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Conserved domains on  [gi|2462587028|ref|XP_054201163|]
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protein MIX23 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIX23 super family cl10753
Intermembrane space protein MIX23; Intermembrane space protein MIX23 regulates or stabilizes ...
 10-77 6.92e-05

Intermembrane space protein MIX23; Intermembrane space protein MIX23 regulates or stabilizes the mitochondrial protein import machinery and is specifically up-regulated under stress conditions. It is critical for the efficient import of proteins into the mitochondrial matrix, particularly if the function of the translocase of the inner membrane 23 is compromised. MIX23, also known as Caffeine-induced death protein 2 (Cid2), is evolutionarily conserved and a homolog of the human protein CCDC58.


The actual alignment was detected with superfamily member pfam09774:

Pssm-ID: 430815  Cd Length: 156  Bit Score: 40.48  E-value: 6.92e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462587028  10 CEEFAEFQELLKVMR-TIDDRIVHELNTTVPTASFAG-----KIDASQTCKQLY-ESLMAAHASRDRVIKNCIAQ 77
Cdd:pfam09774   1 CFNPSLLRSFLRLSRhTIDDSITQRLNALSTPSRSAGfdpssTSLAESACDSFKeEELFPSWQARSDVINYCAGV 75
 
Name Accession Description Interval E-value
MIX23 pfam09774
Intermembrane space protein MIX23; Intermembrane space protein MIX23 regulates or stabilizes ...
 10-77 6.92e-05

Intermembrane space protein MIX23; Intermembrane space protein MIX23 regulates or stabilizes the mitochondrial protein import machinery and is specifically up-regulated under stress conditions. It is critical for the efficient import of proteins into the mitochondrial matrix, particularly if the function of the translocase of the inner membrane 23 is compromised. MIX23, also known as Caffeine-induced death protein 2 (Cid2), is evolutionarily conserved and a homolog of the human protein CCDC58.


Pssm-ID: 430815  Cd Length: 156  Bit Score: 40.48  E-value: 6.92e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462587028  10 CEEFAEFQELLKVMR-TIDDRIVHELNTTVPTASFAG-----KIDASQTCKQLY-ESLMAAHASRDRVIKNCIAQ 77
Cdd:pfam09774   1 CFNPSLLRSFLRLSRhTIDDSITQRLNALSTPSRSAGfdpssTSLAESACDSFKeEELFPSWQARSDVINYCAGV 75
 
Name Accession Description Interval E-value
MIX23 pfam09774
Intermembrane space protein MIX23; Intermembrane space protein MIX23 regulates or stabilizes ...
 10-77 6.92e-05

Intermembrane space protein MIX23; Intermembrane space protein MIX23 regulates or stabilizes the mitochondrial protein import machinery and is specifically up-regulated under stress conditions. It is critical for the efficient import of proteins into the mitochondrial matrix, particularly if the function of the translocase of the inner membrane 23 is compromised. MIX23, also known as Caffeine-induced death protein 2 (Cid2), is evolutionarily conserved and a homolog of the human protein CCDC58.


Pssm-ID: 430815  Cd Length: 156  Bit Score: 40.48  E-value: 6.92e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462587028  10 CEEFAEFQELLKVMR-TIDDRIVHELNTTVPTASFAG-----KIDASQTCKQLY-ESLMAAHASRDRVIKNCIAQ 77
Cdd:pfam09774   1 CFNPSLLRSFLRLSRhTIDDSITQRLNALSTPSRSAGfdpssTSLAESACDSFKeEELFPSWQARSDVINYCAGV 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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