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Conserved domains on  [gi|2462587438|ref|XP_054201358|]
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CKLF-like MARVEL transmembrane domain-containing protein 8 isoform X1 [Homo sapiens]

Protein Classification

MARVEL domain-containing protein( domain architecture ID 10472694)

MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing protein may be involved in membrane apposition and vesicle-trafficking events

Gene Ontology:  GO:0016020
PubMed:  12468223

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 72-185 1.69e-09

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


:

Pssm-ID: 366555  Cd Length: 136  Bit Score: 53.87  E-value: 1.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587438  72 LVLGLLVWTLIAGTEYFRV---PAFGWVMFVAVFYWVLTVFFLIIYITMtYTRIPQVPWTTVGLCFNGSAFVLYLSAAVV 148
Cdd:pfam01284  14 LVFAIIVLGLIASLIAYAGsypSAVNFAVFVAVFSFLIALFFLLLYLFG-YSYFPSIAWPLIDLIFDALAALFWLAAFIA 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462587438 149 DASSVSP-------ERDSHNFNSWAASSFFAFLVTICYAGNTYF 185
Cdd:pfam01284  93 LAAALRGhsenqgsGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
 
Name Accession Description Interval E-value
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 72-185 1.69e-09

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 53.87  E-value: 1.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587438  72 LVLGLLVWTLIAGTEYFRV---PAFGWVMFVAVFYWVLTVFFLIIYITMtYTRIPQVPWTTVGLCFNGSAFVLYLSAAVV 148
Cdd:pfam01284  14 LVFAIIVLGLIASLIAYAGsypSAVNFAVFVAVFSFLIALFFLLLYLFG-YSYFPSIAWPLIDLIFDALAALFWLAAFIA 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462587438 149 DASSVSP-------ERDSHNFNSWAASSFFAFLVTICYAGNTYF 185
Cdd:pfam01284  93 LAAALRGhsenqgsGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
 
Name Accession Description Interval E-value
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 72-185 1.69e-09

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 53.87  E-value: 1.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587438  72 LVLGLLVWTLIAGTEYFRV---PAFGWVMFVAVFYWVLTVFFLIIYITMtYTRIPQVPWTTVGLCFNGSAFVLYLSAAVV 148
Cdd:pfam01284  14 LVFAIIVLGLIASLIAYAGsypSAVNFAVFVAVFSFLIALFFLLLYLFG-YSYFPSIAWPLIDLIFDALAALFWLAAFIA 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462587438 149 DASSVSP-------ERDSHNFNSWAASSFFAFLVTICYAGNTYF 185
Cdd:pfam01284  93 LAAALRGhsenqgsGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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