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Conserved domains on  [gi|2462573298|ref|XP_054198047|]
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latent-transforming growth factor beta-binding protein 1 isoform X28 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
1263-1305 7.48e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 7.48e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573298 1263 CDNVLAPNVTKQECCCTS-GAGWGDNCEifPCPVLGTAEFTEMC 1305
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
688-723 4.79e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.13  E-value: 4.79e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462573298  688 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTA 723
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTD 38
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
1439-1481 1.23e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 1.23e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573298 1439 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1481
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1148-1189 1.24e-08

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 1.24e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573298  1148 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 1189
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1066-1106 3.58e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 3.58e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573298  1066 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 1106
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1025-1056 1.28e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.28e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2462573298  1025 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 1056
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
984-1023 5.25e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.25e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462573298   984 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 1023
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
626-656 1.43e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.43e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462573298   626 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 656
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
861-902 1.49e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.49e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462573298   861 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 902
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1107-1137 2.68e-05

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 2.68e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298 1107 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 1137
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1566-1600 1.18e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.18e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2462573298  1566 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1600
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
903-943 2.22e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.22e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573298   903 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 943
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
567-602 5.62e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.18  E-value: 5.62e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462573298  567 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 602
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
944-977 2.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462573298  944 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 977
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
1263-1305 7.48e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 7.48e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573298 1263 CDNVLAPNVTKQECCCTS-GAGWGDNCEifPCPVLGTAEFTEMC 1305
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
688-723 4.79e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.13  E-value: 4.79e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462573298  688 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTA 723
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTD 38
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
1439-1481 1.23e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 1.23e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573298 1439 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1481
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1148-1189 1.24e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 1.24e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573298  1148 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 1189
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1148-1189 8.03e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 8.03e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462573298 1148 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 1189
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1066-1106 3.58e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 3.58e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573298  1066 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 1106
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1066-1106 1.24e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.24e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462573298 1066 DIDECQHRHLC-AHGQCRNTEGSFQCVCDQGYRasglGDHCE 1106
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1025-1056 1.28e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.28e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2462573298  1025 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 1056
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1025-1057 3.02e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462573298 1025 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 1057
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
984-1023 5.25e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.25e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462573298   984 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 1023
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
626-656 1.43e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.43e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462573298   626 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 656
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
861-902 1.49e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.49e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462573298   861 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 902
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1107-1137 2.68e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 2.68e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298 1107 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 1137
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
984-1015 3.91e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.91e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462573298  984 DVDECLEPNVCAN-GDCSNLEGSYMCSCHKGYT 1015
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1107-1147 4.17e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 4.17e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573298  1107 DINECLEDkSVCQRG-DCINTAGSYDCTCPDGFQldDNKTCQ 1147
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
626-656 5.25e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 5.25e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298  626 DINECQLQGVCPN-GECLNTMGSYRCTCKIGF 656
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
861-891 1.08e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 1.08e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298  861 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 891
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1566-1600 1.18e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.18e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2462573298  1566 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1600
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
861-902 1.86e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462573298  861 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 902
Cdd:cd00054      1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
903-943 2.22e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.22e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573298   903 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 943
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1566-1600 3.46e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 3.46e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462573298 1566 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1600
Cdd:cd00054      1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
567-602 5.62e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.18  E-value: 5.62e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462573298  567 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 602
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1107-1147 6.00e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 6.00e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462573298 1107 DINEClEDKSVCQR-GDCINTAGSYDCTCPDGFQLddnKTCQ 1147
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG---RNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
1566-1599 1.22e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.22e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462573298 1566 DVNECDELNNrmsLC-KNAKCINTDGSYKCLCLPG 1599
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
903-935 1.88e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.88e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462573298  903 DVDECLRPDVCGEGH-CVNTVGAFRCEyCDSGYR 935
Cdd:cd00054      1 DIDECASGNPCQNGGtCVNTVGSYRCS-CPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
626-655 2.14e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.14e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298  626 DINEC-QLQGVCP-NGECLNTMGSYRCTCKIG 655
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
944-977 2.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462573298  944 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 977
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
1066-1095 3.83e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.83e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298 1066 DIDEC-QHRHLC-AHGQCRNTEGSFQCVCDQG 1095
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
1172-1193 4.28e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.23  E-value: 4.28e-03
                           10        20
                   ....*....|....*....|..
gi 2462573298 1172 HCVCQQGFSISADGRTCEDVNE 1193
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA smart00179
Calcium-binding EGF-like domain;
944-976 4.50e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.50e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2462573298   944 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFR 976
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1025-1054 9.20e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 9.20e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298 1025 DIDECQQG-NLC-VNGQCKNTEGSFRCTCGQG 1054
Cdd:pfam07645    1 DVDECATGtHNCpANTVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
1263-1305 7.48e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 7.48e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573298 1263 CDNVLAPNVTKQECCCTS-GAGWGDNCEifPCPVLGTAEFTEMC 1305
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
688-723 4.79e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.13  E-value: 4.79e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462573298  688 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTA 723
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTD 38
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
1439-1481 1.23e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 1.23e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573298 1439 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1481
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1148-1189 1.24e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 1.24e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573298  1148 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 1189
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1148-1189 8.03e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 8.03e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462573298 1148 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 1189
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1066-1106 3.58e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 3.58e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573298  1066 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 1106
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1066-1106 1.24e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.24e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462573298 1066 DIDECQHRHLC-AHGQCRNTEGSFQCVCDQGYRasglGDHCE 1106
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1025-1056 1.28e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.28e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2462573298  1025 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 1056
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1025-1057 3.02e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462573298 1025 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 1057
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
984-1023 5.25e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.25e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462573298   984 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 1023
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
626-656 1.43e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.43e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462573298   626 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 656
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
861-902 1.49e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.49e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462573298   861 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 902
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1107-1137 2.68e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 2.68e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298 1107 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 1137
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
984-1015 3.91e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.91e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462573298  984 DVDECLEPNVCAN-GDCSNLEGSYMCSCHKGYT 1015
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1107-1147 4.17e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 4.17e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573298  1107 DINECLEDkSVCQRG-DCINTAGSYDCTCPDGFQldDNKTCQ 1147
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
626-656 5.25e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 5.25e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298  626 DINECQLQGVCPN-GECLNTMGSYRCTCKIGF 656
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
861-891 1.08e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 1.08e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298  861 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 891
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1566-1600 1.18e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.18e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2462573298  1566 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1600
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
861-902 1.86e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462573298  861 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 902
Cdd:cd00054      1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
903-943 2.22e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.22e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573298   903 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 943
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1566-1600 3.46e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 3.46e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462573298 1566 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1600
Cdd:cd00054      1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
567-602 5.62e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.18  E-value: 5.62e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462573298  567 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 602
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1107-1147 6.00e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 6.00e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462573298 1107 DINEClEDKSVCQR-GDCINTAGSYDCTCPDGFQLddnKTCQ 1147
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG---RNCE 38
EGF smart00181
Epidermal growth factor-like domain;
1028-1058 1.06e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.27  E-value: 1.06e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2462573298  1028 ECQQGNLCVNGQCKNTEGSFRCTCGQGYQLS 1058
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGD 31
EGF_CA pfam07645
Calcium-binding EGF domain;
1566-1599 1.22e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.22e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462573298 1566 DVNECDELNNrmsLC-KNAKCINTDGSYKCLCLPG 1599
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
1069-1097 1.65e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 1.65e-03
                            10        20
                    ....*....|....*....|....*....
gi 2462573298  1069 ECQHRHLCAHGQCRNTEGSFQCVCDQGYR 1097
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
EGF smart00181
Epidermal growth factor-like domain;
629-661 1.79e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 1.79e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2462573298   629 ECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPT 661
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
903-935 1.88e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.88e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462573298  903 DVDECLRPDVCGEGH-CVNTVGAFRCEyCDSGYR 935
Cdd:cd00054      1 DIDECASGNPCQNGGtCVNTVGSYRCS-CPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
626-655 2.14e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.14e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298  626 DINEC-QLQGVCP-NGECLNTMGSYRCTCKIG 655
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
944-977 2.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462573298  944 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 977
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
1151-1180 3.04e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 3.04e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462573298 1151 ECEHPGLCGPQGECLNTEGSFHCVCQQGFS 1180
Cdd:cd00053      1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYT 30
EGF smart00181
Epidermal growth factor-like domain;
987-1015 3.32e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.73  E-value: 3.32e-03
                            10        20
                    ....*....|....*....|....*....
gi 2462573298   987 ECLEPNVCANGDCSNLEGSYMCSCHKGYT 1015
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
EGF_CA pfam07645
Calcium-binding EGF domain;
1066-1095 3.83e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.83e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298 1066 DIDEC-QHRHLC-AHGQCRNTEGSFQCVCDQG 1095
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
1172-1193 4.28e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.23  E-value: 4.28e-03
                           10        20
                   ....*....|....*....|..
gi 2462573298 1172 HCVCQQGFSISADGRTCEDVNE 1193
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA smart00179
Calcium-binding EGF-like domain;
944-976 4.50e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.50e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2462573298   944 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFR 976
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYT 33
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
1132-1151 6.27e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.46  E-value: 6.27e-03
                           10        20
                   ....*....|....*....|.
gi 2462573298 1132 CTCPDGFQLD-DNKTCQDINE 1151
Cdd:pfam12662    2 CSCPPGYQLDpDGRTCVDIDE 22
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
855-898 6.42e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.06  E-value: 6.42e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573298  855 QQRKCVDIDECTQVQHLCSQGrCENTEGSFLCICPAGFMASEEG 898
Cdd:cd01475    180 QGKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA pfam07645
Calcium-binding EGF domain;
1148-1178 8.75e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 8.75e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298 1148 DINECEHPG-LCGPQGECLNTEGSFHCVCQQG 1178
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1025-1054 9.20e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 9.20e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573298 1025 DIDECQQG-NLC-VNGQCKNTEGSFRCTCGQG 1054
Cdd:pfam07645    1 DVDECATGtHNCpANTVCVNTIGSFECRCPDG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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