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Conserved domains on  [gi|2462602339|ref|XP_054208479|]
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ankyrin repeat domain-containing protein 34B isoform X1 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-140 4.95e-26

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 107.73  E-value: 4.95e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  31 EGGAYINESNDRGETPLMIACKTKHVDhqsvskakMVKYLLENNADPNIQDKSGKTALMHAClEKAGPEVVSLLLKSGAD 110
Cdd:COG0666   108 EAGADVNARDKDGETPLHLAAYNGNLE--------IVKLLLEAGADVNAQDNDGNTPLHLAA-ANGNLEIVKLLLEAGAD 178

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462602339 111 LSLQDHSSYSALVYAINSEDTETLKVLLSA 140
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLLLEA 208
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-140 4.95e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 107.73  E-value: 4.95e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  31 EGGAYINESNDRGETPLMIACKTKHVDhqsvskakMVKYLLENNADPNIQDKSGKTALMHAClEKAGPEVVSLLLKSGAD 110
Cdd:COG0666   108 EAGADVNARDKDGETPLHLAAYNGNLE--------IVKLLLEAGADVNAQDNDGNTPLHLAA-ANGNLEIVKLLLEAGAD 178

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462602339 111 LSLQDHSSYSALVYAINSEDTETLKVLLSA 140
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLLLEA 208
Ank_2 pfam12796
Ankyrin repeats (3 copies);
31-115 8.02e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 8.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  31 EGGAYINESNDRGETPLMIACKTKHVDhqsvskakMVKYLLEnNADPNIQDKsGKTALMHACLEKAgPEVVSLLLKSGAD 110
Cdd:pfam12796  18 ENGADANLQDKNGRTALHLAAKNGHLE--------IVKLLLE-HADVNLKDN-GRTALHYAARSGH-LEIVKLLLEKGAD 86


                  ....*
gi 2462602339 111 LSLQD 115
Cdd:pfam12796  87 INVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-139 2.46e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 59.29  E-value: 2.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  33 GAYINESNDRGETPLMIACKTKHVDHQ----------SVSKAKMVKYLLENNADPNIQDKSGKTALMHAClEKAGPEVVS 102
Cdd:PHA03100  131 GANVNIKNSDGENLLHLYLESNKIDLKilkllidkgvDINAKNRVNYLLSYGVPINIKDVYGFTPLHYAV-YNNNPEFVK 209

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462602339 103 LLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLLS 139
Cdd:PHA03100  210 YLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 42-79 5.43e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 5.43e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462602339   42 RGETPLMIACKTKHVDhqsvskakMVKYLLENNADPNI 79
Cdd:smart00248   1 DGRTPLHLAAENGNLE--------VVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-140 4.95e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 107.73  E-value: 4.95e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  31 EGGAYINESNDRGETPLMIACKTKHVDhqsvskakMVKYLLENNADPNIQDKSGKTALMHAClEKAGPEVVSLLLKSGAD 110
Cdd:COG0666   108 EAGADVNARDKDGETPLHLAAYNGNLE--------IVKLLLEAGADVNAQDNDGNTPLHLAA-ANGNLEIVKLLLEAGAD 178

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462602339 111 LSLQDHSSYSALVYAINSEDTETLKVLLSA 140
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-154 1.30e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.16  E-value: 1.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  31 EGGAYINESNDRGETPLMIACKTKHVDhqsvskakMVKYLLENNADPNIQDKSGKTALMHAClEKAGPEVVSLLLKSGAD 110
Cdd:COG0666   174 EAGADVNARDNDGETPLHLAAENGHLE--------IVKLLLEAGADVNAKDNDGKTALDLAA-ENGNLEIVKLLLEAGAD 244

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462602339 111 LSLQDHSSYSALVYAINSEDTETLKVLLSACKAKGKEVIIITTA 154
Cdd:COG0666   245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
31-115 8.02e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 8.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  31 EGGAYINESNDRGETPLMIACKTKHVDhqsvskakMVKYLLEnNADPNIQDKsGKTALMHACLEKAgPEVVSLLLKSGAD 110
Cdd:pfam12796  18 ENGADANLQDKNGRTALHLAAKNGHLE--------IVKLLLE-HADVNLKDN-GRTALHYAARSGH-LEIVKLLLEKGAD 86


                  ....*
gi 2462602339 111 LSLQD 115
Cdd:pfam12796  87 INVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
47-139 7.32e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 7.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  47 LMIACKTKHVDhqsvskakMVKYLLENNADPNIQDKSGKTALMHACleKAG-PEVVSLLLKSgADLSLQDHsSYSALVYA 125
Cdd:pfam12796   1 LHLAAKNGNLE--------LVKLLLENGADANLQDKNGRTALHLAA--KNGhLEIVKLLLEH-ADVNLKDN-GRTALHYA 68

                          90
                  ....*....|....
gi 2462602339 126 INSEDTETLKVLLS 139
Cdd:pfam12796  69 ARSGHLEIVKLLLE 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
63-140 3.95e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 3.95e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462602339  63 KAKMVKYLLENNADPNIQDKSGKTALMHAClEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLLSA 140
Cdd:COG0666    66 DLLVALLLLAAGADINAKDDGGNTLLHAAA-RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-139 2.46e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 59.29  E-value: 2.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  33 GAYINESNDRGETPLMIACKTKHVDHQ----------SVSKAKMVKYLLENNADPNIQDKSGKTALMHAClEKAGPEVVS 102
Cdd:PHA03100  131 GANVNIKNSDGENLLHLYLESNKIDLKilkllidkgvDINAKNRVNYLLSYGVPINIKDVYGFTPLHYAV-YNNNPEFVK 209

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462602339 103 LLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLLS 139
Cdd:PHA03100  210 YLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
PHA03095 PHA03095
ankyrin-like protein; Provisional
 33-122 3.10e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 59.27  E-value: 3.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  33 GAYINESNDRGETPLMIACKTKHVDhqsvskAKMVKYLLENNADPNIQDKSGKTALmhACLEK---AGPEVVSLLLKSGA 109
Cdd:PHA03095  107 GADVNAKDKVGRTPLHVYLSGFNIN------PKVIRLLLRKGADVNALDLYGMTPL--AVLLKsrnANVELLRLLIDAGA 178

                          90
                  ....*....|...
gi 2462602339 110 DLSLQDHSSYSAL 122
Cdd:PHA03095  179 DVYAVDDRFRSLL 191
Ank_5 pfam13857
Ankyrin repeats (many copies);
36-91 5.31e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 52.35  E-value: 5.31e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462602339  36 INESNDRGETPLMIACKTKHVDhqsvskakMVKYLLENNADPNIQDKSGKTALMHA 91
Cdd:pfam13857   9 LNRLDGEGYTPLHVAAKYGALE--------IVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 31-140 2.77e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.19  E-value: 2.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  31 EGGAYINESNDRGETPLmiacktkHVDHQSVSKAKMVKYLLENNADPNIQDKSGKTALmHACL--EKAGPEVVSLLLKSG 108
Cdd:PHA03095   71 EAGADVNAPERCGFTPL-------HLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPL-HVYLsgFNINPKVIRLLLRKG 142

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462602339 109 ADLSLQDHSSYSAL-VYAINSE-DTETLKVLLSA 140
Cdd:PHA03095  143 ADVNALDLYGMTPLaVLLKSRNaNVELLRLLIDA 176
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-138 2.83e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.83  E-value: 2.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  33 GAYINESNDRGETPLMIACKTKhvdhqsVSKAKMVKYLLENNADPNIQDKSGKTALmHACLEKAGPEV------------ 100
Cdd:PHA03100   96 GANVNAPDNNGITPLLYAISKK------SNSYSIVEYLLDNGANVNIKNSDGENLL-HLYLESNKIDLkilkllidkgvd 168

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462602339 101 ------VSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLL 138
Cdd:PHA03100  169 inaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLL 212
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 33-140 7.90e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 54.61  E-value: 7.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  33 GAYINES-NDRGETPLMIACKTKHVDhqsvskakMVKYLLENNADPNIQDkSGKTALMHACLEKAGPEVVSLLLKSGADL 111
Cdd:PHA02875   91 GKFADDVfYKDGMTPLHLATILKKLD--------IMKLLIARGADPDIPN-TDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                          90       100
                  ....*....|....*....|....*....
gi 2462602339 112 SLQDHSSYSALVYAINSEDTETLKVLLSA 140
Cdd:PHA02875  162 DIEDCCGCTPLIIAMAKGDIAICKMLLDS 190
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 35-175 1.53e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.52  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  35 YINESNDrgetplMIACKTKH---VDHQSVS--KAKMVKYLLENNADPNIQDKSGKTALMHACLEKA----GPEVVSLLL 105
Cdd:PHA03100   20 YIIMEDD------LNDYSYKKpvlPLYLAKEarNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdVKEIVKLLL 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462602339 106 KSGADLSLQDHSSYSALVYAIN--SEDTETLKVLLS-ACKakgkeviiiTTAKSPCGKHTTKQYLNMPPVDID 175
Cdd:PHA03100   94 EYGANVNAPDNNGITPLLYAISkkSNSYSIVEYLLDnGAN---------VNIKNSDGENLLHLYLESNKIDLK 157
Ank_4 pfam13637
Ankyrin repeats (many copies);
45-105 4.97e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 4.97e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462602339  45 TPLMIACKTKHVDhqsvskakMVKYLLENNADPNIQDKSGKTALMHACleKAG-PEVVSLLL 105
Cdd:pfam13637   3 TALHAAAASGHLE--------LLRLLLEKGADINAVDGNGETALHFAA--SNGnVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 42-82 5.10e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 43.05  E-value: 5.10e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462602339  42 RGETPLMIAC-KTKHVDhqsvskakMVKYLLENNADPNIQDK 82
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLE--------IVKLLLSKGADVNARDK 34
Ank_2 pfam12796
Ankyrin repeats (3 copies);
88-147 9.31e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.95  E-value: 9.31e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  88 LMHACLEKAgPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLLSACKAKGKE 147
Cdd:pfam12796   1 LHLAAKNGN-LELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD 59
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 31-116 2.11e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.88  E-value: 2.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  31 EGGAYINESNDRGETPLMIACK-------------TKHVD----------HQSVSKAKMVKYLLENNADPNIQDKSGKTA 87
Cdd:PHA02874  178 EKGAYANVKDNNGESPLHNAAEygdyacikllidhGNHIMnkckngftplHNAIIHNRSAIELLINNASINDQDIDGSTP 257

                          90       100
                  ....*....|....*....|....*....
gi 2462602339  88 LMHACLEKAGPEVVSLLLKSGADLSLQDH 116
Cdd:PHA02874  258 LHHAINPPCDIDIIDILLYHKADISIKDN 286
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 14-138 2.88e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.50  E-value: 2.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  14 LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKtkhvdhqsVSKAKMVKYLLENNADPNIqdksgktaLMHACL 93
Cdd:PHA02874   39 LIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIK--------IGAHDIIKLLIDNGVDTSI--------LPIPCI 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462602339  94 EKagpEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLL 138
Cdd:PHA02874  103 EK---DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLF 144
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 35-138 3.10e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 45.20  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  35 YINESNDRGETPLMiACktkhVDHQSVSKaKMVKYLLENNADPNIQDKSGKTALMHACL---EKAGPEVVSLLLKSGADL 111
Cdd:PHA02859   43 FVNDCNDLYETPIF-SC----LEKDKVNV-EILKFLIENGADVNFKTRDNNLSALHHYLsfnKNVEPEILKILIDSGSSI 116

                          90       100
                  ....*....|....*....|....*....
gi 2462602339 112 SLQDHSSYSAL-VYAIN-SEDTETLKVLL 138
Cdd:PHA02859  117 TEEDEDGKNLLhMYMCNfNVRINVIKLLI 145
PHA03095 PHA03095
ankyrin-like protein; Provisional
 63-140 3.63e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.17  E-value: 3.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  63 KAKMVKYLLENNADPNIQDKSGKTALmHACLEKAGP---EVVSLLLKSGADLSLQDHSSYSAL-VYAINSEDTETLKVLL 138
Cdd:PHA03095   26 TVEEVRRLLAAGADVNFRGEYGKTPL-HLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLI 104


                  ..
gi 2462602339 139 SA 140
Cdd:PHA03095  105 KA 106
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 42-79 5.43e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 5.43e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462602339   42 RGETPLMIACKTKHVDhqsvskakMVKYLLENNADPNI 79
Cdd:smart00248   1 DGRTPLHLAAENGNLE--------VVKLLLDKGADINA 30
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 43-162 5.85e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 45.37  E-value: 5.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  43 GETPLMIACKTKHVDhqsvskakMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADlslqdhssySAL 122
Cdd:PHA02875  168 GCTPLIIAMAKGDIA--------ICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGAD---------CNI 230

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462602339 123 VYAINSEDTETLKVLLSACKAKGKEVIIITTAKSPCGKHT 162
Cdd:PHA02875  231 MFMIEGEECTILDMICNMCTNLESEAIDALIADIAIRIHK 270
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 84-116 6.11e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 6.11e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462602339  84 GKTALMHACLEKAGPEVVSLLLKSGADLSLQDH 116
Cdd:pfam00023   2 GNTPLHLAAGRRGNLEIVKLLLSKGADVNARDK 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 31-106 1.03e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 1.03e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462602339  31 EGGAYINESNDRGETPLMIACKTKHVdhqsvskaKMVKYLLENNADPNIQDKSGKTALMHAcLEKAGPEVVSLLLK 106
Cdd:PTZ00322  103 TGGADPNCRDYDGRTPLHIACANGHV--------QVVRVLLEFGADPTLLDKDGKTPLELA-EENGFREVVQLLSR 169
Ank_5 pfam13857
Ankyrin repeats (many copies);
70-125 1.40e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 1.40e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462602339  70 LLEN-NADPNIQDKSGKTALMHACLEKAgPEVVSLLLKSGADLSLQDHSSYSALVYA 125
Cdd:pfam13857   1 LLEHgPIDLNRLDGEGYTPLHVAAKYGA-LEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 67-141 1.50e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.50  E-value: 1.50e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462602339  67 VKYLLENNADPNIQDKSGKTALMHACLeKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLLSAC 141
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACA-NGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHS 171
PHA02917 PHA02917
ankyrin-like protein; Provisional
 31-138 2.71e-04

ankyrin-like protein; Provisional


Pssm-ID: 165231 [Multi-domain]  Cd Length: 661  Bit Score: 43.83  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  31 EGGAYINESNDrGETPLMIACKTKHVDHQSVSKA---------------KMVKYLLENNADPNIQDKSGKTaLMHACLEK 95
Cdd:PHA02917  385 EGGDAVNHLDD-GEIPIGHLCKSNYGCYNFYTYTykkglcdmsyacpilSTINICLPYLKDINMIDKRGET-LLHKAVRY 462

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462602339  96 AGPEVVSLLLKSGADLSLQDHSSYSALVYAIN-SEDTETLKVLL 138
Cdd:PHA02917  463 NKQSLVSLLLESGSDVNIRSNNGYTCIAIAINeSRNIELLKMLL 506
Ank_4 pfam13637
Ankyrin repeats (many copies);
86-138 2.91e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 2.91e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462602339  86 TALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLL 138
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 42-79 3.69e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 3.69e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462602339  42 RGETPLMIACKTKHVDhqsvskakMVKYLLENNADPNI 79
Cdd:pfam13606   1 DGNTPLHLAARNGRLE--------IVKLLLENGADINA 30
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 31-139 7.98e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.87  E-value: 7.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  31 EGGAYINESNDRGETPLMIACKTKHVDhqsvskakMVKYLLENNADPNIQDKSGKTALmHACLEKAGPEVVSLLLKSGAD 110
Cdd:PHA02874  112 DCGIDVNIKDAELKTFLHYAIKKGDLE--------SIKMLFEYGADVNIEDDNGCYPI-HIAIKHNFFDIIKLLLEKGAY 182

                          90       100
                  ....*....|....*....|....*....
gi 2462602339 111 LSLQDHSSYSALVYAINSEDTETLKVLLS 139
Cdd:PHA02874  183 ANVKDNNGESPLHNAAEYGDYACIKLLID 211
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 65-138 1.58e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.20  E-value: 1.58e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462602339  65 KMVKYLLENNADPNIQDKSGKTALmHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLL 138
Cdd:PHA02876  159 LIAEMLLEGGADVNAKDIYCITPI-HYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAII 231
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-140 1.74e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 40.32  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  35 YINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQ 114
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                          90       100
                  ....*....|....*....|....*.
gi 2462602339 115 DHSSYSALVYAINSEDTETLKVLLSA 140
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEA 109
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 14-126 2.09e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.63  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602339  14 LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLmiacktkHVDHQSVSKAKMVKYLLENNADPNIQDK-SGKTALmHAC 92
Cdd:PHA02878  205 LHHAVKHYNKPIVHILLENGASTDARDKCGNTPL-------HISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTAL-HSS 276

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462602339  93 LEKagPEVVSLLLKSGADLSLQDHSSYSALVYAI 126
Cdd:PHA02878  277 IKS--ERKLKLLLEYGADINSLNSYKLTPLSSAV 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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