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Conserved domains on  [gi|2462565740|ref|XP_054177152|]
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fizzy-related protein homolog isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
232-504 5.52e-50

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 5.52e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 232 VLSVGLGTCVYLWSACTSQVTRLcdLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW 311
Cdd:COG2319    93 LASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 312 NA--EQLSSGSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAA 389
Cdd:COG2319   171 SPdgKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 390 VKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQV 468
Cdd:COG2319   249 VRSVAFSPDGR-LLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLL 323

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2462565740 469 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 504
Cdd:COG2319   324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
232-504 5.52e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 5.52e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 232 VLSVGLGTCVYLWSACTSQVTRLcdLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW 311
Cdd:COG2319    93 LASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 312 NA--EQLSSGSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAA 389
Cdd:COG2319   171 SPdgKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 390 VKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQV 468
Cdd:COG2319   249 VRSVAFSPDGR-LLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLL 323

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2462565740 469 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 504
Cdd:COG2319   324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 225-503 2.92e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.79  E-value: 2.92e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 225 VDWSSLN--VLSVGLGTCVYLWSACTSQVtrLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGH 302
Cdd:cd00200    15 VAFSPDGklLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 303 TARVGALAWNAEQ--LSSGSRDRMILQRDIRTPplQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPV 380
Cdd:cd00200    93 TSYVSSVAFSPDGriLSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 381 QQYTEHLAAVKAIAWSPHQHGLLASGGgtaDRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILV 459
Cdd:cd00200   171 ATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLAS--GSEDGTIRV 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2462565740 460 WKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 503
Cdd:cd00200   246 WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 334-373 1.10e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.10e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462565740  334 PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 373
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 328-504 4.33e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 4.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 328 RDIRTPPLQserrLQGhRQEVCGLKW-STDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASg 406
Cdd:PLN00181  520 RDIHYPVVE----LAS-RSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS- 593

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 407 gGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVStHGYSQNQILVW--KYPSLTqVAKLTGHSYRVLYLAMS 484
Cdd:PLN00181  594 -GSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSYVRFV 670

                         170       180
                  ....*....|....*....|
gi 2462565740 485 pDGEAIVTGAGDETLRFWNV 504
Cdd:PLN00181  671 -DSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
336-373 1.07e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462565740 336 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 373
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
232-504 5.52e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 5.52e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 232 VLSVGLGTCVYLWSACTSQVTRLcdLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW 311
Cdd:COG2319    93 LASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 312 NA--EQLSSGSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAA 389
Cdd:COG2319   171 SPdgKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 390 VKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQV 468
Cdd:COG2319   249 VRSVAFSPDGR-LLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLL 323

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2462565740 469 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 504
Cdd:COG2319   324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
241-504 2.10e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.01  E-value: 2.10e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 241 VYLWSACTSQVTRlcDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNA--EQLSS 318
Cdd:COG2319   144 VRLWDLATGKLLR--TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKLLAS 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 319 GSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPH 398
Cdd:COG2319   222 GSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 399 QHgLLASGGgtADRCIRFWNTLTGQPLQCID-TGSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYR 477
Cdd:COG2319   300 GK-LLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELLRTLTGHTGA 374

                         250       260
                  ....*....|....*....|....*..
gi 2462565740 478 VLYLAMSPDGEAIVTGAGDETLRFWNV 504
Cdd:COG2319   375 VTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
257-504 7.59e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 7.59e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 257 LSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPP 334
Cdd:COG2319    74 LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGK 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 335 LQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCI 414
Cdd:COG2319   154 LL--RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK-LLASGS--ADGTV 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 415 RFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTG 493
Cdd:COG2319   229 RLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLAS--GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG 306

                         250
                  ....*....|.
gi 2462565740 494 AGDETLRFWNV 504
Cdd:COG2319   307 SDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 225-503 2.92e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.79  E-value: 2.92e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 225 VDWSSLN--VLSVGLGTCVYLWSACTSQVtrLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGH 302
Cdd:cd00200    15 VAFSPDGklLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 303 TARVGALAWNAEQ--LSSGSRDRMILQRDIRTPplQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPV 380
Cdd:cd00200    93 TSYVSSVAFSPDGriLSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 381 QQYTEHLAAVKAIAWSPHQHGLLASGGgtaDRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILV 459
Cdd:cd00200   171 ATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLAS--GSEDGTIRV 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2462565740 460 WKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 503
Cdd:cd00200   246 WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 262-504 9.18e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 9.18e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 262 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPplQSER 339
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETG--ECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 340 RLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWNT 419
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSS--QDGTIKLWDL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 420 LTGQPLQCIdTG--SQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDE 497
Cdd:cd00200   165 RTGKCVATL-TGhtGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241


                  ....*..
gi 2462565740 498 TLRFWNV 504
Cdd:cd00200   242 TIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
243-504 1.61e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.27  E-value: 1.61e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 243 LWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGS 320
Cdd:COG2319    18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFspDGRLLASAS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 321 RDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQH 400
Cdd:COG2319    98 ADGTVRLWDLATGLLL--RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 401 gLLASGGgtADRCIRFWNTLTGQPLQCID-TGSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVL 479
Cdd:COG2319   176 -LLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLAS--GSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                         250       260
                  ....*....|....*....|....*
gi 2462565740 480 YLAMSPDGEAIVTGAGDETLRFWNV 504
Cdd:COG2319   251 SVAFSPDGRLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 299-504 7.06e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 7.06e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 299 LEGHTARVGALAWNAEQ--LSSGSRDRMILQRDIRTPplQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSS 376
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 377 LSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSkHANELVSThGYSQN 455
Cdd:cd00200    83 GECVRTLTGHTSYVSSVAFSPDGR-ILSSSS--RDKTIKVWDVETGKCLTTLRGhTDWVNSVAFS-PDGTFVAS-SSQDG 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2462565740 456 QILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 504
Cdd:cd00200   158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
268-504 5.87e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 5.87e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 268 GWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQE 347
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 348 VCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQC 427
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGS--ADGTVRLWDLATGKLLRT 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462565740 428 IDTGSQ-VCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 504
Cdd:COG2319   158 LTGHSGaVTSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
WD40 COG2319
WD40 repeat [General function prediction only];
232-419 7.75e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 7.75e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 232 VLSVGLGTCVYLWSActSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW 311
Cdd:COG2319   219 LASGSADGTVRLWDL--ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 312 --NAEQLSSGSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAA 389
Cdd:COG2319   297 spDGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                         170       180       190
                  ....*....|....*....|....*....|
gi 2462565740 390 VKAIAWSPHQHgLLASGGgtADRCIRFWNT 419
Cdd:COG2319   375 VTSVAFSPDGR-TLASGS--ADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 337-504 9.63e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.04  E-value: 9.63e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 337 SERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGGtaDRCIRF 416
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT-YLASGSS--DKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 417 WNTLTGQPLQCIdTG--SQVCNLAWSKHaNELVSThGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA 494
Cdd:cd00200    78 WDLETGECVRTL-TGhtSYVSSVAFSPD-GRILSS-SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154

                         170
                  ....*....|
gi 2462565740 495 GDETLRFWNV 504
Cdd:cd00200   155 QDGTIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
354-506 5.40e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 5.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 354 STDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRciRFWNTLTGQPLQCIDTGSQ 433
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLL--LLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462565740 434 VCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFS 506
Cdd:COG2319    81 VLSVAFSPDGRLLAS--ASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 334-373 1.10e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.10e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462565740  334 PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 373
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 328-504 4.33e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 4.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 328 RDIRTPPLQserrLQGhRQEVCGLKW-STDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASg 406
Cdd:PLN00181  520 RDIHYPVVE----LAS-RSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS- 593

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565740 407 gGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVStHGYSQNQILVW--KYPSLTqVAKLTGHSYRVLYLAMS 484
Cdd:PLN00181  594 -GSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSYVRFV 670

                         170       180
                  ....*....|....*....|
gi 2462565740 485 pDGEAIVTGAGDETLRFWNV 504
Cdd:PLN00181  671 -DSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
336-373 1.07e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462565740 336 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 373
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 464-503 2.44e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.44e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462565740  464 SLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 503
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
466-503 7.81e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 7.81e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462565740 466 TQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 503
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 376-418 1.49e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.49e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462565740  376 SLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWN 418
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGS--DDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 260-312 1.49e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.03  E-value: 1.49e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462565740 260 EGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN 312
Cdd:pfam12894  37 EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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