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Conserved domains on  [gi|2462583253|ref|XP_054180819|]
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nuclear encoded mitochondrial protein C21orf2 isoform X3 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-133 1.93e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 1.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583253  15 SELHSVRKLNCWGSRLTDI-SICQEMPSLEVITLSVNSISTL-EPVSRCQRLSELYLRRNRIPSLAElfYLKGLPRLRVL 92
Cdd:COG4886   133 ANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEEL 210

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462583253  93 WLAENpccgtsphryRMT----VLRTLPRLQKLD---NQAVTEEELSR 133
Cdd:COG4886   211 DLSGN----------QLTdlpePLANLTNLETLDlsnNQLTDLPELGN 248
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-133 1.93e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 1.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583253  15 SELHSVRKLNCWGSRLTDI-SICQEMPSLEVITLSVNSISTL-EPVSRCQRLSELYLRRNRIPSLAElfYLKGLPRLRVL 92
Cdd:COG4886   133 ANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEEL 210

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462583253  93 WLAENpccgtsphryRMT----VLRTLPRLQKLD---NQAVTEEELSR 133
Cdd:COG4886   211 DLSGN----------QLTdlpePLANLTNLETLDlsnNQLTDLPELGN 248
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 40-130 4.26e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 4.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583253  40 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRL 118
Cdd:cd21340   120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                          90
                  ....*....|..
gi 2462583253 119 QKLDNQAVTEEE 130
Cdd:cd21340   198 EVLDGKEITDTE 209
LRR_8 pfam13855
Leucine rich repeat;
19-74 2.26e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.26e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462583253  19 SVRKLNCWGSRLTdiSICQE----MPSLEVITLSVNSISTLEPVS--RCQRLSELYLRRNRI 74
Cdd:pfam13855   2 NLRSLDLSNNRLT--SLDDGafkgLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 104-122 1.17e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 35.75  E-value: 1.17e-03
                           10
                   ....*....|....*....
gi 2462583253  104 PHRYRMTVLRTLPRLQKLD 122
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-133 1.93e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 1.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583253  15 SELHSVRKLNCWGSRLTDI-SICQEMPSLEVITLSVNSISTL-EPVSRCQRLSELYLRRNRIPSLAElfYLKGLPRLRVL 92
Cdd:COG4886   133 ANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEEL 210

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462583253  93 WLAENpccgtsphryRMT----VLRTLPRLQKLD---NQAVTEEELSR 133
Cdd:COG4886   211 DLSGN----------QLTdlpePLANLTNLETLDlsnNQLTDLPELGN 248
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 40-130 4.26e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 4.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583253  40 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRL 118
Cdd:cd21340   120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                          90
                  ....*....|..
gi 2462583253 119 QKLDNQAVTEEE 130
Cdd:cd21340   198 EVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-98 1.49e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 1.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583253  15 SELHSVRKLNCWGSRLTDISIC-QEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAElfyLKGLPRLRVLW 93
Cdd:COG4886   202 GNLTNLEELDLSGNQLTDLPEPlANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP---LANLTNLKTLD 278


                  ....*
gi 2462583253  94 LAENP 98
Cdd:COG4886   279 LSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-77 3.26e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 3.26e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462583253  15 SELHSVRKLNCWGSRLTDISICQEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSL 77
Cdd:COG4886   225 ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 30-130 1.65e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583253  30 LTDISICqemPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAelfYLKGLPRLRVLWLAENpccgtsphryRM 109
Cdd:cd21340    17 IDNLSLC---KNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGN----------RI 80

                          90       100
                  ....*....|....*....|....*.
gi 2462583253 110 TV---LRTLPRLQ--KLDNQAVTEEE 130
Cdd:cd21340    81 SVvegLENLTNLEelHIENQRLPPGE 106
LRR_8 pfam13855
Leucine rich repeat;
19-74 2.26e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.26e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462583253  19 SVRKLNCWGSRLTdiSICQE----MPSLEVITLSVNSISTLEPVS--RCQRLSELYLRRNRI 74
Cdd:pfam13855   2 NLRSLDLSNNRLT--SLDDGafkgLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
64-134 1.23e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.44  E-value: 1.23e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462583253  64 LSELYLRRNRIPSLAELFYLKGLPRLRVLWLAENPCCgTSPHrYRMTVLRTLPRLQKLDNQAVTEEELSRA 134
Cdd:pfam14580  90 LTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPH-YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 40-80 1.39e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 1.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462583253  40 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRN-RIPSLAEL 80
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDL 42
LRR_8 pfam13855
Leucine rich repeat;
40-98 4.67e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 4.67e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462583253  40 PSLEVITLSVNSISTLEPVS--RCQRLSELYLRRNRIPSL-AELFYlkGLPRLRVLWLAENP 98
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLsPGAFS--GLPSLRYLDLSGNR 60
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 19-59 1.03e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462583253  19 SVRKLNCWGSRLTDISICQEMPSLEVITLSVNS-ISTLEPVS 59
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 104-122 1.17e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 35.75  E-value: 1.17e-03
                           10
                   ....*....|....*....
gi 2462583253  104 PHRYRMTVLRTLPRLQKLD 122
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 62-98 1.38e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462583253  62 QRLSELYLRRNRIPSLAELfylKGLPRLRVLWLAENP 98
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPL---AKLPNLETLDLSGNN 34
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-122 2.30e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583253  15 SELHSVRKLNCWGSRLTDISICQEMPSLEVITLSVNsistlEPVSRCQRLSELYLRRNRIPSLAElfYLKGLPRLRVLWL 94
Cdd:COG4886    71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDL 143

                          90       100
                  ....*....|....*....|....*....
gi 2462583253  95 AENPCcgTS-PhryrmTVLRTLPRLQKLD 122
Cdd:COG4886   144 SNNQL--TDlP-----EPLGNLTNLKSLD 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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