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Conserved domains on  [gi|2462629070|ref|XP_054182845|]
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neuronal membrane glycoprotein M6-b isoform X4 [Homo sapiens]

Protein Classification

myelin proteolipid family protein( domain architecture ID 10472648)

myelin proteolipid family protein similar to human myelin proteolipid protein (PLP) that plays an important role in the formation or maintenance of the multilamellar structure of myelin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
1-172 1.83e-84

Myelin proteolipid protein (PLP or lipophilin);


:

Pssm-ID: 460144  Cd Length: 231  Bit Score: 249.52  E-value: 1.83e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629070   1 MQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWS 80
Cdd:pfam01275  65 FQYVIYGIAAFFFLLGLLLLAEGFLTTGATKQVYGAFRSTVGGRCSCAVFMGITYVLALVWLLVFAFLAIPVFIFTNFWS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629070  81 TCEVIKSPQTNgttgveQICVDIRQYGIIPWNAFPGKICGSA-LENICNTNEFYMSYHLFIVACAGAGATVIALIHFLMI 159
Cdd:pfam01275 145 TCQNINVLSTN------QLCIDFRQFGFLPWNATPGKVCGMTeLKAFCKDYEEKMTFHLFILAFAGAGATLLALVHYLMC 218

                         170
                  ....*....|...
gi 2462629070 160 LSSNWAYLKDASK 172
Cdd:pfam01275 219 LTANYAHLRDHGR 231
 
Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
1-172 1.83e-84

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 460144  Cd Length: 231  Bit Score: 249.52  E-value: 1.83e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629070   1 MQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWS 80
Cdd:pfam01275  65 FQYVIYGIAAFFFLLGLLLLAEGFLTTGATKQVYGAFRSTVGGRCSCAVFMGITYVLALVWLLVFAFLAIPVFIFTNFWS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629070  81 TCEVIKSPQTNgttgveQICVDIRQYGIIPWNAFPGKICGSA-LENICNTNEFYMSYHLFIVACAGAGATVIALIHFLMI 159
Cdd:pfam01275 145 TCQNINVLSTN------QLCIDFRQFGFLPWNATPGKVCGMTeLKAFCKDYEEKMTFHLFILAFAGAGATLLALVHYLMC 218

                         170
                  ....*....|...
gi 2462629070 160 LSSNWAYLKDASK 172
Cdd:pfam01275 219 LTANYAHLRDHGR 231
PLP smart00002
Myelin proteolipid protein (PLP or lipophilin);
77-137 1.94e-33

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 128322  Cd Length: 60  Bit Score: 114.12  E-value: 1.94e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462629070   77 NIWSTCEVIKSPQTNgTTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYH 137
Cdd:smart00002   1 NTWTTCQSITFPEKT-TTSIGTLCVDARQYGILPWNAFPGKVCGSNLLSICKTSEFQMTFH 60
 
Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
1-172 1.83e-84

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 460144  Cd Length: 231  Bit Score: 249.52  E-value: 1.83e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629070   1 MQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWS 80
Cdd:pfam01275  65 FQYVIYGIAAFFFLLGLLLLAEGFLTTGATKQVYGAFRSTVGGRCSCAVFMGITYVLALVWLLVFAFLAIPVFIFTNFWS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629070  81 TCEVIKSPQTNgttgveQICVDIRQYGIIPWNAFPGKICGSA-LENICNTNEFYMSYHLFIVACAGAGATVIALIHFLMI 159
Cdd:pfam01275 145 TCQNINVLSTN------QLCIDFRQFGFLPWNATPGKVCGMTeLKAFCKDYEEKMTFHLFILAFAGAGATLLALVHYLMC 218

                         170
                  ....*....|...
gi 2462629070 160 LSSNWAYLKDASK 172
Cdd:pfam01275 219 LTANYAHLRDHGR 231
PLP smart00002
Myelin proteolipid protein (PLP or lipophilin);
77-137 1.94e-33

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 128322  Cd Length: 60  Bit Score: 114.12  E-value: 1.94e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462629070   77 NIWSTCEVIKSPQTNgTTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYH 137
Cdd:smart00002   1 NTWTTCQSITFPEKT-TTSIGTLCVDARQYGILPWNAFPGKVCGSNLLSICKTSEFQMTFH 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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