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Conserved domains on  [gi|2462502117|ref|XP_054189788|]
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tryptophan--tRNA ligase, mitochondrial isoform X4 [Homo sapiens]

Protein Classification

tryptophan--tRNA ligase( domain architecture ID 1000926)

tryptophan--tRNA ligase is a class I tRNA synthetase and aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA

EC:  6.1.1.2
Gene Ontology:  GO:0006436|GO:0004830|GO:0005524

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00927 super family cl35130
tryptophanyl-tRNA synthetase; Reviewed
 34-284 1.72e-61

tryptophanyl-tRNA synthetase; Reviewed


The actual alignment was detected with superfamily member PRK00927:

Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 197.62  E-value: 1.72e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  34 KKRVFSGIQPTGILHLGNYLGAIESW------------------------------------------------------ 59
Cdd:PRK00927    1 KKRVLSGIQPTGKLHLGNYLGAIKNWvelqdeyecffciadlhaltvpqdpeelrentrelaadylacgidpekstifvq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  60 --VSEHTQLSWILSCMVRLPRLQHLHQWKVHTRSCWGGSS------PahgtssgsstrfqqevwgVLSSARV---HSQYV 128
Cdd:PRK00927   81 shVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSaglftyP------------------VLMAADIllyKADLV 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 129 CVGV---------------FN--------------LASMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAV 179
Cdd:PRK00927  143 PVGEdqkqhleltrdiarrFNnlygevfpvpepliPKVGARVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKAV 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 180 TDFT--SEVTYDPPGRAGVSNIVAVHAAVTGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHL 255
Cdd:PRK00927  223 TDSErlREIRYDLPNKPEVSNLLTIYSALSGESIEELEAeyEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAYL 302

                         330       340
                  ....*....|....*....|....*....
gi 2462502117 256 EKVLQIGSAKAKELAYTVCQEVKKLVGFL 284
Cdd:PRK00927  303 DEILAEGAEKARAVASKTLKEVREAMGLL 331
 
Name Accession Description Interval E-value
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 34-284 1.72e-61

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 197.62  E-value: 1.72e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  34 KKRVFSGIQPTGILHLGNYLGAIESW------------------------------------------------------ 59
Cdd:PRK00927    1 KKRVLSGIQPTGKLHLGNYLGAIKNWvelqdeyecffciadlhaltvpqdpeelrentrelaadylacgidpekstifvq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  60 --VSEHTQLSWILSCMVRLPRLQHLHQWKVHTRSCWGGSS------PahgtssgsstrfqqevwgVLSSARV---HSQYV 128
Cdd:PRK00927   81 shVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSaglftyP------------------VLMAADIllyKADLV 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 129 CVGV---------------FN--------------LASMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAV 179
Cdd:PRK00927  143 PVGEdqkqhleltrdiarrFNnlygevfpvpepliPKVGARVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKAV 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 180 TDFT--SEVTYDPPGRAGVSNIVAVHAAVTGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHL 255
Cdd:PRK00927  223 TDSErlREIRYDLPNKPEVSNLLTIYSALSGESIEELEAeyEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAYL 302

                         330       340
                  ....*....|....*....|....*....
gi 2462502117 256 EKVLQIGSAKAKELAYTVCQEVKKLVGFL 284
Cdd:PRK00927  303 DEILAEGAEKARAVASKTLKEVREAMGLL 331
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 33-284 2.50e-56

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 184.10  E-value: 2.50e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  33 SKKRVFSGIQPTGILHLGNYLGAIESW----------------------------------------------------- 59
Cdd:COG0180     2 SKKRVLSGIQPTGRLHLGNYLGALKNWvelqdeyecfffiadlhalttpqdpeelrentrevaadylaagldpekstifv 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  60 ---VSEHTQLSWILSCMVRLPRLQHLHQWKVHTRSCWGGSSPAhgtssgsstrfqqevwG-----VLSSARV---HSQYV 128
Cdd:COG0180    82 qsdVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNGKENVNA----------------GlltypVLMAADIllyKADLV 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 129 CVGV---------------FN--------------LASMKKVKSLrDPSAKMSKSDpdkLATVRITDSPEEIVQKFRKAV 179
Cdd:COG0180   146 PVGEdqkqhleltrdiarrFNhrygevfpepealiPEEGARIPGL-DGRKKMSKSY---GNTINLLDDPKEIRKKIKSAV 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 180 TDfTSEVTYDPPGRAGVSNIVAVHAAVTG-LSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLE 256
Cdd:COG0180   222 TD-SERLRYDDPGKPEVCNLFTIYSAFSGkEEVEELEAeyRAGGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELD 300

                         330       340
                  ....*....|....*....|....*...
gi 2462502117 257 KVLQIGSAKAKELAYTVCQEVKKLVGFL 284
Cdd:COG0180   301 EILAEGAEKARAIAAKTLAEVREAMGLL 328
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 36-236 1.24e-42

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 147.35  E-value: 1.24e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  36 RVFSGIQPTGILHLGNYLGAIESW-------------------------------------------------------- 59
Cdd:cd00806     1 RVLSGIQPSGSLHLGHYLGAFRFWvwlqeagyelfffiadlhaltvkqldpeelrqntrenakdylacgldpekstiffq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  60 --VSEHTQLSWILSCMVRLPRLQHLHQWKvhtrscwggsSPAHGTSSGSSTRFqqeVWGVLSSARV-HSQ--YVCVGV-- 132
Cdd:cd00806    81 sdVPEHYELAWLLSCVVTFGELERMTGFK----------DKSAQGESVNIGLL---TYPVLQAADIlLYKacLVPVGIdq 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 133 -------------FN-------------LASMKKVKSLRDPSAKMSKSDPDklATVRITDSPEEIVQKFRKAVTDFTSEV 186
Cdd:cd00806   148 dphleltrdiarrFNklygeifpkpaalLSKGAFLPGLQGPSKKMSKSDPN--NAIFLTDSPKEIKKKIMKAATDGGRTE 225

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462502117 187 TYDPPGRAGVSNIVAVHAAVTGLSVEEVVR----RSAGMNTARYKLAVADAVIE 236
Cdd:cd00806   226 HRRDGGGPGVSNLVEIYSAFFNDDDEELEEideyRSGGLGYGECKKLLAEAIQE 279
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 33-283 1.45e-26

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 105.88  E-value: 1.45e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  33 SKKRVFSGIQPTGILHLGNYLGAIESW----------------------------------------------------- 59
Cdd:TIGR00233   1 KKFRVLTGIQPSGKMHLGHYLGAIQTKwlqqfgvelficiadlhaitvkqtdpdalrkareelaadylavgldpektfif 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  60 ----VSEHTQLSWILSCMVRLPRLQHLHQWKvhtrscwgGSSPAHGTSSGSST--------------------------- 108
Cdd:TIGR00233  81 lqsdYPEHYELAWLLSCQVTFGELKRMTQFK--------DKSQAENVPIGLLSypvlqaadillyqadlvpvgidqdqhl 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 109 --------RFQQEVWGVLS-SARVHSQyvcvgvfnlaSMKKVKSLRDPsaKMSKSDPDklATVRITDSPEEIVQKFRKAV 179
Cdd:TIGR00233 153 eltrdlaeRFNKKFKNFFPkPESLISK----------FFPRLMGLSGK--KMSKSDPN--SAIFLTDTPKQIKKKIRKAA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 180 TDFTSEVTYDPPGRAGVSNIVAVHAAVT-----GLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEklKLDK 252
Cdd:TIGR00233 219 TDGGRVTLFEHREKPGVPNLLVIYQYLSfflidDDKLKEIYEayKSGKLGYGECKKALIEVLQEFLKEIQERRA--EIAE 296

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2462502117 253 DHLEKVLQIGSAKAKELAYTVCQEVKKLVGF 283
Cdd:TIGR00233 297 EILDKILEPGAKKARETANKTLADVYKAMGL 327
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
30-239 5.01e-12

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 64.99  E-value: 5.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  30 QKDSKKRVFSGIQPTGILHLGnYLGAIESWVS------------------------------------------------ 61
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLG-YLVPLMKLRQfqqaghevffligdlhaiigdpsksperkllsretvlenaikaqlacg 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  62 ---------------EHTQLSWILSCMVRLPRLQHLHQWK-VHTRSCWGGSSPAHGTS-----SGSSTRFQQEV------ 114
Cdd:pfam00579  80 ldpekaeivnnsdwlEHLELAWLLRDLGKHFSLNRMLQFKdVKKRLEQGPGISLGEFTypllqAYDILLLKADLqpggsd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 115 -WGVLSSARvHSQYVcvgvFNLASMKKVKSL-------RDPSAKMSKSDPdkLATVRITDSPEEIVQKFRKAVTDFTSEV 186
Cdd:pfam00579 160 qWGNIELGR-DLARR----FNKKIFKKPVGLtnplltgLDGGKKMSKSAG--NSAIFLDDDPESVYKKIQKAYTDPDREV 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462502117 187 TYDPPGRAGVSN-IVAVHAAVTGLSV---------EEVVRRSAGMNtarYKLAVADAVIEKFA 239
Cdd:pfam00579 233 RKDLKLFTFLSNeEIEILEAELGKSPyreaeellaREVTGLVHGGD---LKKAAAEAVNKLLQ 292
 
Name Accession Description Interval E-value
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 34-284 1.72e-61

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 197.62  E-value: 1.72e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  34 KKRVFSGIQPTGILHLGNYLGAIESW------------------------------------------------------ 59
Cdd:PRK00927    1 KKRVLSGIQPTGKLHLGNYLGAIKNWvelqdeyecffciadlhaltvpqdpeelrentrelaadylacgidpekstifvq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  60 --VSEHTQLSWILSCMVRLPRLQHLHQWKVHTRSCWGGSS------PahgtssgsstrfqqevwgVLSSARV---HSQYV 128
Cdd:PRK00927   81 shVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSaglftyP------------------VLMAADIllyKADLV 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 129 CVGV---------------FN--------------LASMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAV 179
Cdd:PRK00927  143 PVGEdqkqhleltrdiarrFNnlygevfpvpepliPKVGARVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKAV 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 180 TDFT--SEVTYDPPGRAGVSNIVAVHAAVTGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHL 255
Cdd:PRK00927  223 TDSErlREIRYDLPNKPEVSNLLTIYSALSGESIEELEAeyEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAYL 302

                         330       340
                  ....*....|....*....|....*....
gi 2462502117 256 EKVLQIGSAKAKELAYTVCQEVKKLVGFL 284
Cdd:PRK00927  303 DEILAEGAEKARAVASKTLKEVREAMGLL 331
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 33-284 2.50e-56

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 184.10  E-value: 2.50e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  33 SKKRVFSGIQPTGILHLGNYLGAIESW----------------------------------------------------- 59
Cdd:COG0180     2 SKKRVLSGIQPTGRLHLGNYLGALKNWvelqdeyecfffiadlhalttpqdpeelrentrevaadylaagldpekstifv 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  60 ---VSEHTQLSWILSCMVRLPRLQHLHQWKVHTRSCWGGSSPAhgtssgsstrfqqevwG-----VLSSARV---HSQYV 128
Cdd:COG0180    82 qsdVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNGKENVNA----------------GlltypVLMAADIllyKADLV 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 129 CVGV---------------FN--------------LASMKKVKSLrDPSAKMSKSDpdkLATVRITDSPEEIVQKFRKAV 179
Cdd:COG0180   146 PVGEdqkqhleltrdiarrFNhrygevfpepealiPEEGARIPGL-DGRKKMSKSY---GNTINLLDDPKEIRKKIKSAV 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 180 TDfTSEVTYDPPGRAGVSNIVAVHAAVTG-LSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLE 256
Cdd:COG0180   222 TD-SERLRYDDPGKPEVCNLFTIYSAFSGkEEVEELEAeyRAGGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELD 300

                         330       340
                  ....*....|....*....|....*...
gi 2462502117 257 KVLQIGSAKAKELAYTVCQEVKKLVGFL 284
Cdd:COG0180   301 EILAEGAEKARAIAAKTLAEVREAMGLL 328
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 36-236 1.24e-42

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 147.35  E-value: 1.24e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  36 RVFSGIQPTGILHLGNYLGAIESW-------------------------------------------------------- 59
Cdd:cd00806     1 RVLSGIQPSGSLHLGHYLGAFRFWvwlqeagyelfffiadlhaltvkqldpeelrqntrenakdylacgldpekstiffq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  60 --VSEHTQLSWILSCMVRLPRLQHLHQWKvhtrscwggsSPAHGTSSGSSTRFqqeVWGVLSSARV-HSQ--YVCVGV-- 132
Cdd:cd00806    81 sdVPEHYELAWLLSCVVTFGELERMTGFK----------DKSAQGESVNIGLL---TYPVLQAADIlLYKacLVPVGIdq 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 133 -------------FN-------------LASMKKVKSLRDPSAKMSKSDPDklATVRITDSPEEIVQKFRKAVTDFTSEV 186
Cdd:cd00806   148 dphleltrdiarrFNklygeifpkpaalLSKGAFLPGLQGPSKKMSKSDPN--NAIFLTDSPKEIKKKIMKAATDGGRTE 225

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462502117 187 TYDPPGRAGVSNIVAVHAAVTGLSVEEVVR----RSAGMNTARYKLAVADAVIE 236
Cdd:cd00806   226 HRRDGGGPGVSNLVEIYSAFFNDDDEELEEideyRSGGLGYGECKKLLAEAIQE 279
PLN02886 PLN02886
aminoacyl-tRNA ligase
 23-284 3.09e-37

aminoacyl-tRNA ligase


Pssm-ID: 215478 [Multi-domain]  Cd Length: 389  Bit Score: 135.71  E-value: 3.09e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  23 SAAAPALQKDS------KKRVFSGIQPTGILHLGNYLGAIESW------------------------------------- 59
Cdd:PLN02886   29 ATAATAPEKEAppkvarKKRVVSGVQPTGSIHLGNYLGAIKNWvalqetydtffcvvdlhaitlphdprelgkatrstaa 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  60 -------------------VSEHTQLSWILSCMVRLPRLQHLHQWKVHTRScwggsspaHGTSSGSSTRFqqeVWGVLSS 120
Cdd:PLN02886  109 iylacgidpskasvfvqshVPAHAELMWLLSCSTPIGWLNKMIQFKEKSRK--------AGDENVGVGLL---TYPVLMA 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 121 ARV---HSQYVCVG----------------VFNLASMKKVK-------------------------SLRDPSAKMSKSDP 156
Cdd:PLN02886  178 SDIllyQADLVPVGedqkqhleltrdiaerVNNLYGGRKWKklggrggsvfkvpealippagarvmSLTDGTSKMSKSAP 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 157 DKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPPGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIE 236
Cdd:PLN02886  258 SDQSRINLLDPPDVIANKIKRCKTDSFPGLEFDNPERPECNNLLSIYQLVTGKTKEEVLAECGDMRWGDFKPLLTDALIE 337

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 2462502117 237 KFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 284
Cdd:PLN02886  338 HLSPIQVRYEEIMSDPSYLDSVLKEGADAAAEIADRTLANVYQAMGFV 385
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 33-283 1.45e-26

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 105.88  E-value: 1.45e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  33 SKKRVFSGIQPTGILHLGNYLGAIESW----------------------------------------------------- 59
Cdd:TIGR00233   1 KKFRVLTGIQPSGKMHLGHYLGAIQTKwlqqfgvelficiadlhaitvkqtdpdalrkareelaadylavgldpektfif 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  60 ----VSEHTQLSWILSCMVRLPRLQHLHQWKvhtrscwgGSSPAHGTSSGSST--------------------------- 108
Cdd:TIGR00233  81 lqsdYPEHYELAWLLSCQVTFGELKRMTQFK--------DKSQAENVPIGLLSypvlqaadillyqadlvpvgidqdqhl 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 109 --------RFQQEVWGVLS-SARVHSQyvcvgvfnlaSMKKVKSLRDPsaKMSKSDPDklATVRITDSPEEIVQKFRKAV 179
Cdd:TIGR00233 153 eltrdlaeRFNKKFKNFFPkPESLISK----------FFPRLMGLSGK--KMSKSDPN--SAIFLTDTPKQIKKKIRKAA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 180 TDFTSEVTYDPPGRAGVSNIVAVHAAVT-----GLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEklKLDK 252
Cdd:TIGR00233 219 TDGGRVTLFEHREKPGVPNLLVIYQYLSfflidDDKLKEIYEayKSGKLGYGECKKALIEVLQEFLKEIQERRA--EIAE 296

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2462502117 253 DHLEKVLQIGSAKAKELAYTVCQEVKKLVGF 283
Cdd:TIGR00233 297 EILDKILEPGAKKARETANKTLADVYKAMGL 327
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
30-239 5.01e-12

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 64.99  E-value: 5.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  30 QKDSKKRVFSGIQPTGILHLGnYLGAIESWVS------------------------------------------------ 61
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLG-YLVPLMKLRQfqqaghevffligdlhaiigdpsksperkllsretvlenaikaqlacg 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  62 ---------------EHTQLSWILSCMVRLPRLQHLHQWK-VHTRSCWGGSSPAHGTS-----SGSSTRFQQEV------ 114
Cdd:pfam00579  80 ldpekaeivnnsdwlEHLELAWLLRDLGKHFSLNRMLQFKdVKKRLEQGPGISLGEFTypllqAYDILLLKADLqpggsd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 115 -WGVLSSARvHSQYVcvgvFNLASMKKVKSL-------RDPSAKMSKSDPdkLATVRITDSPEEIVQKFRKAVTDFTSEV 186
Cdd:pfam00579 160 qWGNIELGR-DLARR----FNKKIFKKPVGLtnplltgLDGGKKMSKSAG--NSAIFLDDDPESVYKKIQKAYTDPDREV 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462502117 187 TYDPPGRAGVSN-IVAVHAAVTGLSV---------EEVVRRSAGMNtarYKLAVADAVIEKFA 239
Cdd:pfam00579 233 RKDLKLFTFLSNeEIEILEAELGKSPyreaeellaREVTGLVHGGD---LKKAAAEAVNKLLQ 292
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 33-282 9.98e-12

tryptophanyl-tRNA synthetase II; Reviewed


Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 64.11  E-value: 9.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  33 SKKRVFSGIQPTGILHLGNYLGA--------------------------------------------------------- 55
Cdd:PRK12282    1 TKPIILTGDRPTGKLHLGHYVGSlknrvalqneheqfvliadqqaltdnaknpekirrnilevaldylavgidpakstif 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  56 IESWVSEHTQLSWILSCMVRLPRLQHLHQWKVHTRscwggsspAHGTSSGSSTRFQqeVWGVLSSARV---HSQYVCVG- 131
Cdd:PRK12282   81 IQSQIPELAELTMYYMNLVTVARLERNPTVKTEIA--------QKGFGRSIPAGFL--TYPVSQAADItafKATLVPVGd 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 132 --------------VFN--------------LASMKKVKSLrDPSAKMSKSDPDKLAtvrITDSPEEIVQKFRKAVTDfT 183
Cdd:PRK12282  151 dqlpmieqtreivrRFNslygtdvlvepealLPEAGRLPGL-DGKAKMSKSLGNAIY---LSDDADTIKKKVMSMYTD-P 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 184 SEVTYDPPGRAGVSNIVAVHAAV--TGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVL 259
Cdd:PRK12282  226 NHIRVEDPGKVEGNVVFTYLDAFdpDKAEVAELKAhyQRGGLGDVKCKRYLEEVLQELLAPIRERRAEFAKDPGYVLEIL 305

                         330       340
                  ....*....|....*....|...
gi 2462502117 260 QIGSAKAKELAYTVCQEVKKLVG 282
Cdd:PRK12282  306 KAGSEKAREVAAQTLSEVKDAMG 328
PRK12556 PRK12556
tryptophanyl-tRNA synthetase; Provisional
 32-283 9.88e-07

tryptophanyl-tRNA synthetase; Provisional


Pssm-ID: 183592 [Multi-domain]  Cd Length: 332  Bit Score: 49.34  E-value: 9.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  32 DSKKRVFSGIQPTGILHLGNYLGAIE-----------------------------------------SW----------- 59
Cdd:PRK12556    1 MSEKIMLTGIKPTGYPHLGNYIGAIKpalqmaknyegkalyfiadyhalnavhdpeqfrsytrevaaTWlslgldpedvi 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117  60 ------VSEHTQLSWILSCMVRLPRLQHLHQWKVHT-RSCWGGSSPAHGTSSGSSTR----------FQQEVWGVlssAR 122
Cdd:PRK12556   81 fyrqsdVPEIFELAWILSCLTPKGLMNRAHAYKAKVdQNKEAGLDLDAGVNMGLYTYpilmaadillFQATHVPV---GK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 123 VHSQYV-----CVGVFN-----LASMKKVkSLRDPSA--------KMSKSDPDklaTVRITDSPEEIVQKFRKAVTDFTs 184
Cdd:PRK12556  158 DQIQHIeiardIATYFNhtfgdTFTLPEY-VIQEEGAilpgldgrKMSKSYGN---VIPLFAEQEKLRKLIFKIKTDSS- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 185 evtydPPGRAGVSNIVAVHAAVTGLSVEEVV-----RRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVL 259
Cdd:PRK12556  233 -----LPNEPKDPETSALFTIYKEFATEEEVqsmreKYETGIGWGDVKKELFRVVDRELAGPREKYAMYMNEPSLLDEAL 307

                         330       340
                  ....*....|....*....|....
gi 2462502117 260 QIGSAKAKELAYTVCQEVKKLVGF 283
Cdd:PRK12556  308 EKGAERAREIAKPNLAEIKKAIGF 331
PRK12283 PRK12283
tryptophanyl-tRNA synthetase; Reviewed
 33-84 1.65e-05

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 183401 [Multi-domain]  Cd Length: 398  Bit Score: 45.71  E-value: 1.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462502117  33 SKKRVFSGIQPTGILHLGNYLGAIESWVsehtqlswilscmvrlpRLQHLHQ 84
Cdd:PRK12283    1 FPDRVLSGMRPTGRLHLGHYHGVLKNWV-----------------KLQHEYE 35
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 143-256 9.57e-05

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 43.32  E-value: 9.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 143 SLRDPSAKMSKSDPDklATVRITDSPEEIVQKFRKAvtdftsevtYDPPGRA---GVSNIVAVHA--------------- 204
Cdd:PRK08560  207 GLDGGGIKMSKSKPG--SAIFVHDSPEEIRRKIKKA---------YCPPGEVegnPVLEIAKYHIfprydpfvierpeky 275

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462502117 205 --AVTGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKreiEKLKLDKDHLE 256
Cdd:PRK08560  276 ggDLEYESYEELERdyAEGKLHPMDLKNAVAEYLIEILEPVR---EYLEEGPELLE 328
PRK12284 PRK12284
tryptophanyl-tRNA synthetase; Reviewed
 36-56 1.94e-03

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237036 [Multi-domain]  Cd Length: 431  Bit Score: 39.22  E-value: 1.94e-03
                          10        20
                  ....*....|....*....|.
gi 2462502117  36 RVFSGIQPTGILHLGNYLGAI 56
Cdd:PRK12284    4 RVLTGITTTGTPHLGNYAGAI 24
Tyr_Trp_RS_core cd00395
catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA ...
 141-236 2.74e-03

catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS)/Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. These enzymes attach Tyr or Trp, respectively, to the appropriate tRNA. These class I enzymes are homodimers, which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173893 [Multi-domain]  Cd Length: 273  Bit Score: 38.44  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502117 141 VKSLRDPsaKMSKSDPDKLATVRITDSPEEIVQKFRKAVtdftsevtydppgragVSNIVAVHAAVTGLSVEEVVRRSAG 220
Cdd:cd00395   191 VTKLDGP--KFGKSESGPKWLDTEKTSPYEFYQFWINAV----------------DSDVINILKYFTFLSKEEIERLEQE 252

                          90       100
                  ....*....|....*....|
gi 2462502117 221 MNTAR----YKLAVADAVIE 236
Cdd:cd00395   253 QYEAPgyrvAQKTLAEEVTK 272
PTZ00126 PTZ00126
tyrosyl-tRNA synthetase; Provisional
 143-192 4.40e-03

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 240282 [Multi-domain]  Cd Length: 383  Bit Score: 38.13  E-value: 4.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462502117 143 SLRDPSAKMSKSDPDklATVRITDSPEEIVQKFRKAvtdftsevtYDPPG 192
Cdd:PTZ00126  250 GLLEGQEKMSKSDPN--SAIFMEDSEEDVNRKIKKA---------YCPPG 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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