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Conserved domains on  [gi|2462570115|ref|XP_054196511|]
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flagellum-associated coiled-coil domain-containing protein 1 isoform X3 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000095)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
113-393 6.45e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.43  E-value: 6.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  113 SEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSsemdlrcaEMKQNFENKNRELKEAhEAELSELENNY 192
Cdd:TIGR02168  665 SAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELE--------ELEEELEQLRKELEEL-SRQISALRKDL 735
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  193 KAALKAEKLAAQEkLEEMGKEYKYLKNMFRTYQDSIyDEMEEKWSKQKAKWKK-DEKFERENILLQQKKKMTKKFEMESG 271
Cdd:TIGR02168  736 ARLEAEVEQLEER-IAQLSKELTELEAEIEELEERL-EEAEEELAEAEAEIEElEAQIEQLKEELKALREALDELRAELT 813
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  272 EEDKKIN-------------ESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVMQEELHAQALILESLNTNLYYTQ 338
Cdd:TIGR02168  814 LLNEEAAnlrerleslerriAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLR 893
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462570115  339 LELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIhLKQKIISKNEEICE 393
Cdd:TIGR02168  894 SELEELSEELRELESKRSELRRELEELREKLAQLELRLEG-LEVRIDNLQERLSE 947
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
113-393 6.45e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.43  E-value: 6.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  113 SEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSsemdlrcaEMKQNFENKNRELKEAhEAELSELENNY 192
Cdd:TIGR02168  665 SAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELE--------ELEEELEQLRKELEEL-SRQISALRKDL 735
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  193 KAALKAEKLAAQEkLEEMGKEYKYLKNMFRTYQDSIyDEMEEKWSKQKAKWKK-DEKFERENILLQQKKKMTKKFEMESG 271
Cdd:TIGR02168  736 ARLEAEVEQLEER-IAQLSKELTELEAEIEELEERL-EEAEEELAEAEAEIEElEAQIEQLKEELKALREALDELRAELT 813
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  272 EEDKKIN-------------ESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVMQEELHAQALILESLNTNLYYTQ 338
Cdd:TIGR02168  814 LLNEEAAnlrerleslerriAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLR 893
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462570115  339 LELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIhLKQKIISKNEEICE 393
Cdd:TIGR02168  894 SELEELSEELRELESKRSELRRELEELREKLAQLELRLEG-LEVRIDNLQERLSE 947
PTZ00121 PTZ00121
MAEBL; Provisional
149-419 1.07e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  149 QSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKnmfRTYQDSI 228
Cdd:PTZ00121  1558 KKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKK---AEEEKKK 1634
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  229 YDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEE 308
Cdd:PTZ00121  1635 VEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEE 1714
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  309 LRKTKEVMQEElHAQALILESLNtnlyyTQLELQKEKAIVGNLEKMLQTKFAE-TEEKYKHTIQILTEENIHLKQKIISK 387
Cdd:PTZ00121  1715 KKKAEELKKAE-EENKIKAEEAK-----KEAEEDKKKAEEAKKDEEEKKKIAHlKKEEEKKAEEIRKEKEAVIEEELDEE 1788
                          250       260       270
                   ....*....|....*....|....*....|..
gi 2462570115  388 NEEICEGCSGRLASItvsKDDSDTVQDGSKKG 419
Cdd:PTZ00121  1789 DEKRRMEVDKKIKDI---FDNFANIIEGGKEG 1817
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
113-393 6.45e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.43  E-value: 6.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  113 SEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSsemdlrcaEMKQNFENKNRELKEAhEAELSELENNY 192
Cdd:TIGR02168  665 SAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELE--------ELEEELEQLRKELEEL-SRQISALRKDL 735
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  193 KAALKAEKLAAQEkLEEMGKEYKYLKNMFRTYQDSIyDEMEEKWSKQKAKWKK-DEKFERENILLQQKKKMTKKFEMESG 271
Cdd:TIGR02168  736 ARLEAEVEQLEER-IAQLSKELTELEAEIEELEERL-EEAEEELAEAEAEIEElEAQIEQLKEELKALREALDELRAELT 813
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  272 EEDKKIN-------------ESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVMQEELHAQALILESLNTNLYYTQ 338
Cdd:TIGR02168  814 LLNEEAAnlrerleslerriAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLR 893
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462570115  339 LELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIhLKQKIISKNEEICE 393
Cdd:TIGR02168  894 SELEELSEELRELESKRSELRRELEELREKLAQLELRLEG-LEVRIDNLQERLSE 947
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
127-356 1.56e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.28  E-value: 1.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  127 ISDLEEQISELTAIIEQMNRDHQSAQKLLS------SEMDLRCAEMKQNFENKNRELKEAhEAELSELENNyKAALKAEK 200
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYalaneiSRLEQQKQILRERLANLERQLEEL-EAQLEELESK-LDELAEEL 339
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  201 LAAQEKLEEMGKEYKYLKNMFRTYQDsIYDEMEEKWSKQKAKWkkdEKFERENILLQQKKKMTKKfEMESGEEDKkinES 280
Cdd:TIGR02168  340 AELEEKLEELKEELESLEAELEELEA-ELEELESRLEELEEQL---ETLRSKVAQLELQIASLNN-EIERLEARL---ER 411
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  281 CSAVFENFIQEKEELLKQHQSDTLQ------------LEELRKTKEVMQEELHAQALILESLNTNLYYTQLELQKEKAIV 348
Cdd:TIGR02168  412 LEDRRERLQQEIEELLKKLEEAELKelqaeleeleeeLEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARL 491

                   ....*...
gi 2462570115  349 GNLEKMLQ 356
Cdd:TIGR02168  492 DSLERLQE 499
PTZ00121 PTZ00121
MAEBL; Provisional
149-419 1.07e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  149 QSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKnmfRTYQDSI 228
Cdd:PTZ00121  1558 KKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKK---AEEEKKK 1634
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  229 YDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEE 308
Cdd:PTZ00121  1635 VEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEE 1714
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115  309 LRKTKEVMQEElHAQALILESLNtnlyyTQLELQKEKAIVGNLEKMLQTKFAE-TEEKYKHTIQILTEENIHLKQKIISK 387
Cdd:PTZ00121  1715 KKKAEELKKAE-EENKIKAEEAK-----KEAEEDKKKAEEAKKDEEEKKKIAHlKKEEEKKAEEIRKEKEAVIEEELDEE 1788
                          250       260       270
                   ....*....|....*....|....*....|..
gi 2462570115  388 NEEICEGCSGRLASItvsKDDSDTVQDGSKKG 419
Cdd:PTZ00121  1789 DEKRRMEVDKKIKDI---FDNFANIIEGGKEG 1817
PRK12704 PRK12704
phosphodiesterase; Provisional
231-388 2.00e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.15  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115 231 EMEEKWSKQKAKWKKDEKfERENILLQQKKKMTKKfemesgEE--DKKInescsavfENFIQEKEELLKQHQSDTLQLEE 308
Cdd:PRK12704   61 EAKEEIHKLRNEFEKELR-ERRNELQKLEKRLLQK------EEnlDRKL--------ELLEKREEELEKKEKELEQKQQE 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570115 309 LRKTKEVMQEELHAQALILESLNtnlyytqlELQKEKAivgnlEKMLqtkFAETEEKYKHTIQIL---TEENIHLKQKII 385
Cdd:PRK12704  126 LEKKEEELEELIEEQLQELERIS--------GLTAEEA-----KEIL---LEKVEEEARHEAAVLikeIEEEAKEEADKK 189

                  ...
gi 2462570115 386 SKN 388
Cdd:PRK12704  190 AKE 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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