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Conserved domains on  [gi|2462564525|ref|XP_054176561|]
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zinc finger protein interacting with ribonucleoprotein K isoform X3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142358)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-413 5.12e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 5.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564525 233 CNECGKFFSQTSHLNDHRR--IHTGE--RPYECSE--CGKLFRQNSSLVDHQKIHTGARPYEC--SQCGKSFSQKATLVK 304
Cdd:COG5048   292 SKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEP 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564525 305 HQRVhtgerpykcgecgnsfsqsailnQHRRIHTGAKPYEC--GQCGKSFSQKATLIKHQRVHTGERPY--KCGDCGKSF 380
Cdd:COG5048   372 PQSL-----------------------QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSF 428

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2462564525 381 SQSSILIQHRRIHTGARPYECGQCGKSFSQKSG 413
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-242 5.23e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462564525 217 SLVQHQRVHTGERPWECNECGKFFSQ 242
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-413 5.12e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 5.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564525 233 CNECGKFFSQTSHLNDHRR--IHTGE--RPYECSE--CGKLFRQNSSLVDHQKIHTGARPYEC--SQCGKSFSQKATLVK 304
Cdd:COG5048   292 SKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEP 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564525 305 HQRVhtgerpykcgecgnsfsqsailnQHRRIHTGAKPYEC--GQCGKSFSQKATLIKHQRVHTGERPY--KCGDCGKSF 380
Cdd:COG5048   372 PQSL-----------------------QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSF 428

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2462564525 381 SQSSILIQHRRIHTGARPYECGQCGKSFSQKSG 413
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-270 1.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.81e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462564525 245 HLNDHRRIHTGERPYECSECGKLFRQ 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-242 5.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462564525 217 SLVQHQRVHTGERPWECNECGKFFSQ 242
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-413 5.12e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 5.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564525 233 CNECGKFFSQTSHLNDHRR--IHTGE--RPYECSE--CGKLFRQNSSLVDHQKIHTGARPYEC--SQCGKSFSQKATLVK 304
Cdd:COG5048   292 SKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEP 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564525 305 HQRVhtgerpykcgecgnsfsqsailnQHRRIHTGAKPYEC--GQCGKSFSQKATLIKHQRVHTGERPY--KCGDCGKSF 380
Cdd:COG5048   372 PQSL-----------------------QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSF 428

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2462564525 381 SQSSILIQHRRIHTGARPYECGQCGKSFSQKSG 413
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-430 2.16e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564525 234 NECGKFFSQTSHLNDHRRIHTGERPYECSECGKlFRQNSSLVDHQKIHTGARPYECSQCGKSFSQKATLVKHQRVHTGER 313
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564525 314 PYKCGECGNSFSQSAILNQHRRIHTGA-------KPYECGQCGKSFSQKATLIKHQR--VHTGE--RPYKCG--DCGKSF 380
Cdd:COG5048   254 SSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLF 333

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462564525 381 SQSSILIQHRRIHTGARPYEC--GQCGKSFSQKS-----GLIQHQVVHTGERPYECN 430
Cdd:COG5048   334 SRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETL 390
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-300 5.89e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 5.89e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462564525 229 RPWECNECGKFFSQTSHLNDHRRIHTGERPYECS--ECGKLFRQNSSLVDHQKIHTGARPYECSQCGKSFSQKA 300
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-270 1.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.81e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462564525 245 HLNDHRRIHTGERPYECSECGKLFRQ 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
358-382 3.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.08e-03
                          10        20
                  ....*....|....*....|....*
gi 2462564525 358 LIKHQRVHTGERPYKCGDCGKSFSQ 382
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
330-354 3.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.78e-03
                          10        20
                  ....*....|....*....|....*
gi 2462564525 330 LNQHRRIHTGAKPYECGQCGKSFSQ 354
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-242 5.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462564525 217 SLVQHQRVHTGERPWECNECGKFFSQ 242
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
302-326 5.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.55e-03
                          10        20
                  ....*....|....*....|....*
gi 2462564525 302 LVKHQRVHTGERPYKCGECGNSFSQ 326
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 287-309 8.18e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.18e-03
                          10        20
                  ....*....|....*....|...
gi 2462564525 287 YECSQCGKSFSQKATLVKHQRVH 309
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 343-365 8.18e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.18e-03
                          10        20
                  ....*....|....*....|...
gi 2462564525 343 YECGQCGKSFSQKATLIKHQRVH 365
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-298 8.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462564525 273 SLVDHQKIHTGARPYECSQCGKSFSQ 298
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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