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Conserved domains on  [gi|2462580353|ref|XP_054179411|]
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EF-hand calcium-binding domain-containing protein 8 isoform X4 [Homo sapiens]

Protein Classification

WD40 repeat and EF-hand domain-containing protein( domain architecture ID 13829546)

WD40 repeat and EF-hand domain-containing protein may be involved in protein-protein interactions as a molecular scaffold, in binding intracellular calcium, and in calcium signal transduction

CATH:  2.130.10.10|1.10.238.10
Gene Ontology:  GO:0005509|GO:0005515
PubMed:  10191494|1644165|21468892|30069656|10322433|28707401

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 322-592 2.00e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 2.00e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 322 HPNWCEQVKFIPQMNVVVSCSA--------IEKSSLVLTILPAKaskkprlsvlrlrKGILCFDYCPDRNFLVTGGYDAF 393
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGdgtikvwdLETGELLRTLKGHT-------------GPVRDVAASADGTYLASGSSDKT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 394 IRLWNpFVSKRPVWLMKGHQTSVTHILVdSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKffalgNCPITSAyFFEKD 473
Cdd:cd00200    75 IRLWD-LETGECVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-----TDWVNSV-AFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 474 NTLICSTYSIGILKGY-LEAQGLIkaRKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQhve 552
Cdd:cd00200   147 GTFVASSSQDGTIKLWdLRTGKCV--ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG--- 221

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2462580353 553 MTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPE 592
Cdd:cd00200   222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT 261
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 554-676 5.19e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 5.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 554 TAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEqLEISGI--IHMNKVFYVTGWSKRIthFLFHKTKPVLLcyh 631
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT-GPVRDVaaSADGTYLASGSSDKTI--RLWDLETGECV--- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462580353 632 wQTY--HTEDILSMAKYRN-QFLGTSSYSGDILFWNTGTLKPIFNFNA 676
Cdd:cd00200    87 -RTLtgHTSYVSSVAFSPDgRILSSSSRDKTIKVWDVETGKCLTTLRG 133
EFh super family cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 67-119 8.54e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


The actual alignment was detected with superfamily member pfam13833:

Pssm-ID: 415501 [Multi-domain]  Cd Length: 54  Bit Score: 34.98  E-value: 8.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462580353  67 STGALGMDAFIKAMKKV-LSSVSDEMLKELFLKVDSDCEGFVTWQKYVDYMMRE 119
Cdd:pfam13833   1 EKGVITREELKRALALLgLKDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 322-592 2.00e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 2.00e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 322 HPNWCEQVKFIPQMNVVVSCSA--------IEKSSLVLTILPAKaskkprlsvlrlrKGILCFDYCPDRNFLVTGGYDAF 393
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGdgtikvwdLETGELLRTLKGHT-------------GPVRDVAASADGTYLASGSSDKT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 394 IRLWNpFVSKRPVWLMKGHQTSVTHILVdSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKffalgNCPITSAyFFEKD 473
Cdd:cd00200    75 IRLWD-LETGECVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-----TDWVNSV-AFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 474 NTLICSTYSIGILKGY-LEAQGLIkaRKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQhve 552
Cdd:cd00200   147 GTFVASSSQDGTIKLWdLRTGKCV--ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG--- 221

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2462580353 553 MTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPE 592
Cdd:cd00200   222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT 261
WD40 COG2319
WD40 repeat [General function prediction only];
380-667 2.73e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 2.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 380 PDRNFLVTGGYDAFIRLWNPfVSKRPVWLMKGHQTSVTHILVdSRNNSILISVSKDKNIRVWDMLDYICLQSFCGkffal 459
Cdd:COG2319   130 PDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTG----- 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 460 GNCPITSAYFFEKDNTLICSTY--SIGILKgyLEAQGLIkaRKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTG 537
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSAdgTVRLWD--LATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 538 RktmEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMN-KVFYVTGWSKRIT 616
Cdd:COG2319   279 E---LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKTLASGSDDGTVR 355

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462580353 617 hfLFHKTKPVLLcyHWQTYHTEDILSMA-KYRNQFLGTSSYSGDILFWNTGT 667
Cdd:COG2319   356 --LWDLATGELL--RTLTGHTGAVTSVAfSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 402-442 1.44e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462580353  402 SKRPVWLMKGHQTSVTHILVdSRNNSILISVSKDKNIRVWD 442
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 554-676 5.19e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 5.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 554 TAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEqLEISGI--IHMNKVFYVTGWSKRIthFLFHKTKPVLLcyh 631
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT-GPVRDVaaSADGTYLASGSSDKTI--RLWDLETGECV--- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462580353 632 wQTY--HTEDILSMAKYRN-QFLGTSSYSGDILFWNTGTLKPIFNFNA 676
Cdd:cd00200    87 -RTLtgHTSYVSSVAFSPDgRILSSSSRDKTIKVWDVETGKCLTTLRG 133
WD40 pfam00400
WD domain, G-beta repeat;
403-442 1.11e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462580353 403 KRPVWLMKGHQTSVTHILVdSRNNSILISVSKDKNIRVWD 442
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF-SPDGKLLASGSDDGTVKVWD 39
EF-hand_8 pfam13833
EF-hand domain pair;
67-119 8.54e-03

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 34.98  E-value: 8.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462580353  67 STGALGMDAFIKAMKKV-LSSVSDEMLKELFLKVDSDCEGFVTWQKYVDYMMRE 119
Cdd:pfam13833   1 EKGVITREELKRALALLgLKDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 322-592 2.00e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 2.00e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 322 HPNWCEQVKFIPQMNVVVSCSA--------IEKSSLVLTILPAKaskkprlsvlrlrKGILCFDYCPDRNFLVTGGYDAF 393
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGdgtikvwdLETGELLRTLKGHT-------------GPVRDVAASADGTYLASGSSDKT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 394 IRLWNpFVSKRPVWLMKGHQTSVTHILVdSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKffalgNCPITSAyFFEKD 473
Cdd:cd00200    75 IRLWD-LETGECVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-----TDWVNSV-AFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 474 NTLICSTYSIGILKGY-LEAQGLIkaRKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQhve 552
Cdd:cd00200   147 GTFVASSSQDGTIKLWdLRTGKCV--ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG--- 221

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2462580353 553 MTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPE 592
Cdd:cd00200   222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT 261
WD40 COG2319
WD40 repeat [General function prediction only];
380-667 2.73e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 2.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 380 PDRNFLVTGGYDAFIRLWNPfVSKRPVWLMKGHQTSVTHILVdSRNNSILISVSKDKNIRVWDMLDYICLQSFCGkffal 459
Cdd:COG2319   130 PDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTG----- 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 460 GNCPITSAYFFEKDNTLICSTY--SIGILKgyLEAQGLIkaRKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTG 537
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSAdgTVRLWD--LATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 538 RktmEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMN-KVFYVTGWSKRIT 616
Cdd:COG2319   279 E---LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKTLASGSDDGTVR 355

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462580353 617 hfLFHKTKPVLLcyHWQTYHTEDILSMA-KYRNQFLGTSSYSGDILFWNTGT 667
Cdd:COG2319   356 --LWDLATGELL--RTLTGHTGAVTSVAfSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 371-578 2.32e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 2.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 371 KGILCFDYCPDRNFLVTGGYDAFIRLWNpFVSKRPVWLMKGHQTSVTHILVdSRNNSILISVSKDKNIRVWDMLDYICLQ 450
Cdd:cd00200    94 SYVSSVAFSPDGRILSSSSRDKTIKVWD-VETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 451 SFCGKffalgNCPITSAYFFEKDNTLICST---------YSIGILKGYLEAqglikarkrttHCSPLCAVLYSKIFKQVV 521
Cdd:cd00200   172 TLTGH-----TGEVNSVAFSPDGEKLLSSSsdgtiklwdLSTGKCLGTLRG-----------HENGVNSVAFSPDGYLLA 235

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462580353 522 SGCLRGTVSVWEVVTGRKTMEFavSGGQHvEMTAMALDESERCLLTGLRDGTMKMWN 578
Cdd:cd00200   236 SGSEDGTIRVWDLRTGECVQTL--SGHTN-SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
372-578 4.15e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 4.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 372 GILCFDYCPDRNFLVTGGYDAFIRLWNPfVSKRPVWLMKGHQTSVTHILVdSRNNSILISVSKDKNIRVWDMLDYICLQS 451
Cdd:COG2319   206 AVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRT 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 452 FCGkffalGNCPITSAYFFeKDNTLICSTYSIGILKGYlEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSV 531
Cdd:COG2319   284 LTG-----HSGGVNSVAFS-PDGKLLASGSDDGTVRLW-DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2462580353 532 WEVVTGRKTMEFAVSGGQHvemTAMALDESERCLLTGLRDGTMKMWN 578
Cdd:COG2319   357 WDLATGELLRTLTGHTGAV---TSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
347-680 2.12e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 2.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 347 SSLVLTILPAKASKKPRLSVLRLRKGILCFDYCPDRNFLVTGGYDAFIRLWNPfVSKRPVWLMKGHQTSVTHILVdSRNN 426
Cdd:COG2319    55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAF-SPDG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 427 SILISVSKDKNIRVWDMLDYICLQSFC--------------GKFFALGNcpitsayffeKDNTL----ICSTYSIGILKG 488
Cdd:COG2319   133 KTLASGSADGTVRLWDLATGKLLRTLTghsgavtsvafspdGKLLASGS----------DDGTVrlwdLATGKLLRTLTG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 489 yleaqglikarkrttHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRktmEFAVSGGQHVEMTAMALDESERCLLTG 568
Cdd:COG2319   203 ---------------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK---LLRTLTGHSGSVRSVAFSPDGRLLASG 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 569 LRDGTMKMWNYNIGKCLLTFPSPEqleiSGIIHM-----NKVFYVTGWSKRIThfLFHKTKPVLLcyHWQTYHTEDILSM 643
Cdd:COG2319   265 SADGTVRLWDLATGELLRTLTGHS----GGVNSVafspdGKLLASGSDDGTVR--LWDLATGKLL--RTLTGHTGAVRSV 336

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2462580353 644 AKYRN-QFLGTSSYSGDILFWNTGTLKPIFNFNASRSP 680
Cdd:COG2319   337 AFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 504-674 2.45e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 2.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 504 HCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAvsgGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGK 583
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK---GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 584 CLLTFPSPEQLEISGIIH-MNKVFYVTGWSKRITHFLFHKTKPVLLCyhwqTYHTEDILSmAKYR--NQFLGTSSYSGDI 660
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSpDGRILSSSSRDKTIKVWDVETGKCLTTL----RGHTDWVNS-VAFSpdGTFVASSSQDGTI 159

                         170
                  ....*....|....
gi 2462580353 661 LFWNTGTLKPIFNF 674
Cdd:cd00200   160 KLWDLRTGKCVATL 173
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 370-442 7.26e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 7.26e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462580353 370 RKGILCFDYCPDRNFLVTGGYDAFIRLWNpFVSKRPVWLMKGHQTSVTHILVdSRNNSILISVSKDKNIRVWD 442
Cdd:cd00200   219 ENGVNSVAFSPDGYLLASGSEDGTIRVWD-LRTGECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
380-589 2.95e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 380 PDRNFLVTGGYDAFIRLWNpfVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFAL 459
Cdd:COG2319     4 ADGAALAAASADLALALLA--AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 460 gncpitSAYFFEKDNTLICSTYSIGILKgYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRk 539
Cdd:COG2319    82 ------LSVAFSPDGRLLASASADGTVR-LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK- 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462580353 540 tmEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFP 589
Cdd:COG2319   154 --LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 201
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 402-442 1.44e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462580353  402 SKRPVWLMKGHQTSVTHILVdSRNNSILISVSKDKNIRVWD 442
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 554-676 5.19e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 5.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580353 554 TAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEqLEISGI--IHMNKVFYVTGWSKRIthFLFHKTKPVLLcyh 631
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT-GPVRDVaaSADGTYLASGSSDKTI--RLWDLETGECV--- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462580353 632 wQTY--HTEDILSMAKYRN-QFLGTSSYSGDILFWNTGTLKPIFNFNA 676
Cdd:cd00200    87 -RTLtgHTSYVSSVAFSPDgRILSSSSRDKTIKVWDVETGKCLTTLRG 133
WD40 pfam00400
WD domain, G-beta repeat;
403-442 1.11e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462580353 403 KRPVWLMKGHQTSVTHILVdSRNNSILISVSKDKNIRVWD 442
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF-SPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 370-398 1.80e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.80e-03
                           10        20
                   ....*....|....*....|....*....
gi 2462580353  370 RKGILCFDYCPDRNFLVTGGYDAFIRLWN 398
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
370-398 4.35e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 4.35e-03
                          10        20
                  ....*....|....*....|....*....
gi 2462580353 370 RKGILCFDYCPDRNFLVTGGYDAFIRLWN 398
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
EF-hand_8 pfam13833
EF-hand domain pair;
67-119 8.54e-03

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 34.98  E-value: 8.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462580353  67 STGALGMDAFIKAMKKV-LSSVSDEMLKELFLKVDSDCEGFVTWQKYVDYMMRE 119
Cdd:pfam13833   1 EKGVITREELKRALALLgLKDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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