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Conserved domains on  [gi|2462584183|ref|XP_054181270|]
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GRAM domain-containing protein 4 isoform X9 [Homo sapiens]

Protein Classification

PTZ00121 and PH-GRAM_GRAMDC4 domain-containing protein( domain architecture ID 10280254)

protein containing domains PTZ00121, PRT_C, and PH-GRAM_GRAMDC4

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PH-GRAM_GRAMDC4 cd13221
GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like ...
 352-457 4.55e-56

GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; GRAMDC4 is a membrane protein. Nothing is known about its function. Paralogs include: GRAMDC1A, GRAMDC1B, GRAMDC1C, GRAMDC2, GRAMDC3, and GRAMDC-like proteins. It contains a single PH-GRAM domain at its N-terminus. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


:

Pssm-ID: 270041  Cd Length: 104  Bit Score: 181.38  E-value: 4.55e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462584183 352 LAVCENGWRCCLINRDrKMPTDYIRNGVLYVTENYLCFESSKSgSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVST 431
Cdd:cd13221     1 LPVWENGWRCCLINRD-KMPTDYIRNGRLYLTENYLCFESSSS-SSKKNVVIPLTDITRIEKAKPYSFLPGSGMSIEVSV 78

                          90       100
                  ....*....|....*....|....*.
gi 2462584183 432 PSTQKPLVFGAMVHRDEAFETILSQY 457
Cdd:cd13221    79 SSADKPLFFGAMFRRDEFFDIIALGA 104
PRT_C super family cl07117
Plant phosphoribosyltransferase C-terminal; This domain is found at the C-terminus of ...
 197-289 9.76e-03

Plant phosphoribosyltransferase C-terminal; This domain is found at the C-terminus of phosphoribosyltransferases and phosphoribosyltransferase-like proteins. It contains putative transmembrane regions. It often appears together with calcium-ion dependent C2 domains (pfam00168).


The actual alignment was detected with superfamily member pfam08372:

Pssm-ID: 337028  Cd Length: 156  Bit Score: 36.87  E-value: 9.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462584183 197 VAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLAVGLYagikfflidfiFKRCPRLRA 276
Cdd:pfam08372  67 VAGRVQTVVGDIATQGERLQALLSWRDPRATALFVLFCLLAAVVLYVVPFKVLALLSGFY-----------YLRHPRFRS 135

                          90
                  ....*....|....
gi 2462584183 277 KY-DTPYIIWRSLP 289
Cdd:pfam08372 136 RMpSVPLNFFRRLP 149
 
Name Accession Description Interval E-value
PH-GRAM_GRAMDC4 cd13221
GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like ...
 352-457 4.55e-56

GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; GRAMDC4 is a membrane protein. Nothing is known about its function. Paralogs include: GRAMDC1A, GRAMDC1B, GRAMDC1C, GRAMDC2, GRAMDC3, and GRAMDC-like proteins. It contains a single PH-GRAM domain at its N-terminus. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 270041  Cd Length: 104  Bit Score: 181.38  E-value: 4.55e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462584183 352 LAVCENGWRCCLINRDrKMPTDYIRNGVLYVTENYLCFESSKSgSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVST 431
Cdd:cd13221     1 LPVWENGWRCCLINRD-KMPTDYIRNGRLYLTENYLCFESSSS-SSKKNVVIPLTDITRIEKAKPYSFLPGSGMSIEVSV 78

                          90       100
                  ....*....|....*....|....*.
gi 2462584183 432 PSTQKPLVFGAMVHRDEAFETILSQY 457
Cdd:cd13221    79 SSADKPLFFGAMFRRDEFFDIIALGA 104
GRAM pfam02893
GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other ...
 338-460 2.00e-21

GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Note the alignment is lacking the last two beta strands and alpha helix.


Pssm-ID: 397160  Cd Length: 112  Bit Score: 88.96  E-value: 2.00e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462584183 338 NFHEIFNLTENERPLAVCengwrCCLINRDRkmptdYIRNGVLYVTENYLCFESSKSGSSKRnKVIKLVDITDIQKYKVL 417
Cdd:pfam02893   2 LFRKKFKLPPEERLIASY-----SCYLNRDG-----GPVQGRLYLTNYRLCFRSLPKGWSTK-VVIPLVDIEEIEKLKGG 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462584183 418 SVLPGSGMGIAVSTPStqkPLVFGAMVHRDEAFETILSQYIKI 460
Cdd:pfam02893  71 ANLFPNGIQVETGSND---KFSFAGFVTRDEAIEFILALLKNA 110
GRAM smart00568
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;
344-415 1.38e-09

domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;


Pssm-ID: 214725 [Multi-domain]  Cd Length: 60  Bit Score: 53.75  E-value: 1.38e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462584183  344 NLTENERPLAVcengWRCCLINrdrkmptDYIRNGVLYVTENYLCFESSKSGSSKrNKVIKLVDITDIQKYK 415
Cdd:smart00568   1 KLPEEEKLIAD----YSCYLSR-------TGPVQGRLYISNYRLCFRSNLPGKLT-KVVIPLADITRIEKST 60
PRT_C pfam08372
Plant phosphoribosyltransferase C-terminal; This domain is found at the C-terminus of ...
 197-289 9.76e-03

Plant phosphoribosyltransferase C-terminal; This domain is found at the C-terminus of phosphoribosyltransferases and phosphoribosyltransferase-like proteins. It contains putative transmembrane regions. It often appears together with calcium-ion dependent C2 domains (pfam00168).


Pssm-ID: 337028  Cd Length: 156  Bit Score: 36.87  E-value: 9.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462584183 197 VAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLAVGLYagikfflidfiFKRCPRLRA 276
Cdd:pfam08372  67 VAGRVQTVVGDIATQGERLQALLSWRDPRATALFVLFCLLAAVVLYVVPFKVLALLSGFY-----------YLRHPRFRS 135

                          90
                  ....*....|....
gi 2462584183 277 KY-DTPYIIWRSLP 289
Cdd:pfam08372 136 RMpSVPLNFFRRLP 149
 
Name Accession Description Interval E-value
PH-GRAM_GRAMDC4 cd13221
GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like ...
 352-457 4.55e-56

GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; GRAMDC4 is a membrane protein. Nothing is known about its function. Paralogs include: GRAMDC1A, GRAMDC1B, GRAMDC1C, GRAMDC2, GRAMDC3, and GRAMDC-like proteins. It contains a single PH-GRAM domain at its N-terminus. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 270041  Cd Length: 104  Bit Score: 181.38  E-value: 4.55e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462584183 352 LAVCENGWRCCLINRDrKMPTDYIRNGVLYVTENYLCFESSKSgSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVST 431
Cdd:cd13221     1 LPVWENGWRCCLINRD-KMPTDYIRNGRLYLTENYLCFESSSS-SSKKNVVIPLTDITRIEKAKPYSFLPGSGMSIEVSV 78

                          90       100
                  ....*....|....*....|....*.
gi 2462584183 432 PSTQKPLVFGAMVHRDEAFETILSQY 457
Cdd:cd13221    79 SSADKPLFFGAMFRRDEFFDIIALGA 104
GRAM pfam02893
GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other ...
 338-460 2.00e-21

GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Note the alignment is lacking the last two beta strands and alpha helix.


Pssm-ID: 397160  Cd Length: 112  Bit Score: 88.96  E-value: 2.00e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462584183 338 NFHEIFNLTENERPLAVCengwrCCLINRDRkmptdYIRNGVLYVTENYLCFESSKSGSSKRnKVIKLVDITDIQKYKVL 417
Cdd:pfam02893   2 LFRKKFKLPPEERLIASY-----SCYLNRDG-----GPVQGRLYLTNYRLCFRSLPKGWSTK-VVIPLVDIEEIEKLKGG 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462584183 418 SVLPGSGMGIAVSTPStqkPLVFGAMVHRDEAFETILSQYIKI 460
Cdd:pfam02893  71 ANLFPNGIQVETGSND---KFSFAGFVTRDEAIEFILALLKNA 110
PH-GRAM cd10570
Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins ...
 355-457 3.55e-13

Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; Myotubularin-related proteins are a subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids. Mutations in this family cause the human neuromuscular disorders myotubular myopathy and type 4B Charcot-Marie-Tooth syndrome. 6 of the 13 MTMRs (MTMRs 5, 9-13) contain naturally occurring substitutions of residues required for catalysis by PTP family enzymes. Although these proteins are predicted to be enzymatically inactive, they are thought to function as antagonists of endogenous phosphatase activity or interaction modules. Most MTMRs contain a N-terminal PH-GRAM domain, a Rac-induced recruitment domain (RID) domain, a PTP domain (which may be active or inactive), a SET-interaction domain, and a C-terminal coiled-coil region. In addition some members contain DENN domain N-terminal to the PH-GRAM domain and FYVE, PDZ, and PH domains C-terminal to the coiled-coil region. The GRAM domain, found in myotubularins, glucosyltransferases, and other putative membrane-associated proteins, is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 275393  Cd Length: 94  Bit Score: 65.10  E-value: 3.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462584183 355 CENGWRCCLINRDRKMPtdyiRNGVLYVTENYLCFESSKSGsSKRNKVIKLVDITDIQKYKVLSVLPgSGMGIAVSTPST 434
Cdd:cd10570     2 EKLGVRFCCALRPRKLP----LEGTLYLSTYRLIFSSKADG-DETKLVIPLVDITDVEKIAGASFLP-SGLIITCKDFRT 75

                          90       100
                  ....*....|....*....|...
gi 2462584183 435 QKPLVFGAMvhrdEAFETILSQY 457
Cdd:cd10570    76 IKFSFDSED----EAVKVIARVL 94
PH-GRAM_GRAMDC cd13220
GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like ...
 378-456 8.62e-11

GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; The GRAMDC proteins are membrane proteins. Nothing is known about its function. Members include: GRAMDC1A, GRAMDC1B, GRAMDC1C, GRAMDC2, GRAMDC3, GRAMDC4, and GRAMDC-like proteins. All of the members, except for GRAMDC4 are included in this hierarchy. Each contains a single PH-GRAM domain at their N-terminus. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 275406  Cd Length: 94  Bit Score: 58.29  E-value: 8.62e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462584183 378 GVLYVTENYLCFESSKSGsSKRNKVIKLVDITDIQKYKVLSVLPGSgmgIAVSTPSTQkpLVFGAMVHRDEAFETILSQ 456
Cdd:cd13220    21 GRLYISENHLCFYSNIFG-WETKLVIPFKDITSIEKKKTALIFPNA---IEITTKGEK--YFFTSFLSRDSAYKLLTRV 93
GRAM smart00568
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;
344-415 1.38e-09

domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;


Pssm-ID: 214725 [Multi-domain]  Cd Length: 60  Bit Score: 53.75  E-value: 1.38e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462584183  344 NLTENERPLAVcengWRCCLINrdrkmptDYIRNGVLYVTENYLCFESSKSGSSKrNKVIKLVDITDIQKYK 415
Cdd:smart00568   1 KLPEEEKLIAD----YSCYLSR-------TGPVQGRLYISNYRLCFRSNLPGKLT-KVVIPLADITRIEKST 60
PH-GRAM1_TCB1D9_TCB1D9B cd13351
TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin ...
 357-451 1.62e-03

TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1; TBC1D9 and TCB1D9B may act as a GTPase-activating proteins for Rab family protein(s). TBC1D9 and TCB1D9B contain two N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the first repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 275420  Cd Length: 99  Bit Score: 37.76  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462584183 357 NGWRCCLINRdrKMPtdyiRNGVLYVTENYLCFESSKSGSSKRnKVIKLVDITDIQKYKVLsVLPGSgmgIAVSTPStqK 436
Cdd:cd13351     6 NYYSCSYWKG--RVP----RQGWLYLSVNHLCFYSFLLGKEAK-LVIRWTDVTQLEKNNSL-LLPDS---IKVVTRD--K 72

                          90
                  ....*....|....*
gi 2462584183 437 PLVFGAMVHRDEAFE 451
Cdd:cd13351    73 EHYFSMFLNISETFK 87
PH-GRAM2_TBC1D8 cd13353
TBC1 domain family member 8 (TBC1D8; also called Vascular Rab-GAP/TBC-containing protein) ...
 378-456 8.78e-03

TBC1 domain family member 8 (TBC1D8; also called Vascular Rab-GAP/TBC-containing protein) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2; TBC1D8 may act as a GTPase-activating protein for Rab family protein(s). TBC1D8 contains two N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the second repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 270160  Cd Length: 96  Bit Score: 35.59  E-value: 8.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462584183 378 GVLYVTENYLCFESSKSGSSkrNKVIKLVDITDIQKYKVLSVLPGSgmgIAVSTpSTQKPLVFGAMVHRDEAFETILSQ 456
Cdd:cd13353    23 GRMYTSDSYICFASKEDGSC--NVILPLREVVSIEKMEDTSLLPNP---IIVSI-RSKMAFQFIELKDRDSLVESLLAR 95
PRT_C pfam08372
Plant phosphoribosyltransferase C-terminal; This domain is found at the C-terminus of ...
 197-289 9.76e-03

Plant phosphoribosyltransferase C-terminal; This domain is found at the C-terminus of phosphoribosyltransferases and phosphoribosyltransferase-like proteins. It contains putative transmembrane regions. It often appears together with calcium-ion dependent C2 domains (pfam00168).


Pssm-ID: 337028  Cd Length: 156  Bit Score: 36.87  E-value: 9.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462584183 197 VAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLAVGLYagikfflidfiFKRCPRLRA 276
Cdd:pfam08372  67 VAGRVQTVVGDIATQGERLQALLSWRDPRATALFVLFCLLAAVVLYVVPFKVLALLSGFY-----------YLRHPRFRS 135

                          90
                  ....*....|....
gi 2462584183 277 KY-DTPYIIWRSLP 289
Cdd:pfam08372 136 RMpSVPLNFFRRLP 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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