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Conserved domains on  [gi|2462577943|ref|XP_054200250|]
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protein TANC1 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1088-1294 1.35e-52

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 187.08  E-value: 1.35e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1088 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHL 1167
Cdd:COG0666     54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1168 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1247
Cdd:COG0666    134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2462577943 1248 HVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATSKPDIL 1294
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
PHA03100 super family cl39094
ankyrin repeat protein; Provisional
 957-1214 3.59e-12

ankyrin repeat protein; Provisional


The actual alignment was detected with superfamily member PHA03100:

Pssm-ID: 476869 [Multi-domain]  Cd Length: 422  Bit Score: 70.46  E-value: 3.59e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  957 EEVVTLLLEFGACLDGTSENGMTALCYAAAAGH-----MKLVCLLTKKGVRVDHLDKKGqcalVHsalrghgdILQYLLT 1031
Cdd:PHA03100    48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNG----IT--------PLLYAIS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1032 CEwspgppqpgtlrkshalqqaltaaasMGHSSVVQCLLgmekEHEVEVNgTDTLWGETALTAAA--GRGKLEVCELLLG 1109
Cdd:PHA03100   116 KK--------------------------SNSYSIVEYLL----DNGANVN-IKNSDGENLLHLYLesNKIDLKILKLLID 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1110 HGAAVSRTNRrgvpplfcaarqghwqiVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLS 1189
Cdd:PHA03100   165 KGVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227

                          250       260
                   ....*....|....*....|....*
gi 2462577943 1190 ALSWACLKGHRAVVQYLVEEGAAID 1214
Cdd:PHA03100   228 PLHIAILNNNKEIFKLLLNNGPSIK 252
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1282-1419 1.37e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 1.37e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1282 AAWAMATSKPDILIILLQKLMEE-----------GNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLN 1350
Cdd:COG3914     85 ALLLQALGRYEEALALYRRALALnpdnaealfnlGNLLLALGRLEEALAALRRALALNPDF-------------AEAYLN 151

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462577943 1351 LSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLL 1419
Cdd:COG3914    152 LGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
NACHT super family cl26020
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
530-831 2.60e-08

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5635:

Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 59.05  E-value: 2.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  530 FVHSIAALLCRSHQLAAYR-DLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIpeeeyIILIDGLNEAEF 608
Cdd:COG5635    196 LLRYLALELAERYLDAEDPiPILIELRDLAEEASLEDLLAEALEKRGGEPEDALERLLRNGRL-----LLLLDGLDEVPD 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  609 hkPDYGDTLSSFITKIISKFPAwLKLIVTVRANFQEIISALPFVKLSLDDFpDNKDIHSDLHAYVQHRVHSSQDILSNIS 688
Cdd:COG5635    271 --EADRDEVLNQLRRFLERYPK-ARVIITSRPEGYDSSELEGFEVLELAPL-SDEQIEEFLKKWFEATERKAERLLEALE 346

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  689 LNGKadatligkvsshlvLRSL-GSYLYLKLTLDLFQRGHlviksasykVVPVSLSELYLLQCNMkFMTQSAFERALPIL 767
Cdd:COG5635    347 ENPE--------------LRELaRNPLLLTLLALLLRERG---------ELPDTRAELYEQFVEL-LLERWDEQRGLTIY 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  768 N-------------VALASLH----PMTDEQIFQAINAgHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWL 830
Cdd:COG5635    403 RelsreelrellseLALAMQEngrtEFAREELEEILRE-YLGRRKDAEALLDELLLRTGLLVERGEGRYSFAHRSFQEYL 481


                   .
gi 2462577943  831 V 831
Cdd:COG5635    482 A 482
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1088-1294 1.35e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 187.08  E-value: 1.35e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1088 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHL 1167
Cdd:COG0666     54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1168 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1247
Cdd:COG0666    134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2462577943 1248 HVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATSKPDIL 1294
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1125-1217 1.79e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 93.26  E-value: 1.79e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1125 LFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAlsSLDKEGLSALSWACLKGHRAVVQ 1204
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2462577943 1205 YLVEEGAAIDQTD 1217
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1101-1277 3.59e-22

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 101.67  E-value: 3.59e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1101 LEVCELLLGHGAAVSRTNRRGVPPLFCAA--RQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA--CEGHLSTVEFLLSK 1176
Cdd:PHA03100    86 KEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDK 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1177 GAALSSLDKeglsalswaclkghravVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRP 1256
Cdd:PHA03100   166 GVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228

                          170       180
                   ....*....|....*....|.
gi 2462577943 1257 LDRAIGCRNTSVVVALLRKGA 1277
Cdd:PHA03100   229 LHIAILNNNKEIFKLLLNNGP 249
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 957-1214 3.59e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.46  E-value: 3.59e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  957 EEVVTLLLEFGACLDGTSENGMTALCYAAAAGH-----MKLVCLLTKKGVRVDHLDKKGqcalVHsalrghgdILQYLLT 1031
Cdd:PHA03100    48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNG----IT--------PLLYAIS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1032 CEwspgppqpgtlrkshalqqaltaaasMGHSSVVQCLLgmekEHEVEVNgTDTLWGETALTAAA--GRGKLEVCELLLG 1109
Cdd:PHA03100   116 KK--------------------------SNSYSIVEYLL----DNGANVN-IKNSDGENLLHLYLesNKIDLKILKLLID 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1110 HGAAVSRTNRrgvpplfcaarqghwqiVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLS 1189
Cdd:PHA03100   165 KGVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227

                          250       260
                   ....*....|....*....|....*
gi 2462577943 1190 ALSWACLKGHRAVVQYLVEEGAAID 1214
Cdd:PHA03100   228 PLHIAILNNNKEIFKLLLNNGPSIK 252
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1282-1419 1.37e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 1.37e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1282 AAWAMATSKPDILIILLQKLMEE-----------GNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLN 1350
Cdd:COG3914     85 ALLLQALGRYEEALALYRRALALnpdnaealfnlGNLLLALGRLEEALAALRRALALNPDF-------------AEAYLN 151

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462577943 1351 LSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLL 1419
Cdd:COG3914    152 LGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
Ank_2 pfam12796
Ankyrin repeats (3 copies);
955-1030 9.32e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 9.32e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462577943  955 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLV-CLLTKKGVRVDHldkKGQCALVHSALRGHGDILQYLL 1030
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVkLLLEHADVNLKD---NGRTALHYAARSGHLEIVKLLL 81
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
530-831 2.60e-08

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 59.05  E-value: 2.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  530 FVHSIAALLCRSHQLAAYR-DLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIpeeeyIILIDGLNEAEF 608
Cdd:COG5635    196 LLRYLALELAERYLDAEDPiPILIELRDLAEEASLEDLLAEALEKRGGEPEDALERLLRNGRL-----LLLLDGLDEVPD 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  609 hkPDYGDTLSSFITKIISKFPAwLKLIVTVRANFQEIISALPFVKLSLDDFpDNKDIHSDLHAYVQHRVHSSQDILSNIS 688
Cdd:COG5635    271 --EADRDEVLNQLRRFLERYPK-ARVIITSRPEGYDSSELEGFEVLELAPL-SDEQIEEFLKKWFEATERKAERLLEALE 346

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  689 LNGKadatligkvsshlvLRSL-GSYLYLKLTLDLFQRGHlviksasykVVPVSLSELYLLQCNMkFMTQSAFERALPIL 767
Cdd:COG5635    347 ENPE--------------LRELaRNPLLLTLLALLLRERG---------ELPDTRAELYEQFVEL-LLERWDEQRGLTIY 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  768 N-------------VALASLH----PMTDEQIFQAINAgHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWL 830
Cdd:COG5635    403 RelsreelrellseLALAMQEngrtEFAREELEEILRE-YLGRRKDAEALLDELLLRTGLLVERGEGRYSFAHRSFQEYL 481


                   .
gi 2462577943  831 V 831
Cdd:COG5635    482 A 482
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1088-1207 8.60e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 53.86  E-value: 8.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1088 GETALTAAAGRGKLEVCELLLGHGAAVS---------RTNRR-----GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ 1153
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462577943 1154 GRTPLMV--------AACEghlsTVEFLLS--KGAALSSLD----KEGLSALSWACLKGHRAVVQYLV 1207
Cdd:cd22192    169 GNTVLHIlvlqpnktFACQ----MYDLILSydKEDDLQPLDlvpnNQGLTPFKLAAKEGNIVMFQHLV 232
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1153-1178 3.58e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 3.58e-04
                            10        20
                    ....*....|....*....|....*.
gi 2462577943  1153 QGRTPLMVAACEGHLSTVEFLLSKGA 1178
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1088-1299 5.90e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 44.69  E-value: 5.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1088 GETALTAAAgRGKLEVCELLLGHGAAVSR------------TNR--RGVPPLFCAARQGHWQIVRLLLERGCDVNL---- 1149
Cdd:TIGR00870   82 GDTLLHAIS-LEYVDAVEAILLHLLAAFRksgplelandqyTSEftPGITALHLAAHRQNYEIVKLLLERGASVPAracg 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1150 -----SDKQ-----GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKeglsaLSWACLkgHRAVVQ--------------- 1204
Cdd:TIGR00870  161 dffvkSQGVdsfyhGESPLNAAACLGSPSIVALLSEDPADILTADS-----LGNTLL--HLLVMEnefkaeyeelscqmy 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1205 -YLVEEGAAIDQTDK-------NGRTPLDLAAFYGDAETVLYLVE-KGAVIEHVDH------SGMRPLDRAIGCRNTSVV 1269
Cdd:TIGR00870  234 nFALSLLDKLRDSKElevilnhQGLTPLKLAAKEGRIVLFRLKLAiKYKQKKFVAWpngqqlLSLYWLEELDGWRRKQSV 313

                          250       260       270
                   ....*....|....*....|....*....|
gi 2462577943 1270 VALLrkgaklgnAAWAMATSKPDILIILLQ 1299
Cdd:TIGR00870  314 LELI--------VVFVIGLKFPELSDMYLI 335
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1309-1421 1.45e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.53  E-value: 1.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1309 YKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARA 1388
Cdd:TIGR02917  510 IQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQY 576

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2462577943 1389 KRNSRQFVAALADLQEAVKLCPTNQEVKRLLAR 1421
Cdd:TIGR02917  577 YLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
TPR_14 pfam13428
Tetratricopeptide repeat;
1380-1422 2.66e-03

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 37.40  E-value: 2.66e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462577943 1380 EAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1422
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1088-1294 1.35e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 187.08  E-value: 1.35e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1088 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHL 1167
Cdd:COG0666     54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1168 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1247
Cdd:COG0666    134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2462577943 1248 HVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATSKPDIL 1294
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1081-1283 2.56e-51

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 183.62  E-value: 2.56e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1081 NGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1160
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1161 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLV 1240
Cdd:COG0666    160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 2462577943 1241 EKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAA 1283
Cdd:COG0666    240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
942-1257 6.35e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 167.82  E-value: 6.35e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  942 LNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRG 1021
Cdd:COG0666     19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1022 HGDILQYLLtcewspgppqpgtlrkshalqqaltaaasmghssvvqcllgmekEHEVEVNGTDTlWGETALTAAAGRGKL 1101
Cdd:COG0666     99 DLEIVKLLL--------------------------------------------EAGADVNARDK-DGETPLHLAAYNGNL 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1102 EVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALS 1181
Cdd:COG0666    134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462577943 1182 SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1257
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
909-1224 9.38e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 155.88  E-value: 9.38e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  909 AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAG 988
Cdd:COG0666     19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  989 HMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLtcewspgppqpgtlrkshalqqaltaaasmghssvvqc 1068
Cdd:COG0666     99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-------------------------------------- 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1069 llgmekEHEVEVNGTDTlWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1148
Cdd:COG0666    141 ------EAGADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462577943 1149 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPL 1224
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1069-1327 3.17e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 154.34  E-value: 3.17e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1069 LLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1148
Cdd:COG0666      2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1149 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAA 1228
Cdd:COG0666     82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAA 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1229 FYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA------KLGNAA--WAMATSKPDILIILLQK 1300
Cdd:COG0666    162 ANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAdvnakdNDGKTAldLAAENGNLEIVKLLLEA 241

                          250       260
                   ....*....|....*....|....*..
gi 2462577943 1301 LMEEGNVMYKKGKMKEAAQRYQYALRK 1327
Cdd:COG0666    242 GADLNAKDKDGLTALLLAAAAGAALIV 268
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1125-1217 1.79e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 93.26  E-value: 1.79e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1125 LFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAlsSLDKEGLSALSWACLKGHRAVVQ 1204
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2462577943 1205 YLVEEGAAIDQTD 1217
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1101-1277 3.59e-22

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 101.67  E-value: 3.59e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1101 LEVCELLLGHGAAVSRTNRRGVPPLFCAA--RQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA--CEGHLSTVEFLLSK 1176
Cdd:PHA03100    86 KEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDK 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1177 GAALSSLDKeglsalswaclkghravVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRP 1256
Cdd:PHA03100   166 GVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228

                          170       180
                   ....*....|....*....|.
gi 2462577943 1257 LDRAIGCRNTSVVVALLRKGA 1277
Cdd:PHA03100   229 LHIAILNNNKEIFKLLLNNGP 249
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1158-1250 6.47e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 89.02  E-value: 6.47e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1158 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEgAAIDQTDkNGRTPLDLAAFYGDAETVL 1237
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2462577943 1238 YLVEKGAVIEHVD 1250
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1092-1178 5.88e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 5.88e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1092 LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERgCDVNLSDkQGRTPLMVAACEGHLSTVE 1171
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78


                   ....*..
gi 2462577943 1172 FLLSKGA 1178
Cdd:pfam12796   79 LLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 915-1227 9.26e-20

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 94.71  E-value: 9.26e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  915 RNLYTPNVKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLGHE---EVVTLLLEFGACLDGTSENGMTAL-CYAAAAG 988
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  989 HMKLVCLLTKKGVRVDHLDKKGQCALvHSALRG---HGDILQYLLtcewspgppqpgtlrkshalqqaltaaasmghssv 1065
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLL----------------------------------- 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1066 vqcllgmekEHEVEVNGTDtLWGETALTA--AAGRGKLEVCELLLGHGAAVSRTNRRGVPPL-----FCAARQGhwqIVR 1138
Cdd:PHA03095   140 ---------RKGADVNALD-LYGMTPLAVllKSRNANVELLRLLIDAGADVYAVDDRFRSLLhhhlqSFKPRAR---IVR 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1139 LLLERGCDVNLSDKQGRTPLMVAA--CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQT 1216
Cdd:PHA03095   207 ELIRAGCDPAATDMLGNTPLHSMAtgSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAV 286

                          330
                   ....*....|.
gi 2462577943 1217 DKNGRTPLDLA 1227
Cdd:PHA03095   287 SSDGNTPLSLM 297
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 967-1283 1.12e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 88.10  E-value: 1.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  967 GACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGP-PQPGTlr 1045
Cdd:PHA02874    25 GNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSIlPIPCI-- 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1046 kshalqqaltaaasmgHSSVVQCLLgmekEHEVEVNGTDTLwGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPL 1125
Cdd:PHA02874   103 ----------------EKDMIKTIL----DCGIDVNIKDAE-LKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPI 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1126 FCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKgHRAVVQY 1205
Cdd:PHA02874   162 HIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH-NRSAIEL 240

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462577943 1206 LVEEgAAIDQTDKNGRTPLDLAAFYG-DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAA 1283
Cdd:PHA02874   241 LINN-ASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIKDIIANAVLIKEA 318
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1061-1151 9.10e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.38  E-value: 9.10e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1061 GHSSVVQCLLgmekEHEVEVNGTDTlWGETALTAAAGRGKLEVCELLLGHGAAVSRTNrrGVPPLFCAARQGHWQIVRLL 1140
Cdd:pfam12796    8 GNLELVKLLL----ENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVKLL 80

                           90
                   ....*....|.
gi 2462577943 1141 LERGCDVNLSD 1151
Cdd:pfam12796   81 LEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1101-1279 1.25e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.53  E-value: 1.25e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1101 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGH-WQIVRLLLERGCDVNLSDKQGRTPLMVAAC--EGHLSTVEFLLSKG 1177
Cdd:PHA03095    63 KDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKG 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1178 AALSSLDKEGLSALSwACLKGHRA---VVQYLVEEGAAIDQTDKNGRTPLD--LAAFYGDAETVLYLVEKGAVIEHVDHS 1252
Cdd:PHA03095   143 ADVNALDLYGMTPLA-VLLKSRNAnveLLRLLIDAGADVYAVDDRFRSLLHhhLQSFKPRARIVRELIRAGCDPAATDML 221

                          170       180       190
                   ....*....|....*....|....*....|
gi 2462577943 1253 GMRPLDRAI---GCRNtSVVVALLRKGAKL 1279
Cdd:PHA03095   222 GNTPLHSMAtgsSCKR-SLVLPLLIAGISI 250
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1191-1279 1.52e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 1.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1191 LSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVieHVDHSGMRPLDRAIGCRNTSVVV 1270
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78


                   ....*....
gi 2462577943 1271 ALLRKGAKL 1279
Cdd:pfam12796   79 LLLEKGADI 87
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1136-1279 1.89e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.14  E-value: 1.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1136 IVRLLLERGCDVNLSDKQGRTPL---MVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL-SWACLKGHRAVVQYLVEEGA 1211
Cdd:PHA03095    29 EVRRLLAAGADVNFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGA 108

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462577943 1212 AIDQTDKNGRTPLD--LAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV--VVALLRKGAKL 1279
Cdd:PHA03095   109 DVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVelLRLLIDAGADV 180
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 957-1214 3.59e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.46  E-value: 3.59e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  957 EEVVTLLLEFGACLDGTSENGMTALCYAAAAGH-----MKLVCLLTKKGVRVDHLDKKGqcalVHsalrghgdILQYLLT 1031
Cdd:PHA03100    48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNG----IT--------PLLYAIS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1032 CEwspgppqpgtlrkshalqqaltaaasMGHSSVVQCLLgmekEHEVEVNgTDTLWGETALTAAA--GRGKLEVCELLLG 1109
Cdd:PHA03100   116 KK--------------------------SNSYSIVEYLL----DNGANVN-IKNSDGENLLHLYLesNKIDLKILKLLID 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1110 HGAAVSRTNRrgvpplfcaarqghwqiVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLS 1189
Cdd:PHA03100   165 KGVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227

                          250       260
                   ....*....|....*....|....*
gi 2462577943 1190 ALSWACLKGHRAVVQYLVEEGAAID 1214
Cdd:PHA03100   228 PLHIAILNNNKEIFKLLLNNGPSIK 252
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1282-1419 1.37e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 1.37e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1282 AAWAMATSKPDILIILLQKLMEE-----------GNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLN 1350
Cdd:COG3914     85 ALLLQALGRYEEALALYRRALALnpdnaealfnlGNLLLALGRLEEALAALRRALALNPDF-------------AEAYLN 151

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462577943 1351 LSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLL 1419
Cdd:COG3914    152 LGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1135-1284 2.18e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.37  E-value: 2.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1135 QIVRLLLERGCDVNLSDK-QGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI 1213
Cdd:PHA02878   148 EITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462577943 1214 DQTDKNGRTPLDLAAFY-GDAETVLYLVEKGAVIEHVDH-SGMRPLDRAIgcRNTSVVVALLRKGAKLGNAAW 1284
Cdd:PHA02878   228 DARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADINSLNS 298
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1305-1422 2.68e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 2.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1305 GNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYA 1384
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2462577943 1385 RARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1422
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLA 119
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1305-1425 3.00e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 3.00e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1305 GNVMYKKGKMKEAAQRYQYALRKFPRegfgedmrpfnelRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYA 1384
Cdd:COG0457     49 GLAYLRLGRYEEALADYEQALELDPD-------------DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2462577943 1385 RARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEE 1425
Cdd:COG0457    116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEK 156
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1273-1412 4.28e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 62.52  E-value: 4.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1273 LRKGAKLGNAAWAMATSKPDILIILlqklmeeGNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLS 1352
Cdd:COG4783     20 YDEAEALLEKALELDPDNPEAFALL-------GEILLQLGDLDEAIVLLHEALELDPDE-------------PEARLNLG 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1353 RCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTN 1412
Cdd:COG4783     80 LALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 863-1279 7.63e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 67.40  E-value: 7.63e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  863 LNRQQTMELGHHILKAhifkglskktGISSSHLQALWIGYSTEGLSAALASLRNlytPNVKVSRLLILGGANVNYRtEVL 942
Cdd:PHA02876   112 LNKHKLDEACIHILKE----------AISGNDIHYDKINESIEYMKLIKERIQQ---DELLIAEMLLEGGADVNAK-DIY 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  943 NNAPILCVQSHlGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGH 1022
Cdd:PHA02876   178 CITPIHYAAER-GNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLSLLKAIRNEDLETS 256

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1023 ------GDILQYLLTCEWSPgppqpgtlrkshalqqALTAAASMGHSSVVQCLLgmekEHEVEVNGTDtLWGETALTAAA 1096
Cdd:PHA02876   257 lllydaGFSVNSIDDCKNTP----------------LHHASQAPSLSRLVPKLL----ERGADVNAKN-IKGETPLYLMA 315

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1097 GRG-KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQ-IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLL 1174
Cdd:PHA02876   316 KNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLL 395

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1175 SKGAALSSLDKEGLSALSWA-CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYG-DAETVLYLVEKGAVIEHVDHS 1252
Cdd:PHA02876   396 DYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQ 475

                          410       420
                   ....*....|....*....|....*..
gi 2462577943 1253 GMRPLDRAIGCRntSVVVALLRKGAKL 1279
Cdd:PHA02876   476 NQYPLLIALEYH--GIVNILLHYGAEL 500
Ank_2 pfam12796
Ankyrin repeats (3 copies);
955-1030 9.32e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 9.32e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462577943  955 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLV-CLLTKKGVRVDHldkKGQCALVHSALRGHGDILQYLL 1030
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVkLLLEHADVNLKD---NGRTALHYAARSGHLEIVKLLL 81
Ank_2 pfam12796
Ankyrin repeats (3 copies);
981-1118 1.08e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.74  E-value: 1.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  981 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTcewspgppqpgtlrkshalqqaltaaasm 1060
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE----------------------------- 51

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462577943 1061 ghssvvqcllgmekehevEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTN 1118
Cdd:pfam12796   52 ------------------HADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1298-1425 1.91e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.59  E-value: 1.91e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1298 LQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPK 1377
Cdd:COG4783      4 AEALYALAQALLLAGDYDEAEALLEKALELDPDN-------------PEAFALLGEILLQLGDLDEAIVLLHEALELDPD 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2462577943 1378 SYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEE 1425
Cdd:COG4783     71 EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRA 118
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1307-1414 2.17e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 59.03  E-value: 2.17e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1307 VMYKKGKMKEAAQRYQYALRKFPREGfgedmrpfnelrvSLYLNLSRCRRKTNDFGMAEEFaSKALELKPKSYEAFYARA 1386
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNA-------------DALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLA 66

                           90       100
                   ....*....|....*....|....*...
gi 2462577943 1387 RAKRNSRQFVAALADLQEAVKLCPTNQE 1414
Cdd:COG3063     67 ELLLELGDYDEALAYLERALELDPSALR 94
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1305-1424 2.34e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 60.02  E-value: 2.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1305 GNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYA 1384
Cdd:COG4235     24 GRAYLRLGRYDEALAAYEKALRLDPDN-------------ADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2462577943 1385 RARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEE 1424
Cdd:COG4235     91 LGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAE 130
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1316-1425 2.74e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 60.02  E-value: 2.74e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1316 EAAQRYQYALRKFPREGFGedmrpfnelrvslYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQF 1395
Cdd:COG4235      1 EAIARLRQALAANPNDAEG-------------WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDT 67

                           90       100       110
                   ....*....|....*....|....*....|
gi 2462577943 1396 VAALADLQEAVKLCPTNQEVKRLLARVEEE 1425
Cdd:COG4235     68 EEAEELLERALALDPDNPEALYLLGLAAFQ 97
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1294-1422 8.24e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.86  E-value: 8.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1294 LIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALE 1373
Cdd:COG3914     74 LLLLAALLELAALLLQALGRYEEALALYRRALALNPDN-------------AEALFNLGNLLLALGRLEEALAALRRALA 140

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2462577943 1374 LKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1422
Cdd:COG3914    141 LNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNA 189
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1092-1258 1.31e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 63.35  E-value: 1.31e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1092 LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHlSTVE 1171
Cdd:PLN03192   529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKH-HKIF 607

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1172 FLLSKGAALSSLDKEGlSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVD- 1250
Cdd:PLN03192   608 RILYHFASISDPHAAG-DLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANt 686


                   ....*...
gi 2462577943 1251 HSGMRPLD 1258
Cdd:PLN03192   687 DDDFSPTE 694
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1269-1414 1.34e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 60.31  E-value: 1.34e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1269 VVALLRKGAKLGNAAWAMATSKPDiliiLLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPRegfgedmrpfnelRVSLY 1348
Cdd:COG4785     48 LAAAALAAAALAAERIDRALALPD----LAQLYYERGVAYDSLGDYDLAIADFDQALELDPD-------------LAEAY 110

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462577943 1349 LNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQE 1414
Cdd:COG4785    111 NNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPE 176
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1314-1422 1.54e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.43  E-value: 1.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1314 MKEAAQRYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSR 1393
Cdd:COG5010     23 LVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSG 102

                           90       100
                   ....*....|....*....|....*....
gi 2462577943 1394 QFVAALADLQEAVKLCPTNQEVKRLLARV 1422
Cdd:COG5010    103 DKDEAKEYYEKALALSPDNPNAYSNLAAL 131
Ank_4 pfam13637
Ankyrin repeats (many copies);
1121-1174 2.68e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.59  E-value: 2.68e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462577943 1121 GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLL 1174
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1271-1410 2.73e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 57.66  E-value: 2.73e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1271 ALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGfgedmrpfnelrvSLYLN 1350
Cdd:COG5010     27 YEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNP-------------ELYYN 93

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1351 LSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCP 1410
Cdd:COG5010     94 LALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
Ank_4 pfam13637
Ankyrin repeats (many copies);
1090-1141 3.07e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.59  E-value: 3.07e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462577943 1090 TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLL 1141
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
1187-1240 3.35e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.20  E-value: 3.35e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462577943 1187 GLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLV 1240
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1089-1220 3.82e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.16  E-value: 3.82e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1089 ETALTAAAGRGKLEVCELLLGHGAAVSRT-NRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHL 1167
Cdd:PHA02875    69 ESELHDAVEEGDVKAVEELLDLGKFADDVfYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462577943 1168 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1220
Cdd:PHA02875   149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNG 201
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1137-1206 6.72e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 61.07  E-value: 6.72e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1137 VRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL 1206
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1295-1425 7.58e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.97  E-value: 7.58e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1295 IILLQKLMEE-----------GNVMYKKGKMKEAAQRYQYALrkfpregfgeDMRPFNElrvSLYLNLSRCRRKTNDFGM 1363
Cdd:COG2956     62 IRIHQKLLERdpdraeallelAQDYLKAGLLDRAEELLEKLL----------ELDPDDA---EALRLLAEIYEQEGDWEK 128

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462577943 1364 AEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEE 1425
Cdd:COG2956    129 AIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLE 190
PHA03095 PHA03095
ankyrin-like protein; Provisional
 901-1167 9.48e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.04  E-value: 9.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  901 GYSTEGLSAALASLRNLYTpnVKVSRLLILGGANVNYRTEVLNNApilcVQSHLG----HEEVVTLLLEFGACLDGTSEN 976
Cdd:PHA03095    78 APERCGFTPLHLYLYNATT--LDVIKLLIKAGADVNAKDKVGRTP----LHVYLSgfniNPKVIRLLLRKGADVNALDLY 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  977 GMTAL-CYAAAAG-HMKLVCLLTKKGVRVDHLDKKGQCALVHsalrghgdILQYlltcewspgppqpgtLRKShalqqal 1054
Cdd:PHA03095   152 GMTPLaVLLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHH--------HLQS---------------FKPR------- 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1055 taaasmghSSVVQCLLgmekEHEVEVNGTDTLwGETALTAAA--GRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQG 1132
Cdd:PHA03095   202 --------ARIVRELI----RAGCDPAATDML-GNTPLHSMAtgSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFN 268

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 2462577943 1133 HWQIVRLLLERGCDVNLSDKQGRTPL--MVAACEGHL 1167
Cdd:PHA03095   269 NPRACRRLIALGADINAVSSDGNTPLslMVRNNNGRA 305
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
530-831 2.60e-08

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 59.05  E-value: 2.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  530 FVHSIAALLCRSHQLAAYR-DLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIpeeeyIILIDGLNEAEF 608
Cdd:COG5635    196 LLRYLALELAERYLDAEDPiPILIELRDLAEEASLEDLLAEALEKRGGEPEDALERLLRNGRL-----LLLLDGLDEVPD 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  609 hkPDYGDTLSSFITKIISKFPAwLKLIVTVRANFQEIISALPFVKLSLDDFpDNKDIHSDLHAYVQHRVHSSQDILSNIS 688
Cdd:COG5635    271 --EADRDEVLNQLRRFLERYPK-ARVIITSRPEGYDSSELEGFEVLELAPL-SDEQIEEFLKKWFEATERKAERLLEALE 346

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  689 LNGKadatligkvsshlvLRSL-GSYLYLKLTLDLFQRGHlviksasykVVPVSLSELYLLQCNMkFMTQSAFERALPIL 767
Cdd:COG5635    347 ENPE--------------LRELaRNPLLLTLLALLLRERG---------ELPDTRAELYEQFVEL-LLERWDEQRGLTIY 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  768 N-------------VALASLH----PMTDEQIFQAINAgHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWL 830
Cdd:COG5635    403 RelsreelrellseLALAMQEngrtEFAREELEEILRE-YLGRRKDAEALLDELLLRTGLLVERGEGRYSFAHRSFQEYL 481


                   .
gi 2462577943  831 V 831
Cdd:COG5635    482 A 482
Ank_2 pfam12796
Ankyrin repeats (3 copies);
926-1007 3.31e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.81  E-value: 3.31e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  926 RLLILGGANVNYRTEVLNNAPILCVQShlGHEEVVTLLLEFgACLDGTsENGMTALCYAAAAGHMKLVCLLTKKGVRVDH 1005
Cdd:pfam12796   14 KLLLENGADANLQDKNGRTALHLAAKN--GHLEIVKLLLEH-ADVNLK-DNGRTALHYAARSGHLEIVKLLLEKGADINV 89


                   ..
gi 2462577943 1006 LD 1007
Cdd:pfam12796   90 KD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1075-1227 3.53e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 58.35  E-value: 3.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1075 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQG 1154
Cdd:PHA02878   155 SYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCG 234

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462577943 1155 RTPLMVAAceGHL---STVEFLLSKGA---ALSSLdkEGLSALSWAcLKGHRaVVQYLVEEGAAIDQTDKNGRTPLDLA 1227
Cdd:PHA02878   235 NTPLHISV--GYCkdyDILKLLLEHGVdvnAKSYI--LGLTALHSS-IKSER-KLKLLLEYGADINSLNSYKLTPLSSA 307
Ank_4 pfam13637
Ankyrin repeats (many copies);
977-1030 3.84e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 3.84e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462577943  977 GMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1030
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
946-996 4.24e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 4.24e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462577943  946 PILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLL 996
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
1154-1207 4.36e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 4.36e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462577943 1154 GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLV 1207
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1305-1405 6.42e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.78  E-value: 6.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1305 GNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYA 1384
Cdd:COG0457     83 GLALQALGRYEEALEDYDKALELDPDD-------------AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYN 149

                           90       100
                   ....*....|....*....|.
gi 2462577943 1385 RARAKRNSRQFVAALADLQEA 1405
Cdd:COG0457    150 LGIALEKLGRYEEALELLEKL 170
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1088-1277 7.08e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.92  E-value: 7.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1088 GETALTAAAGRGKLEVCELLLGHGAaVSRTNRRGV-PPLFCAARQGHWQIVRLLLERGCDVN-LSDKQGRTPLMVAACEG 1165
Cdd:PHA02875    35 GISPIKLAMKFRDSEAIKLLMKHGA-IPDVKYPDIeSELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILK 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1166 HLSTVEFLLSKGA--ALSSLDKegLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKG 1243
Cdd:PHA02875   114 KLDIMKLLIARGAdpDIPNTDK--FSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG 191

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 2462577943 1244 AVIEHVDHSG-MRPLDRAIGCRNTSVVVALLRKGA 1277
Cdd:PHA02875   192 ANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGA 226
Ank_5 pfam13857
Ankyrin repeats (many copies);
1173-1227 9.39e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.42  E-value: 9.39e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462577943 1173 LLSKG-AALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLA 1227
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1305-1425 1.26e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.12  E-value: 1.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1305 GNVMYKKGKMKEAAQRYQYALRKfpregfgedmrpfNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYA 1384
Cdd:COG2956     49 GNLYRRRGEYDRAIRIHQKLLER-------------DPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRL 115

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2462577943 1385 RARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEE 1425
Cdd:COG2956    116 LAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLE 156
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1059-1226 1.32e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 56.80  E-value: 1.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1059 SMGHSSVVQCLLGMEKEHEVevngTDTLwGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1138
Cdd:PLN03192   534 STGNAALLEELLKAKLDPDI----GDSK-GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1139 LLLERGcdvNLSDKQ-GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1217
Cdd:PLN03192   609 ILYHFA---SISDPHaAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685

                          170
                   ....*....|
gi 2462577943 1218 -KNGRTPLDL 1226
Cdd:PLN03192   686 tDDDFSPTEL 695
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1348-1422 1.43e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 54.63  E-value: 1.43e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462577943 1348 YLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1422
Cdd:COG0457     11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1344-1422 3.27e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.35  E-value: 3.27e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462577943 1344 RVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1422
Cdd:COG4783      3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81
Ank_5 pfam13857
Ankyrin repeats (many copies);
1106-1161 4.17e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.50  E-value: 4.17e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462577943 1106 LLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVA 1161
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1101-1187 4.75e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.90  E-value: 4.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1101 LEVCEL-----------LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLST 1169
Cdd:PTZ00322    84 VELCQLaasgdavgariLLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV 163

                           90
                   ....*....|....*...
gi 2462577943 1170 VEFLLSKGAALSSLDKEG 1187
Cdd:PTZ00322   164 VQLLSRHSQCHFELGANA 181
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1354-1425 7.45e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.01  E-value: 7.45e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462577943 1354 CRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALAdLQEAVKLCPTNQEVKRLLARVEEE 1425
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLE 71
Ank_4 pfam13637
Ankyrin repeats (many copies);
1220-1273 8.34e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 8.34e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462577943 1220 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALL 1273
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1088-1207 8.60e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 53.86  E-value: 8.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1088 GETALTAAAGRGKLEVCELLLGHGAAVS---------RTNRR-----GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ 1153
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462577943 1154 GRTPLMV--------AACEghlsTVEFLLS--KGAALSSLD----KEGLSALSWACLKGHRAVVQYLV 1207
Cdd:cd22192    169 GNTVLHIlvlqpnktFACQ----MYDLILSydKEDDLQPLDlvpnNQGLTPFKLAAKEGNIVMFQHLV 232
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 919-1149 9.26e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.46  E-value: 9.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  919 TPNVKVSRLLILGGANVNYrtEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTK 998
Cdd:PHA02875    12 FGELDIARRLLDIGINPNF--EIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLD 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  999 KGVRVDH-LDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQaltaaasMGHSSVVQCLLgmekEHE 1077
Cdd:PHA02875    90 LGKFADDvFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVM-------MGDIKGIELLI----DHK 158

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462577943 1078 VEVNGTDTlWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW-QIVRLLLERGCDVNL 1149
Cdd:PHA02875   159 ACLDIEDC-CGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKiDIVRLFIKRGADCNI 230
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1125-1277 9.30e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.10  E-value: 9.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1125 LFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQ 1204
Cdd:PLN03192   529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462577943 1205 YLVEEGAAIDQtdKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1277
Cdd:PLN03192   609 ILYHFASISDP--HAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1158-1239 1.03e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 53.75  E-value: 1.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1158 LMVAACE----GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDA 1233
Cdd:PTZ00322    82 LTVELCQlaasGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFR 161


                   ....*.
gi 2462577943 1234 ETVLYL 1239
Cdd:PTZ00322   162 EVVQLL 167
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1309-1424 1.07e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 49.22  E-value: 1.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1309 YKKGKMKEAAQRYQYALRKFPRegfgedmrpfNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSY---EAFYAR 1385
Cdd:COG1729      4 LKAGDYDEAIAAFKAFLKRYPN----------SPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkapDALLKL 73

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2462577943 1386 ARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEE 1424
Cdd:COG1729     74 GLSYLELGDYDKARATLEELIKKYPDSEAAKEARARLAR 112
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1305-1390 2.07e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 48.45  E-value: 2.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1305 GNVMYKKGKMKEAAQRYQYALRKFPREGFGEDMrpfnelrvslYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYA 1384
Cdd:COG1729     37 GEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDA----------LLKLGLSYLELGDYDKARATLEELIKKYPDSEAAKEA 106


                   ....*.
gi 2462577943 1385 RARAKR 1390
Cdd:COG1729    107 RARLAR 112
PHA02946 PHA02946
ankyin-like protein; Provisional
 1105-1308 3.31e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 51.59  E-value: 3.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1105 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL--MVAACEGHLSTVEFLLSKGAAL-S 1181
Cdd:PHA02946    56 EELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKInN 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1182 SLDKEGLSALsWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPL--DLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDr 1259
Cdd:PHA02946   136 SVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLH- 213

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1260 aIGC----RNTSVVVALL-----RKGAKLGNAAWAM--ATSKPDILIillQKLMEEGNVM 1308
Cdd:PHA02946   214 -IVCsktvKNVDIINLLLpstdvNKQNKFGDSPLTLliKTLSPAHLI---NKLLSTSNVI 269
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1317-1415 4.18e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.91  E-value: 4.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1317 AAQRYQYALRKFPREGFGEDMRPFNELR----VSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNS 1392
Cdd:COG4785     41 LADLALALAAAALAAAALAAERIDRALAlpdlAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLL 120

                           90       100
                   ....*....|....*....|...
gi 2462577943 1393 RQFVAALADLQEAVKLCPTNQEV 1415
Cdd:COG4785    121 GDYDAALEDFDRALELDPDYAYA 143
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1301-1427 5.38e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.11  E-value: 5.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1301 LMEEGNVMYKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYE 1380
Cdd:COG2956    147 YCELAELYLEQGDYDEAIEALEKALKLDPDC-------------ARALLLLAELYLEQGDYEEAIAALERALEQDPDYLP 213

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2462577943 1381 AFYARARAKRNSRQFVAALADLQEAVKLCPTNqEVKRLLARVEEECK 1427
Cdd:COG2956    214 ALPRLAELYEKLGDPEEALELLRKALELDPSD-DLLLALADLLERKE 259
PHA02798 PHA02798
ankyrin-like protein; Provisional
 1100-1252 5.95e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 50.99  E-value: 5.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1100 KLEVCELLLGHGAAVSRTNRRGVPPLfCA------ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFL 1173
Cdd:PHA02798    50 STDIVKLFINLGANVNGLDNEYSTPL-CTilsnikDYKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYINNLEIL 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1174 L---SKGAALSSLDKEGLSALSWACLKGHRA---VVQYLVEEGAAIDQ-TDKNGRTPLDLAAFYG----DAETVLYLVEK 1242
Cdd:PHA02798   129 LfmiENGADTTLLDKDGFTMLQVYLQSNHHIdieIIKLLLEKGVDINThNNKEKYDTLHCYFKYNidriDADILKLFVDN 208

                          170
                   ....*....|
gi 2462577943 1243 GAVIEHVDHS 1252
Cdd:PHA02798   209 GFIINKENKS 218
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 1101-1229 6.16e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 49.05  E-value: 6.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1101 LEVCELLLGHGAAVS-RTNRRGVPPLfcaarqGHW---------QIVRLLLERGCDVNLSDKQGRTPLMV--AACEGHLS 1168
Cdd:PHA02859    66 VEILKFLIENGADVNfKTRDNNLSAL------HHYlsfnknvepEILKILIDSGSSITEEDEDGKNLLHMymCNFNVRIN 139

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462577943 1169 TVEFLLSKGAALSSLDKEGLSAL-SWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAF 1229
Cdd:PHA02859   140 VIKLLIDSGVSFLNKDFDNNNILySYILFHSDKKIFDFLTSLGIDINETNKSGYNCYDLIKF 201
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1112-1242 3.47e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 48.99  E-value: 3.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1112 AAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ--------------GRTPLMVAACEGHLSTVEFLLSKG 1177
Cdd:cd22194    132 AEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHAKGvffnpkykhegfyfGETPLALAACTNQPEIVQLLMEKE 211

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462577943 1178 AA-LSSLDKEG---LSALSWAC--LKGHRAVVQYLVE------EGAAIDQ-TDKNGRTPLDLAAFYGDAETVLYLVEK 1242
Cdd:cd22194    212 STdITSQDSRGntvLHALVTVAedSKTQNDFVKRMYDmillksENKNLETiRNNEGLTPLQLAAKMGKAEILKYILSR 289
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 914-1158 6.07e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.94  E-value: 6.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  914 LRNLYTPNVKVSRLLI--LGGANVNYRTEVLNNAPILCVQShLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMK 991
Cdd:PLN03192   494 LKNFLQHHKELHDLNVgdLLGDNGGEHDDPNMASNLLTVAS-TGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYED 572

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  992 LVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLrkshalqqaltaaasmghssvvqcllg 1071
Cdd:PLN03192   573 CVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISDPHAAGDL--------------------------- 625

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1072 mekehevevngtdtlwgetaLTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDV---N 1148
Cdd:PLN03192   626 --------------------LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVdkaN 685

                          250
                   ....*....|
gi 2462577943 1149 LSDKQGRTPL 1158
Cdd:PLN03192   686 TDDDFSPTEL 695
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1088-1242 6.10e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.09  E-value: 6.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1088 GETALTAAAGRGKLEVCELLLghGAAVSRTNR-------RGVPPLFCAARQGHWQIVRLLLERGCDVN----------LS 1150
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNLNLVRELIARGADVVspratgtffrPG 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1151 DKQ----GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID----------QT 1216
Cdd:cd22192    129 PKNliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDLILSYDkeddlqpldlVP 208

                          170       180
                   ....*....|....*....|....*.
gi 2462577943 1217 DKNGRTPLDLAAFYGDAETVLYLVEK 1242
Cdd:cd22192    209 NNQGLTPFKLAAKEGNIVMFQHLVQK 234
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 919-1148 1.03e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.97  E-value: 1.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  919 TPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKL--VCLL 996
Cdd:PHA03100    83 TDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLL 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943  997 TKKGVRVDHLDKkgqcalvhsalrghgdilqylltcewspgppqpgtlrkshalqqaltaaasmghssvVQCLLgmekEH 1076
Cdd:PHA03100   163 IDKGVDINAKNR---------------------------------------------------------VNYLL----SY 181

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462577943 1077 EVEVNGTDtLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1148
Cdd:PHA03100   182 GVPINIKD-VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1167-1300 1.08e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.49  E-value: 1.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1167 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVI 1246
Cdd:COG0666      1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462577943 1247 EHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL------GNAA--WAMATSKPDILIILLQK 1300
Cdd:COG0666     81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVnardkdGETPlhLAAYNGNLEIVKLLLEA 142
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1153-1185 2.18e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 2.18e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462577943 1153 QGRTPLMVAACE-GHLSTVEFLLSKGAALSSLDK 1185
Cdd:pfam00023    1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1124-1152 2.53e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 2.53e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462577943 1124 PLFCAA-RQGHWQIVRLLLERGCDVNLSDK 1152
Cdd:pfam00023    5 PLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1088-1259 2.68e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 46.03  E-value: 2.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1088 GETALTAAA---GRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGH-----------WQIVRLLLERGCDVNLS--- 1150
Cdd:cd21882     26 GKTCLHKAAlnlNDGVNEAIMLLLEAAPDSGNPKELVNAPCTDEFYQGQtalhiaienrnLNLVRLLVENGADVSARatg 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1151 ---DKQGRT-------PLMVAACEGHLSTVEFLLSKG---AALSSLDKEGLSALSWACLKGHRAVVQY---------LVE 1208
Cdd:cd21882    106 rffRKSPGNlfyfgelPLSLAACTNQEEIVRLLLENGaqpAALEAQDSLGNTVLHALVLQADNTPENSafvcqmynlLLS 185

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462577943 1209 EGAAIDQT-------DKNGRTPLDLAAFYGDAETVLYLVEKGAviehvdHSGMRPLDR 1259
Cdd:cd21882    186 YGAHLDPTqqleeipNHQGLTPLKLAAVEGKIVMFQHILQREF------SGPYQPLSR 237
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1153-1178 3.58e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 3.58e-04
                            10        20
                    ....*....|....*....|....*.
gi 2462577943  1153 QGRTPLMVAACEGHLSTVEFLLSKGA 1178
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1311-1422 3.78e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 3.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1311 KGKMKEAAQRYQYALRKFPRegfgedmrpfnelRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKR 1390
Cdd:COG2956     21 NGQPDKAIDLLEEALELDPE-------------TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462577943 1391 NSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1422
Cdd:COG2956     88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEI 119
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1088-1299 5.90e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 44.69  E-value: 5.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1088 GETALTAAAgRGKLEVCELLLGHGAAVSR------------TNR--RGVPPLFCAARQGHWQIVRLLLERGCDVNL---- 1149
Cdd:TIGR00870   82 GDTLLHAIS-LEYVDAVEAILLHLLAAFRksgplelandqyTSEftPGITALHLAAHRQNYEIVKLLLERGASVPAracg 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1150 -----SDKQ-----GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKeglsaLSWACLkgHRAVVQ--------------- 1204
Cdd:TIGR00870  161 dffvkSQGVdsfyhGESPLNAAACLGSPSIVALLSEDPADILTADS-----LGNTLL--HLLVMEnefkaeyeelscqmy 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1205 -YLVEEGAAIDQTDK-------NGRTPLDLAAFYGDAETVLYLVE-KGAVIEHVDH------SGMRPLDRAIGCRNTSVV 1269
Cdd:TIGR00870  234 nFALSLLDKLRDSKElevilnhQGLTPLKLAAKEGRIVLFRLKLAiKYKQKKFVAWpngqqlLSLYWLEELDGWRRKQSV 313

                          250       260       270
                   ....*....|....*....|....*....|
gi 2462577943 1270 VALLrkgaklgnAAWAMATSKPDILIILLQ 1299
Cdd:TIGR00870  314 LELI--------VVFVIGLKFPELSDMYLI 335
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1120-1148 6.60e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.78  E-value: 6.60e-04
                           10        20
                   ....*....|....*....|....*....
gi 2462577943 1120 RGVPPLFCAARQGHWQIVRLLLERGCDVN 1148
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1219-1247 1.15e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 1.15e-03
                            10        20
                    ....*....|....*....|....*....
gi 2462577943  1219 NGRTPLDLAAFYGDAETVLYLVEKGAVIE 1247
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1309-1421 1.45e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.53  E-value: 1.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1309 YKKGKMKEAAQRYQYALRKFPREgfgedmrpfnelrVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARA 1388
Cdd:TIGR02917  510 IQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQY 576

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2462577943 1389 KRNSRQFVAALADLQEAVKLCPTNQEVKRLLAR 1421
Cdd:TIGR02917  577 YLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1203-1292 1.78e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.35  E-value: 1.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1203 VQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNA 1282
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177

                           90
                   ....*....|
gi 2462577943 1283 AwamATSKPD 1292
Cdd:PTZ00322   178 G---ANAKPD 184
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1124-1257 2.41e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462577943 1124 PLFCAARQGHWQ-IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAL------SSLdKEGLSALSWACL 1196
Cdd:cd22192     20 PLLLAAKENDVQaIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELvnepmtSDL-YQGETALHIAVV 98

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462577943 1197 KGHRAVVQYLVEEGAAIDQ----------TDKN----GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1257
Cdd:cd22192     99 NQNLNLVRELIARGADVVSpratgtffrpGPKNliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
TPR_14 pfam13428
Tetratricopeptide repeat;
1380-1422 2.66e-03

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 37.40  E-value: 2.66e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462577943 1380 EAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1422
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1120-1149 3.05e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 3.05e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2462577943  1120 RGVPPLFCAARQGHWQIVRLLLERGCDVNL 1149
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TPR_12 pfam13424
Tetratricopeptide repeat;
1305-1377 5.29e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.37  E-value: 5.29e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462577943 1305 GNVMYKKGKMKEAAQRYQYALRKFpREGFGEDmrpfNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPK 1377
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKALEIA-RRLLGPD----HPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1372-1422 6.47e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.38  E-value: 6.47e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462577943 1372 LELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARV 1422
Cdd:COG0457      1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLA 51
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1219-1251 9.91e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 9.91e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462577943 1219 NGRTPLDLAA-FYGDAETVLYLVEKGAVIEHVDH 1251
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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