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Conserved domains on  [gi|2462502115|ref|XP_054189787|]
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tryptophan--tRNA ligase, mitochondrial isoform X6 [Homo sapiens]

Protein Classification

tryptophan--tRNA ligase( domain architecture ID 11479345)

tryptophan--tRNA ligase is a class I tRNA synthetase and aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA

EC:  6.1.1.2
Gene Ontology:  GO:0006436|GO:0004830|GO:0005524

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 5-331 5.28e-166

tryptophanyl-tRNA synthetase; Reviewed


:

Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 465.33  E-value: 5.28e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   5 KKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQ 84
Cdd:PRK00927    1 KKRVLSGIQPTGKLHLGNYLGAIKNWVELQDEYEC-FFCIADLHALTVPQDPEELRENTRELAADYLACGIDPEKSTIFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  85 QSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLA 164
Cdd:PRK00927   80 QSHVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSAGLFTYPVLMAADILLYKADLVPVGEDQKQHLELTRDIA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 165 QGFNKKYGEFFPVPESILTSMK-KVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFT--SEVTYDPPGRA 241
Cdd:PRK00927  160 RRFNNLYGEVFPVPEPLIPKVGaRVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKAVTDSErlREIRYDLPNKP 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 242 GVSNIVAVHAAVTGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYT 319
Cdd:PRK00927  240 EVSNLLTIYSALSGESIEELEAeyEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAYLDEILAEGAEKARAVASK 319

                         330
                  ....*....|..
gi 2462502115 320 VCQEVKKLVGFL 331
Cdd:PRK00927  320 TLKEVREAMGLL 331
 
Name Accession Description Interval E-value
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 5-331 5.28e-166

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 465.33  E-value: 5.28e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   5 KKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQ 84
Cdd:PRK00927    1 KKRVLSGIQPTGKLHLGNYLGAIKNWVELQDEYEC-FFCIADLHALTVPQDPEELRENTRELAADYLACGIDPEKSTIFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  85 QSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLA 164
Cdd:PRK00927   80 QSHVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSAGLFTYPVLMAADILLYKADLVPVGEDQKQHLELTRDIA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 165 QGFNKKYGEFFPVPESILTSMK-KVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFT--SEVTYDPPGRA 241
Cdd:PRK00927  160 RRFNNLYGEVFPVPEPLIPKVGaRVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKAVTDSErlREIRYDLPNKP 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 242 GVSNIVAVHAAVTGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYT 319
Cdd:PRK00927  240 EVSNLLTIYSALSGESIEELEAeyEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAYLDEILAEGAEKARAVASK 319

                         330
                  ....*....|..
gi 2462502115 320 VCQEVKKLVGFL 331
Cdd:PRK00927  320 TLKEVREAMGLL 331
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 4-331 1.36e-159

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 448.73  E-value: 1.36e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   4 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILF 83
Cdd:COG0180     2 SKKRVLSGIQPTGRLHLGNYLGALKNWVELQDEYEC-FFFIADLHALTTPQDPEELRENTREVAADYLAAGLDPEKSTIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  84 QQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG-TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQD 162
Cdd:COG0180    81 VQSDVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNGKENvNAGLLTYPVLMAADILLYKADLVPVGEDQKQHLELTRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 163 LAQGFNKKYGEFFPVPESILT-SMKKVKSLrDPSAKMSKSDpdkLATVRITDSPEEIVQKFRKAVTDfTSEVTYDPPGRA 241
Cdd:COG0180   161 IARRFNHRYGEVFPEPEALIPeEGARIPGL-DGRKKMSKSY---GNTINLLDDPKEIRKKIKSAVTD-SERLRYDDPGKP 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 242 GVSNIVAVHAAVTG-LSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAY 318
Cdd:COG0180   236 EVCNLFTIYSAFSGkEEVEELEAeyRAGGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELDEILAEGAEKARAIAA 315

                         330
                  ....*....|...
gi 2462502115 319 TVCQEVKKLVGFL 331
Cdd:COG0180   316 KTLAEVREAMGLL 328
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 7-283 3.80e-134

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 382.70  E-value: 3.80e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   7 RVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQ-DPAVLRQSILDMTAVLLACGINPEKSILFQQ 85
Cdd:cd00806     1 RVLSGIQPSGSLHLGHYLGAFRFWVWLQEAGYELFFFIADLHALTVKQlDPEELRQNTRENAKDYLACGLDPEKSTIFFQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  86 SQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDgTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQ 165
Cdd:cd00806    81 SDVPEHYELAWLLSCVVTFGELERMTGFKDKSAQGESV-NIGLLTYPVLQAADILLYKACLVPVGIDQDPHLELTRDIAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 166 GFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDklATVRITDSPEEIVQKFRKAVTDFTSEVTYDPPGRAGVSN 245
Cdd:cd00806   160 RFNKLYGEIFPKPAALLSKGAFLPGLQGPSKKMSKSDPN--NAIFLTDSPKEIKKKIMKAATDGGRTEHRRDGGGPGVSN 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2462502115 246 IVAVHAAVTGLSVEEVVR----RSAGMNTARYKLAVADAVIE 283
Cdd:cd00806   238 LVEIYSAFFNDDDEELEEideyRSGGLGYGECKKLLAEAIQE 279
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 4-330 3.60e-100

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 298.09  E-value: 3.60e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   4 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVlYSIVDLHSITVPQ-DPAVLRQSILDMTAVLLACGINPEKSIL 82
Cdd:TIGR00233   1 KKFRVLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELF-ICIADLHAITVKQtDPDALRKAREELAADYLAVGLDPEKTFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  83 FQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTtkQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQD 162
Cdd:TIGR00233  80 FLQSDYPEHYELAWLLSCQVTFGELKRMTQFKDKS--QAENVPIGLLSYPVLQAADILLYQADLVPVGIDQDQHLELTRD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 163 LAQGFNKKYGEFFPVPESILT-SMKKVKSLRDpsAKMSKSDPDklATVRITDSPEEIVQKFRKAVTDFTSEVTYDPPGRA 241
Cdd:TIGR00233 158 LAERFNKKFKNFFPKPESLISkFFPRLMGLSG--KKMSKSDPN--SAIFLTDTPKQIKKKIRKAATDGGRVTLFEHREKP 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 242 GVSNIVAVHAAVT-----GLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEklKLDKDHLEKVLQIGSAKAK 314
Cdd:TIGR00233 234 GVPNLLVIYQYLSfflidDDKLKEIYEayKSGKLGYGECKKALIEVLQEFLKEIQERRA--EIAEEILDKILEPGAKKAR 311

                         330
                  ....*....|....*.
gi 2462502115 315 ELAYTVCQEVKKLVGF 330
Cdd:TIGR00233 312 ETANKTLADVYKAMGL 327
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
1-286 3.71e-68

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 214.83  E-value: 3.71e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   1 MKDSKKRVFSGIQPTGILHLGnYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAV---LRQSILDMTAV---LLACG 74
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLG-YLVPLMKLRQFQQAGHEVFFLIGDLHAIIGDPSKSPerkLLSRETVLENAikaQLACG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  75 INPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG--TVGLLTYPVLQAADILLYKSTHVPVGED 152
Cdd:pfam00579  80 LDPEKAEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFKDVKKRLEQGPgiSLGEFTYPLLQAYDILLLKADLQPGGSD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 153 QVQHMELVQDLAQGFNKKygeFFPVPESILTsmkKVKSLRDPSAKMSKSDPdkLATVRITDSPEEIVQKFRKAVTDFTSE 232
Cdd:pfam00579 160 QWGNIELGRDLARRFNKK---IFKKPVGLTN---PLLTGLDGGKKMSKSAG--NSAIFLDDDPESVYKKIQKAYTDPDRE 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462502115 233 VTYDPPGRAGVSN-IVAVHAAVTGLSV---------EEVVRRSAGMNtarYKLAVADAVIEKFA 286
Cdd:pfam00579 232 VRKDLKLFTFLSNeEIEILEAELGKSPyreaeellaREVTGLVHGGD---LKKAAAEAVNKLLQ 292
 
Name Accession Description Interval E-value
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 5-331 5.28e-166

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 465.33  E-value: 5.28e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   5 KKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQ 84
Cdd:PRK00927    1 KKRVLSGIQPTGKLHLGNYLGAIKNWVELQDEYEC-FFCIADLHALTVPQDPEELRENTRELAADYLACGIDPEKSTIFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  85 QSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLA 164
Cdd:PRK00927   80 QSHVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSAGLFTYPVLMAADILLYKADLVPVGEDQKQHLELTRDIA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 165 QGFNKKYGEFFPVPESILTSMK-KVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFT--SEVTYDPPGRA 241
Cdd:PRK00927  160 RRFNNLYGEVFPVPEPLIPKVGaRVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKAVTDSErlREIRYDLPNKP 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 242 GVSNIVAVHAAVTGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYT 319
Cdd:PRK00927  240 EVSNLLTIYSALSGESIEELEAeyEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAYLDEILAEGAEKARAVASK 319

                         330
                  ....*....|..
gi 2462502115 320 VCQEVKKLVGFL 331
Cdd:PRK00927  320 TLKEVREAMGLL 331
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 4-331 1.36e-159

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 448.73  E-value: 1.36e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   4 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILF 83
Cdd:COG0180     2 SKKRVLSGIQPTGRLHLGNYLGALKNWVELQDEYEC-FFFIADLHALTTPQDPEELRENTREVAADYLAAGLDPEKSTIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  84 QQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG-TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQD 162
Cdd:COG0180    81 VQSDVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNGKENvNAGLLTYPVLMAADILLYKADLVPVGEDQKQHLELTRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 163 LAQGFNKKYGEFFPVPESILT-SMKKVKSLrDPSAKMSKSDpdkLATVRITDSPEEIVQKFRKAVTDfTSEVTYDPPGRA 241
Cdd:COG0180   161 IARRFNHRYGEVFPEPEALIPeEGARIPGL-DGRKKMSKSY---GNTINLLDDPKEIRKKIKSAVTD-SERLRYDDPGKP 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 242 GVSNIVAVHAAVTG-LSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAY 318
Cdd:COG0180   236 EVCNLFTIYSAFSGkEEVEELEAeyRAGGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELDEILAEGAEKARAIAA 315

                         330
                  ....*....|...
gi 2462502115 319 TVCQEVKKLVGFL 331
Cdd:COG0180   316 KTLAEVREAMGLL 328
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 7-283 3.80e-134

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 382.70  E-value: 3.80e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   7 RVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQ-DPAVLRQSILDMTAVLLACGINPEKSILFQQ 85
Cdd:cd00806     1 RVLSGIQPSGSLHLGHYLGAFRFWVWLQEAGYELFFFIADLHALTVKQlDPEELRQNTRENAKDYLACGLDPEKSTIFFQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  86 SQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDgTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQ 165
Cdd:cd00806    81 SDVPEHYELAWLLSCVVTFGELERMTGFKDKSAQGESV-NIGLLTYPVLQAADILLYKACLVPVGIDQDPHLELTRDIAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 166 GFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDklATVRITDSPEEIVQKFRKAVTDFTSEVTYDPPGRAGVSN 245
Cdd:cd00806   160 RFNKLYGEIFPKPAALLSKGAFLPGLQGPSKKMSKSDPN--NAIFLTDSPKEIKKKIMKAATDGGRTEHRRDGGGPGVSN 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2462502115 246 IVAVHAAVTGLSVEEVVR----RSAGMNTARYKLAVADAVIE 283
Cdd:cd00806   238 LVEIYSAFFNDDDEELEEideyRSGGLGYGECKKLLAEAIQE 279
PLN02886 PLN02886
aminoacyl-tRNA ligase
 5-331 1.79e-113

aminoacyl-tRNA ligase


Pssm-ID: 215478 [Multi-domain]  Cd Length: 389  Bit Score: 334.09  E-value: 1.79e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   5 KKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQ 84
Cdd:PLN02886   46 KKRVVSGVQPTGSIHLGNYLGAIKNWVALQETYDT-FFCVVDLHAITLPHDPRELGKATRSTAAIYLACGIDPSKASVFV 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  85 QSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQ-KHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDL 163
Cdd:PLN02886  125 QSHVPAHAELMWLLSCSTPIGWLNKMIQFKEKSRKAgDENVGVGLLTYPVLMASDILLYQADLVPVGEDQKQHLELTRDI 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 164 AQGFNKKYG------------EFFPVPES-ILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFT 230
Cdd:PLN02886  205 AERVNNLYGgrkwkklggrggSVFKVPEAlIPPAGARVMSLTDGTSKMSKSAPSDQSRINLLDPPDVIANKIKRCKTDSF 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 231 SEVTYDPPGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGS 310
Cdd:PLN02886  285 PGLEFDNPERPECNNLLSIYQLVTGKTKEEVLAECGDMRWGDFKPLLTDALIEHLSPIQVRYEEIMSDPSYLDSVLKEGA 364

                         330       340
                  ....*....|....*....|.
gi 2462502115 311 AKAKELAYTVCQEVKKLVGFL 331
Cdd:PLN02886  365 DAAAEIADRTLANVYQAMGFV 385
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 4-330 3.60e-100

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 298.09  E-value: 3.60e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   4 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVlYSIVDLHSITVPQ-DPAVLRQSILDMTAVLLACGINPEKSIL 82
Cdd:TIGR00233   1 KKFRVLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELF-ICIADLHAITVKQtDPDALRKAREELAADYLAVGLDPEKTFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  83 FQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTtkQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQD 162
Cdd:TIGR00233  80 FLQSDYPEHYELAWLLSCQVTFGELKRMTQFKDKS--QAENVPIGLLSYPVLQAADILLYQADLVPVGIDQDQHLELTRD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 163 LAQGFNKKYGEFFPVPESILT-SMKKVKSLRDpsAKMSKSDPDklATVRITDSPEEIVQKFRKAVTDFTSEVTYDPPGRA 241
Cdd:TIGR00233 158 LAERFNKKFKNFFPKPESLISkFFPRLMGLSG--KKMSKSDPN--SAIFLTDTPKQIKKKIRKAATDGGRVTLFEHREKP 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 242 GVSNIVAVHAAVT-----GLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEklKLDKDHLEKVLQIGSAKAK 314
Cdd:TIGR00233 234 GVPNLLVIYQYLSfflidDDKLKEIYEayKSGKLGYGECKKALIEVLQEFLKEIQERRA--EIAEEILDKILEPGAKKAR 311

                         330
                  ....*....|....*.
gi 2462502115 315 ELAYTVCQEVKKLVGF 330
Cdd:TIGR00233 312 ETANKTLADVYKAMGL 327
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 4-329 3.47e-76

tryptophanyl-tRNA synthetase II; Reviewed


Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 237.06  E-value: 3.47e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   4 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYsIVDLHSIT-VPQDPAVLRQSILDMTAVLLACGINPEKSIL 82
Cdd:PRK12282    1 TKPIILTGDRPTGKLHLGHYVGSLKNRVALQNEHEQFVL-IADQQALTdNAKNPEKIRRNILEVALDYLAVGIDPAKSTI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  83 FQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTtKQKHDG---TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMEL 159
Cdd:PRK12282   80 FIQSQIPELAELTMYYMNLVTVARLERNPTVKTEI-AQKGFGrsiPAGFLTYPVSQAADITAFKATLVPVGDDQLPMIEQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 160 VQDLAQGFNKKYG-EFFPVPESILTSMKKVKSLrDPSAKMSKSDPDKLAtvrITDSPEEIVQKFRKAVTDfTSEVTYDPP 238
Cdd:PRK12282  159 TREIVRRFNSLYGtDVLVEPEALLPEAGRLPGL-DGKAKMSKSLGNAIY---LSDDADTIKKKVMSMYTD-PNHIRVEDP 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 239 GRAGVSNIVAVHAAV--TGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAK 314
Cdd:PRK12282  234 GKVEGNVVFTYLDAFdpDKAEVAELKAhyQRGGLGDVKCKRYLEEVLQELLAPIRERRAEFAKDPGYVLEILKAGSEKAR 313

                         330
                  ....*....|....*
gi 2462502115 315 ELAYTVCQEVKKLVG 329
Cdd:PRK12282  314 EVAAQTLSEVKDAMG 328
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
1-286 3.71e-68

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 214.83  E-value: 3.71e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   1 MKDSKKRVFSGIQPTGILHLGnYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAV---LRQSILDMTAV---LLACG 74
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLG-YLVPLMKLRQFQQAGHEVFFLIGDLHAIIGDPSKSPerkLLSRETVLENAikaQLACG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  75 INPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG--TVGLLTYPVLQAADILLYKSTHVPVGED 152
Cdd:pfam00579  80 LDPEKAEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFKDVKKRLEQGPgiSLGEFTYPLLQAYDILLLKADLQPGGSD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 153 QVQHMELVQDLAQGFNKKygeFFPVPESILTsmkKVKSLRDPSAKMSKSDPdkLATVRITDSPEEIVQKFRKAVTDFTSE 232
Cdd:pfam00579 160 QWGNIELGRDLARRFNKK---IFKKPVGLTN---PLLTGLDGGKKMSKSAG--NSAIFLDDDPESVYKKIQKAYTDPDRE 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462502115 233 VTYDPPGRAGVSN-IVAVHAAVTGLSV---------EEVVRRSAGMNtarYKLAVADAVIEKFA 286
Cdd:pfam00579 232 VRKDLKLFTFLSNeEIEILEAELGKSPyreaeellaREVTGLVHGGD---LKKAAAEAVNKLLQ 292
PRK12556 PRK12556
tryptophanyl-tRNA synthetase; Provisional
 3-330 6.00e-68

tryptophanyl-tRNA synthetase; Provisional


Pssm-ID: 183592 [Multi-domain]  Cd Length: 332  Bit Score: 215.74  E-value: 6.00e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   3 DSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSV-LYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSI 81
Cdd:PRK12556    1 MSEKIMLTGIKPTGYPHLGNYIGAIKPALQMAKNYEGKaLYFIADYHALNAVHDPEQFRSYTREVAATWLSLGLDPEDVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  82 LFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG-------TVGLLTYPVLQAADILLYKSTHVPVGEDQV 154
Cdd:PRK12556   81 FYRQSDVPEIFELAWILSCLTPKGLMNRAHAYKAKVDQNKEAGldldagvNMGLYTYPILMAADILLFQATHVPVGKDQI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 155 QHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDpSAKMSKSDPDklaTVRITDSPEEIVQKFRKAVTDFTsevt 234
Cdd:PRK12556  161 QHIEIARDIATYFNHTFGDTFTLPEYVIQEEGAILPGLD-GRKMSKSYGN---VIPLFAEQEKLRKLIFKIKTDSS---- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 235 ydPPGRAGVSNIVAVHAAVTGLSVEEVV-----RRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIG 309
Cdd:PRK12556  233 --LPNEPKDPETSALFTIYKEFATEEEVqsmreKYETGIGWGDVKKELFRVVDRELAGPREKYAMYMNEPSLLDEALEKG 310

                         330       340
                  ....*....|....*....|.
gi 2462502115 310 SAKAKELAYTVCQEVKKLVGF 330
Cdd:PRK12556  311 AERAREIAKPNLAEIKKAIGF 331
PRK12283 PRK12283
tryptophanyl-tRNA synthetase; Reviewed
 4-329 6.99e-59

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 183401 [Multi-domain]  Cd Length: 398  Bit Score: 194.40  E-value: 6.99e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   4 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVP-QDPAVLRQSILDMTAVLLACGINPEKSIL 82
Cdd:PRK12283    1 FPDRVLSGMRPTGRLHLGHYHGVLKNWVKLQHEYEC-FFFVADWHALTTHyETPEVIEKNVWDMVIDWLAAGVDPAQATL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  83 FQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHD--GTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELV 160
Cdd:PRK12283   80 FIQSKVPEHAELHLLLSMITPLGWLERVPTYKDQQEKLKEKdlSTYGFLGYPLLQSADILIYRAGLVPVGEDQVPHVEMT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 161 QDLAQGFNKKYG-------------------------------------------------------------------- 172
Cdd:PRK12283  160 REIARRFNHLYGrepgfeekaeaaikklgkkraklyhelrnayqeegddealeqarallqeqqnlsmgdrerlfgylega 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 173 --EFFPVPESILTSMKKVKSLrDpSAKMSKSDPDklaTVRITDSPEEIVQKFRKAVTDfTSEVTYDPPGRAGVSNIVAVH 250
Cdd:PRK12283  240 gkIILPEPQALLTEASKMPGL-D-GQKMSKSYGN---TIGLREDPESVTKKIRTMPTD-PARVRRTDPGDPEKCPVWQLH 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 251 AAVTGLSVEEVVR---RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKL 327
Cdd:PRK12283  314 QVYSDEETKEWVQkgcRSAGIGCLECKQPVIDAILREQQPMRERAQKYEDDPSLVRAIVADGCEKARKVARETMRDVREA 393


                  ..
gi 2462502115 328 VG 329
Cdd:PRK12283  394 MG 395
PRK12284 PRK12284
tryptophanyl-tRNA synthetase; Reviewed
 7-329 3.36e-50

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237036 [Multi-domain]  Cd Length: 431  Bit Score: 172.50  E-value: 3.36e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   7 RVFSGIQPTGILHLGNYLGAIESWVR--LQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQ 84
Cdd:PRK12284    4 RVLTGITTTGTPHLGNYAGAIRPAIAasRQPGVES-FYFLADYHALIKCDDPARIQRSTLEIAATWLAAGLDPERVTFYR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  85 QSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG-------TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHM 157
Cdd:PRK12284   83 QSDIPEIPELTWLLTCVAGKGLLNRAHAYKAAVDKNVAAGedpdagvTAGLFMYPVLMAADILMFNAHKVPVGRDQIQHI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 158 ELVQDLAQGFNKKYG-EFFPVPESILTsmKKVKSL-----RdpsaKMSKSDPDklaTVRITDSPEEIVQKFRKAVTDftS 231
Cdd:PRK12284  163 EMARDIAQRFNHLYGgEFFVLPEAVIE--ESVATLpgldgR----KMSKSYDN---TIPLFAPREELKKAIFSIVTD--S 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 232 EVTYDPPGRAGvSNIVAVHAAVTGLSVEEVVRRS--AGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIG 309
Cdd:PRK12284  232 RAPGEPKDTEG-SALFQLYQAFATPEETAAFRQAlaDGIGWGDAKQRLFERIDRELAPMRERYEALIARPADIEDILLAG 310

                         330       340
                  ....*....|....*....|
gi 2462502115 310 SAKAKELAYTVCQEVKKLVG 329
Cdd:PRK12284  311 AAKARRIATPFLAELREAVG 330
Tyr_Trp_RS_core cd00395
catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA ...
 8-283 2.24e-33

catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS)/Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. These enzymes attach Tyr or Trp, respectively, to the appropriate tRNA. These class I enzymes are homodimers, which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173893 [Multi-domain]  Cd Length: 273  Bit Score: 124.34  E-value: 2.24e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   8 VFSGIQPTG-ILHLGNYLGaIESWVRLQDEYDSVLYSIVDLHSITV----------PQDPAVLRQSILDMTAVLLACGI- 75
Cdd:cd00395     2 LYCGIDPTAdSLHIGHLIG-LLTFRRFQHAGHRPIFLIGGQTGIIGdpsgkksertLNDPEEVRQNIRRIAAQYLAVGIf 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  76 -NPEKSILFQQSQV---SEHTQLSWILSCMVRLPRLQHLHQWKAKTtkqKHDGTVGLLTYPVLQAADILLYKSTH----V 147
Cdd:cd00395    81 eDPTQATLFNNSDWpgpLAHIQFLRDLGKHVYVNYMERKTSFQSRS---EEGISATEFTYPPLQAADFLLLNTTEgcdiQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 148 PVGEDQVQHMELVQDLAQGFNkkygeFFPVPESILTSMkkVKSLRDPsaKMSKSDPDKLATVRITDSPEEIVQKFRKAVt 227
Cdd:cd00395   158 PGGSDQWGNITLGRELARRFN-----GFTIAEGLTIPL--VTKLDGP--KFGKSESGPKWLDTEKTSPYEFYQFWINAV- 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 228 dftsevtydppgragVSNIVAVHAAVTGLSVEEVVRRSAGMNTAR----YKLAVADAVIE 283
Cdd:cd00395   228 ---------------DSDVINILKYFTFLSKEEIERLEQEQYEAPgyrvAQKTLAEEVTK 272
PRK12285 PRK12285
tryptophanyl-tRNA synthetase; Reviewed
 8-227 1.07e-20

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237037 [Multi-domain]  Cd Length: 368  Bit Score: 91.46  E-value: 1.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   8 VFSGIQPTGILHLGNYLGAIESwVRLQDEYDSVLYSIVDLHS-----ITVPQDPAVLRQSILDmtavLLACGINPEKSIL 82
Cdd:PRK12285   69 VYTGFMPSGPMHIGHKMVFDEL-KWHQEFGANVYIPIADDEAyaargLSWEETREWAYEYILD----LIALGFDPDKTEI 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  83 FQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTkqkhdgtVGLLTYPVLQAADILL------YKSTHVPVGEDQVQH 156
Cdd:PRK12285  144 YFQSENIKVYDLAFELAKKVNFSELKAIYGFTGETN-------IGHIFYPATQAADILHpqleegPKPTLVPVGIDQDPH 216

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462502115 157 MELVQDLAQGFNKKYGefFPVPESILtsMKKVKSLRdpSAKMSKSDPDklATVRITDSPEEIVQKFRKAVT 227
Cdd:PRK12285  217 IRLTRDIAERLHGGYG--FIKPSSTY--HKFMPGLT--GGKMSSSKPE--SAIYLTDDPETVKKKIMKALT 279
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 4-239 5.22e-12

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 65.66  E-value: 5.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   4 SKKRVFSGIQPTGILHLGNYLgaiesWVR----LQDE-YDSVLYsIVDLHS-ITVPQDPAVLRQSILDMTAVLLACGINP 77
Cdd:PRK08560   29 EEPKAYIGFEPSGKIHLGHLL-----TMNkladLQKAgFKVTVL-LADWHAyLNDKGDLEEIRKVAEYNKKVFEALGLDP 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  78 EKS--IL---FQQSqvSEHTQLSWILSCMVRLPRLQHlhqwkAKT--TKQKHDGTVGLLTYPVLQAADILlYKSTHVPV- 149
Cdd:PRK08560  103 DKTefVLgseFQLD--KEYWLLVLKLAKNTTLARARR-----SMTimGRRMEEPDVSKLVYPLMQVADIF-YLDVDIAVg 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 150 GEDQVQ-HMeLVQDLAQGFNkkygefFPVPESILTSMkkVKSLRDPSAKMSKSDPDklATVRITDSPEEIVQKFRKAvtd 228
Cdd:PRK08560  175 GMDQRKiHM-LAREVLPKLG------YKKPVCIHTPL--LTGLDGGGIKMSKSKPG--SAIFVHDSPEEIRRKIKKA--- 240

                         250
                  ....*....|.
gi 2462502115 229 ftsevtYDPPG 239
Cdd:PRK08560  241 ------YCPPG 245
PTZ00126 PTZ00126
tyrosyl-tRNA synthetase; Provisional
 129-239 2.58e-06

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 240282 [Multi-domain]  Cd Length: 383  Bit Score: 48.53  E-value: 2.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 129 LTYPVLQAADILLYKSTHVPVGEDQVQhmelVQDLAqgfnKKYGEFFPVPES-ILTSMKKVKSLRDPSAKMSKSDPDklA 207
Cdd:PTZ00126  196 ILYPCMQCADIFYLKADICQLGMDQRK----VNMLA----REYCDKKKIKKKpIILSHHMLPGLLEGQEKMSKSDPN--S 265

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462502115 208 TVRITDSPEEIVQKFRKAvtdftsevtYDPPG 239
Cdd:PTZ00126  266 AIFMEDSEEDVNRKIKKA---------YCPPG 288
PTZ00348 PTZ00348
tyrosyl-tRNA synthetase; Provisional
 66-236 3.01e-06

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 173541 [Multi-domain]  Cd Length: 682  Bit Score: 48.74  E-value: 3.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  66 MTAVLLACGINPEKSI-LFQQSQVSEHTQLSWILscMVRLPRLQHLHQWKAKTT---KQKHDGTVGLLTYPVLQAADILL 141
Cdd:PTZ00348   96 LIEVWKAAGMDMDKVLfLWSSEEITNHANTYWRT--VLDIGRQNTIARIKKCCTimgKTEGTLTAAQVLYPLMQCADIFF 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 142 YKSTHVPVGEDQVQHMELVQDLAQGFNKKYgeffpvpESILTSMKKVKSLRDPSAKMSKSDPDklATVRITDSPEEIVQK 221
Cdd:PTZ00348  174 LKADICQLGLDQRKVNMLAREYCDLIGRKL-------KPVILSHHMLAGLKQGQAKMSKSDPD--SAIFMEDTEEDVARK 244

                         170
                  ....*....|....*....
gi 2462502115 222 FRKA----VTDFTSEVTYD 236
Cdd:PTZ00348  245 IRQAycprVKQSASEITDD 263
tyrS TIGR00234
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ...
 2-233 3.08e-05

tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272976 [Multi-domain]  Cd Length: 378  Bit Score: 45.08  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   2 KDSKKRVFSGIQPTGI-LHLGNYLgAIESWVRLQDEYDSVLYSIVDLHS-ITVPQDPAVLRQsILDMTAVL--------- 70
Cdd:TIGR00234  28 LERPLKLYLGFDPTAPsLHLGHLV-PLLKLRDFQQAGHEVIVLLGDFTAlIGDPTGKSEVRK-ILTREEVQenaenikkq 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  71 LACGINPEKSILFQQSqvsehtqlSWILSC----MVR-LPRLQHLHQWKAK---TTKQKHDGTVGLLTYPVLQAADIL-L 141
Cdd:TIGR00234 106 IARFLDFEKAKFVYNS--------EWLLKLnytdFIRlLGKIFTVNRMLRRdafSSRFEENISLHEFIYPLLQAYDFVyL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 142 YKSTHVPvGEDQVQHMELVQDLAQGFNKKYGEFFPVPesILTSMKKVKSLRDPSAKMSkSDPDKLAT-VRITDSPEEIVQ 220
Cdd:TIGR00234 178 NVDLQLG-GSDQWFNIRKGRDLARENLPSLQFGLTVP--LLTPADGEKMGKSLGGAVS-LDEGKYDFyQKVINTPDELVK 253

                         250
                  ....*....|...
gi 2462502115 221 KFRKAVTDFTSEV 233
Cdd:TIGR00234 254 KYLKLFTFLGLEE 266
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 6-225 3.83e-05

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 44.52  E-value: 3.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   6 KRVFSGIQPTGI-LHLGNYLgAIESWVRLQDEYDSVLYSIVDLHS-ITVPQDPAVLRqSILDMTAVLLACginpeKSILF 83
Cdd:cd00805     1 LKVYIGFDPTAPsLHLGHLV-PLMKLRDFQQAGHEVIVLIGDATAmIGDPSGKSEER-KLLDLELIRENA-----KYYKK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  84 Q-----QSQVSEHTQL----SWILSC----MVRLPRLQHLHQWKAK-TTKQKHDGTVGL----LTYPVLQAADIL-LYKS 144
Cdd:cd00805    74 QlkailDFIPPEKAKFvnnsDWLLSLytldFLRLGKHFTVNRMLRRdAVKVRLEEEEGIsfseFIYPLLQAYDFVyLDVD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 145 THVPvGEDQVQHMELVQDLAQGFNKK--YGEFFPvpesILTSMKkvkslrdpSAKMSKSDPDKlATVRITDSPEEIVQKF 222
Cdd:cd00805   154 LQLG-GSDQRGNITLGRDLIRKLGYKkvVGLTTP----LLTGLD--------GGKMSKSEGNA-IWDPVLDSPYDVYQKI 219


                  ...
gi 2462502115 223 RKA 225
Cdd:cd00805   220 RNA 222
PLN02486 PLN02486
aminoacyl-tRNA ligase
 70-224 7.82e-04

aminoacyl-tRNA ligase


Pssm-ID: 178104  Cd Length: 383  Bit Score: 40.88  E-value: 7.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  70 LLACGINPEKSILFQQSQ-VSehtqlSWILSCMVRLprlqhlhqWKAKTTKQKH-----DGT--VGLLTYPVLQAA---- 137
Cdd:PLN02486  140 IIACGFDVERTFIFSDFDyVG-----GAFYKNMVKI--------AKCVTLNQVRgifgfSGEdnIGKISFPAVQAApsfp 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115 138 ---DILLYKSTH----VPVGEDQVQHMELVQDLAQ--GFNKK---YGEFFPvpesiltsmkkvkSLRDPSAKMSKSDPDk 205
Cdd:PLN02486  207 ssfPHLFGGKDKlrclIPCAIDQDPYFRMTRDVAPrlGYYKPaliESRFFP-------------ALQGESGKMSASDPN- 272

                         170
                  ....*....|....*....
gi 2462502115 206 lATVRITDSPEEIVQKFRK 224
Cdd:PLN02486  273 -SAIYVTDTPKEIKNKINK 290
class_I_aaRS_core cd00802
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ...
 8-202 2.06e-03

catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173901 [Multi-domain]  Cd Length: 143  Bit Score: 37.84  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115   8 VFSGIQPTGILHLGNYLGAIeSWVRLQDEYDSVLYSIVDLHSITvPQDPAVLRQSIldmtavllACGINPEKsilfqqsq 87
Cdd:cd00802     2 TFSGITPNGYLHIGHLRTIV-TFDFLAQAYRKLGYKVRCIALID-DAGGLIGDPAN--------KKGENAKA-------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462502115  88 vsehtqlswilscMVRlprlqhlhQWKAKTTKQkhdgtvglLTYPVLQAADILL---YKSTHVPVGEDQVQHMELVQDLA 164
Cdd:cd00802    64 -------------FVE--------RWIERIKED--------VEYMFLQAADFLLlyeTECDIHLGGSDQLGHIELGLELL 114

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2462502115 165 QGFNKKYgeffpVPESILTSMKKVKSLRdpsaKMSKSD 202
Cdd:cd00802   115 KKAGGPA-----RPFGLTFGRVMGADGT----KMSKSK 143
nt_trans cd02156
nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily ...
 8-74 2.27e-03

nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and the cytidylyltransferases, all of which have a conserved dinucleotide-binding domain.


Pssm-ID: 173912 [Multi-domain]  Cd Length: 105  Bit Score: 37.13  E-value: 2.27e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462502115   8 VFSGIQPtGILHLGNYLGaIESWVRLQDEydsVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACG 74
Cdd:cd02156     2 ARFPGEP-GYLHIGHAKL-ICRAKGIADQ---CVVRIDDNPPVKVWQDPHELEERKESIEEDISVCG 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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