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Conserved domains on  [gi|2462508050|ref|XP_054192032|]
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guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-340 2.41e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 269.59  E-value: 2.41e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050  48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT-----TNKVHAIPLRssWVMTCAYapsGNYVACGGLDNICS 122
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPVR--DVAASAD---GTYLASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 123 IYNLKTREgnvrVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS 201
Cdd:cd00200    77 LWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 202 GACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICgitSVSFSK 280
Cdd:cd00200   153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN---SVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 281 SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Cdd:cd00200   230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-340 2.41e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 269.59  E-value: 2.41e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050  48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT-----TNKVHAIPLRssWVMTCAYapsGNYVACGGLDNICS 122
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPVR--DVAASAD---GTYLASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 123 IYNLKTREgnvrVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS 201
Cdd:cd00200    77 LWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 202 GACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICgitSVSFSK 280
Cdd:cd00200   153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN---SVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 281 SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Cdd:cd00200   230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-340 1.39e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 204.37  E-value: 1.39e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050  46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 126 LKTRegnvRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGAC 204
Cdd:COG2319   191 LATG----KLLRTLTGHTGAVRSVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 205 DASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIicGITSVSFSKSGRL 284
Cdd:COG2319   267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPDGKT 344

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462508050 285 LLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 216-254 4.90e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 4.90e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462508050  216 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD 254
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 97-331 7.19e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 7.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050  97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-----REGNVRVSrELAGHTGYLSCC-RFLDDNQIVTSSGDTTCALWD 170
Cdd:PLN00181  483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESiikdgRDIHYPVV-ELASRSKLSGICwNSYIKSQVASSNFEGVVQVWD 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 171 IETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFtghESDINAICF-FPN--GNAFATGSD 246
Cdd:PLN00181  562 VARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI---KTKANICCVqFPSesGRSLAFGSA 638

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 247 DATCRLFDLRADQ-ELMTY-SHDNIicgITSVSFSKSGRLLLAGYDDfNCNVWDaLKADRAGV-------LAGHDNRVSC 317
Cdd:PLN00181  639 DHKVYYYDLRNPKlPLCTMiGHSKT---VSYVRFVDSSTLVSSSTDN-TLKLWD-LSMSISGInetplhsFMGHTNVKNF 713

                         250
                  ....*....|....
gi 2462508050 318 LGVTDDGMAVATGS 331
Cdd:PLN00181  714 VGLSVSDGYIATGS 727
WD40 pfam00400
WD domain, G-beta repeat;
216-254 2.67e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 2.67e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462508050 216 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD 254
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-340 2.41e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 269.59  E-value: 2.41e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050  48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT-----TNKVHAIPLRssWVMTCAYapsGNYVACGGLDNICS 122
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPVR--DVAASAD---GTYLASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 123 IYNLKTREgnvrVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS 201
Cdd:cd00200    77 LWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 202 GACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICgitSVSFSK 280
Cdd:cd00200   153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN---SVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 281 SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Cdd:cd00200   230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-340 1.39e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 204.37  E-value: 1.39e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050  46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 126 LKTRegnvRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGAC 204
Cdd:COG2319   191 LATG----KLLRTLTGHTGAVRSVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 205 DASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIicGITSVSFSKSGRL 284
Cdd:COG2319   267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPDGKT 344

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462508050 285 LLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
26-340 3.00e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 3.00e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050  26 ADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105
Cdd:COG2319     7 AALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 106 APSGNYVACGGLDNICSIYNLKTRegnvRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHT 184
Cdd:COG2319    87 SPDGRLLASASADGTVRLWDLATG----LLLRTLTGHTGAVRSVAFSPDGKtLASGSADGTVRLWDLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 185 GDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY 264
Cdd:COG2319   163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL 242

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462508050 265 SHDNIicGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Cdd:COG2319   243 TGHSG--SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
46-256 2.52e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.61  E-value: 2.52e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050  46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 126 LKTREgnvrVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGAC 204
Cdd:COG2319   275 LATGE----LLRTLTGHSGGVNSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462508050 205 DASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 256
Cdd:COG2319   351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
150-340 1.81e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 150 RFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI 229
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 230 NAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNiicGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL 308
Cdd:COG2319    82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTG---AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462508050 309 AGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Cdd:COG2319   159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 218-340 1.64e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 1.64e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 218 CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNiicGITSVSFSKSGRLLLAGYDDFNCNV 296
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTG---PVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462508050 297 WDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-170 3.00e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 3.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050  45 MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIY 124
Cdd:cd00200   167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2462508050 125 NLKTREgnvrVSRELAGHTGYLSCCRFLDD-NQIVTSSGDTTCALWD 170
Cdd:cd00200   247 DLRTGE----CVQTLSGHTNSVTSLAWSPDgKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-128 1.27e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 1.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050  46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319   321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                  ...
gi 2462508050 126 LKT 128
Cdd:COG2319   401 LAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 216-254 4.90e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 4.90e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462508050  216 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD 254
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 97-331 7.19e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 7.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050  97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-----REGNVRVSrELAGHTGYLSCC-RFLDDNQIVTSSGDTTCALWD 170
Cdd:PLN00181  483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESiikdgRDIHYPVV-ELASRSKLSGICwNSYIKSQVASSNFEGVVQVWD 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 171 IETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFtghESDINAICF-FPN--GNAFATGSD 246
Cdd:PLN00181  562 VARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI---KTKANICCVqFPSesGRSLAFGSA 638

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 247 DATCRLFDLRADQ-ELMTY-SHDNIicgITSVSFSKSGRLLLAGYDDfNCNVWDaLKADRAGV-------LAGHDNRVSC 317
Cdd:PLN00181  639 DHKVYYYDLRNPKlPLCTMiGHSKT---VSYVRFVDSSTLVSSSTDN-TLKLWD-LSMSISGInetplhsFMGHTNVKNF 713

                         250
                  ....*....|....
gi 2462508050 318 LGVTDDGMAVATGS 331
Cdd:PLN00181  714 VGLSVSDGYIATGS 727
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 40-171 7.26e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 7.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050  40 VGRIQMRTRrtLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSwvMTCAYAPS--GNYVACGG 116
Cdd:PLN00181  562 VARSQLVTE--MKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFPSesGRSLAFGS 637

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462508050 117 LDNICSIYNLKtregNVRVSR-ELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDI 171
Cdd:PLN00181  638 ADHKVYYYDLR----NPKLPLcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
216-254 2.67e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 2.67e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462508050 216 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD 254
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-83 5.13e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.13e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462508050   49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD 83
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
49-83 1.89e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 1.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462508050  49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD 83
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
306-340 1.24e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.24e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462508050 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 307-340 2.35e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.35e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462508050  307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
183-212 8.73e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 8.73e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462508050 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWD 212
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-212 2.57e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.57e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462508050  183 HTGDVMSLSLAPDTRLFVSGACDASAKLWD 212
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 311-339 3.03e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 3.03e-03
                          10        20
                  ....*....|....*....|....*....
gi 2462508050 311 HDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVW 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 134-170 4.54e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 4.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462508050  134 RVSRELAGHTGYLSCCRFL-DDNQIVTSSGDTTCALWD 170
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 153-301 4.91e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 38.72  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 153 DDNQIVTSSGDTTCALWDIETGQQTTTFTG-------HTGDVMSLSLAPDTR-LFVSGACDASAKLWDVREGMCRQTFTG 224
Cdd:PTZ00421   87 DPQKLFTASEDGTIMGWGIPEEGLTQNISDpivhlqgHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKC 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508050 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRadqelmtysHDNIICGITSVSFSKSGRLLLAGYDD----FNCN----- 295
Cdd:PTZ00421  167 HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR---------DGTIVSSVEAHASAKSQRCLWAKRKDliitLGCSksqqr 237


                  ....*....
gi 2462508050 296 ---VWDALK 301
Cdd:PTZ00421  238 qimLWDTRK 246
WD40 pfam00400
WD domain, G-beta repeat;
137-170 9.02e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 9.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462508050 137 RELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWD 170
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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