NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462510048|ref|XP_054192991|]
View 

peroxisomal membrane protein PEX14 isoform X2 [Homo sapiens]

Protein Classification

peroxisomal membrane protein PEX14( domain architecture ID 10520091)

peroxisomal membrane protein PEX14 is a receptor-docking protein which is located on the cytoplasmic surface of the peroxisomal membrane and binds peroxisomal targeting signal (PTS) receptors carrying proteins bound for the peroxisomal matrix.

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Pex14_N pfam04695
Pex14 N-terminal domain; Family of peroxisomal membrane anchor proteins which bind the PTS1 ...
9-49 4.14e-13

Pex14 N-terminal domain; Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes. Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein.


:

Pssm-ID: 461395 [Multi-domain]  Cd Length: 46  Bit Score: 62.96  E-value: 4.14e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462510048   9 MIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQ 49
Cdd:pfam04695   5 LLEQARKFLQDPSVRNAPREKKVAFLKSKGLSDEEIEELLG 45
 
Name Accession Description Interval E-value
Pex14_N pfam04695
Pex14 N-terminal domain; Family of peroxisomal membrane anchor proteins which bind the PTS1 ...
9-49 4.14e-13

Pex14 N-terminal domain; Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes. Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein.


Pssm-ID: 461395 [Multi-domain]  Cd Length: 46  Bit Score: 62.96  E-value: 4.14e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462510048   9 MIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQ 49
Cdd:pfam04695   5 LLEQARKFLQDPSVRNAPREKKVAFLKSKGLSDEEIEELLG 45
 
Name Accession Description Interval E-value
Pex14_N pfam04695
Pex14 N-terminal domain; Family of peroxisomal membrane anchor proteins which bind the PTS1 ...
9-49 4.14e-13

Pex14 N-terminal domain; Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes. Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein.


Pssm-ID: 461395 [Multi-domain]  Cd Length: 46  Bit Score: 62.96  E-value: 4.14e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462510048   9 MIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQ 49
Cdd:pfam04695   5 LLEQARKFLQDPSVRNAPREKKVAFLKSKGLSDEEIEELLG 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH