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Conserved domains on  [gi|2462594588|ref|XP_054204752|]
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bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X4 [Homo sapiens]

Protein Classification

phosphoribosylaminoimidazolesuccinocarboxamide synthase( domain architecture ID 10105474)

phosphoribosylaminoimidazolesuccinocarboxamide synthase catalyzes the conversion of 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) in the de novo biosynthesis of purine nucleotides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 33-284 0e+00

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


:

Pssm-ID: 133471  Cd Length: 252  Bit Score: 507.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  33 LNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAF 112
Cdd:cd01416     1 LKLGKKLIEGKTKIVYELPDQPGLVLIQSKDRITAGDGARKDEIEGKAAISNKTTSNVFELLQEAGIKTHFVKQCSPTAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 113 IAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMS 192
Cdd:cd01416    81 IARKCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFSPPKLEFFYKDDANHDPQWSEEQLLEAKLNCGGLKIGKKEVDIMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 193 HATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVK 272
Cdd:cd01416   161 KSTIAIFEILEKAWATQDCTLVDMKIEFGVDVTTGEILLADVIDNDSWRLWPSGDKRLMKDKQVYRNLKEVTDEALQEVK 240

                         250
                  ....*....|..
gi 2462594588 273 KNFEWVAERVEL 284
Cdd:cd01416   241 KNYEWVADKLEL 252
AIRC super family cl00310
AIR carboxylase; Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl) ...
 294-394 6.65e-31

AIR carboxylase; Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.


The actual alignment was detected with superfamily member TIGR01162:

Pssm-ID: 469715  Cd Length: 156  Bit Score: 115.41  E-value: 6.65e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 294 VVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYE------------------------------ 343
Cdd:TIGR01162   1 VGIIMGSDSDLPTMKKAADILEEFGIPYELRVVSAHRTPELMLEYAKTAEergikviiagaggaahlpgmvaaltplpvi 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462594588 344 -----------------------GLGCSTVLSPEG--SAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIR 394
Cdd:TIGR01162  81 gvpvpskalsgldsllsivqmpsGVPVATVAIGNAgnAALLAAQILGIKDPELAEKLKEYRENQKEEVLKKNKKLE 156
 
Name Accession Description Interval E-value
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 33-284 0e+00

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 507.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  33 LNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAF 112
Cdd:cd01416     1 LKLGKKLIEGKTKIVYELPDQPGLVLIQSKDRITAGDGARKDEIEGKAAISNKTTSNVFELLQEAGIKTHFVKQCSPTAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 113 IAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMS 192
Cdd:cd01416    81 IARKCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFSPPKLEFFYKDDANHDPQWSEEQLLEAKLNCGGLKIGKKEVDIMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 193 HATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVK 272
Cdd:cd01416   161 KSTIAIFEILEKAWATQDCTLVDMKIEFGVDVTTGEILLADVIDNDSWRLWPSGDKRLMKDKQVYRNLKEVTDEALQEVK 240

                         250
                  ....*....|..
gi 2462594588 273 KNFEWVAERVEL 284
Cdd:cd01416   241 KNYEWVADKLEL 252
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 38-266 9.21e-96

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 285.80  E-value: 9.21e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  38 KLYEGKTKEVYELLDsPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQC 117
Cdd:pfam01259   1 LLYEGKVKDVYETDD-PDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 118 EMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKfcfaglLIGQTEVDIMSHATQA 197
Cdd:pfam01259  80 KIIPLEVVVRNYAAGSLGKRLPGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALG------LATEEEAEEIRELALK 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462594588 198 IFEILEKSWLPQNCTLVDMKIEFGVDvTTKEIVLADVIDNDSWRLWPSGD--RSQQK-DKQSYRD----LKEVTPE 266
Cdd:pfam01259 154 INEILKEYAAERGIILVDTKLEFGLD-SDGEIVLADEITPDSSRFWDADTyeKSQESlDKDRFRDdlgdVEEAYQE 228
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 36-287 2.33e-66

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 210.73  E-value: 2.33e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  36 GKKLYEGKTKEVYELlDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAP 115
Cdd:PRK09362    4 KELLYEGKAKIVYST-DDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQLVK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 116 QCEMIPIEWVCRRIATGSFLKRNpGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKfcfaglLIGQTEVDIMSHAT 195
Cdd:PRK09362   83 KVEIIPLEVVVRNVAAGSLVKRL-GIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALG------WATPEELAEIKELA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 196 QAIFEILEKSWLPQNCTLVDMKIEFGVDvTTKEIVLADVIDNDSWRLWpsgdrsqqkDKQSYRDL-KEVTPEGLQMVKKN 274
Cdd:PRK09362  156 LKINDVLKGLFAGAGIRLVDFKLEFGRD-KDGEIVLADEISPDTCRLW---------DKETNEKLdKDRFRRDLGGVIEA 225

                         250
                  ....*....|...
gi 2462594588 275 FEWVAERVELLLK 287
Cdd:PRK09362  226 YEEVLKRLGELLE 238
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 33-259 3.09e-64

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 205.70  E-value: 3.09e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  33 LNIGKKLYEGKTKEVYELLDspGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAF 112
Cdd:COG0152     1 MPKLELLYEGKVKDVYATDD--DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 113 IAPQCEMIPIEWVCRRIATGSFLKR-------NPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKfcfaglLIGQ 185
Cdd:COG0152    79 LVKKLEMIPVEVVVRNYAAGSLWKRyqagialPLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALG------LATE 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462594588 186 TEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDvTTKEIVLADVIDNDSWRLWPSGDRsQQKDKQSYRD 259
Cdd:COG0152   153 EEAEELRELALKINERLSELAAERGIILVDTKLEFGRD-ADGEIVLADEITPDSSRLWDADTY-ESLDKDRFRD 224
purE TIGR01162
phosphoribosylaminoimidazole carboxylase, PurE protein; Phosphoribosylaminoimidazole ...
 294-394 6.65e-31

phosphoribosylaminoimidazole carboxylase, PurE protein; Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. This model represents PurK, an N5-CAIR mutase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273474  Cd Length: 156  Bit Score: 115.41  E-value: 6.65e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 294 VVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYE------------------------------ 343
Cdd:TIGR01162   1 VGIIMGSDSDLPTMKKAADILEEFGIPYELRVVSAHRTPELMLEYAKTAEergikviiagaggaahlpgmvaaltplpvi 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462594588 344 -----------------------GLGCSTVLSPEG--SAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIR 394
Cdd:TIGR01162  81 gvpvpskalsgldsllsivqmpsGVPVATVAIGNAgnAALLAAQILGIKDPELAEKLKEYRENQKEEVLKKNKKLE 156
AIRC pfam00731
AIR carboxylase; Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl) ...
 294-377 4.27e-23

AIR carboxylase; Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.


Pssm-ID: 459917  Cd Length: 147  Bit Score: 93.97  E-value: 4.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 294 VVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYE------------------------------ 343
Cdd:pfam00731   1 VGIIMGSDSDLPVMKKAAKILKEFGIPYEVRVVSAHRTPERLLEYAKEAEerglkviiagaggaahlpgmvaalttlpvi 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462594588 344 -----------------------GLGCSTVL--SPEGSAQFAAQIFGLSNHLVWSKLRA 377
Cdd:pfam00731  81 gvpvkssaldgldsllsivqmpsGVPVATVAigGAKNAALLAAQILALSDPELAEKLKE 139
AIRC smart01001
AIR carboxylase; Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl) ...
 292-386 3.36e-20

AIR carboxylase; Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyse the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.


Pssm-ID: 214965  Cd Length: 152  Bit Score: 86.43  E-value: 3.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  292 CRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYE---------------------------- 343
Cdd:smart01001   1 PLVGIIMGSTSDLPVMEEAAKTLEEFGIPYEVGVASAHRTPDRLFEYAKEAEdrgikviiagaggaahlpgvvaalttlp 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462594588  344 -------------------------GLGCSTVL----SPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISL 386
Cdd:smart01001  81 vigvpvssgylggldsllsivqmpsGIPVATVAigidGAFNAALLAAQILALNDPELAAKLAAYRINQTEEV 152
PurE COG0041
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; ...
 293-347 3.10e-09

Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439811  Cd Length: 161  Bit Score: 55.45  E-value: 3.10e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462594588 293 RVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRI--KAEYEGLGC 347
Cdd:COG0041     2 KVGIIMGSDSDWPTMKKAAKILDEFGIPYEVRVVSAHRTPDRLFEYakTAEERGLKV 58
PLN02948 PLN02948
phosphoribosylaminoimidazole carboxylase
 278-333 8.40e-05

phosphoribosylaminoimidazole carboxylase


Pssm-ID: 178534 [Multi-domain]  Cd Length: 577  Bit Score: 44.67  E-value: 8.40e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462594588 278 VAERVELLLKSES-QC--------RVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPD 333
Cdd:PLN02948  388 VEARLDQLLAEESaDPdalpkgtpLVGIIMGSDSDLPTMKDAAEILDSFGVPYEVTIVSAHRTPE 452
 
Name Accession Description Interval E-value
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 33-284 0e+00

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 507.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  33 LNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAF 112
Cdd:cd01416     1 LKLGKKLIEGKTKIVYELPDQPGLVLIQSKDRITAGDGARKDEIEGKAAISNKTTSNVFELLQEAGIKTHFVKQCSPTAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 113 IAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMS 192
Cdd:cd01416    81 IARKCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFSPPKLEFFYKDDANHDPQWSEEQLLEAKLNCGGLKIGKKEVDIMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 193 HATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVK 272
Cdd:cd01416   161 KSTIAIFEILEKAWATQDCTLVDMKIEFGVDVTTGEILLADVIDNDSWRLWPSGDKRLMKDKQVYRNLKEVTDEALQEVK 240

                         250
                  ....*....|..
gi 2462594588 273 KNFEWVAERVEL 284
Cdd:cd01416   241 KNYEWVADKLEL 252
SAICAR_synt cd00476
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ...
 38-283 2.74e-113

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133468  Cd Length: 230  Bit Score: 330.58  E-value: 2.74e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  38 KLYEGKTKEVYELLDspGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQC 117
Cdd:cd00476     1 TLYRGKTKIVYETKD--GVLLLEFKDDISAGDGARRNFLDEKGDITAKLTLFIFKYLSEAGIPTHFVERLGPRTLLVDKL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 118 EMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFcfagllIGQTEVDIMSHATQA 197
Cdd:cd00476    79 K*IPLEVVVRNRATGSFVKRYGGFKEGREFPPPLVEFFYKDDAEHDPIVSEDQLERLGF------IGKVDVER*KELAVK 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 198 IFEILEKSWLPQNCTLVDMKIEFGVDVtTKEIVLADVIDNDSWRLWPSGDRSQQKDkqsyrdlKEVTPEGLQMVKKNFEW 277
Cdd:cd00476   153 INTVLKKLFSPAGLELWDFKLEFGLDE-EGEIVLGDEISPDSSRLWRKGGEPYDKD-------LFRRRASLGQIIEKYEE 224


                  ....*.
gi 2462594588 278 VAERVE 283
Cdd:cd00476   225 VAELVR 230
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 38-266 9.21e-96

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 285.80  E-value: 9.21e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  38 KLYEGKTKEVYELLDsPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQC 117
Cdd:pfam01259   1 LLYEGKVKDVYETDD-PDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 118 EMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKfcfaglLIGQTEVDIMSHATQA 197
Cdd:pfam01259  80 KIIPLEVVVRNYAAGSLGKRLPGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALG------LATEEEAEEIRELALK 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462594588 198 IFEILEKSWLPQNCTLVDMKIEFGVDvTTKEIVLADVIDNDSWRLWPSGD--RSQQK-DKQSYRD----LKEVTPE 266
Cdd:pfam01259 154 INEILKEYAAERGIILVDTKLEFGLD-SDGEIVLADEITPDSSRFWDADTyeKSQESlDKDRFRDdlgdVEEAYQE 228
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 36-287 2.33e-66

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 210.73  E-value: 2.33e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  36 GKKLYEGKTKEVYELlDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAP 115
Cdd:PRK09362    4 KELLYEGKAKIVYST-DDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQLVK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 116 QCEMIPIEWVCRRIATGSFLKRNpGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKfcfaglLIGQTEVDIMSHAT 195
Cdd:PRK09362   83 KVEIIPLEVVVRNVAAGSLVKRL-GIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALG------WATPEELAEIKELA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 196 QAIFEILEKSWLPQNCTLVDMKIEFGVDvTTKEIVLADVIDNDSWRLWpsgdrsqqkDKQSYRDL-KEVTPEGLQMVKKN 274
Cdd:PRK09362  156 LKINDVLKGLFAGAGIRLVDFKLEFGRD-KDGEIVLADEISPDTCRLW---------DKETNEKLdKDRFRRDLGGVIEA 225

                         250
                  ....*....|...
gi 2462594588 275 FEWVAERVELLLK 287
Cdd:PRK09362  226 YEEVLKRLGELLE 238
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 33-259 3.09e-64

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 205.70  E-value: 3.09e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  33 LNIGKKLYEGKTKEVYELLDspGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAF 112
Cdd:COG0152     1 MPKLELLYEGKVKDVYATDD--DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 113 IAPQCEMIPIEWVCRRIATGSFLKR-------NPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKfcfaglLIGQ 185
Cdd:COG0152    79 LVKKLEMIPVEVVVRNYAAGSLWKRyqagialPLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALG------LATE 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462594588 186 TEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDvTTKEIVLADVIDNDSWRLWPSGDRsQQKDKQSYRD 259
Cdd:COG0152   153 EEAEELRELALKINERLSELAAERGIILVDTKLEFGRD-ADGEIVLADEITPDSSRLWDADTY-ESLDKDRFRD 224
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 38-284 2.26e-61

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 197.67  E-value: 2.26e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  38 KLYEGKTKEVYELlDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQC 117
Cdd:cd01415     1 LLYEGKAKIVYAT-DDPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEKLSDREQLVKKV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 118 EMIPIEWVCRRIATGSFLKRNpGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKfcfaglLIGQTEVDIMSHATQA 197
Cdd:cd01415    80 EIIPLEVVVRNIAAGSLVKRL-GIEEGTVLDPPIVEFYYKNDELGDPLINEDHILALG------LATEEELKEIKELALK 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 198 IFEILEKSWLPQNCTLVDMKIEFGVDvTTKEIVLADVIDNDSWRLWpsgdrsqqkDKQSYRDL-KEVTPEGLQMVKKNFE 276
Cdd:cd01415   153 INEVLSEFFAEIGIILVDFKLEFGRD-KDGEIVLADEISPDTCRLW---------DKETGEKLdKDRFRRDLGDVIEAYE 222


                  ....*...
gi 2462594588 277 WVAERVEL 284
Cdd:cd01415   223 EVLKRLGE 230
purE TIGR01162
phosphoribosylaminoimidazole carboxylase, PurE protein; Phosphoribosylaminoimidazole ...
 294-394 6.65e-31

phosphoribosylaminoimidazole carboxylase, PurE protein; Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. This model represents PurK, an N5-CAIR mutase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273474  Cd Length: 156  Bit Score: 115.41  E-value: 6.65e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 294 VVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYE------------------------------ 343
Cdd:TIGR01162   1 VGIIMGSDSDLPTMKKAADILEEFGIPYELRVVSAHRTPELMLEYAKTAEergikviiagaggaahlpgmvaaltplpvi 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462594588 344 -----------------------GLGCSTVLSPEG--SAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIR 394
Cdd:TIGR01162  81 gvpvpskalsgldsllsivqmpsGVPVATVAIGNAgnAALLAAQILGIKDPELAEKLKEYRENQKEEVLKKNKKLE 156
AIRC pfam00731
AIR carboxylase; Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl) ...
 294-377 4.27e-23

AIR carboxylase; Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.


Pssm-ID: 459917  Cd Length: 147  Bit Score: 93.97  E-value: 4.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 294 VVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYE------------------------------ 343
Cdd:pfam00731   1 VGIIMGSDSDLPVMKKAAKILKEFGIPYEVRVVSAHRTPERLLEYAKEAEerglkviiagaggaahlpgmvaalttlpvi 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462594588 344 -----------------------GLGCSTVL--SPEGSAQFAAQIFGLSNHLVWSKLRA 377
Cdd:pfam00731  81 gvpvkssaldgldsllsivqmpsGVPVATVAigGAKNAALLAAQILALSDPELAEKLKE 139
AIRC smart01001
AIR carboxylase; Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl) ...
 292-386 3.36e-20

AIR carboxylase; Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyse the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.


Pssm-ID: 214965  Cd Length: 152  Bit Score: 86.43  E-value: 3.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  292 CRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYE---------------------------- 343
Cdd:smart01001   1 PLVGIIMGSTSDLPVMEEAAKTLEEFGIPYEVGVASAHRTPDRLFEYAKEAEdrgikviiagaggaahlpgvvaalttlp 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462594588  344 -------------------------GLGCSTVL----SPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISL 386
Cdd:smart01001  81 vigvpvssgylggldsllsivqmpsGIPVATVAigidGAFNAALLAAQILALNDPELAAKLAAYRINQTEEV 152
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 38-259 1.75e-14

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 72.97  E-value: 1.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  38 KLYEGKTKEVYELLDspGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLqEAGIKTAFT------------- 104
Cdd:cd01414     1 LIYSGKVRDVYDLGD--GRLLFVATDRISAFDVILPPDIPGKGEVLTQISAFWFELT-EDIIPNHLIstdvedlpeikep 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 105 RKCGETAFIAPQCEMIPIEWVCRRIATGSFLKR------------NPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLI 172
Cdd:cd01414    78 EDPDGRSMVVKKAKPIPIECIVRGYLTGSGWKEyqkggtvcgiklPEGLREAQKLPEPIFTPSTKAEEGHDENISFEEAV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 173 AakfcfaglLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVtTKEIVLADVIDN-DSWRLWPSGDRSQQ 251
Cdd:cd01414   158 E--------IIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDE-NGEIILIDEVLTpDSSRFWPADSYEPG 228

                         250
                  ....*....|...
gi 2462594588 252 K-----DKQSYRD 259
Cdd:cd01414   229 KeqpsfDKQFVRD 241
PurE COG0041
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; ...
 293-347 3.10e-09

Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439811  Cd Length: 161  Bit Score: 55.45  E-value: 3.10e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462594588 293 RVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRI--KAEYEGLGC 347
Cdd:COG0041     2 KVGIIMGSDSDWPTMKKAAKILDEFGIPYEVRVVSAHRTPDRLFEYakTAEERGLKV 58
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 37-281 1.70e-06

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 49.50  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588  37 KKLYEGKTKEVYELLDspGKVLLQSKDQITAGNAarknHLEG---KAAISNKITSCIFQllqeagiktaftrkcgETAFI 113
Cdd:PRK12607   16 PNVYRGKVRDNYDLPD--GRRVMVATDRISAFDR----VLPAipyKGQVLNQTAAFWFE----------------ATKDI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 114 AP---------------QCEMIPIEWVCRRIATGSFL------KRN------P-GVKEGYKFYPPKVELFFK-DDANNDP 164
Cdd:PRK12607   74 CPnhvlavpdpnvvvgkRCEPFPVEMVVRGYLAGSTWrlykagKREmygvtlPdGLRENQKLPEPIITPTTKaEEGGHDE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594588 165 QWSEEQLIAakfcfAGLLiGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKeIVLADVIDN-DSWRLW 243
Cdd:PRK12607  154 PISPEEILA-----QGLL-TPEDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDADGR-IVLIDEIHTpDSSRYW 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2462594588 244 psgdrsqqkDKQSYRDL--KEVTPEGLQmvkKNF--EWVAER 281
Cdd:PRK12607  227 ---------YADGYEERfaAGEPQEQLD---KEFvrQWLIER 256
PLN02948 PLN02948
phosphoribosylaminoimidazole carboxylase
 278-333 8.40e-05

phosphoribosylaminoimidazole carboxylase


Pssm-ID: 178534 [Multi-domain]  Cd Length: 577  Bit Score: 44.67  E-value: 8.40e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462594588 278 VAERVELLLKSES-QC--------RVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPD 333
Cdd:PLN02948  388 VEARLDQLLAEESaDPdalpkgtpLVGIIMGSDSDLPTMKDAAEILDSFGVPYEVTIVSAHRTPE 452
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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