NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462496000|ref|XP_054188713|]
View 

complement factor H-related protein 4 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 92-281 3.37e-13

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 69.30  E-value: 3.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000  92 DVEIENGFISESSSIYILNEETQYNCKPGYATadgNSSGSI--TCLQNGWSTQPICIKF-CDMPV-FENSRAKSNGMWFK 167
Cdd:PHA02927   29 NMKFKNSVETDANANYNIGDTIEYLCLPGYRK---QKMGPIyaKCTGTGWTLFNQCIKRrCPSPRdIDNGQLDIGGVDFG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 168 lhDTLDYECYDGYESsYGNTTDSIVCGEDG---WS-HLPTCynSSENCGPPPPISNGDTTSFpQKVYLPWSRVEYQCQSY 243
Cdd:PHA02927  106 --SSITYSCNSGYQL-IGESKSYCELGSTGsmvWNpEAPIC--ESVKCQSPPSISNGRHNGY-EDFYTDGSVVTYSCNSG 179

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2462496000 244 YELQGSKYVTCSNGDWSEPPRCISMKpCEFPEIQHGHL 281
Cdd:PHA02927  180 YSLIGNSGVLCSGGEWSDPPTCQIVK-CPHPTISNGYL 216
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 236-451 8.02e-09

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 56.20  E-value: 8.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 236 VEYQCQSYYELQ--GSKYVTCSNGDWSEPPRCISMKpCEFP-EIQHGHLYYENtrrpyfpVATGQSYSYYCDQNF--VTP 310
Cdd:PHA02927   50 IEYLCLPGYRKQkmGPIYAKCTGTGWTLFNQCIKRR-CPSPrDIDNGQLDIGG-------VDFGSSITYSCNSGYqlIGE 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 311 SGSYWDYIHCTQDGWLPTVP-CLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATAdGNSSgsITCLQNGWSAQ 389
Cdd:PHA02927  122 SKSYCELGSTGSMVWNPEAPiCESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI-GNSG--VLCSGGEWSDP 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462496000 390 PIC-IKFCDMPVFENSRAKSNGMR-FKLHDTLDYECYDGYEISyGNTTGSIVCGEDGWSHFPTC 451
Cdd:PHA02927  199 PTCqIVKCPHPTISNGYLSSGFKRsYSYNDNVDFKCKYGYKLS-GSSSSTCSPGNTWQPELPKC 261
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 92-281 3.37e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 69.30  E-value: 3.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000  92 DVEIENGFISESSSIYILNEETQYNCKPGYATadgNSSGSI--TCLQNGWSTQPICIKF-CDMPV-FENSRAKSNGMWFK 167
Cdd:PHA02927   29 NMKFKNSVETDANANYNIGDTIEYLCLPGYRK---QKMGPIyaKCTGTGWTLFNQCIKRrCPSPRdIDNGQLDIGGVDFG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 168 lhDTLDYECYDGYESsYGNTTDSIVCGEDG---WS-HLPTCynSSENCGPPPPISNGDTTSFpQKVYLPWSRVEYQCQSY 243
Cdd:PHA02927  106 --SSITYSCNSGYQL-IGESKSYCELGSTGsmvWNpEAPIC--ESVKCQSPPSISNGRHNGY-EDFYTDGSVVTYSCNSG 179

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2462496000 244 YELQGSKYVTCSNGDWSEPPRCISMKpCEFPEIQHGHL 281
Cdd:PHA02927  180 YSLIGNSGVLCSGGEWSDPPTCQIVK-CPHPTISNGYL 216
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 211-266 2.55e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 52.85  E-value: 2.55e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462496000 211 CGPPPPISNGDTTSfPQKVYLPWSRVEYQCQSYYELQGSKYVTC-SNGDWS-EPPRCI 266
Cdd:cd00033     1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGSSTITCtENGGWSpPPPTCE 57
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 236-451 8.02e-09

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 56.20  E-value: 8.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 236 VEYQCQSYYELQ--GSKYVTCSNGDWSEPPRCISMKpCEFP-EIQHGHLYYENtrrpyfpVATGQSYSYYCDQNF--VTP 310
Cdd:PHA02927   50 IEYLCLPGYRKQkmGPIYAKCTGTGWTLFNQCIKRR-CPSPrDIDNGQLDIGG-------VDFGSSITYSCNSGYqlIGE 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 311 SGSYWDYIHCTQDGWLPTVP-CLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATAdGNSSgsITCLQNGWSAQ 389
Cdd:PHA02927  122 SKSYCELGSTGSMVWNPEAPiCESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI-GNSG--VLCSGGEWSDP 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462496000 390 PIC-IKFCDMPVFENSRAKSNGMR-FKLHDTLDYECYDGYEISyGNTTGSIVCGEDGWSHFPTC 451
Cdd:PHA02927  199 PTCqIVKCPHPTISNGYLSSGFKRsYSYNDNVDFKCKYGYKLS-GSSSSTCSPGNTWQPELPKC 261
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 211-265 2.02e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.52  E-value: 2.02e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496000  211 CGPPPPISNGDTTSfPQKVYLPWSRVEYQCQSYYELQGSKYVTC-SNGDWS-EPPRC 265
Cdd:smart00032   1 CPPPPDIENGTVTS-SSGTYSYGDTVTYSCDPGYTLIGSSTITClENGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
211-265 7.60e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 43.26  E-value: 7.60e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496000 211 CGPPPPISNGDTTSfPQKVYLPWSRVEYQCQSYYELQGSKYVTCS-NGDWS-EPPRC 265
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 341-393 2.44e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.98  E-value: 2.44e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462496000 341 EIENGFISESSSIYILNKEIQYKCKPGYATadgNSSGSITCLQNG-WS-AQPICI 393
Cdd:cd00033     6 VPENGTVTGSKGSYSYGSTVTYSCNEGYTL---VGSSTITCTENGgWSpPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 341-392 7.50e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.51  E-value: 7.50e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462496000  341 EIENGFISESSSIYILNKEIQYKCKPGYATadgNSSGSITCLQNG-WS-AQPIC 392
Cdd:smart00032   6 DIENGTVTSSSGTYSYGDTVTYSCDPGYTL---IGSSTITCLENGtWSpPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 92-281 3.37e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 69.30  E-value: 3.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000  92 DVEIENGFISESSSIYILNEETQYNCKPGYATadgNSSGSI--TCLQNGWSTQPICIKF-CDMPV-FENSRAKSNGMWFK 167
Cdd:PHA02927   29 NMKFKNSVETDANANYNIGDTIEYLCLPGYRK---QKMGPIyaKCTGTGWTLFNQCIKRrCPSPRdIDNGQLDIGGVDFG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 168 lhDTLDYECYDGYESsYGNTTDSIVCGEDG---WS-HLPTCynSSENCGPPPPISNGDTTSFpQKVYLPWSRVEYQCQSY 243
Cdd:PHA02927  106 --SSITYSCNSGYQL-IGESKSYCELGSTGsmvWNpEAPIC--ESVKCQSPPSISNGRHNGY-EDFYTDGSVVTYSCNSG 179

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2462496000 244 YELQGSKYVTCSNGDWSEPPRCISMKpCEFPEIQHGHL 281
Cdd:PHA02927  180 YSLIGNSGVLCSGGEWSDPPTCQIVK-CPHPTISNGYL 216
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 70-266 2.00e-11

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 64.29  E-value: 2.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000  70 YIHCTQDGWSPTVPCLRTCSKSDVEIENGFISESSSIYilNEETQYNCKPGY-------ATADGNSSGSITclqngWSTQ 142
Cdd:PHA02927   67 YAKCTGTGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYqligeskSYCELGSTGSMV-----WNPE 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 143 -PIC--IKFCDMPVFENSRAKSNGMWFKLHDTLDYECYDGYeSSYGNTtdSIVCGEDGWSHLPTCynSSENCgPPPPISN 219
Cdd:PHA02927  140 aPICesVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGY-SLIGNS--GVLCSGGEWSDPPTC--QIVKC-PHPTISN 213

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2462496000 220 GDTTSFPQKVYLPWSRVEYQCQSYYELQGSKYVTCSNGDWSEP--PRCI 266
Cdd:PHA02927  214 GYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPelPKCV 262
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 211-266 2.55e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 52.85  E-value: 2.55e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462496000 211 CGPPPPISNGDTTSfPQKVYLPWSRVEYQCQSYYELQGSKYVTC-SNGDWS-EPPRCI 266
Cdd:cd00033     1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGSSTITCtENGGWSpPPPTCE 57
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 236-451 8.02e-09

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 56.20  E-value: 8.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 236 VEYQCQSYYELQ--GSKYVTCSNGDWSEPPRCISMKpCEFP-EIQHGHLYYENtrrpyfpVATGQSYSYYCDQNF--VTP 310
Cdd:PHA02927   50 IEYLCLPGYRKQkmGPIYAKCTGTGWTLFNQCIKRR-CPSPrDIDNGQLDIGG-------VDFGSSITYSCNSGYqlIGE 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 311 SGSYWDYIHCTQDGWLPTVP-CLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATAdGNSSgsITCLQNGWSAQ 389
Cdd:PHA02927  122 SKSYCELGSTGSMVWNPEAPiCESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI-GNSG--VLCSGGEWSDP 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462496000 390 PIC-IKFCDMPVFENSRAKSNGMR-FKLHDTLDYECYDGYEISyGNTTGSIVCGEDGWSHFPTC 451
Cdd:PHA02927  199 PTCqIVKCPHPTISNGYLSSGFKRsYSYNDNVDFKCKYGYKLS-GSSSSTCSPGNTWQPELPKC 261
PHA02639 PHA02639
EEV host range protein; Provisional
 88-272 6.62e-08

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 53.90  E-value: 6.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000  88 CSKSDvEIENGFISESSSIYILNEETQYNCKPGYATADGNSSGSITCLQNG-WSTQ-PIC-IKFC-DMPVFENSRAKSNG 163
Cdd:PHA02639   22 CDKPD-DISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAiWSNKaPFCmLKECnDPPSIINGKIYNKR 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 164 MWFKLHDTLDYECYDGYESSYGNT-TDSIVCGED-GWS-HLPTCynSSENCgPPPPISNGDTTSFP-QKVYLPWSRVEYQ 239
Cdd:PHA02639  101 EMYKVGDEIYYVCNEHKGVQYSLVgNEKITCIQDkSWKpDPPIC--KMINC-RFPALQNGYINGIPsNKKFYYKTRVGFS 177

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2462496000 240 CQSYYELQGSKYVTCS-NGDW-SEPPRCISMKPCE 272
Cdd:PHA02639  178 CKSGFDLVGEKYSTCNiNATWfPSIPTCVRNKPID 212
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 211-265 2.02e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.52  E-value: 2.02e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496000  211 CGPPPPISNGDTTSfPQKVYLPWSRVEYQCQSYYELQGSKYVTC-SNGDWS-EPPRC 265
Cdd:smart00032   1 CPPPPDIENGTVTS-SSGTYSYGDTVTYSCDPGYTLIGSSTITClENGTWSpPPPTC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 224-394 1.60e-06

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 49.61  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 224 SFPQKVYLPWSRVEYQCQSYYElqgSKYVTCSNGDWSEPPRCISMKPCEFP-EIQHGhlYYENTRRPYfpvATGQSYSYY 302
Cdd:PHA02831   34 SYENKVYEENENLEYKCNNNFD---KVFVTCNNGSWSTKNMCIGKRNCKDPvTILNG--YIKNKKDQY---SFGDSVTYA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 303 CDQNFVTP-SGSYWDYIHCTQDGWLPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSgsiTC 381
Cdd:PHA02831  106 CKVNKLEKySIVGNETVKCINKQWVPKYPVCKLIRCKYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVS---TC 182

                         170
                  ....*....|....*
gi 2462496000 382 LQNG--WSAQPICIK 394
Cdd:PHA02831  183 DINSiwYPGIPKCVK 197
Sushi pfam00084
Sushi repeat (SCR repeat);
211-265 7.60e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 43.26  E-value: 7.60e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496000 211 CGPPPPISNGDTTSfPQKVYLPWSRVEYQCQSYYELQGSKYVTCS-NGDWS-EPPRC 265
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 204-351 4.61e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 44.55  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 204 CYNSSENCGPPPPISNGDTTSfPQKVYLPWSRVEYQCQSY-----YELQGSKYVTCS-NGDWS-EPPRCiSMKPCEFPEI 276
Cdd:PHA02817   17 SLCDLNKCCYPPSIKNGYIYN-KKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEkDGKWNkEFPVC-KIIRCRFPAL 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496000 277 QHGHLY-YENTRRPYFPvatgQSYSYYCDQNFVTPSGSYwdYIHCTQDGWLPTVPclrTCSKSDIEIENGFISESS 351
Cdd:PHA02817   95 QNGFVNgIPDSKKFYYE----SEVSFSCKPGFVLIGTKY--SVCGINSSWIPKVP---ICSRDNITYNKIYINKVN 161
PHA02831 PHA02831
EEV host range protein; Provisional
 84-266 5.96e-05

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 44.60  E-value: 5.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000  84 CLRTCSKSDVEIENgFISESSSIYILNEETQYNCKPGYatadgnSSGSITCLQNGWSTQPICI--KFCDMPV-FENSRAK 160
Cdd:PHA02831   18 CICVFNKNDAKYSN-VDSYENKVYEENENLEYKCNNNF------DKVFVTCNNGSWSTKNMCIgkRNCKDPVtILNGYIK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 161 SNGMWFKLHDTLDYECYDGYESSY---GNTTdsIVCGEDGW-SHLPTCynSSENCgPPPPISNGDTTSFPQKVYLPwSRV 236
Cdd:PHA02831   91 NKKDQYSFGDSVTYACKVNKLEKYsivGNET--VKCINKQWvPKYPVC--KLIRC-KYPALQNGFLNVFEKKFYYG-DIV 164

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462496000 237 EYQCQSYYELQGSKYVTCS-NGDW-SEPPRCI 266
Cdd:PHA02831  165 NFKCKKGFILLGSSVSTCDiNSIWyPGIPKCV 196
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 149-394 1.03e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 44.31  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 149 CDMPVFENSRAKSNGMWFKLHDTLDYECYDGYESSYGNTtdsiVCGEDGWSHLPTCYNSSEncgppppISNGDTTSFPQK 228
Cdd:PHA02954   21 CTVPTMNNAKLTSTETSFNDKQKVTFTCDSGYYSLDPNA----VCETDKWKYENPCKKMCT-------VSDYVSELYDKP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 229 VYLPWSRVEYQCQSYyelqgSKYVTCS----NGDWSEPPRCISMKpCEFPEIQHGHLyyENTRRPYfpvATGQSYSYYCD 304
Cdd:PHA02954   90 LYEVNSTITLICKDE-----TKYFRCEekngNTSWNDTVTCPNAE-CQPLQLEHGSC--QPVKEKY---SFGEHITINCD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 305 QNFVTPSGSywdYIHCTQDGWLPTVPCLRTCSKSdiEIENGFISESSsiYILNKEIQYKCKPGYATADGNSSgsiTCLQN 384
Cdd:PHA02954  159 VGYEVIGAS---YISCTANSWNVIPSCQQKCDIP--SLSNGLISGST--FSIGGVIHLSCKSGFTLTGSPSS---TCIDG 228

                         250
                  ....*....|.
gi 2462496000 385 GWS-AQPICIK 394
Cdd:PHA02954  229 KWNpVLPICVR 239
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 78-213 2.28e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 43.15  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000  78 WSPTVPCLRTCSKSdVEIENGFISESSSIYILNEETQYNCKPGYATAdgnSSGSITCLQNGWSTQPICIKFCDMPVFENS 157
Cdd:PHA02954  119 WNDTVTCPNAECQP-LQLEHGSCQPVKEKYSFGEHITINCDVGYEVI---GASYISCTANSWNVIPSCQQKCDIPSLSNG 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496000 158 RAksNGMWFKLHDTLDYECYDGYESSygnTTDSIVCGEDGWSH-LPTCYNSSENCGP 213
Cdd:PHA02954  195 LI--SGSTFSIGGVIHLSCKSGFTLT---GSPSSTCIDGKWNPvLPICVRSNEEFDP 246
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 341-393 2.44e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.98  E-value: 2.44e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462496000 341 EIENGFISESSSIYILNKEIQYKCKPGYATadgNSSGSITCLQNG-WS-AQPICI 393
Cdd:cd00033     6 VPENGTVTGSKGSYSYGSTVTYSCNEGYTL---VGSSTITCTENGgWSpPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 94-146 5.53e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 37.83  E-value: 5.53e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462496000  94 EIENGFISESSSIYILNEETQYNCKPGYATadgNSSGSITCLQNG-WS-TQPICI 146
Cdd:cd00033     6 VPENGTVTGSKGSYSYGSTVTYSCNEGYTL---VGSSTITCTENGgWSpPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 341-392 7.50e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.51  E-value: 7.50e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462496000  341 EIENGFISESSSIYILNKEIQYKCKPGYATadgNSSGSITCLQNG-WS-AQPIC 392
Cdd:smart00032   6 DIENGTVTSSSGTYSYGDTVTYSCDPGYTL---IGSSTITCLENGtWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 94-145 1.47e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 36.74  E-value: 1.47e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462496000   94 EIENGFISESSSIYILNEETQYNCKPGYATadgNSSGSITCLQNG-WS-TQPIC 145
Cdd:smart00032   6 DIENGTVTSSSGTYSYGDTVTYSCDPGYTL---IGSSTITCLENGtWSpPPPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 50-279 2.46e-03

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 39.68  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000  50 QSYSYYCDQNFVTPSGSywdyIHCTQDGWSPTVPCLRTCSKSDV--EIENGFISESSSIYIL--NEETQY-NCKpgyaTA 124
Cdd:PHA02954   42 QKVTFTCDSGYYSLDPN----AVCETDKWKYENPCKKMCTVSDYvsELYDKPLYEVNSTITLicKDETKYfRCE----EK 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 125 DGNSSGSITCLQNGWSTQPICIKFCD-MPVFENsraksngmwFKLHDTLDYECYDGYE---SSYgnttdsIVCGEDGWSH 200
Cdd:PHA02954  114 NGNTSWNDTVTCPNAECQPLQLEHGScQPVKEK---------YSFGEHITINCDVGYEvigASY------ISCTANSWNV 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 201 LPTCYNSSENCGPPPPISNGDTTSFPQKVYLpwsrveyQCQSYYELQGSKYVTCSNGDWSEP-PRCISMKPcEFPEIQHG 279
Cdd:PHA02954  179 IPSCQQKCDIPSLSNGLISGSTFSIGGVIHL-------SCKSGFTLTGSPSSTCIDGKWNPVlPICVRSNE-EFDPVDDG 250
PHA02639 PHA02639
EEV host range protein; Provisional
 209-340 2.67e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 39.65  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 209 ENCGPPPPISNGDTTSfPQKVYLPWSRVEYQCQSY----YELQGSKYVTCS-NGDWSEPPRCISMKPCEFPEIQHGHLY- 282
Cdd:PHA02639   83 KECNDPPSIINGKIYN-KREMYKVGDEIYYVCNEHkgvqYSLVGNEKITCIqDKSWKPDPPICKMINCRFPALQNGYINg 161

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 283 YENTRRPYFPVATGqsysYYCDQNFVTPSGSYWDyihCTQDG-WLPTVP-CLRTCSKSDI 340
Cdd:PHA02639  162 IPSNKKFYYKTRVG----FSCKSGFDLVGEKYST---CNINAtWFPSIPtCVRNKPIDDI 214
PHA02817 PHA02817
EEV Host range protein; Provisional
 265-395 4.30e-03

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 38.77  E-value: 4.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496000 265 CISMKPCEFPEIQHGHLYyeNTRRPYfpvATGQSYSYYCDQNFVTPSGSYW--DYIHCTQDG-WLPTVPCLRTCSKSDIE 341
Cdd:PHA02817   19 CDLNKCCYPPSIKNGYIY--NKKTEY---NIGSNVTFFCGNNTRGVRYTLVgeKNIICEKDGkWNKEFPVCKIIRCRFPA 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496000 342 IENGFIS--ESSSIYILNKEIQYKCKPGYATAdgNSSGSITCLQNGWSAQ-PICIKF 395
Cdd:PHA02817   94 LQNGFVNgiPDSKKFYYESEVSFSCKPGFVLI--GTKYSVCGINSSWIPKvPICSRD 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH