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Conserved domains on  [gi|2462496012|ref|XP_054188719|]
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coagulation factor XIII B chain isoform X4 [Homo sapiens]

Protein Classification

CCP domain-containing protein( domain architecture ID 13332024)

CCP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 182-403 9.86e-25

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 103.96  E-value: 9.86e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 182 TYEEGDVVQFFCHENYYLS--GSDLIQCYNFGWypeSPVCEGRRNRCPPPPLPINSKIQTHSTTYrhGEIVHIECELNFE 259
Cdd:PHA02927   43 NYNIGDTIEYLCLPGYRKQkmGPIYAKCTGTGW---TLFNQCIKRRCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQ 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 260 IHGSAEIRCEDGK-----WT-EPPKCiegqEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG 333
Cdd:PHA02927  118 LIGESKSYCELGStgsmvWNpEAPIC----ESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGG 193

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462496012 334 KWTLPPECveNNENCKHpPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSP--PVCL 403
Cdd:PHA02927  194 EWSDPPTC--QIVKCPH-PTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPelPKCV 262
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 43-280 9.13e-14

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 71.61  E-value: 9.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012  43 CTKPD------LSNGYISDVKLLYKIQENMRYGCASGYKTTGgKDEEVVQCLSDGWSSQPTCRKEHetCLAP-ELYNGNY 115
Cdd:PHA02927   21 CTIPSrpinmkFKNSVETDANANYNIGDTIEYLCLPGYRKQK-MGPIYAKCTGTGWTLFNQCIKRR--CPSPrDIDNGQL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 116 STTQKTFKvkDKVQYECATGYYTAGGKKT--EEVECLTYGWS-LTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF 192
Cdd:PHA02927   98 DIGGVDFG--SSITYSCNSGYQLIGESKSycELGSTGSMVWNpEAPICESVKCQSPPSISNGRHNGYEDFYTDGSVVTYS 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 193 CHENYYLSGSDLIQCYNFGWyPESPVCEgrRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGK 272
Cdd:PHA02927  176 CNSGYSLIGNSGVLCSGGEW-SDPPTCQ--IVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGN 252

                         250
                  ....*....|
gi 2462496012 273 WTEP--PKCI 280
Cdd:PHA02927  253 TWQPelPKCV 262
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 476-530 5.31e-08

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 49.77  E-value: 5.31e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012 476 CTSPPLIKHGVIISSTvDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT-TPPLC 530
Cdd:cd00033     1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 182-403 9.86e-25

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 103.96  E-value: 9.86e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 182 TYEEGDVVQFFCHENYYLS--GSDLIQCYNFGWypeSPVCEGRRNRCPPPPLPINSKIQTHSTTYrhGEIVHIECELNFE 259
Cdd:PHA02927   43 NYNIGDTIEYLCLPGYRKQkmGPIYAKCTGTGW---TLFNQCIKRRCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQ 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 260 IHGSAEIRCEDGK-----WT-EPPKCiegqEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG 333
Cdd:PHA02927  118 LIGESKSYCELGStgsmvWNpEAPIC----ESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGG 193

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462496012 334 KWTLPPECveNNENCKHpPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSP--PVCL 403
Cdd:PHA02927  194 EWSDPPTC--QIVKCPH-PTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPelPKCV 262
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 43-280 9.13e-14

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 71.61  E-value: 9.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012  43 CTKPD------LSNGYISDVKLLYKIQENMRYGCASGYKTTGgKDEEVVQCLSDGWSSQPTCRKEHetCLAP-ELYNGNY 115
Cdd:PHA02927   21 CTIPSrpinmkFKNSVETDANANYNIGDTIEYLCLPGYRKQK-MGPIYAKCTGTGWTLFNQCIKRR--CPSPrDIDNGQL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 116 STTQKTFKvkDKVQYECATGYYTAGGKKT--EEVECLTYGWS-LTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF 192
Cdd:PHA02927   98 DIGGVDFG--SSITYSCNSGYQLIGESKSycELGSTGSMVWNpEAPICESVKCQSPPSISNGRHNGYEDFYTDGSVVTYS 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 193 CHENYYLSGSDLIQCYNFGWyPESPVCEgrRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGK 272
Cdd:PHA02927  176 CNSGYSLIGNSGVLCSGGEW-SDPPTCQ--IVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGN 252

                         250
                  ....*....|
gi 2462496012 273 WTEP--PKCI 280
Cdd:PHA02927  253 TWQPelPKCV 262
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 226-280 7.25e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.86  E-value: 7.25e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012 226 CPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKCI 280
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCtENGGWSpPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 165-219 1.15e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.15  E-value: 1.15e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496012  165 CSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVC 219
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGtWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
165-219 2.47e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.27  E-value: 2.47e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496012 165 CSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVC 219
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGtWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 476-530 5.31e-08

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 49.77  E-value: 5.31e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012 476 CTSPPLIKHGVIISSTvDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT-TPPLC 530
Cdd:cd00033     1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 476-530 4.82e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.14  E-value: 4.82e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012  476 CTSPPLIKHGVIISSTvDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT-TPPLC 530
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
476-530 1.84e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 42.49  E-value: 1.84e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012 476 CTSPPLIKHGVIiSSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT-TPPLC 530
Cdd:pfam00084   1 CPPPPDIPNGKV-SATKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 46-99 3.34e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.98  E-value: 3.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496012  46 PDLSNGYISDVKLLYKIQENMRYGCASGYKTTGgkdEEVVQCLSDG-WS-SQPTCR 99
Cdd:cd00033     5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG---SSTITCTENGgWSpPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 46-98 5.58e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.28  E-value: 5.58e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462496012   46 PDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGkdeEVVQCLSDG-WS-SQPTC 98
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGS---STITCLENGtWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
105-160 7.34e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 37.86  E-value: 7.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462496012 105 CLAPE-LYNGNYSTTQKTFKVKDKVQYECATGYYTAGGkktEEVECLTYG-WS-LTPKC 160
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRLVGS---PTITCQEDGtWSpPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 182-403 9.86e-25

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 103.96  E-value: 9.86e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 182 TYEEGDVVQFFCHENYYLS--GSDLIQCYNFGWypeSPVCEGRRNRCPPPPLPINSKIQTHSTTYrhGEIVHIECELNFE 259
Cdd:PHA02927   43 NYNIGDTIEYLCLPGYRKQkmGPIYAKCTGTGW---TLFNQCIKRRCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQ 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 260 IHGSAEIRCEDGK-----WT-EPPKCiegqEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG 333
Cdd:PHA02927  118 LIGESKSYCELGStgsmvWNpEAPIC----ESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGG 193

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462496012 334 KWTLPPECveNNENCKHpPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSP--PVCL 403
Cdd:PHA02927  194 EWSDPPTC--QIVKCPH-PTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPelPKCV 262
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 226-469 1.39e-19

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 88.94  E-value: 1.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 226 CPPPPLPINSKIQTH-----STTYRHGEIVHIECELNFEIH--GSAEIRCEDGKWTEPPKCIegqeKVACEEPPFIENGA 298
Cdd:PHA02927   21 CTIPSRPINMKFKNSvetdaNANYNIGDTIEYLCLPGYRKQkmGPIYAKCTGTGWTLFNQCI----KRRCPSPRDIDNGQ 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 299 ANLHSKIYynGDKVTYACKSGYLLHGSNEITCNRGK-----WTlPPECVENNENCKHPPVVMNGAvADGILASYATGSSV 373
Cdd:PHA02927   97 LDIGGVDF--GSSITYSCNSGYQLIGESKSYCELGStgsmvWN-PEAPICESVKCQSPPSISNGR-HNGYEDFYTDGSVV 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 374 EYRCNEYYLLRGSKISRCEQGKWSSPPVCLepcTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTplSEL 453
Cdd:PHA02927  173 TYSCNSGYSLIGNSGVLCSGGEWSDPPTCQ---IVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSS--SST 247

                         250
                  ....*....|....*.
gi 2462496012 454 SVQCNRGEVKYPLCTR 469
Cdd:PHA02927  248 CSPGNTWQPELPKCVR 263
PHA02831 PHA02831
EEV host range protein; Provisional
 181-347 5.44e-15

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 75.41  E-value: 5.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 181 QTYEEGDVVQFFCHENYylsGSDLIQCYNFGWYPESpVCEGRRNrCPPPPLPINSKIQTHSTTYRHGEIVHIECELN--- 257
Cdd:PHA02831   38 KVYEENENLEYKCNNNF---DKVFVTCNNGSWSTKN-MCIGKRN-CKDPVTILNGYIKNKKDQYSFGDSVTYACKVNkle 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 258 -FEIHGSAEIRCEDGKWT-EPPKCiegqEKVACEEPPfIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKW 335
Cdd:PHA02831  113 kYSIVGNETVKCINKQWVpKYPVC----KLIRCKYPA-LQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSI 187

                         170
                  ....*....|....
gi 2462496012 336 TLP--PECVENNEN 347
Cdd:PHA02831  188 WYPgiPKCVKDKVH 201
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 102-346 1.30e-14

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 75.12  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 102 HETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTeeveCLTYGWSLTPKCTKLkCSSLRLIENGYFHPVKQ 181
Cdd:PHA02954   18 YSTCTVPTMNNAKLTSTETSFNDKQKVTFTCDSGYYSLDPNAV----CETDKWKYENPCKKM-CTVSDYVSELYDKPLYE 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 182 TYE------EGDVVQFFCHE-NYYLSGSDLIQCYNfgwypespvcegrrNRCPPPPLPINSkIQTHSTTYRHGEIVHIEC 254
Cdd:PHA02954   93 VNStitlicKDETKYFRCEEkNGNTSWNDTVTCPN--------------AECQPLQLEHGS-CQPVKEKYSFGEHITINC 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 255 ELNFEIHGSAEIRCEDGKWTEPPKCiegQEKVaceEPPFIENGAanLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGK 334
Cdd:PHA02954  158 DVGYEVIGASYISCTANSWNVIPSC---QQKC---DIPSLSNGL--ISGSTFSIGGVIHLSCKSGFTLTGSPSSTCIDGK 229

                         250
                  ....*....|...
gi 2462496012 335 WT-LPPECVENNE 346
Cdd:PHA02954  230 WNpVLPICVRSNE 242
PHA02831 PHA02831
EEV host range protein; Provisional
 111-281 5.17e-14

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 72.72  E-value: 5.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 111 YNGNYSTTQKTFKVKDKVQYECATGYYTAGgkkteeVECLTYGWSLTPKCT-KLKCSSLRLIENGYFHPVKQTYEEGDVV 189
Cdd:PHA02831   29 YSNVDSYENKVYEENENLEYKCNNNFDKVF------VTCNNGSWSTKNMCIgKRNCKDPVTILNGYIKNKKDQYSFGDSV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 190 QFFCH----ENYYLSGSDLIQCYNFGWYPESPVCegRRNRCPPPPLPiNSKIQTHSTTYRHGEIVHIECELNFEIHGSAE 265
Cdd:PHA02831  103 TYACKvnklEKYSIVGNETVKCINKQWVPKYPVC--KLIRCKYPALQ-NGFLNVFEKKFYYGDIVNFKCKKGFILLGSSV 179

                         170
                  ....*....|....*...
gi 2462496012 266 IRCEDGKWTEP--PKCIE 281
Cdd:PHA02831  180 STCDINSIWYPgiPKCVK 197
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 43-280 9.13e-14

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 71.61  E-value: 9.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012  43 CTKPD------LSNGYISDVKLLYKIQENMRYGCASGYKTTGgKDEEVVQCLSDGWSSQPTCRKEHetCLAP-ELYNGNY 115
Cdd:PHA02927   21 CTIPSrpinmkFKNSVETDANANYNIGDTIEYLCLPGYRKQK-MGPIYAKCTGTGWTLFNQCIKRR--CPSPrDIDNGQL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 116 STTQKTFKvkDKVQYECATGYYTAGGKKT--EEVECLTYGWS-LTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF 192
Cdd:PHA02927   98 DIGGVDFG--SSITYSCNSGYQLIGESKSycELGSTGSMVWNpEAPICESVKCQSPPSISNGRHNGYEDFYTDGSVVTYS 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 193 CHENYYLSGSDLIQCYNFGWyPESPVCEgrRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGK 272
Cdd:PHA02927  176 CNSGYSLIGNSGVLCSGGEW-SDPPTCQ--IVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGN 252

                         250
                  ....*....|
gi 2462496012 273 WTEP--PKCI 280
Cdd:PHA02927  253 TWQPelPKCV 262
PHA02639 PHA02639
EEV host range protein; Provisional
 163-344 2.18e-13

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 71.23  E-value: 2.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 163 LKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY----NFGWYPESPVCEGRrnRCPPPPLPINSKIQ 238
Cdd:PHA02639   20 IYCDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIkdknNAIWSNKAPFCMLK--ECNDPPSIINGKIY 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 239 THSTTYRHGEIVHIECE----LNFEIHGSAEIRC-EDGKWT-EPPKCiegqEKVACEEPPfIENGAAN--LHSKIYYNGD 310
Cdd:PHA02639   98 NKREMYKVGDEIYYVCNehkgVQYSLVGNEKITCiQDKSWKpDPPIC----KMINCRFPA-LQNGYINgiPSNKKFYYKT 172

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2462496012 311 KVTYACKSGYLLHGSNEITCNRGKWTLP--PECVEN 344
Cdd:PHA02639  173 RVGFSCKSGFDLVGEKYSTCNINATWFPsiPTCVRN 208
PHA02831 PHA02831
EEV host range protein; Provisional
 60-219 3.43e-13

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 70.02  E-value: 3.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012  60 YKIQENMRYGCASGYkttggkDEEVVQCLSDGWSSQPTCRKEhETCLAP-ELYNGNYSTTQKTFKVKDKVQYECATG--- 135
Cdd:PHA02831   40 YEENENLEYKCNNNF------DKVFVTCNNGSWSTKNMCIGK-RNCKDPvTILNGYIKNKKDQYSFGDSVTYACKVNkle 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 136 YYTAGGKKTeeVECLTYGW-SLTPKCTKLKCSSLRLiENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQC-YNFGWY 213
Cdd:PHA02831  113 KYSIVGNET--VKCINKQWvPKYPVCKLIRCKYPAL-QNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCdINSIWY 189


                  ....*.
gi 2462496012 214 PESPVC 219
Cdd:PHA02831  190 PGIPKC 195
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 40-285 6.12e-13

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 70.12  E-value: 6.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012  40 FKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTggkDEEVVqCLSDGWSSQPTCRKEHETC-LAPELYNgnystt 118
Cdd:PHA02954   18 YSTCTVPTMNNAKLTSTETSFNDKQKVTFTCDSGYYSL---DPNAV-CETDKWKYENPCKKMCTVSdYVSELYD------ 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 119 QKTFKVKDKVQYEC--ATGYYtaggkKTEEVECLTyGWSLTPKCTKLKCSSLRLiENGYFHPVKQTYEEGDVVQFFCHEN 196
Cdd:PHA02954   88 KPLYEVNSTITLICkdETKYF-----RCEEKNGNT-SWNDTVTCPNAECQPLQL-EHGSCQPVKEKYSFGEHITINCDVG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 197 YYLSGSDLIQCYNFGWyPESPVCEgrrNRCPPPPLpinSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEP 276
Cdd:PHA02954  161 YEVIGASYISCTANSW-NVIPSCQ---QKCDIPSL---SNGLISGSTFSIGGVIHLSCKSGFTLTGSPSSTCIDGKWNPV 233

                         250
                  ....*....|
gi 2462496012 277 -PKCIEGQEK 285
Cdd:PHA02954  234 lPICVRSNEE 243
PHA02831 PHA02831
EEV host range protein; Provisional
 304-465 1.47e-11

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 65.40  E-value: 1.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 304 KIYYNGDKVTYACKSGYllhGSNEITCNRGKWTLPPECVeNNENCKHPPVVMNGAVADGiLASYATGSSVEYRCN----E 379
Cdd:PHA02831   38 KVYEENENLEYKCNNNF---DKVFVTCNNGSWSTKNMCI-GKRNCKDPVTILNGYIKNK-KDQYSFGDSVTYACKvnklE 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 380 YYLLRGSKISRCEQGKW-SSPPVCLepcTVNVDYMNRNNIEMKwKYEGKVLHGDLIDFVCKQGYDLSpltplSELSVQCN 458
Cdd:PHA02831  113 KYSIVGNETVKCINKQWvPKYPVCK---LIRCKYPALQNGFLN-VFEKKFYYGDIVNFKCKKGFILL-----GSSVSTCD 183


                  ....*..
gi 2462496012 459 RGEVKYP 465
Cdd:PHA02831  184 INSIWYP 190
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 226-280 7.25e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.86  E-value: 7.25e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012 226 CPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKCI 280
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCtENGGWSpPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 165-219 1.15e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.15  E-value: 1.15e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496012  165 CSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVC 219
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGtWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 165-220 1.87e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.70  E-value: 1.87e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012 165 CSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCE 220
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 288-342 2.10e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.32  E-value: 2.10e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012 288 CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR-GKWT-LPPECV 342
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEnGGWSpPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 288-341 3.20e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 3.20e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496012  288 CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWTLP-PEC 341
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITClENGTWSPPpPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 226-279 1.19e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 54.45  E-value: 1.19e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496012  226 CPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKC 279
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITClENGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
165-219 2.47e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.27  E-value: 2.47e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496012 165 CSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVC 219
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGtWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 348-402 2.73e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.24  E-value: 2.73e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012 348 CKHPPVVMNGAVaDGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWS-SPPVC 402
Cdd:cd00033     1 CPPPPVPENGTV-TGSKGSYSYGSTVTYSCNEGYTLVGSSTITCtENGGWSpPPPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 5-219 6.21e-09

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 57.79  E-value: 6.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012   5 KKLSFFCLAGYTTesgrQEEQTTCTTEGWSPEPRCFKKCTKPDlsngYISDV--KLLYKIQENMRYGCASGYKTTGGKDE 82
Cdd:PHA02954   42 QKVTFTCDSGYYS----LDPNAVCETDKWKYENPCKKMCTVSD----YVSELydKPLYEVNSTITLICKDETKYFRCEEK 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012  83 EVvqclSDGWSSQPTCrkEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKteeVECLTYGWSLTPKCTK 162
Cdd:PHA02954  114 NG----NTSWNDTVTC--PNAECQPLQLEHGSCQPVKEKYSFGEHITINCDVGYEVIGASY---ISCTANSWNVIPSCQQ 184

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012 163 lKCsSLRLIENGYFHpvKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVC 219
Cdd:PHA02954  185 -KC-DIPSLSNGLIS--GSTFSIGGVIHLSCKSGFTLTGSPSSTCIDGKWNPVLPIC 237
PHA02639 PHA02639
EEV host range protein; Provisional
 43-219 8.74e-09

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 57.37  E-value: 8.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012  43 CTKPD-LSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQPTCRKEHETCLAPELYNGNYSTTQK 120
Cdd:PHA02639   22 CDKPDdISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAiWSNKAPFCMLKECNDPPSIINGKIYNKRE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 121 TFKVKDKVQYEC----ATGYYTAGgkkTEEVECLT-YGWSLTPKCTKLKCSSLRLIENGYFH--PVKQTYEEGDVVQFFC 193
Cdd:PHA02639  102 MYKVGDEIYYVCnehkGVQYSLVG---NEKITCIQdKSWKPDPPICKMINCRFPALQNGYINgiPSNKKFYYKTRVGFSC 178

                         170       180
                  ....*....|....*....|....*..
gi 2462496012 194 HENYYLSGSDLIQC-YNFGWYPESPVC 219
Cdd:PHA02639  179 KSGFDLVGEKYSTCnINATWFPSIPTC 205
PHA02817 PHA02817
EEV Host range protein; Provisional
 224-345 1.55e-08

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 55.72  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 224 NRCPPPPLPINSKIQTHSTTYRHGEIVHIECELN-----FEIHGSAEIRCE-DGKWT-EPPKCiegqEKVACEEPPfIEN 296
Cdd:PHA02817   22 NKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEkDGKWNkEFPVC----KIIRCRFPA-LQN 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462496012 297 GAAN--LHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLP--PECVENN 345
Cdd:PHA02817   97 GFVNgiPDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPkvPICSRDN 149
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 476-530 5.31e-08

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 49.77  E-value: 5.31e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012 476 CTSPPLIKHGVIISSTvDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT-TPPLC 530
Cdd:cd00033     1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 280-465 5.63e-08

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 54.67  E-value: 5.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 280 IEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC----NRGKWT-LPPECVEnnENCKHPPVV 354
Cdd:PHA02639   14 VHGVKSIYCDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCikdkNNAIWSnKAPFCML--KECNDPPSI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 355 MNGAVADGiLASYATGSSVEYRCNEY----YLLRGSKISRCEQGK-WS-SPPVC-LEPC---TVNVDYMNRNNIEMKWKY 424
Cdd:PHA02639   92 INGKIYNK-REMYKVGDEIYYVCNEHkgvqYSLVGNEKITCIQDKsWKpDPPICkMINCrfpALQNGYINGIPSNKKFYY 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2462496012 425 EGKVlhgdliDFVCKQGYDLspltpLSELSVQCNRGEVKYP 465
Cdd:PHA02639  171 KTRV------GFSCKSGFDL-----VGEKYSTCNINATWFP 200
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 306-530 1.80e-07

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 52.73  E-value: 1.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 306 YYNGDKVTYACKSGYLLH--GSNEITCNRGKWTLPPECVEnnENCKHPPVVMNGAVADGilaSYATGSSVEYRCNEYYLL 383
Cdd:PHA02927   44 YNIGDTIEYLCLPGYRKQkmGPIYAKCTGTGWTLFNQCIK--RRCPSPRDIDNGQLDIG---GVDFGSSITYSCNSGYQL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 384 RGSKISRCEQGKWSSppvclepctvnvdymnrnnieMKWkyegkvlhgdlidfvckqgydlSPLTPLSElSVQCNrgevk 463
Cdd:PHA02927  119 IGESKSYCELGSTGS---------------------MVW----------------------NPEAPICE-SVKCQ----- 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012 464 yplctrkeskgmctSPPLIKHGVIiSSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLC 530
Cdd:PHA02927  150 --------------SPPSISNGRH-NGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPTC 201
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 348-402 1.92e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.91  E-value: 1.92e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012  348 CKHPPVVMNGAVADGIlASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWS-SPPVC 402
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITClENGTWSpPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 160-227 2.11e-07

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 52.25  E-value: 2.11e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462496012 160 CTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHEN-----YYLSGSDLIQCYNFG-WYPESPVCEGRRNRCP 227
Cdd:PHA02817   19 CDLNKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGkWNKEFPVCKIIRCRFP 92
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 476-530 4.82e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.14  E-value: 4.82e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012  476 CTSPPLIKHGVIISSTvDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT-TPPLC 530
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 288-419 1.76e-06

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 49.55  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012 288 CEEPPFIENGAANLHSKIYYNGDKVTYACKSG-----YLLHGSNEITCNR-GKWTL-PPECveNNENCKHPpVVMNGAVa 360
Cdd:PHA02817   24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKdGKWNKeFPVC--KIIRCRFP-ALQNGFV- 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462496012 361 DGILAS--YATGSSVEYRCNEYYLLRGSKISRCEQGKWSSP--PVCLE-PCTVNVDYMNRNNIE 419
Cdd:PHA02817  100 NGIPDSkkFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPkvPICSRdNITYNKIYINKVNID 163
Sushi pfam00084
Sushi repeat (SCR repeat);
226-279 2.00e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.18  E-value: 2.00e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496012 226 CPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKC 279
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCqEDGTWSpPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
288-341 3.26e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.41  E-value: 3.26e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496012 288 CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWTLP-PEC 341
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCqEDGTWSPPfPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 41-142 5.61e-06

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 48.01  E-value: 5.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012  41 KKCTKPDLSNGYISDVKLLYKIQENMRYGCASG-----YKTTGgkdEEVVQCLSDG-WSSQPTcRKEHETCLAPELYNG- 113
Cdd:PHA02817   23 KCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVG---EKNIICEKDGkWNKEFP-VCKIIRCRFPALQNGf 98

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462496012 114 -NYSTTQKTFKVKDKVQYECATGYYTAGGK 142
Cdd:PHA02817   99 vNGIPDSKKFYYESEVSFSCKPGFVLIGTK 128
Sushi pfam00084
Sushi repeat (SCR repeat);
476-530 1.84e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 42.49  E-value: 1.84e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012 476 CTSPPLIKHGVIiSSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT-TPPLC 530
Cdd:pfam00084   1 CPPPPDIPNGKV-SATKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 27-140 1.99e-05

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 1.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012  27 TCTTEGWSPEPRCFKK--CTKP-DLSNGYISDVKLLYKIQENMRYGCA----SGYKTTGgkdEEVVQCLSDGW-SSQPTC 98
Cdd:PHA02831   60 TCNNGSWSTKNMCIGKrnCKDPvTILNGYIKNKKDQYSFGDSVTYACKvnklEKYSIVG---NETVKCINKQWvPKYPVC 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462496012  99 RKEHetCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAG 140
Cdd:PHA02831  137 KLIR--CKYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLG 176
Sushi pfam00084
Sushi repeat (SCR repeat);
348-402 4.81e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 41.33  E-value: 4.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496012 348 CKHPPVVMNGAVAdGILASYATGSSVEYRCNEYYLLRGSKISRCEQ-GKWSSP-PVC 402
Cdd:pfam00084   1 CPPPPDIPNGKVS-ATKNEYNYGASVSYECDPGYRLVGSPTITCQEdGTWSPPfPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 46-99 3.34e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.98  E-value: 3.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496012  46 PDLSNGYISDVKLLYKIQENMRYGCASGYKTTGgkdEEVVQCLSDG-WS-SQPTCR 99
Cdd:cd00033     5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG---SSTITCTENGgWSpPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 46-98 5.58e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.28  E-value: 5.58e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462496012   46 PDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGkdeEVVQCLSDG-WS-SQPTC 98
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGS---STITCLENGtWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
105-160 7.34e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 37.86  E-value: 7.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462496012 105 CLAPE-LYNGNYSTTQKTFKVKDKVQYECATGYYTAGGkktEEVECLTYG-WS-LTPKC 160
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRLVGS---PTITCQEDGtWSpPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 108-160 7.79e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 37.83  E-value: 7.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462496012 108 PELYNGNYSTTQKTFKVKDKVQYECATGYYTAGgkkTEEVECLTYG-WS-LTPKC 160
Cdd:cd00033     5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG---SSTITCTENGgWSpPPPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 27-131 7.89e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 42.00  E-value: 7.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496012  27 TCTTEGWSPEPRCFKKCTKPDLSNGYISDVKllYKIQENMRYGCASGYKTTGGKDEevvQCLSDGWSS-QPTCRKEHETC 105
Cdd:PHA02954  170 SCTANSWNVIPSCQQKCDIPSLSNGLISGST--FSIGGVIHLSCKSGFTLTGSPSS---TCIDGKWNPvLPICVRSNEEF 244

                          90       100
                  ....*....|....*....|....*.
gi 2462496012 106 LAPElyNGNYSTTQKTFKVKDKVQYE 131
Cdd:PHA02954  245 DPVD--DGPDDETDLSKLSKDVVQYE 268
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 108-160 9.40e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.51  E-value: 9.40e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462496012  108 PELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGkktEEVECLTYG-WS-LTPKC 160
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGS---STITCLENGtWSpPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 7-78 1.61e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 40.79  E-value: 1.61e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496012   7 LSFFCLAGYTT--ESGrqeeqTTCTTEGWSPEPRC-FKKCTKPDLSNGYISD-VKLLYKIQENMRYGCASGYKTTG 78
Cdd:PHA02927  172 VTYSCNSGYSLigNSG-----VLCSGGEWSDPPTCqIVKCPHPTISNGYLSSgFKRSYSYNDNVDFKCKYGYKLSG 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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