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Conserved domains on  [gi|2462562121|ref|XP_054175407|]
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putative zinc finger protein 730 isoform X2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 9.71e-33

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.85  E-value: 9.71e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462562121   13 LTFRDVAIEFSLEEWQCLDTEQQNLYRNVMLDNYRNLVFLGIAVSKPDLITCLEQEKEPWN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-507 3.13e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 152 KIFQCDKYVKVFHKFSNSNRHKIRHTSKKPFKC--KECGKLFCILSHLAQHKKIHTGEKSYKCE------EYGKAFNESS 223
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 224 NCTTH------------------------KRITEKKPYKCKEC------GKAFNWFSH----------------FTTHKR 257
Cdd:COG5048   112 SSSSNsndnnllsshslppssrdpqlpdlLSISNLRNNPLPGNnsssvnTPQSNSLHPplpanslskdpssnlsLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 258 IHTGEKPYQCEKCGKFFNQSTNLTTHKRIHTGEKPYKCEECGKAFNQSSNLTEHKKIHTKEQPYKCEKCGKAFKWSSTLT 337
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 338 KHKRIHNGE-------KPYKCEECGKAFNRSSTLNRHK--ITHTGE--KPY--KYKECGKAFNQSSTLTIHKIIHTVEKF 404
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFscPYSLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 405 YKC--EECGKAFSRISH-----LITHKRIHTGEKPYKCE--ECGRAFNQSSTLTTHKRIHTGEKPYECE--ECGKAFNRS 473
Cdd:COG5048   352 AKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2462562121 474 STLTTHKIIHSgEKIYKCKECGKAFRRFSHLTRH 507
Cdd:COG5048   432 YNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 9.71e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.85  E-value: 9.71e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462562121   13 LTFRDVAIEFSLEEWQCLDTEQQNLYRNVMLDNYRNLVFLGIAVSKPDLITCLEQEKEPWN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 2.88e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.67  E-value: 2.88e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462562121  13 LTFRDVAIEFSLEEWQCLDTEQQNLYRNVMLDNYRNLVFLG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 2.63e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 2.63e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462562121  13 LTFRDVAIEFSLEEWQCLDTEQQNLYRNVMLDNYRNLVFL 52
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-507 3.13e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 152 KIFQCDKYVKVFHKFSNSNRHKIRHTSKKPFKC--KECGKLFCILSHLAQHKKIHTGEKSYKCE------EYGKAFNESS 223
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 224 NCTTH------------------------KRITEKKPYKCKEC------GKAFNWFSH----------------FTTHKR 257
Cdd:COG5048   112 SSSSNsndnnllsshslppssrdpqlpdlLSISNLRNNPLPGNnsssvnTPQSNSLHPplpanslskdpssnlsLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 258 IHTGEKPYQCEKCGKFFNQSTNLTTHKRIHTGEKPYKCEECGKAFNQSSNLTEHKKIHTKEQPYKCEKCGKAFKWSSTLT 337
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 338 KHKRIHNGE-------KPYKCEECGKAFNRSSTLNRHK--ITHTGE--KPY--KYKECGKAFNQSSTLTIHKIIHTVEKF 404
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFscPYSLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 405 YKC--EECGKAFSRISH-----LITHKRIHTGEKPYKCE--ECGRAFNQSSTLTTHKRIHTGEKPYECE--ECGKAFNRS 473
Cdd:COG5048   352 AKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2462562121 474 STLTTHKIIHSgEKIYKCKECGKAFRRFSHLTRH 507
Cdd:COG5048   432 YNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-304 1.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462562121 279 NLTTHKRIHTGEKPYKCEECGKAFNQ 304
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 9.71e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.85  E-value: 9.71e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462562121   13 LTFRDVAIEFSLEEWQCLDTEQQNLYRNVMLDNYRNLVFLGIAVSKPDLITCLEQEKEPWN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 2.88e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.67  E-value: 2.88e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462562121  13 LTFRDVAIEFSLEEWQCLDTEQQNLYRNVMLDNYRNLVFLG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 2.63e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 2.63e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462562121  13 LTFRDVAIEFSLEEWQCLDTEQQNLYRNVMLDNYRNLVFL 52
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-507 3.13e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 152 KIFQCDKYVKVFHKFSNSNRHKIRHTSKKPFKC--KECGKLFCILSHLAQHKKIHTGEKSYKCE------EYGKAFNESS 223
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 224 NCTTH------------------------KRITEKKPYKCKEC------GKAFNWFSH----------------FTTHKR 257
Cdd:COG5048   112 SSSSNsndnnllsshslppssrdpqlpdlLSISNLRNNPLPGNnsssvnTPQSNSLHPplpanslskdpssnlsLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 258 IHTGEKPYQCEKCGKFFNQSTNLTTHKRIHTGEKPYKCEECGKAFNQSSNLTEHKKIHTKEQPYKCEKCGKAFKWSSTLT 337
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 338 KHKRIHNGE-------KPYKCEECGKAFNRSSTLNRHK--ITHTGE--KPY--KYKECGKAFNQSSTLTIHKIIHTVEKF 404
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFscPYSLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 405 YKC--EECGKAFSRISH-----LITHKRIHTGEKPYKCE--ECGRAFNQSSTLTTHKRIHTGEKPYECE--ECGKAFNRS 473
Cdd:COG5048   352 AKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2462562121 474 STLTTHKIIHSgEKIYKCKECGKAFRRFSHLTRH 507
Cdd:COG5048   432 YNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
193-452 7.08e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 7.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 193 ILSHLAQHKKIHTGEKSYKCEeygkafNESSNCTTHKRITEKKPYKCKECGKAFNWFSHFTTHKRIHTG-EKPYQCEKCG 271
Cdd:COG5048   223 SSSSLPLTTNSQLSPKSLLSQ------SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCN 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 272 KFFNQSTNLTTHKR--IHTGE--KPYKCEE--CGKAFNQSSNLTEHKKIHTKEQPYKCekcgkafKWSSTLTKHKRIHNG 345
Cdd:COG5048   297 ISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE-------KLLNSSSKFSPLLNN 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 346 EkpykceecgkafNRSSTLNRHKITHTGEKPYKYKECGKAFNQSSTLTIHKIIHTVEKFY--KCEECGKAFSRISHLITH 423
Cdd:COG5048   370 E------------PPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPH 437

                         250       260
                  ....*....|....*....|....*....
gi 2462562121 424 KRIHTGEKPYKCEECGRAFNQSSTLTTHK 452
Cdd:COG5048   438 KKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
263-512 1.82e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 263 KPYQCEKCGKFFNQSTNLTTHKRIHTGEKPYKC--EECGKAFNQSSNLTEHKKIHTKEQPYKCEKCGKAFK-WSSTLTKH 339
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNsKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 340 KRIHNGEKPYKCEECGKAF--NRSSTLNRHKITHTGEKPYKYK---------------------ECGKAFNQSSTLTIHK 396
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPssRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpansLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 397 IIHTVEKFYKCEECGKaFSRISHLITHKRIHTGEKPYKCEECGRAF-------NQSSTLTTHKRIHTGE----------- 458
Cdd:COG5048   192 VSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASEsprsslptass 270

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462562121 459 -----------------KPYECEECGKAFNRSSTLTTHK--IIHSGE--KIYKCKE--CGKAFRRFSHLTRHKTIHT 512
Cdd:COG5048   271 qssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
178-492 5.06e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 5.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 178 SKKPFKCKECGKLFCILSHLAQHKKIHTGEKSYKCEEYG--KAFNESSNCTTHKRITEKKPY--KCKECGKAFNWFSHFT 253
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGcdKSFSRPLELSRHLRTHHNNPSdlNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 254 THKRIHTGEKPYQCEKCGkfFNQSTNLTTHKRIHTGEKPYKCEECGKAFNQSSNLTEHKKIHTKEQPykcEKCGKAFKWS 333
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHS--LPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 334 STLTKHKRIHNGEKPYKCEECG---KAFNRSSTLNRHKITHTGEKPYKYKECGKAFNQSSTLTIHKIIHTVE--KFYKCE 408
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSssySIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSasESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 409 ECGKAFSRISHLITHKRIHTG-EKPYKCEECGRAFNQSSTLTTHKR--IHTGE--KPYECEE--CGKAFNRSSTLTTHKI 481
Cdd:COG5048   265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330
                  ....*....|.
gi 2462562121 482 IHSGEKIYKCK 492
Cdd:COG5048   345 LHTSISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-304 1.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462562121 279 NLTTHKRIHTGEKPYKCEECGKAFNQ 304
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 289-372 2.52e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462562121 289 GEKPYKCE--ECGKAFNQSSNLTEHKKiHTKEQPYKCEkcgkafkwSSTLTKHKRIHNGEKPYKCEECGKAFNRSSTLNR 366
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 2462562121 367 HkITHT 372
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
448-472 8.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.63e-04
                          10        20
                  ....*....|....*....|....*
gi 2462562121 448 LTTHKRIHTGEKPYECEECGKAFNR 472
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
419-444 9.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.62e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462562121 419 HLITHKRIHTGEKPYKCEECGRAFNQ 444
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
336-360 2.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.07e-03
                          10        20
                  ....*....|....*....|....*
gi 2462562121 336 LTKHKRIHNGEKPYKCEECGKAFNR 360
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-368 2.30e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462562121 296 EECGKAFNQSSNLTeHKKIHTKEQPYKCEKCGKAFKWSSTLTKHKRIHNGEKPYKCEECGKAFNRSSTLNRHK 368
Cdd:COG5048    10 SSNNSVLSSTPKST-LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSR 81
zf-H2C2_2 pfam13465
Zinc-finger double domain;
364-388 4.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.49e-03
                          10        20
                  ....*....|....*....|....*
gi 2462562121 364 LNRHKITHTGEKPYKYKECGKAFNQ 388
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
251-276 4.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.77e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462562121 251 HFTTHKRIHTGEKPYQCEKCGKFFNQ 276
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
307-331 5.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.11e-03
                          10        20
                  ....*....|....*....|....*
gi 2462562121 307 NLTEHKKIHTKEQPYKCEKCGKAFK 331
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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