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Conserved domains on  [gi|2462508169|ref|XP_054192091|]
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sodium/hydrogen exchanger 11 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 784-891 2.77e-11

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


:

Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 61.57  E-value: 2.77e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  784 DVLIDFFKERAKLACFDSGDTICKGGEMPQGIYLIISGMAILHSLsptfgiesnqrcDRGSRDMFTEFCTTGDIIGELSC 863
Cdd:cd00038      7 DEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKL------------DEDGREQIVGFLGPGDLFGELAL 74

                           90       100
                   ....*....|....*....|....*...
gi 2462508169  864 LLKREIEYTVICETSLQACFISLEDLYE 891
Cdd:cd00038     75 LGNGPRSATVRALTDSELLVLPRSDFRR 102
NhaP super family cl42993
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
94-294 3.21e-11

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG0025:

Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 66.91  E-value: 3.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169   94 LIRGESLIICSIASIFFgnfrgnRIHFSI-----FRDLHVGIELSYDILGSIIFGYWCAKIIQCILAdVFSNMLTNIILC 168
Cdd:COG0025    146 ILEGESLLNDATALVLF------VLALAAalgggFSLGEALLDFLLAILGGILVGLLLGWLLGRLLR-RLPDPLLEILLT 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  169 FSMVYMTFYIVEFLGMSGTLALAAVGL---NLDSLTFKPKIELVITKFLRIFSSVYEHLIYAFFGIVIgcgELSHYEFHT 245
Cdd:COG0025    219 LALPFLAYLLAEALHGSGVLAVVVAGLvlgNAGRRSLSPETRLQLLEFWETLEFLLNSLLFVLLGAQL---PLILLGALG 295

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2462508169  246 IPFIFILFTTVNLVRLLTILLVSPILMHSnyeYNWRWGVVITWSGIKGV 294
Cdd:COG0025    296 LGGILLVLLALLVVRPLWVFLSLALRGSR---LSWRERLFLSWGGPRGI 341
Ion_trans super family cl37996
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 520-642 6.40e-06

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


The actual alignment was detected with superfamily member pfam00520:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 48.80  E-value: 6.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  520 FEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLKIII--LKRKYFQQCWNTLEFFILVIGIIDI 597
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2462508169  598 FCVYFVKLRpdNLALIQLTVIMGYLRIIRFLPLFKIIVPILIRIA 642
Cdd:pfam00520   84 VLSSVGSLS--GLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSL 126
 
Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 784-891 2.77e-11

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 61.57  E-value: 2.77e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  784 DVLIDFFKERAKLACFDSGDTICKGGEMPQGIYLIISGMAILHSLsptfgiesnqrcDRGSRDMFTEFCTTGDIIGELSC 863
Cdd:cd00038      7 DEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKL------------DEDGREQIVGFLGPGDLFGELAL 74

                           90       100
                   ....*....|....*....|....*...
gi 2462508169  864 LLKREIEYTVICETSLQACFISLEDLYE 891
Cdd:cd00038     75 LGNGPRSATVRALTDSELLVLPRSDFRR 102
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
94-294 3.21e-11

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 66.91  E-value: 3.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169   94 LIRGESLIICSIASIFFgnfrgnRIHFSI-----FRDLHVGIELSYDILGSIIFGYWCAKIIQCILAdVFSNMLTNIILC 168
Cdd:COG0025    146 ILEGESLLNDATALVLF------VLALAAalgggFSLGEALLDFLLAILGGILVGLLLGWLLGRLLR-RLPDPLLEILLT 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  169 FSMVYMTFYIVEFLGMSGTLALAAVGL---NLDSLTFKPKIELVITKFLRIFSSVYEHLIYAFFGIVIgcgELSHYEFHT 245
Cdd:COG0025    219 LALPFLAYLLAEALHGSGVLAVVVAGLvlgNAGRRSLSPETRLQLLEFWETLEFLLNSLLFVLLGAQL---PLILLGALG 295

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2462508169  246 IPFIFILFTTVNLVRLLTILLVSPILMHSnyeYNWRWGVVITWSGIKGV 294
Cdd:COG0025    296 LGGILLVLLALLVVRPLWVFLSLALRGSR---LSWRERLFLSWGGPRGI 341
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 784-909 8.44e-10

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 59.62  E-value: 8.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  784 DVLIDFFKERAKLACFDSGDTICKGGEMPQGIYLIISGMAILHSLSPtfgiesnqrcdrGSRDMFTEFCTTGDIIGELSC 863
Cdd:COG0664      6 DEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISE------------DGREQILGFLGPGDFFGELSL 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462508169  864 LLKREIEYTVICETSLQACFISLEDLYEGFDAFwPSLEYKIWLKLA 909
Cdd:COG0664     74 LGGEPSPATAEALEDSELLRIPREDLEELLERN-PELARALLRLLA 118
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 799-891 5.54e-08

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 51.07  E-value: 5.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  799 FDSGDTICKGGEMPQGIYLIISGMAILHSLSPTfgiesnqrcdrgSRDMFTEFCTTGDIIGELSCLLKREIEYTVICETS 878
Cdd:pfam00027    4 YKAGEVIFREGDPADSLYIVLSGKVKVYRTLED------------GREQILAVLGPGDFFGELALLGGEPRSATVVALTD 71

                           90
                   ....*....|...
gi 2462508169  879 LQACFISLEDLYE 891
Cdd:pfam00027   72 SELLVIPREDFLE 84
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 94-291 1.10e-07

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 55.34  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169   94 LIRGESLI--ICSI--ASIFFGNFRGNRIHFSIFRdlhVGIELSYDILGSIIFGYWCAKIIQCILADVFSNMLTNIILCF 169
Cdd:pfam00999  142 LLLGESVLndGVAVvlLAVLLALAQGVGGGSDLGW---LLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVL 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  170 SMVYMTFYIVEFLGMSGTLALAAVGLNLDSLTFKPKIElviTKFLRIFSSVYEHLIYAFFGIVIGCGELshyEFHTIPFI 249
Cdd:pfam00999  219 LLALLAALLAEALGVSGILGAFLAGLVLSEYPFANKLS---EKLEPFGYGLFNPLFFVLVGLSLDLSSL---LLSVWILV 292

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2462508169  250 FILFTTVNLVRLLTILLVSPILmhsnyEYNWRWGVVITWSGI 291
Cdd:pfam00999  293 LLALVAILLGRFLGVFLLLRLL-----GLSLREALIIGFGGL 329
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 520-642 6.40e-06

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 48.80  E-value: 6.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  520 FEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLKIII--LKRKYFQQCWNTLEFFILVIGIIDI 597
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2462508169  598 FCVYFVKLRpdNLALIQLTVIMGYLRIIRFLPLFKIIVPILIRIA 642
Cdd:pfam00520   84 VLSSVGSLS--GLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSL 126
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 799-897 3.43e-04

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 41.23  E-value: 3.43e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169   799 FDSGDTICKGGEMPQGIYLIISGMAILHSLSPtfgiesnqrcdrGSRDMFTEFCTTGDIIGELSCLLKREIEYTVICETS 878
Cdd:smart00100   22 YPAGEVIIRQGDVGDSFYIIVSGEVEVYKVLE------------DGEEQIVGTLGPGDFFGELALLTNSRRAASAAAVAL 89

                            90       100
                    ....*....|....*....|.
gi 2462508169   879 --LQACFISLEDLYEGFDAFW 897
Cdd:smart00100   90 elATLLRIDFRDFLQLLPELP 110
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
 89-328 1.46e-03

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 42.46  E-value: 1.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169   89 KIYIdLIRGESLIICSIASIFFGNFrgnrIHFSIFRDLHVGIElsyDILGSIIF-------GYWCAKIIQCILADVFSNM 161
Cdd:TIGR00840  161 KLYI-IIFGESLLNDAVTVVLYNTF----IKFHKTADEPVTIV---DVFEGCASffvvtcgGLLVGVVFGFLVAFITRFT 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  162 ----LTNIILCFSMVYMTFYIVEFLGMSGTLALAAVGLNLD---SLTFKPKIELVITKFLRIFSSVYEHLIYAFFGIvig 234
Cdd:TIGR00840  233 hhirQIEPLFVFLISYLSYLFAETLHLSGILALIFCGITMKkyvEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGV--- 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  235 cgELSHYEfHTIPFIFILFTTV--NLVRLLTILLVSPIL-MHSNYEYNWRWGVVITWSGIKGV--FNLlwapdVYNLAER 309
Cdd:TIGR00840  310 --SLVTEN-HEWNWAFVVATLSfcVIYRVLGVRTLSWITnEFRPVEIPYKDQLVIFYAGLRGAvaFAL-----ALLLDEK 381

                          250
                   ....*....|....*....
gi 2462508169  310 KVEVPQMFILYVQVISLLT 328
Cdd:TIGR00840  382 IFPYKFLFVTTTLVVVFFT 400
 
Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 784-891 2.77e-11

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 61.57  E-value: 2.77e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  784 DVLIDFFKERAKLACFDSGDTICKGGEMPQGIYLIISGMAILHSLsptfgiesnqrcDRGSRDMFTEFCTTGDIIGELSC 863
Cdd:cd00038      7 DEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKL------------DEDGREQIVGFLGPGDLFGELAL 74

                           90       100
                   ....*....|....*....|....*...
gi 2462508169  864 LLKREIEYTVICETSLQACFISLEDLYE 891
Cdd:cd00038     75 LGNGPRSATVRALTDSELLVLPRSDFRR 102
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
94-294 3.21e-11

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 66.91  E-value: 3.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169   94 LIRGESLIICSIASIFFgnfrgnRIHFSI-----FRDLHVGIELSYDILGSIIFGYWCAKIIQCILAdVFSNMLTNIILC 168
Cdd:COG0025    146 ILEGESLLNDATALVLF------VLALAAalgggFSLGEALLDFLLAILGGILVGLLLGWLLGRLLR-RLPDPLLEILLT 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  169 FSMVYMTFYIVEFLGMSGTLALAAVGL---NLDSLTFKPKIELVITKFLRIFSSVYEHLIYAFFGIVIgcgELSHYEFHT 245
Cdd:COG0025    219 LALPFLAYLLAEALHGSGVLAVVVAGLvlgNAGRRSLSPETRLQLLEFWETLEFLLNSLLFVLLGAQL---PLILLGALG 295

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2462508169  246 IPFIFILFTTVNLVRLLTILLVSPILMHSnyeYNWRWGVVITWSGIKGV 294
Cdd:COG0025    296 LGGILLVLLALLVVRPLWVFLSLALRGSR---LSWRERLFLSWGGPRGI 341
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 784-909 8.44e-10

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 59.62  E-value: 8.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  784 DVLIDFFKERAKLACFDSGDTICKGGEMPQGIYLIISGMAILHSLSPtfgiesnqrcdrGSRDMFTEFCTTGDIIGELSC 863
Cdd:COG0664      6 DEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISE------------DGREQILGFLGPGDFFGELSL 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462508169  864 LLKREIEYTVICETSLQACFISLEDLYEGFDAFwPSLEYKIWLKLA 909
Cdd:COG0664     74 LGGEPSPATAEALEDSELLRIPREDLEELLERN-PELARALLRLLA 118
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 799-891 5.54e-08

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 51.07  E-value: 5.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  799 FDSGDTICKGGEMPQGIYLIISGMAILHSLSPTfgiesnqrcdrgSRDMFTEFCTTGDIIGELSCLLKREIEYTVICETS 878
Cdd:pfam00027    4 YKAGEVIFREGDPADSLYIVLSGKVKVYRTLED------------GREQILAVLGPGDFFGELALLGGEPRSATVVALTD 71

                           90
                   ....*....|...
gi 2462508169  879 LQACFISLEDLYE 891
Cdd:pfam00027   72 SELLVIPREDFLE 84
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 94-291 1.10e-07

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 55.34  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169   94 LIRGESLI--ICSI--ASIFFGNFRGNRIHFSIFRdlhVGIELSYDILGSIIFGYWCAKIIQCILADVFSNMLTNIILCF 169
Cdd:pfam00999  142 LLLGESVLndGVAVvlLAVLLALAQGVGGGSDLGW---LLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVL 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  170 SMVYMTFYIVEFLGMSGTLALAAVGLNLDSLTFKPKIElviTKFLRIFSSVYEHLIYAFFGIVIGCGELshyEFHTIPFI 249
Cdd:pfam00999  219 LLALLAALLAEALGVSGILGAFLAGLVLSEYPFANKLS---EKLEPFGYGLFNPLFFVLVGLSLDLSSL---LLSVWILV 292

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2462508169  250 FILFTTVNLVRLLTILLVSPILmhsnyEYNWRWGVVITWSGI 291
Cdd:pfam00999  293 LLALVAILLGRFLGVFLLLRLL-----GLSLREALIIGFGGL 329
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 520-642 6.40e-06

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 48.80  E-value: 6.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  520 FEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLKIII--LKRKYFQQCWNTLEFFILVIGIIDI 597
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2462508169  598 FCVYFVKLRpdNLALIQLTVIMGYLRIIRFLPLFKIIVPILIRIA 642
Cdd:pfam00520   84 VLSSVGSLS--GLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSL 126
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 799-897 3.43e-04

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 41.23  E-value: 3.43e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169   799 FDSGDTICKGGEMPQGIYLIISGMAILHSLSPtfgiesnqrcdrGSRDMFTEFCTTGDIIGELSCLLKREIEYTVICETS 878
Cdd:smart00100   22 YPAGEVIIRQGDVGDSFYIIVSGEVEVYKVLE------------DGEEQIVGTLGPGDFFGELALLTNSRRAASAAAVAL 89

                            90       100
                    ....*....|....*....|.
gi 2462508169   879 --LQACFISLEDLYEGFDAFW 897
Cdd:smart00100   90 elATLLRIDFRDFLQLLPELP 110
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
 89-328 1.46e-03

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 42.46  E-value: 1.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169   89 KIYIdLIRGESLIICSIASIFFGNFrgnrIHFSIFRDLHVGIElsyDILGSIIF-------GYWCAKIIQCILADVFSNM 161
Cdd:TIGR00840  161 KLYI-IIFGESLLNDAVTVVLYNTF----IKFHKTADEPVTIV---DVFEGCASffvvtcgGLLVGVVFGFLVAFITRFT 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  162 ----LTNIILCFSMVYMTFYIVEFLGMSGTLALAAVGLNLD---SLTFKPKIELVITKFLRIFSSVYEHLIYAFFGIvig 234
Cdd:TIGR00840  233 hhirQIEPLFVFLISYLSYLFAETLHLSGILALIFCGITMKkyvEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGV--- 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508169  235 cgELSHYEfHTIPFIFILFTTV--NLVRLLTILLVSPIL-MHSNYEYNWRWGVVITWSGIKGV--FNLlwapdVYNLAER 309
Cdd:TIGR00840  310 --SLVTEN-HEWNWAFVVATLSfcVIYRVLGVRTLSWITnEFRPVEIPYKDQLVIFYAGLRGAvaFAL-----ALLLDEK 381

                          250
                   ....*....|....*....
gi 2462508169  310 KVEVPQMFILYVQVISLLT 328
Cdd:TIGR00840  382 IFPYKFLFVTTTLVVVFFT 400
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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