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Conserved domains on  [gi|2462580363|ref|XP_054179416|]
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EF-hand calcium-binding domain-containing protein 8 isoform X7 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10646020)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; similar to Saccharomyces cerevisiae autophagy-related protein 21 (ATG21) required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy

Gene Ontology:  GO:0005515
PubMed:  10322433

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 299-338 6.62e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 6.62e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462580363  299 PPTLLMTWKGHLNSVADILYVDNFQLVISAGQDRDVKAWK 338
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 299-338 6.62e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 6.62e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462580363  299 PPTLLMTWKGHLNSVADILYVDNFQLVISAGQDRDVKAWK 338
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 299-338 6.62e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 6.62e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462580363  299 PPTLLMTWKGHLNSVADILYVDNFQLVISAGQDRDVKAWK 338
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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