
gi 2462603590 744 LSQHKRIHTGEKPYVCDRCGKAFRN 768
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-376 4.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.59e-03
                          10        20
                  ....*....|....*....|....*
gi 2462603590 352 LIQHKVIHTGEKPYECDECGKAFRN 376
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 363-411 4.95e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 4.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462603590 363 KPYeCDECGKAFRNSSGLIVHKRIHTgekpYKCDVCGKAFSYSSGLAVH 411
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
464-488 4.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.97e-03
                          10        20
                  ....*....|....*....|....*
gi 2462603590 464 LKVHRRLHTGEKPYKCDVCGKAYIS 488
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 724-776 8.78e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 8.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462603590 724 LGEKPFKC--VECGKSFSYSSLLSQHKR-------------------IHTGEKPYVCDRCGKAFRNSSGLTVHK 776
Cdd:COG5189   345 KDGKPYKCpvEGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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