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Conserved domains on  [gi|2462491613|ref|XP_054185576|]
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zinc finger protein 676 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-580 9.68e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 9.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 195 KPYKCEECGKAFSKFSILTKHKVIHTGEKPYKC--EECGKAFNRSSILTKHKIIHTGEKPYKCE-ECGKGFSSVSTLNTH 271
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 272 KAIHAEEKPYKCEECGKASN----------SSSKLME--HKRIHTGEKPYKC-----------EECGKAFSWSSSLTEHK 328
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSsrdpqlpdllSISNLRNnpLPGNNSSSVNTPQsnslhpplpanSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 329 RIHAGEKPYKCEECGKA------------FNRSSILTKHKIIHTGEKPYKCEgcgkafSKVSTLNTHKAIHAEEKPYKC- 395
Cdd:COG5048   192 VSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQ------SPSSLSSSDSSSSASESPRSSl 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 396 --EECGKASNSSSKLMEHKRIHTgekPYKCEECGKAFSWSSSLTEHKR--IHAGE--KPYKCEE--CGKAFTWSSSFTKH 467
Cdd:COG5048   266 ptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 468 KRIHAAEKPYKC--EECGKGFSTFSI------LTKHKIIHTGEKRYKCEECGKAFSWS-SILTEHKIIHTGEKP--YKCE 536
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIITHLSFRPynCKNP 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2462491613 537 ECGKAFSRSSSLTRHKRIHTGEKPYKCEECGKAFKSSSTVSYHK 580
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
KRAB super family cl42959
krueppel associated box;
1-32 1.31e-11

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 1.31e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462491613    1 MLENYRNLVFLGIAAFKPDLIIFLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-580 9.68e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 9.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 195 KPYKCEECGKAFSKFSILTKHKVIHTGEKPYKC--EECGKAFNRSSILTKHKIIHTGEKPYKCE-ECGKGFSSVSTLNTH 271
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 272 KAIHAEEKPYKCEECGKASN----------SSSKLME--HKRIHTGEKPYKC-----------EECGKAFSWSSSLTEHK 328
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSsrdpqlpdllSISNLRNnpLPGNNSSSVNTPQsnslhpplpanSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 329 RIHAGEKPYKCEECGKA------------FNRSSILTKHKIIHTGEKPYKCEgcgkafSKVSTLNTHKAIHAEEKPYKC- 395
Cdd:COG5048   192 VSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQ------SPSSLSSSDSSSSASESPRSSl 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 396 --EECGKASNSSSKLMEHKRIHTgekPYKCEECGKAFSWSSSLTEHKR--IHAGE--KPYKCEE--CGKAFTWSSSFTKH 467
Cdd:COG5048   266 ptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 468 KRIHAAEKPYKC--EECGKGFSTFSI------LTKHKIIHTGEKRYKCEECGKAFSWS-SILTEHKIIHTGEKP--YKCE 536
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIITHLSFRPynCKNP 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2462491613 537 ECGKAFSRSSSLTRHKRIHTGEKPYKCEECGKAFKSSSTVSYHK 580
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
KRAB smart00349
krueppel associated box;
1-32 1.31e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 1.31e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462491613    1 MLENYRNLVFLGIAAFKPDLIIFLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-572 5.92e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.92e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462491613 547 SLTRHKRIHTGEKPYKCEECGKAFKS 572
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-580 9.68e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 9.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 195 KPYKCEECGKAFSKFSILTKHKVIHTGEKPYKC--EECGKAFNRSSILTKHKIIHTGEKPYKCE-ECGKGFSSVSTLNTH 271
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 272 KAIHAEEKPYKCEECGKASN----------SSSKLME--HKRIHTGEKPYKC-----------EECGKAFSWSSSLTEHK 328
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSsrdpqlpdllSISNLRNnpLPGNNSSSVNTPQsnslhpplpanSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 329 RIHAGEKPYKCEECGKA------------FNRSSILTKHKIIHTGEKPYKCEgcgkafSKVSTLNTHKAIHAEEKPYKC- 395
Cdd:COG5048   192 VSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQ------SPSSLSSSDSSSSASESPRSSl 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 396 --EECGKASNSSSKLMEHKRIHTgekPYKCEECGKAFSWSSSLTEHKR--IHAGE--KPYKCEE--CGKAFTWSSSFTKH 467
Cdd:COG5048   266 ptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 468 KRIHAAEKPYKC--EECGKGFSTFSI------LTKHKIIHTGEKRYKCEECGKAFSWS-SILTEHKIIHTGEKP--YKCE 536
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIITHLSFRPynCKNP 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2462491613 537 ECGKAFSRSSSLTRHKRIHTGEKPYKCEECGKAFKSSSTVSYHK 580
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
KRAB smart00349
krueppel associated box;
1-32 1.31e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 1.31e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462491613    1 MLENYRNLVFLGIAAFKPDLIIFLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
290-588 2.24e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 2.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 290 SNSSSKLMEHKRIHTGE----KPYKCEECGKAFSWSSSLTEHKRIHAGEKPYKC--EECGKAFNRSSILTKHKIIHTGEK 363
Cdd:COG5048    11 SNNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 364 PYKCE-GCGKAFSKVSTLNTHKAIHAEEKPYKCEECGKASN----------SSSKLME--HKRIHTGEKPYKC------- 423
Cdd:COG5048    91 SDLNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSsrdpqlpdllSISNLRNnpLPGNNSSSVNTPQsnslhpp 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 424 ----EECGKAFSWSSSLTEHKRIHAGEKPYKCEECGKAFTWSSSFTKHKRIHAAEkPYKCEECGKGFSTFSILTKHKIIH 499
Cdd:COG5048   171 lpanSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLS 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 500 TGEKRYKCEECGKAFSWSSILTEHKIIHTGE-------KPYKCEECGKAFSRSSSLTRHKR--IHTGE--KPYKCEE--C 566
Cdd:COG5048   250 SSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslC 329

                         330       340
                  ....*....|....*....|..
gi 2462491613 567 GKAFKSSSTVSYHKKIHTGENP 588
Cdd:COG5048   330 GKLFSRNDALKRHILLHTSISP 351
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
263-575 4.20e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 4.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 263 SSVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLMEHKRIHTGEKPYKC--EECGKAFSWSSSLTEHKRIHAGEKPYkcE 340
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--L 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 341 ECGKAFNRSSILTKHKIIHTGEKPYKCE-----GCGKAFSKVSTLNTHKAIHAEEKPYK--------------------- 394
Cdd:COG5048    94 NSKSLPLSNSKASSSSLSSSSSNSNDNNllsshSLPPSSRDPQLPDLLSISNLRNNPLPgnnsssvntpqsnslhpplpa 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 395 CEECGKASNSSSKLMEHKRIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAgEKPYKCEECGKAF-----TWSSSFTKHK- 468
Cdd:COG5048   174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSpksllSQSPSSLSSSd 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 469 RIHAAEKPYKCEECGKGFSTFSILTKHKIIHTG-EKRYKCEECGKAFSWSSILTEHK--IIHTGE--KPYKCEE--CGKA 541
Cdd:COG5048   253 SSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKL 332

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2462491613 542 FSRSSSLTRHKRIHTGEKPYKC--EECGKAFKSSST 575
Cdd:COG5048   333 FSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-385 1.16e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 195 KPYKCEECGKAFSKFSILTKHK--VIHTGE--KPYKCEE--CGKAFNRSSILTKHKIIHTGEKPYKCEECGKGFSSVSTL 268
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 269 NthkaihaeekpykceecgkaSNSSSKLMEHKRIHTGEKPYKCEECGKAFSWSSS-LTEHKRIHAGEKPY--KCEECGKA 345
Cdd:COG5048   368 N--------------------NEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPYncKNPPCSKS 427

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2462491613 346 FNRSSILTKHKIIHTGEKPYKCEGCGKAFSKVSTLNTHKA 385
Cdd:COG5048   428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-572 5.92e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.92e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462491613 547 SLTRHKRIHTGEKPYKCEECGKAFKS 572
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 529-581 1.01e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462491613 529 GEKPYKCE--ECGKAFSRSSSLTRHKR-------------------IHTGEKPYKCEECGKAFKSSSTVSYHKK 581
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-319 2.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.22e-04
                          10        20
                  ....*....|....*....|....
gi 2462491613 296 LMEHKRIHTGEKPYKCEECGKAFS 319
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-431 2.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.22e-04
                          10        20
                  ....*....|....*....|....
gi 2462491613 408 LMEHKRIHTGEKPYKCEECGKAFS 431
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 305-384 2.35e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 305 GEKPYKCE--ECGKAFSWSSSLTEHkRIHAGEKPYKCEecgkafNRSSIltKHKIIHTGEKPYKCEGCGKAFSKVSTLNT 382
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHE------NPSPE--KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462491613 383 HK 384
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 417-496 3.39e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 417 GEKPYKCE--ECGKAFSWSSSLTEHkRIHAgekpykceECGKAFTWSSSFTKHKRIHAAEKPYKCEECGKGFSTFSILTK 494
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462491613 495 HK 496
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
520-544 1.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.42e-03
                          10        20
                  ....*....|....*....|....*
gi 2462491613 520 LTEHKIIHTGEKPYKCEECGKAFSR 544
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 333-412 1.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 333 GEKPYKCE--ECGKAFNRSSILTKHKIihtgekpykcEG-CGKAFSKVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLM 409
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML----------HGhQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 2462491613 410 EHK 412
Cdd:COG5189   416 YHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-348 1.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.66e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462491613 323 SLTEHKRIHAGEKPYKCEECGKAFNR 348
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-236 2.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.02e-03
                          10        20
                  ....*....|....*....|....*
gi 2462491613 212 LTKHKVIHTGEKPYKCEECGKAFNR 236
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 533-555 2.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.16e-03
                          10        20
                  ....*....|....*....|...
gi 2462491613 533 YKCEECGKAFSRSSSLTRHKRIH 555
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 193-272 2.68e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 193 GEKPYKCE--ECGKAFSKFSILTKHKvIHTGEKPYKCEecgkafNRSSIltKHKIIHTGEKPYKCEECGKGFSSVSTLNT 270
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHE------NPSPE--KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462491613 271 HK 272
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 221-300 2.87e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491613 221 GEKPYKCE--ECGKAFNRSSILTKHKiihtgekpyKCEECGKGFSSVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLME 298
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462491613 299 HK 300
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-459 3.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.24e-03
                          10        20
                  ....*....|....*....|....*
gi 2462491613 435 SLTEHKRIHAGEKPYKCEECGKAFT 459
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-264 3.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.58e-03
                          10        20
                  ....*....|....*....|....*
gi 2462491613 240 LTKHKIIHTGEKPYKCEECGKGFSS 264
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-376 7.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.78e-03
                          10        20
                  ....*....|....*....|....*
gi 2462491613 352 LTKHKIIHTGEKPYKCEGCGKAFSK 376
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
492-515 8.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.75e-03
                          10        20
                  ....*....|....*....|....
gi 2462491613 492 LTKHKIIHTGEKRYKCEECGKAFS 515
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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