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Conserved domains on  [gi|2462498238|ref|XP_054187726|]
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protein ENTREP2 isoform X7 [Homo sapiens]

Protein Classification

CD20-like domain-containing protein( domain architecture ID 10513721)

CD20-like domain-containing protein similar to Homo sapiens B-lymphocyte antigen CD20 that may be involved in the regulation of B-cell activation and proliferation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD20 pfam04103
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 34-176 5.62e-16

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


:

Pssm-ID: 461174  Cd Length: 155  Bit Score: 74.99  E-value: 5.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  34 ALGATQMALGCLIVAVSFAALALTTSARVRHsCPFWAGFSVLLSGLIGVVSWKRPLSLVITFFMLLSAVCVMLNLAGSIL 113
Cdd:pfam04103   1 VLGVVQILLGLLSIVLGFILYSVSSSLLASG-YPFWGGIIFIISGVLGIAAEKRSTKLLVLLSLLLNLLSLFTAVAGIIL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462498238 114 SCQN-AQLVNSLEGCQLIK--FDSVEVCVCCELQHQSSGCSnlgetlKLNPLQENCNAVRLTLKFL 176
Cdd:pfam04103  80 LSLSlALLTSAHECCMSESdlTPSTSTCSCKSSSEDPECRA------YCSSLRGLFTGILSMLLIL 139
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 235-442 4.75e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 4.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  235 APSPFGTLYDVAINSPGLLYPAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVpadstsllvseGTAT 314
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPG-----------GPAR 2756

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  315 PGSSPSPDGPVGAPAPSEPALPPGRVSPEDPGMGSQVQPGPGHVSRSTSDPTL-CTSSMAGDASSHRPSCSQDLEAGLSE 393
Cdd:PHA03247  2757 PARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAaVLAPAAALPPAASPAGPLPPPTSAQP 2836

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2462498238  394 AVPGSASMSRSATAACRAQLSPAGDpdtwkTDQRPTPEPFPATSKERPR 442
Cdd:PHA03247  2837 TAPPPPPGPPPPSLPLGGSVAPGGD-----VRRRPPSRSPAAKPAAPAR 2880
 
Name Accession Description Interval E-value
CD20 pfam04103
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 34-176 5.62e-16

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


Pssm-ID: 461174  Cd Length: 155  Bit Score: 74.99  E-value: 5.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  34 ALGATQMALGCLIVAVSFAALALTTSARVRHsCPFWAGFSVLLSGLIGVVSWKRPLSLVITFFMLLSAVCVMLNLAGSIL 113
Cdd:pfam04103   1 VLGVVQILLGLLSIVLGFILYSVSSSLLASG-YPFWGGIIFIISGVLGIAAEKRSTKLLVLLSLLLNLLSLFTAVAGIIL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462498238 114 SCQN-AQLVNSLEGCQLIK--FDSVEVCVCCELQHQSSGCSnlgetlKLNPLQENCNAVRLTLKFL 176
Cdd:pfam04103  80 LSLSlALLTSAHECCMSESdlTPSTSTCSCKSSSEDPECRA------YCSSLRGLFTGILSMLLIL 139
PHA03247 PHA03247
large tegument protein UL36; Provisional
 235-442 4.75e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 4.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  235 APSPFGTLYDVAINSPGLLYPAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVpadstsllvseGTAT 314
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPG-----------GPAR 2756

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  315 PGSSPSPDGPVGAPAPSEPALPPGRVSPEDPGMGSQVQPGPGHVSRSTSDPTL-CTSSMAGDASSHRPSCSQDLEAGLSE 393
Cdd:PHA03247  2757 PARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAaVLAPAAALPPAASPAGPLPPPTSAQP 2836

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2462498238  394 AVPGSASMSRSATAACRAQLSPAGDpdtwkTDQRPTPEPFPATSKERPR 442
Cdd:PHA03247  2837 TAPPPPPGPPPPSLPLGGSVAPGGD-----VRRRPPSRSPAAKPAAPAR 2880
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 251-432 1.49e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238 251 GLLYPAELPPPYEAVVGQP-PASQVTSIGQQVAESSSGDPNTSAGFSTPVpadstSLLVSEGTATPGSSPSPDGPVgAPA 329
Cdd:pfam03154 179 GAASPPSPPPPGTTQAATAgPTPSAPSVPPQGSPATSQPPNQTQSTAAPH-----TLIQQTPTLHPQRLPSPHPPL-QPM 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238 330 PSEPalPPGRVSPE---DPGMGSQVQPGPGHVSrstSDPTLCTSSMAGDASSHRPSCSQ-DLEAGLSEAVPGSASmSRSA 405
Cdd:pfam03154 253 TQPP--PPSQVSPQplpQPSLHGQMPPMPHSLQ---TGPSHMQHPVPPQPFPLTPQSSQsQVPPGPSPAAPGQSQ-QRIH 326

                         170       180
                  ....*....|....*....|....*..
gi 2462498238 406 TAACRAQLSPAGDPDTWKTDQRPTPEP 432
Cdd:pfam03154 327 TPPSQSQLQSQQPPREQPLPPAPLSMP 353
 
Name Accession Description Interval E-value
CD20 pfam04103
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 34-176 5.62e-16

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


Pssm-ID: 461174  Cd Length: 155  Bit Score: 74.99  E-value: 5.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  34 ALGATQMALGCLIVAVSFAALALTTSARVRHsCPFWAGFSVLLSGLIGVVSWKRPLSLVITFFMLLSAVCVMLNLAGSIL 113
Cdd:pfam04103   1 VLGVVQILLGLLSIVLGFILYSVSSSLLASG-YPFWGGIIFIISGVLGIAAEKRSTKLLVLLSLLLNLLSLFTAVAGIIL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462498238 114 SCQN-AQLVNSLEGCQLIK--FDSVEVCVCCELQHQSSGCSnlgetlKLNPLQENCNAVRLTLKFL 176
Cdd:pfam04103  80 LSLSlALLTSAHECCMSESdlTPSTSTCSCKSSSEDPECRA------YCSSLRGLFTGILSMLLIL 139
PHA03247 PHA03247
large tegument protein UL36; Provisional
 235-442 4.75e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 4.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  235 APSPFGTLYDVAINSPGLLYPAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVpadstsllvseGTAT 314
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPG-----------GPAR 2756

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  315 PGSSPSPDGPVGAPAPSEPALPPGRVSPEDPGMGSQVQPGPGHVSRSTSDPTL-CTSSMAGDASSHRPSCSQDLEAGLSE 393
Cdd:PHA03247  2757 PARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAaVLAPAAALPPAASPAGPLPPPTSAQP 2836

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2462498238  394 AVPGSASMSRSATAACRAQLSPAGDpdtwkTDQRPTPEPFPATSKERPR 442
Cdd:PHA03247  2837 TAPPPPPGPPPPSLPLGGSVAPGGD-----VRRRPPSRSPAAKPAAPAR 2880
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 287-454 1.20e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 1.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  287 GDPNTSAGFSTPVPADSTSLLVSEGTATPGSS--------PSPDGPVGAPAPSEPALPPGRVSPEDPGMGSQVQPGPGHV 358
Cdd:PHA03307    69 TGPPPGPGTEAPANESRSTPTWSLSTLAPASParegsptpPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPP 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  359 SRSTSDPTLCTSSMAGDASShrPSCSQDLEAGLSEAVPGSASMSRSATAACRAQLSPAGDPDTWKTDQRPTPEPFPATSK 438
Cdd:PHA03307   149 AASPPAAGASPAAVASDAAS--SRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGR 226

                          170       180
                   ....*....|....*....|
gi 2462498238  439 E----RPRSLVDSKAYADAR 454
Cdd:PHA03307   227 SaaddAGASSSDSSSSESSG 246
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 255-419 2.68e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 2.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  255 PAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTATPGSSPSPDGPVGAPAPSE-- 332
Cdd:PHA03307   269 IWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSps 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  333 ----PALPPGRVSPEDPGMGSQVQPGPGHVSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSRSATAA 408
Cdd:PHA03307   349 rspsPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYA 428

                          170
                   ....*....|.
gi 2462498238  409 CRAQLSPAGDP 419
Cdd:PHA03307   429 RYPLLTPSGEP 439
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 255-443 4.52e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 4.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  255 PAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTA------TPGSSPSPDGPVGAP 328
Cdd:PHA03307   190 PAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpeneCPLPRPAPITLPTRI 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  329 APSEPALP----PGRVSPEDPGMGSQVQPGPGH-VSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSR 403
Cdd:PHA03307   270 WEASGWNGpssrPGPASSSSSPRERSPSPSPSSpGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSR 349

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 2462498238  404 SATAAcraqlSPAGDPDTWKTDQRPTPE---PFPATSKERPRS 443
Cdd:PHA03307   350 SPSPS-----RPPPPADPSSPRKRPRPSrapSSPAASAGRPTR 387
PRK12495 PRK12495
hypothetical protein; Provisional
 279-419 1.19e-03

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 40.62  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238 279 QQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTATPGSSPSPDGPVGAPAPSEPALPPGRVSPEDPGMGSQVQPGPGHV 358
Cdd:PRK12495   66 QPVTEDGAAGDDAGDGAEATAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTSATDEAATDPPATAAARDGPTPDPT 145

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462498238 359 SRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSRSATAACRaQLSPAGDP 419
Cdd:PRK12495  146 AQPATPDERRSPRQRPPVSGEPPTPSTPDAHVAGTLQAARESLVETLARFAR-RAAATDDP 205
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 251-432 1.49e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238 251 GLLYPAELPPPYEAVVGQP-PASQVTSIGQQVAESSSGDPNTSAGFSTPVpadstSLLVSEGTATPGSSPSPDGPVgAPA 329
Cdd:pfam03154 179 GAASPPSPPPPGTTQAATAgPTPSAPSVPPQGSPATSQPPNQTQSTAAPH-----TLIQQTPTLHPQRLPSPHPPL-QPM 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238 330 PSEPalPPGRVSPE---DPGMGSQVQPGPGHVSrstSDPTLCTSSMAGDASSHRPSCSQ-DLEAGLSEAVPGSASmSRSA 405
Cdd:pfam03154 253 TQPP--PPSQVSPQplpQPSLHGQMPPMPHSLQ---TGPSHMQHPVPPQPFPLTPQSSQsQVPPGPSPAAPGQSQ-QRIH 326

                         170       180
                  ....*....|....*....|....*..
gi 2462498238 406 TAACRAQLSPAGDPDTWKTDQRPTPEP 432
Cdd:pfam03154 327 TPPSQSQLQSQQPPREQPLPPAPLSMP 353
PHA03378 PHA03378
EBNA-3B; Provisional
 249-455 2.36e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238 249 SPGLLYPAELPPpyeaVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVPAdSTSLLVSEGTATPGSSPSPDGPVGAP 328
Cdd:PHA03378  700 APTPMRPPAAPP----GRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPA-AAPGRARPPAAAPGRARPPAAAPGAP 774

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238 329 APSEPALPPgrvspedPGMGSQVQPGPGHVSRSTSDPT---LCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSRSA 405
Cdd:PHA03378  775 TPQPPPQAP-------PAPQQRPRGAPTPQPPPQAGPTsmqLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALE 847

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462498238 406 TAACRAQLSPAGDPDTWKTDQRPTPEPFPATSKERPRSLVDSKAYADARV 455
Cdd:PHA03378  848 RQAAAGPTPSPGSGTSDKIVQAPVFYPPVLQPIQVMRQLGSVRAAAASTV 897
motB PRK12799
flagellar motor protein MotB; Reviewed
 271-382 2.89e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 40.08  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238 271 ASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTAT--PGSSPSPDGPVGAPAPSEPALPPGRVSPEDPGMG 348
Cdd:PRK12799  303 AVTPSSAVTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAValSSAGVLPSDVTLPGTVALPAAEPVNMQPQPMSTT 382

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462498238 349 SQVQPGPGHVSRSTSDPTlcTSSMAGDASSHRPS 382
Cdd:PRK12799  383 ETQQSSTGNITSTANGPT--TSLPAAPASNIPVS 414
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
233-442 3.85e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.86  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238 233 DFAPSPFGTLYDVAINSPGLLYPAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPntsagfstPVPADSTSLLVSEGT 312
Cdd:PRK12323  371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRS--------PAPEALAAARQASAR 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238 313 ATPGSSPSPDGPVGAPAPSEPALPPGRVSPEDPGMGSQVQPGPGHVSRSTSDPTLCTSSMAGDASSHRPScsqDLEAGLS 392
Cdd:PRK12323  443 GPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPA---QPDAAPA 519

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462498238 393 EAVpgSASMSRSATAACRAQLSPAGDPDTWKTDQRPTPEPFPATSKERPR 442
Cdd:PRK12323  520 GWV--AESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPR 567
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 249-443 5.94e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.38  E-value: 5.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  249 SPGLLYPAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAG---FSTPVPADSTSLLVSEGTATPGSSPSPDGPV 325
Cdd:PHA03307   125 SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRqaaLPLSSPEETARAPSSPPAEPPPSTPPAAASP 204

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238  326 GAPAPSEPALPPGRVSPEDPGMGSQVQPGPGHVSRSTSDPTLCTSSMAGDASSHRPScSQDLEAGLSEAVPGSASMSRSA 405
Cdd:PHA03307   205 RPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPA-PITLPTRIWEASGWNGPSSRPG 283

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2462498238  406 TAACRAQLSPAGDPDTWKTDQRPTPEPFPATSKERPRS 443
Cdd:PHA03307   284 PASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSS 321
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 282-362 6.85e-03

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 39.04  E-value: 6.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238 282 AESSSGDPNTSAGfsTPVPADSTSLLVSEGTATPGSSPSPDGPVGAPAPSEP-ALPPGRVSPEDPGMGSQVQPGPGHVSR 360
Cdd:PRK13729  120 VKALGANPVTATG--EPVPQMPASPPGPEGEPQPGNTPVSFPPQGSVAVPPPtAFYPGNGVTPPPQVTYQSVPVPNRIQR 197


                  ..
gi 2462498238 361 ST 362
Cdd:PRK13729  198 KT 199
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 259-441 7.12e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.20  E-value: 7.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238 259 PPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSllvSEGTATPGSSPSPDGPVGAPAPSEPALPPG 338
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAP---AEASAAPAPGVAAPEHHPKHVAVPDASDGG 666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498238 339 RVSPEDPGMGSQVQPGPGHVSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSRSATAACRAQLSPAGD 418
Cdd:PRK07764  667 DGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPD 746

                         170       180
                  ....*....|....*....|...
gi 2462498238 419 PDTWKTDQRPTPEPFPATSKERP 441
Cdd:PRK07764  747 DPPDPAGAPAQPPPPPAPAPAAA 769
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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