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Conserved domains on  [gi|2462568433|ref|XP_054178473|]
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G1/S-specific cyclin-E1 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 100-235 6.72e-100

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 291.40  E-value: 6.72e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 100 SPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQEN 179
Cdd:cd20579     1 SPLPVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462568433 180 VVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLLD 235
Cdd:cd20579    81 VVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALK 136
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 230-308 1.86e-51

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20581:

Pssm-ID: 477360  Cd Length: 114  Bit Score: 166.88  E-value: 1.86e-51
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462568433 230 IMKLLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADED 308
Cdd:cd20581    36 IAELLDLCVLDICCLEFPYGVLAASALYHFSSSELMQKVSGYKWCEIEECVKWMVPFAMAIREVGSSKLKFFKGVAIED 114
 
Name Accession Description Interval E-value
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 100-235 6.72e-100

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 291.40  E-value: 6.72e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 100 SPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQEN 179
Cdd:cd20579     1 SPLPVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462568433 180 VVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLLD 235
Cdd:cd20579    81 VVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALK 136
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 112-235 4.49e-53

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 171.55  E-value: 4.49e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 112 EVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMAtQENVVKTLLQLIGIS 191
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLS-KKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462568433 192 SLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLLD 235
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLN 123
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 230-308 1.86e-51

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410284  Cd Length: 114  Bit Score: 166.88  E-value: 1.86e-51
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462568433 230 IMKLLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADED 308
Cdd:cd20581    36 IAELLDLCVLDICCLEFPYGVLAASALYHFSSSELMQKVSGYKWCEIEECVKWMVPFAMAIREVGSSKLKFFKGVAIED 114
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
111-235 7.27e-26

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 107.55  E-value: 7.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 111 EEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMAtQENVVKTLLQLIGI 190
Cdd:COG5024   182 SDIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLS-SRVVSLEKYQLVGI 260

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462568433 191 SSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLLD 235
Cdd:COG5024   261 SALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLD 305
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 147-232 2.54e-19

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 81.48  E-value: 2.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433  147 DWLMEVCEVYKLHRETFYLAQDFFDRYMaTQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDgaCSGDEILTM 226
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFL-SDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77


                   ....*.
gi 2462568433  227 ELMIMK 232
Cdd:smart00385  78 ERLLLE 83
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 226-315 2.81e-12

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 63.03  E-value: 2.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 226 MELMIMKLLDLCVLDVDCLEFPYGILAASALYHFSS-------SELMQKVSGYQWCDIENCVKWMVPFamVIRETGSSKL 298
Cdd:pfam02984  22 LRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKtlnspewTETLEHYTGYSEEDLKPCVKLLLEL--LLNAPSSKLQ 99

                          90
                  ....*....|....*..
gi 2462568433 299 KHFRGVADEDAHNIQTH 315
Cdd:pfam02984 100 AVRRKYSSSKFMKVSTL 116
 
Name Accession Description Interval E-value
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 100-235 6.72e-100

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 291.40  E-value: 6.72e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 100 SPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQEN 179
Cdd:cd20579     1 SPLPVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462568433 180 VVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLLD 235
Cdd:cd20579    81 VVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALK 136
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 106-235 1.47e-90

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 267.64  E-value: 1.47e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 106 SWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLL 185
Cdd:cd20519     1 SWADSEEVWDLMLKKEELYKRDRDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKTQL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462568433 186 QLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLLD 235
Cdd:cd20519    81 QLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALN 130
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 100-234 1.36e-79

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 239.75  E-value: 1.36e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 100 SPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQEN 179
Cdd:cd20580     1 SPLPELSWGNSKDVWLNMLKKESKYVHDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462568433 180 VVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLL 234
Cdd:cd20580    81 INKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKAL 135
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 112-235 4.49e-53

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 171.55  E-value: 4.49e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 112 EVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMAtQENVVKTLLQLIGIS 191
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLS-KKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462568433 192 SLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLLD 235
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLN 123
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 230-308 1.86e-51

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410284  Cd Length: 114  Bit Score: 166.88  E-value: 1.86e-51
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462568433 230 IMKLLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADED 308
Cdd:cd20581    36 IAELLDLCVLDICCLEFPYGVLAASALYHFSSSELMQKVSGYKWCEIEECVKWMVPFAMAIREVGSSKLKFFKGVAIED 114
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 112-235 5.76e-45

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 150.76  E-value: 5.76e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 112 EVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMAtQENVVKTLLQLIGIS 191
Cdd:cd20507     7 DIYKYLRQLEKKYAIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLS-KKQVPRKKLQLVGVT 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462568433 192 SLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLLD 235
Cdd:cd20507    86 ALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 111-235 8.84e-38

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 131.99  E-value: 8.84e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 111 EEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMaTQENVVKTLLQLIGI 190
Cdd:cd20504     4 DDIYEYLRESELKHRPKPDYMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFL-SQMSVLRSKLQLVGT 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462568433 191 SSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLLD 235
Cdd:cd20504    83 ACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLS 127
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 101-235 2.80e-32

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 117.78  E-value: 2.80e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 101 PLPVLSWANreEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMAtqENV 180
Cdd:cd20568     2 PLMVAEYVP--EIFEYLRELELKTLPNPNYMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLS--KRV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462568433 181 VK-TLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLLD 235
Cdd:cd20568    78 VSlNKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLE 133
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 97-237 2.54e-30

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 112.73  E-value: 2.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433  97 SRGSPLPVLSWANreEVWKIMLNKEKTYLRDQhFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMAT 176
Cdd:cd20508     6 NSDDPFQVSEYAK--DIFDYMKEREEKFVVPD-YLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSK 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462568433 177 qENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLLDLC 237
Cdd:cd20508    83 -KVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 123-234 3.30e-30

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 112.07  E-value: 3.30e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 123 TYLRDQH--------FLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQeNVVKTLLQLIGISSLF 194
Cdd:cd20561    10 TYLREMEvkckpkvgYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSM-SVLRGKLQLVGTAAML 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462568433 195 IAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLL 234
Cdd:cd20561    89 LASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVL 128
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 223-293 1.35e-28

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 106.98  E-value: 1.35e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462568433 223 ILTMELMIMKLLDLCVLDVDCLEFPYGILAASALYH-FSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRET 293
Cdd:cd20520    34 SLDRFVRAAQLLDLCILDIGSLQFSYSVLAASALYLvSPDDEAIEQVTGYSWEQLAPCVEWMTPFAEVLEEE 105
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 111-234 8.25e-28

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 106.85  E-value: 8.25e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 111 EEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQeNVVKTLLQLIGI 190
Cdd:cd20560    38 EDIHQYLREAELKHRPKPGYMRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCM-SVLRGKLQLVGT 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462568433 191 SSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLL 234
Cdd:cd20560   117 AAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 139-234 3.00e-26

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 101.72  E-value: 3.00e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 139 PKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQEnVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGAC 218
Cdd:cd20562    39 PSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNY-VNRQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTY 117

                          90
                  ....*....|....*.
gi 2462568433 219 SGDEILTMELMIMKLL 234
Cdd:cd20562   118 TKQEVLEMEIDVLNAL 133
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 141-234 4.31e-26

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 100.09  E-value: 4.31e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 141 MRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQeNVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSG 220
Cdd:cd20536     1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATT-PVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTR 79

                          90
                  ....*....|....
gi 2462568433 221 DEILTMELMIMKLL 234
Cdd:cd20536    80 EQICNLECIILTKL 93
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 130-235 4.68e-26

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 101.65  E-value: 4.68e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 130 FLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQeNVVKTLLQLIGISSLFIAAKLEEIYPPKLHQ 209
Cdd:cd20567    42 YMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVK-QVPRKELQLVGVTAMLIASKYEEIWAPEVND 120

                          90       100
                  ....*....|....*....|....*.
gi 2462568433 210 FAYVTDGACSGDEILTMELMIMKLLD 235
Cdd:cd20567   121 FVYISDNAYTRKQILVMEKTMLNTLE 146
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
111-235 7.27e-26

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 107.55  E-value: 7.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 111 EEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMAtQENVVKTLLQLIGI 190
Cdd:COG5024   182 SDIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLS-SRVVSLEKYQLVGI 260

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462568433 191 SSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLLD 235
Cdd:COG5024   261 SALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLD 305
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 124-236 4.17e-25

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 98.41  E-value: 4.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 124 YLRDqhfLEQHPLLQPK----------MRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMatQENVV-KTLLQLIGISS 192
Cdd:cd20565    11 YLRQ---LEEEQAVRPKylegqevtgnMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFL--QNNPVpKKMLQLVGVTA 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462568433 193 LFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLLDL 236
Cdd:cd20565    86 MFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNE2_rpt2 cd20582
second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 230-293 7.12e-23

second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410285  Cd Length: 99  Bit Score: 91.37  E-value: 7.12e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462568433 230 IMKLLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRET 293
Cdd:cd20582    36 IAQLLDLCILDINSLDFQYRVLAAAALCHFTSFEVVKKASGLEWDCISECVNWMVPFVRTVREC 99
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 129-236 3.22e-22

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 91.08  E-value: 3.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 129 HFLEQHPLlQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQEnVVKTLLQLIGISSLFIAAKLEEIYPPKLH 208
Cdd:cd20566    28 HYLDGKEI-NERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQP-VSRKKLQLVGVTALLLASKYEEMYSPEIG 105

                          90       100
                  ....*....|....*....|....*...
gi 2462568433 209 QFAYVTDGACSGDEILTMELMIMKLLDL 236
Cdd:cd20566   106 DFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 137-234 1.19e-20

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 86.97  E-value: 1.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 137 LQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMAtQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDG 216
Cdd:cd20515    51 IQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLS-LVPIRKSQLQLLGAVCLFLASKLKETIPLTAEKLCIYTDN 129

                          90
                  ....*....|....*...
gi 2462568433 217 ACSGDEILTMELMIMKLL 234
Cdd:cd20515   130 SITLQELLDWELLVLTKL 147
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 142-235 4.52e-20

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 83.91  E-value: 4.52e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 142 RAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQEnVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGD 221
Cdd:cd20542     1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQK-ISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKK 79

                          90
                  ....*....|....
gi 2462568433 222 EILTMELMIMKLLD 235
Cdd:cd20542    80 QVLRMERRVLRRLR 93
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 147-232 2.54e-19

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 81.48  E-value: 2.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433  147 DWLMEVCEVYKLHRETFYLAQDFFDRYMaTQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDgaCSGDEILTM 226
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFL-SDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77


                   ....*.
gi 2462568433  227 ELMIMK 232
Cdd:smart00385  78 ERLLLE 83
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 111-234 3.97e-19

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 83.11  E-value: 3.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 111 EEVWKIMLNKEKTYLRDQHFLE--QHPLLqPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATqENVVKTLLQLI 188
Cdd:cd20573    23 DRVLQTMLKAEETCLPSVSYFKcvQKEIL-PSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSV-EPTKKSRLQLL 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2462568433 189 GISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLL 234
Cdd:cd20573   101 GATCMFLASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKL 146
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 98-231 7.76e-15

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 71.18  E-value: 7.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433  98 RGSPLPVLSWANReeVWKIMLNKEKTYLRD-QHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMAT 176
Cdd:cd20574    13 RALPDPNLLYDDR--VLQNLLTIEERYLPQcSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAV 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462568433 177 QEnVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIM 231
Cdd:cd20574    91 VP-TRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVL 144
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 98-234 7.85e-15

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 71.17  E-value: 7.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433  98 RGSPLPVLSWANReeVWKIMLNKEKTYL-RDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMAT 176
Cdd:cd20575    13 RAGPDPRLLGDQR--VLQNLLRLEERYVpRVSYFQCVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSC 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462568433 177 QEnVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLL 234
Cdd:cd20575    91 VP-TRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKL 147
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 138-235 8.91e-13

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 63.78  E-value: 8.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 138 QPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMaTQENVVKTLLQLIGISSLFIAAKLEEIYP--PKLHQF-AYVT 214
Cdd:cd20528     3 QLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFM-DRYDISEDQLHLVALTCLLLAAKFEELDDniPKISDLnRYLC 81

                          90       100
                  ....*....|....*....|.
gi 2462568433 215 DGACSGDEILTMELMIMKLLD 235
Cdd:cd20528    82 NSVYSKQEYLQMELLILEFFQ 102
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 226-315 2.81e-12

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 63.03  E-value: 2.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 226 MELMIMKLLDLCVLDVDCLEFPYGILAASALYHFSS-------SELMQKVSGYQWCDIENCVKWMVPFamVIRETGSSKL 298
Cdd:pfam02984  22 LRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKtlnspewTETLEHYTGYSEEDLKPCVKLLLEL--LLNAPSSKLQ 99

                          90
                  ....*....|....*..
gi 2462568433 299 KHFRGVADEDAHNIQTH 315
Cdd:pfam02984 100 AVRRKYSSSKFMKVSTL 116
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 145-228 4.14e-12

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 61.27  E-value: 4.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 145 LLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTlLQLIGISSLFIAAKLEEIyPPKLHQFAYVTDgaCSGDEIL 224
Cdd:cd00043     2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRS-PELIAAACLYLACKLEEL-PRTLKEIAKVSG--VSEKELR 77


                  ....
gi 2462568433 225 TMEL 228
Cdd:cd00043    78 KAEK 81
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 139-226 4.97e-12

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 61.56  E-value: 4.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 139 PKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATqENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGAC 218
Cdd:cd20521     1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMV-RKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTY 79


                  ....*...
gi 2462568433 219 SGDEILTM 226
Cdd:cd20521    80 KYEDVVRM 87
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 141-234 5.90e-11

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 58.73  E-value: 5.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 141 MRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQEnVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSG 220
Cdd:cd20517     5 NRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQ-GTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDCFTN 83

                          90
                  ....*....|....
gi 2462568433 221 DEILTMELMIMKLL 234
Cdd:cd20517    84 LELINQEKDILEAL 97
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 142-235 3.51e-10

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 56.56  E-value: 3.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 142 RAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQE-NVVKT-LLQLIGISSLFIAAKLEEIYPPKLHQFA-YVTDGAC 218
Cdd:cd20543     2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDlPKDKPwMLQLLAVACLSLAAKMEETDVPLLVDLQvEEPKYVF 81

                          90
                  ....*....|....*..
gi 2462568433 219 SGDEILTMELMIMKLLD 235
Cdd:cd20543    82 EAKTIQRMELLVLSTLE 98
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 148-233 1.81e-09

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 54.24  E-value: 1.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 148 WLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKtLLQLIGISSLFIAAKLEE----IypPKLHQFAYVTDGACSGDEI 223
Cdd:cd20526     8 WLAELNSQFKFYPETFALAVSILDRFLASVKARPK-YLRCIAISCLFLAAKTNEedevI--PSTKDLVRVSKCGCSVAEV 84

                          90
                  ....*....|.
gi 2462568433 224 LTMELMIM-KL 233
Cdd:cd20526    85 LRMERIILdKL 95
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 145-235 1.33e-07

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 48.92  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 145 LLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQEnVVKTLLQLIGISSLFIAAKLEEIYP--PKLHQFAYVTDGACSGDE 222
Cdd:cd20559     2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRI-VLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEEL 80

                          90
                  ....*....|...
gi 2462568433 223 ILTMELMIMKLLD 235
Cdd:cd20559    81 FIQMEMHILNTLN 93
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 233-281 2.13e-04

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 39.60  E-value: 2.13e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462568433 233 LLDLCVLDVDCLEFPYGILAASALY--------HFSSSELMQKVSGYQWCDIENCVK 281
Cdd:cd20537    27 LLELSLLDYEFLKYRPSLIAAAALYlarkilgePPPSPQLLQLVTGYSENDLQECAK 83
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 216-283 2.15e-03

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 37.23  E-value: 2.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462568433 216 GACSGDeiLTMELMIMKLLDLCVLDVDCLEFPYGILAASALY---HFSSSE----LMQKVSGYQWCDIENCVKWM 283
Cdd:cd20506    15 QASVPD--LKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFlarHTLNPHpwnpTLEHYTGYKAADLKPCVQAL 87
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 149-235 2.28e-03

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 37.96  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 149 LMEVCEVYKLHRETFYLAQDFFDR-YMatQENVVKTLLQLIGISSLFIAAKLEEIYPPkLHQFAYVTDGA-CSGDEILTM 226
Cdd:cd20524    62 LLEFCRAFKLPDSVLATALTYFKRfYL--KNSVMEYHPKEIMLTCLYLACKVEEFNIS-IDQFVGNIKESeKTAEIILEY 138


                  ....*....
gi 2462568433 227 ELMIMKLLD 235
Cdd:cd20524   139 ELLLLQGLN 147
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 226-299 3.17e-03

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 36.90  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568433 226 MELMIMKLLDLCVLDVDCLEFPYGILAASALY------HFSS--SELMQKVSGYQWCDIENCVKWMVPFAmviRETGSSK 297
Cdd:cd20511    20 LENLAFFLVELGLVEYEMLKYSPSMLAASAVYtarctlNKTPewTSTLEFHTGYSESQLMECARLMVRLH---SKAGTGK 96


                  ..
gi 2462568433 298 LK 299
Cdd:cd20511    97 LT 98
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 161-234 7.34e-03

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 35.59  E-value: 7.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462568433 161 ETFYLAQDFFDRYMATQEnVVKTLLQLIGISSLFIAAKL--EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKLL 234
Cdd:cd20584    21 ETFVLAVNILDRFLALMK-VKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTVSDLKRMEKIISEKL 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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